070300|化学专业硕士研究生指导教师ClickNum:360
姓名于京华性别女
民族汉族出生年月1963-04
学历|学位研究生|博士专业技术职务教授
行政职务
联系电话**移动电话**
邮箱chm_yujh@ujn.edu.cn
通讯地址 | 邮编山东省济南市南辛庄西路336号济南大学化学化工学院 | 250022
招生方向(领域)01无机化学,02分析化学,07食品安全与检测,08能源材料化学
研究领域、学习工作经历、学术兼职等情况致力于分析化学方法的理论和应用研究，自主进行了多项原创性的研究，获得了重要的科学发现。在国际上率先开展了微流控纸芯片的准确定量分析、高性能纸电极的制备、特异性识别功能聚合物的设计、便携检测仪器开发的研究。成果受到广泛关注和认可，特别是所研究的纸芯片实验室及与便携设备的设计组装在国际上得到极高的评价，为实现低成本的现场快速检测监控做出了较为突出的贡献。目前主要研究领域包括：

1. 食品安全的检验与控制

利用各种化学传感器与光分析或电化学分析相结合，实现对食品中有害成分的特效识别、快速简便、多组分的在线同时检测，为食品安全问题提供可靠的检测手段。

2. 新型仿生传感器的构建及应用

研究开发新型功能化材料仿生传感器，具有性能好、寿命长、耐酸耐碱、耐高温等特点。可应用于实际样品农药残留检测和药物控释。

3. 化学传感器的开发及利用

致力于高灵敏度、痕量物质的分析方法的建立，开发具有各种功能的新型化学传感器，实现现场即时食品与环境样品多组分同时监测。

4. 生物免疫传感器

利用免疫技术对肿瘤标志物、DNA等生物物质进行测定，基于新型功能纳米材料构建免疫传感器，实现对生命物质的快速、方便的检测。


代表性科研成果及奖励：
（包括项目、鉴定、论文、专著、专利等)主要从事新型仿生传感器的构建及应用、新型免疫分析技术的研究、食品安全的检验与控制。先后主持和参加了多项国家自然科学基金、国家十一五科技支撑计划子课题、国家“863”计划、“973”项目子课题等多项国家级和省级项目。参加的研究课题先后获得国家技术发明二等奖1项，山东省技术发明一等奖1项，省科技进步一等奖1项，省部级科技进步二等、三等奖3项，第一发明人发明专利10项（含受理）。

主持省级以上项目：

1.基于纸芯片实验室的电致化学发光免疫分析研究-国家自然科学基金-（**）

2.基于微流控纸芯片的持久性有机氯农药残留光致电检测-国家自然科学基金-（**）

3.基于分子自组装微球的自修复水泥材料的研究-国家自然科学基金-（**）

4.农药残留现场检测微流控纸芯片的应用基础研究-山东省自然科学基金重点项目-（ZR2012BZ002）

5.高通量电致化学发光多元免疫分析系统的开发及其应用-山东省科技发展计划-（2011GGB01153）

6.新型试剂的合成及流动注射化学发光法在药物分析中的应用-山东省自然科学基金-（Y2007B07）

7.罗丹宁类衍生物的合成与荧光特性及其量子化学研究-山东省自然科学基金-（Y2003B01）

代表性论文：
1. Lei Ge, Shoumei Wang, Jinghua Yu*, Nianqiang Li, Shenguang Ge, Mei Yan. Molecularly Imprinted Polymer Grafted Porous Au-Paper Electrode for an Microfl uidic Electro-Analytical Origami Device[J], Advanced Functional Materials, 2013, 23, 3115-3123. (IF=9.765)

2. Mei Yan, Lei Ge, Weiqiang Gao, Jinghua Yu*, Xianrang Song, Shenguang Ge, Zhiyong Jia, and Chengchao Chu. Electrogenerated Chemiluminescence from phenyleneethynylene derivative and Its Ultrasensitive Immunosensing Application Using Nanotubular Mesoporous Pt-Ag Alloy for Signal Amplification[J], Advanced Functional Materials, 2012, 22, 3899-3906. (IF=9.765) (封面文章)

3. Lei Ge, Jixian Yan, Xianrang Song, Mei Yan, Shenguang Ge, Jinghua Yu*. Three-dimensional paper-based electrochemiluminescence immunodevice for multiplexed measurement of biomarkers and point-of-care testing[J], Biomaterials, 2012, 33, 1024-1031. (IF=7.604)

4. Dejin Zang, Lei Ge, Mei Yan, Xianrang Song, Jinghua Yu*. Electrochemical immunoassay on a 3D microfluidic paper-based device[J], Chem. Commun., 2012, 48, 4683-4685. (IF=6.378) (封面文章)

5. Shaowei Wang, Weijian Dai, Lei Ge, Mei Yan, Jinghua Yu*, Xianrang Song, Shenguang Ge, Jiadong Huang. Rechargeable battery-triggered electrochemi- luminescence detection on microfluidic origami immunodevice based on two electrodes[J], Chem. Commun., 2012, 48, 9971-9973. (IF=6.378) (封面文章)

6. Panpan Wang, Lei Ge, Shenguang Ge, Jinghua Yu*, Mei Yan, Jiadong Huang. A paper-based photoelectrochemical immunoassay for low-cost and multiplexed point-of-care testing[J], Chem. Commun., 2013, 49, 3294-3296. (IF=6.378) (封面文章)

7. Jixian Yan, Mei Yan, Lei Ge, Jinghua Yu*, Shenguang Ge and Jiadong Huang. A microfluidic origami electrochemiluminescence aptamer-device based on a porous Au-paper electrode and a phenyleneethynylene derivative[J], Chem. Commun., 2013, 49, 1383-1385. (IF=6.378) (封面文章)

8. Weiping Li, Long Li, Shenguang Ge, Xianrang Song, Lei Ge, Mei Yan and Jinghua Yu*. A 3D origami multiple electrochemiluminescence immunodevice based on a porous silver-paper electrode and multi-labeled nanoporous gold–carbon spheres[J], Chem. Commun., 2013, 49, 7687-7689. (IF=6.378) (封面文章)

9. Shenguang Ge, Lei Ge, Mei Yan, Xianrang Song, Jinghua Yu*, Jiadong Huang. A Disposable Paper-based Electrochemical Sensor with Addressable Electrode Array for Cancer Screening[J], Chem. Commun., 2012, 48, 9397-9399. (IF=6.378)

10. Jinghua Yu*, Lei Ge, Jiadong Huang, Shoumei Wanga and Shenguang Ge. Microfluidic paper-based chemiluminescence biosensor for simultaneous determination of glucose and uric acid[J], Lab on a Chip, 2011, 11, 1286-1291. (IF=5.697)

11.Yanhu Wang, Lei Ge, Panpan Wang, Mei Yan, Shenguang Ge, Nianqiang Li, Jinghua Yu*, Jiadong Huang. Photoelectrochemical lab-on-paper device equipped with a porous Au-paper electrode and fluidic delayswitch for sensitive detection of DNA hybridization3[J], Lab on a Chip, 2013, 13, 3945-3955. (IF=5.697)

12. Lei Ge, Panpan Wang, Shenguang Ge, Nianqiang Li, Jinghua Yu*, Mei Yan and Jiadong Huang. Photoelectrochemical Lab-on-Paper Device Based on an Integrated Paper Supercapacitor and Internal Light Source[J], Anal. Chem., 2013, 85, 3961-3970. (IF=5.695)

13. Mei Yan, Weiqiang Gao, Shenguang Ge, Lei Ge, Chengchao Chu, Jinghua Yu*, Xianrang Song, Shengnan Hou. A novel conjugated polyfluorene: synthesis, characterization and application in label-free ECL immunoassays for biomarker detection[J], Journal of Materials Chemistry, 2012, 22, 5568-5573. (IF=6.101)

14. Jixian Yan, Lei Ge, Xianrang Song, Mei Yan, Shenguang Ge, Jinghua Yu*. Paper-Based Electrochemiluminescent 3D Immunodevice for Lab-on-Paper, Specific, and Sensitive Point-of-Care Testing[J], Chemistry A European Journal, 2012, 18, 4938-4945. (IF=5.831)

15. Lei Ge, Shoumei Wang, Xianrang Song, Shenguang Ge and Jinghua Yu*. 3D Origami-based multifunction-integrated immunodevice: low-cost and multiplexed sandwich chemiluminescence immunoassay on microfluidic paperbased analytical device[J], Lab on a Chip, 2012, 12, 3150-3158. (IF=5.697)

16. Mei Yan, Dejin Zang, Shenguang Ge, Lei Ge, Jinghua Yu*. A disposable electrochemical immunosensor based on carbon screen-printed electrodes for the detection of prostate specific antigen[J], Biosensors and Bioelectronics, 2012, 38, 355-361. (IF=5.437)

17. Shaowei Wang, Lei Ge, Yan Zhang, Xianrang Song, Nianqiang Li, Shenguang Ge, Jinghua Yu*. Battery-triggered microfluidic paper-based multiplex electrochemi- luminescence immunodevice based on potential-resolution strategy[J], Lab on a Chip, 2012, 12, 4489-4498. (IF=5.697)

18. Shenguang Ge, Mei Yan, Juanjuan Lu, Meng Zhang, Feng Yu, Jinghua Yu*, Xianrang Song, Shilin Yu. Electrochemical Biosensor Based on Graphene Oxide-Au Nanoclusters Composites for L-Cysteine Analysis. Biosensors and Bioelectronics, 2012, 31, 49-54. (IF=5.437)

19. Meng Zhang, Lei Ge, Shenguang Ge , Mei Yan , Jinghua Yu*, Jiadong Huang , Su Liu. Three-dimensional paper-based electrochemiluminescence device for simultaneous detection of Pb²⁺ and Hg²⁺ based on potential-control technique[J], Biosensors and Bioelectronics, 2013, 41, 544-550. (IF=5.437)

20. Yan Zhang, Weiyan Liu , Shenguang Ge , Mei Yan, Shaowei Wang, Jinghua Yu*, Nianqiang Li*, Xianrang Song. Multiplexed sandwich immunoassays using flow-injection electrochemiluminescence with designed substrate spatial-resolved technique for detection of tumor markers[J], Biosensors and Bioelectronics, 2013, 41, 684-690. (IF=5.437)

21. Shoumei Wang, Lei Ge, Long Li, Mei Yan, Shenguang Ge, Jinghua Yu*. Molecularly imprinted polymer grafted paper-based multi-disk micro-disk plate for chemiluminescence detection of pesticide[J], Biosensors and Bioelectronics, 2013, 50, 262-268. (IF=5.437)

22. Shenguang Ge, Lei Ge, Mei Yan, Xianrang Song , Jinghua Yu*, Shanshan Liu. A disposable immunosensor device for point-of-care test of tumor marker based on copper-mediated amplification[J], Biosensors and Bioelectronics, 2013, 43,425-431. (IF=5.437)

23. Juanjuan Lu, Mei Yan, Lei Ge, Shenguang Ge, Shaowei Wang, Jixian Yan, Jinghua Yu*. Electrochemiluminescence of blue-luminescent graphene quantum dots and its application in ultrasensitive aptasensor for adenosine triphosphate detection[J], Biosensors and Bioelectronics, 2013, 47, 271-277. (IF=5.437)

24. Meng Zhang, Heng Liu, Long Chen, Mei Yan, Lei Ge, Shenguang Ge, Jinghua Yu*. A disposable electrochemiluminescence device for ultrasensitive monitoring of K562 leukemia cells based on aptamers and ZnO@carbon quantum dots[J], Biosensors and Bioelectronics, 2013, 49, 79-85. (IF=5.437)

25. Shenguang Ge, Weiyan Liu, Lei Ge, Mei Yan, Jixian Yan, Jiadong Huang, Jinghua Yu*. In situ assembly of porous Au-paper electrode and functionalization of magnetic silica nanoparticles with HRP via click chemistry for Microcystin-LR immunoassay[J], Biosensors and Bioelectronic, 2013, 49, 111-117. (IF=5.437)

26. Yan Zhang, Min Su, Lei Ge, Shenguang Ge, Jinghua Yu*, Xianrang Song. Synthesis and characterization of graphene nanosheets attached to spiky MnO₂ nanospheres and its application in ultrasensitive immunoassay[J], Carbon, 2013, 57, 22-33. (IF=5.868)

27. Juanjuan Lu, Shiquan Liu, Shenguang Ge, Mei Yan, Jinghua Yu*, Xiutao Hu. Ultrasensitive Electrochemical Immunosensor based on Au nanoparticals dotted carbon nanotube-graphene composite and functionalized mesoporous materials[J], Biosensors and Bioelectronics, 2012, 33, 29-35. (IF=5.437)

28. Panpan Wang, Lei Ge, Mei Yan, Xianrang Song, Shenguang Ge, Jinghua Yu*. Paper-based three-dimensional electrochemical immunodevice based on multi-walled carbon nanotubes functionalized paper for sensitive point-of-care testing[J], Biosensors and Bioelectronics, 2012, 32, 238-243. (IF=5.437)

29. Shoumei Wang, Lei Ge, Xianrang Song, Jinghua Yu*, Shenguang Ge, Jiadong Huang, Fang Zeng. Paper-based chemiluminescence ELISA: Lab-on-paper based on chitosan modi?ed paper device and wax-screen-printing[J], Biosensors and Bioelectronics, 2012, 31, 212-218. (IF=5.437)

30. Fang Liu, Yan Zhang, Jinghua Yu*, Shaowei Wang, Shenguang Ge, XianrangSong. Application of ZnO/graphene and S6 aptamers for sensitive photoelectrochemical detection of SK-BR-3 breast cancer cells based on a disposable indium tin oxide device[J]. Biosensors and Bioelectronics, 2014,51，413-420. (IF=5.437)
教学及研究生培养情况主持完成了“山东省精品课程-分析化学”课程和网站建设。

山东省优秀研究生指导教师。

山东省研究生优秀科技创新成果一等奖2项（指导教师）。

山东省优秀硕士论文1项(指导教师)。

全国大学生课外学术科技作品竞赛全国一等奖及交叉创新全国三等奖（指导教师）。

国家级教学成果二等奖1项。

山东省高等教育教学成果一等奖。

山东省研究生教育教学成果一等奖。


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