王博、教授
办公地址：青岛市黄岛区前湾港路579山东科技大学J2-211-1
电子邮箱：wb@sudst.edu.cn
联系电话: **
招生专业及研究方向
招生专业：
硕士生招生专业：化学工程与技术，材料化工（专硕）
博士生招生专业：化学工程与技术，矿物加工
研究方向：
硕士招生方向：绿色化学，药物中间体化学，不对称合成，手性药物中间体，生物催化.
博士生招生方向：绿色化学，药物中间体化学，不对称合成，手性药物中间体，生物催化。
个人经历
2019.12 ---- 现在，山东科技大学化学与生物工程学院教授博导。
2019.04 ---- 2019.11, 海南大学化学工程与技术学院教授博导。
2013.09 ---- 2019.03, 海南大学材料与化工学院教授。
2011.10 ---- 2013.09, 瑞典皇家理工学院化学院生物技术学系博士后研究员。
2004.07 ---- 2005.07, 中国石化股份茂名分公司化工事业部干部。
2008.08 ---- 2011.09, 浙江大学化学与生物工程学院生物化工专业博士
2005.08 ---- 2008.06, 浙江工业大学药学院药物化学硕士。
2000.09 ---- 2004.07, 海南大学理工学院化学工程与工艺专业学士。
科研项目
山东科技大学“山海英才”系列科研启动基金项目，350万元，2020.01 – 2024.12.
国家自然科学基金地区基金项目，**，一石三鸟的使用转氨酶和羰基还原酶的双酶催化体系研究，2019.01-2022.12，48万元，在研，主持。
国家自然科学基金青年项目，**，单酶体系中转胺酶催化的反应平衡消除研究，2016.01-2018.12，24.72万元，在研，主持。
国家重点研发计划项目，2017YFC**，磷酸钙纳米粉体及纳米多孔微球合成工程化技术研发, 2017.06 –2020.12，3200 万元，在研，参研（科研骨干9/41）
国家自然科学基金面上项目，**，恶臭假单胞菌扁桃酸消旋酶催化底物多样性产生机制，2012.01-2015.12，60 万元，已结题，参研。
海南省自然科学基金创新团队项目，2016CXTD006，高ee值生物手性胺的制备研究，2016.01-2017.12，30万元，已结题，主持。
横向课题，S-2-胺基丁酰胺的化学-酶法制备技术开发，2015.01—2016.05，25万元，在研，主持。
海南大学科研启动基金项目，kyqd1408，无催化剂条件下醛与胺缩合成酰胺的合成研究，2014.04-2016.03，10万元，已结题，主持.
学术成就
一、Selected publications:
Xinchun Jv, Shuting Sun, Qun Zhang, Muyao Du, Lan Wang, Bo Wang*, Efficient and Mild Reductive Amination of Carbonyl Compounds Catalysed by Dual-Function Palladium Nanoparticles, ACS Sustainable Chemistry & Engineering, 2020, 2020, 8 (3) , 1618-1626
Yaxu Liu, Ziyi Quan, Shaopo He, Zexi Zhao, Jiang Wang, Bo Wang*, Heterogeneous palladium-based catalyst promoted reduction of oximes to amines: using H₂ of 1 atm in H₂O under mildconditions, React. Chem. Eng., 2019, 4, 1145-1152
Yaxu Liu, Shaopo He, Ziyi Quan, Huizhuo Cai, Yang Zhao, Bo Wang,*Mild palladium-catalysed highly efficient hydrogenation of C≡N, C-NO₂, and C=O bonds using H₂ of 1 atm in H₂O, Green Chem., 2019,21, 830-838
HuihuiRen, Bo Wang,*etal., High-selective hydrogenation of aldehydes promoted by palladium-based catalyst and its application in equilibrium displacement in one-enzyme procedure using ω-transaminase, Org. Chem. Front., 2019,6, 1587-1593
Kuan Zhang, Yi Wang, Tao Sun, Bo Wang,*Hongyu Zhang, Bioinspired Surface Functionalization for Improving Osteogenesis of Electrospun Polycaprolactone Nanofiber, Langmuir, Langmuir 2018, 34, 50, 15544-15550
Jianhui Li, Shaopo He, Kuan Zhang, Ziyi Quan, Qiheng Shan, Zhongliang Sun, Bo Wang,* UV Assisted High-efficient Synthesis of α-Ketoamides Using Air Promoted by A Non-metal Catalyst in Aqueous Solution，ChemCatChem，2018, 10, 4868-4873.
Yujia Cheng, Qiheng Shan, Yue Zhang, Ziyi Quan, Kuan Zhang, Bo Wang,*A highly efficient one-enzyme protocol using omega-transaminase and an amino donor enabling equilibrium displacement assisted by molecular oxygen, Organic Chemistry Frontiers, 2018, 5, 1633-1638.
Jianhui Li, Shaopo He, Kuan Zhang, Ziyi Quan, Qiheng Shan, Zhongliang Sun, Bo Wang,* UV Assisted High-efficient Synthesis of α-Ketoamides Using Air Promoted by A Non-metal Catalyst in Aqueous Solution，ChemCatChem，2018, 10, 4781-4781.
Yue Zhang, Yujia Cheng, Huizhuo Cai, Shaopo He, Qiheng Shan, Hongwei Zhao, Yiping Chen, Bo Wang,*Catalyst-free aerobic oxidation of aldehydesinto acids in water under mild conditions, Green Chemistry, 2017, 19, 5708-5713.
Wang Bo, Land Henrik, and Berglund Per*, Efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase, Chemical Communications, 2013, 49, 161-163.
Wang Bo*, Liu Yanfeng, Zhang Dela, Feng Yuhong and Li Jiacheng, Efficient kinetic resolution of amino acid catalyzed by lipase AS ‘Amano’ via cleavage of amide bond, Tetrahedron: Asymmetry, 2012, 23, 1338-1342.
Wang Bo, Jiang Ling, Wang Jue, Wang Dan, Liu Min and Yu Hongwei*, A tandem and fully enzymatic procedure for green resolution of chiral alcohol: acylation and deacylation in non-aqueous media, Tetrahedron: Asymmetry, 2011, 22, 980-985.
Wang Bo, Tang Xiaoling, Ren Gangfeng, Liu Ji, and Yu Hongwei*, Escherichia coli BioH: an esterase with high activity and enantioselectivity for kinetic resolution of secondary alcohols in organic solvents. Tetrahedron Letters，2010, 51, 6360-6364.
Wang Bo, Liu Ji, Tang Xiaoling, Cheng Cheng, Gu Jiali, Dai Liyan*, Yu Hongwei*, Enzymatic synthesis of (S)-glutaric acid monoesters aided by molecular docking，Tetrahedron Letters，2010，51，309-312.
Wang Bo, Tang Xiaoling, Ren Gangfeng, Liu Ji, Yu Hongwei*, A new high-throughput screening method for determining active and enantioselective hydrolases, Biochemical Engineering Journal, 2009, 46, 345-349.
Wang Bo*, Yu Chuan Ming, Chen Zhi Wei, Su Wei Ke, An efficient method for the synthesis of dialkylchlorophosphates from trialkyl phosphites using bis(trichloromethyl) carbonate, Chinese Chemical Letters, 2008, 19, 904-906.
Wang Dan，Zhang Kuan，Jia Luhan，Zhang Danting，Zhang Yue，Cheng Yujia，Lin Chang，Wang Bo*，nBu4NI-mediated oxidation of methyl ketones to a-ketoamides: using ammonium-, primary/secondary amine-salt as amine moiety ，Organic & Biomolecular Chemistry, 2017,15, 3427-3434.
Wang Dan，Zhang Kuan，Jia Luhan，Zhang Danting，Zhang Yue，Cheng Yujia，Lin Chang，Wang Bo*，Correction: nBu4NI-mediated oxidation of methyl ketones to a-ketoamides: using ammonium-, primary/secondary amine-salt as amine moiety ，Organic & Biomolecular Chemistry, 2017,15, 5095-5095.
Fuyan Liu, Kuan Zhang,Yanfeng Liu,Shan Chen,Yiping Chen,Dela Zhang,Chunfu Lin, Bo Wang*, Solvent-free one-pot oxidation of ethylarenes forthe preparation of a-ketoamides under mildconditions，RSC Advances，2017.1.30，7：7158~7162
Chen Shan, Liu Fuyan, Zhang Kuan, Huang Hansheng, Wang Huani, Gong Yiwei, Zhang Dela, Chen Yiping, Lin Chang, Wang Bo*, An efficient enzymatic aminolysis for kinetic resolution of aromatic alpha-hydroxyl acid in non-aqueous media，Tetrahedron Letters，2016.11.30，57（48）：5312~5314
Hongyin Yang, Wenjian Hu, Shengjue Deng, Tiantian Wu,Bo Wang*，Catalyst-free amidation of aldehyde with amine under mild conditions，New Journal of Chemistry，2015, 39（8）：5912~5915
Jiang Ling, Wang Bo, Li Rongrong, Shen Sa, Yu Hongwei, Ye Lidan, Catalytic promiscuity ofEscherichia coliBioH esterase: Application in the synthesis of 3,4-dihydropyran derivatives, Process Biochemistry, 2014, 49, 1135–1138.
Jiang Ling, Wang Bo, Li Rongrong, Shen Sa, Yu Hongwei, Ye Lidan, “Amano” lipase DF-catalyzed efficient synthesis of 2,2?-arylmethylene dicyclohexane-1,3-dione
derivatives in anhydrous media, Chinese Chemical Letters, 2014, 25，1190-1192.
Tang Xiaoling, Liu Ji, Wang Bo，Yu Hongwei*, Cloning, screening and characterization of enantioselective ester hydrolases from Escherichia coli K-12, World Journal of Microbiology and Biotechnology, 2011, 27, 129-136.
Liu Ji, Tang Xiaoling, Wang Bo, Yu Hongwei*, Min Hang, Cloning, screening and characterization of ester hydrolases with enantioselectivity in typical bacteria, Process Biochemistry, 2010, 45, 475-480
Wang Jue, Wang Dan, Wang Bo,Liu Ji, Mei Zhuohang and Yu Hongwei*, Enhanced activity of Rhizomucormiehei Lipase by directed evolution with simultaneous evolution of the propeptide. Applied Microbiology and Biotechnology,2012, 96, 443 -450.
Wang Dan, Wang Jue, Wang Boand Yu Hongwei*, A New and Efficient Colorimetric High-throughput Screening Method for Triacylglycerol Lipase Directed Evolution, Journal of Molecular Catalysis B: Enzymatic, 2012, 82, 18-23.
Yu Chuan-Ming*, Wang Bo, Chen Zhi-Wei, A Novel Synthesis of Alkylamino Substituted Methylenediphosphonates Using Bis(trichloromethyl) Carbonate and RCONR1R2, Chinese Journal of Chemistry, 2008, 26, 1899-1901.
二、会议论文
Wang Bo, Land Henrik, and Berglund Per*, An efficient one-enzyme cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase. 1st International Symposium on Transaminase Biocatalysis, KTH 2013, Stockholm, 2013, 2.28 -3.1.
Wang Bo*,Yu Hongwei, A Fluorescent high-throughput screening method for determining active and enatioselectivehydrolysases. The International Symposium on Advanced Bio., Nano, and Pharmaceutical Science and Technology, Conference, Beijing, 2009, 5.3-5.6. 3.
Mattias Anderson, Guangning Ma, Wang Bo, Henrik Land, Armando Córdova, Per Berglund, Synthesis of enantiomerically pure Υ-amino alcohols usingω-transaminase, 1st International Symposium on Transaminase Biocatalysis, KTH 2013, Stockholm, 2013, 2.28 -3.1
Jiang Ling, Wang Bo, and Yu Hongwei, Biocatalytic promiscuous: Escherichia coli BioH esterase-catalysed aldol-and koevenagel reactions. The International Symposium on Exploring the Frontiers of Chemical & Biochemical Engineering, Conference, Beijing, 2012, 5.1-5.4.
Chen, Yiping(*)，Chen, Chen，Liang, Zhenyi，Wang, Bo，Liu, Pinghuai，Investigation of Extraction and Purification Technology of Total Saponins from Sindoraglabra Seeds，3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME)，广州，2015.01.19-2015.01.20
论著专利
1、专著
王博，黎吉辉，有机合成反应原理及应用研究，原子能出版社，601000，2015.03.16
李睿，徐晓强，王博，化工催化剂与催化技术研究，水利水电出版社，401000，2014.1.1
2、授权发明专利
王博，一种长春质碱酒石酸盐的制备方法，2016.5.18，中国，CN9.7。
刘艳凤，王博，李嘉诚，周浩浩，韦卓勋，韦卓勋，一种由苯直接羟基化制备苯酚的方法，2016.09.17，中国，CN5.7。
王博，李永曙，梅丽琴，谭成侠，一种核苷化合物催化裂解方法，2012.12.12，中国，ZL0.X
王博，李永曙，谭成侠，一种美洛西林钠溶媒结晶制备方法，2011.05.25，中国，ZL4.3。
于洪巍，王博，徐红娜，一种酶羟化3β-胆固醇乙酸酯制备7β-羟基-3β胆固醇乙酸酯的方法，2015.05.13，中国，ZL7.7
于洪巍，王博，车大庆，酶法制备手性4-取代-2，6-二氧哌啶-3，5-二甲酸单酰胺类化合物的方法，2012.12.05，中国，ZL1.9。
于洪巍，王博，车大庆，酶催化制备(S)-3-取代戊二酸单酯类化合物的方法，2013.04.17，中国，ZL4.9。
于洪巍，王博，汤晓玲，刘击，消旋1-苯基乙醇类化合物的酶拆分方法，2012.10.31，中国，ZL1.2。
陈志卫，苏为科，丁锴，王博，邹振荣，钱振青，一种6,8－二氯辛酸乙酯的化学合成方法，2010.03.10，中国，ZL7.1。
苏为科，李坚军，王博，李佳，章莹，蔡继平，一种双(2－氯乙烷砜基)甲烷化合物的合成方法，2009.09.09，中国，ZL0.X。
于洪巍，王丹，王珏，王博，刘敏，磁性共价固定化酶载体的制备方法，2013.04.24，中国，ZL3.4。
苏为科，陈志卫，王博，一种1－氯辛烷的合成方法，2008.09.03，中国，ZL3.6。
苏为科，陈志卫，楼芳彪，徐园芬，王博，一种3－氯－1,2－苯并异噻唑类化合物的合成方法，2008.05.14，中国，ZL3.8。
讲授课程
化学工艺学（本科），生物催化（本科），高等分离工程（硕士），高等生物化工（博士）。
合作交流