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山东大学研究生导师教师简介-卞小莹

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卞小莹

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教授博士生导师硕士生导师
性别：男
毕业院校：德国萨尔大学
学历：研究生(博士)毕业
学位：博士
在职信息：在职
所在单位：微生物技术研究院
入职时间：2015-07-15
学科：微生物学

办公地点：山东大学青岛校区微生物技术研究院
联系方式：bianxiaoying@sdu.edu.cn

电子邮箱：bianxiaoying@sdu.edu.cn

其他联系方式Other Contact Information

通讯/办公地址 : BinhaiRoda 72, Jimo
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个人简介Personal Profile

卞小莹教授，山东大学“齐鲁青年学者”特聘教授，山东省杰出青年基金获得者，博士生导师。2008年-2014年在德国萨尔大学攻读博士学位和德国亥姆霍兹药物研究所从事博士后研究，均师从德国科学院院士Rolf Müller教授；2015年获“齐鲁青年学者”特聘教授作为高层次人才加盟山东大学微生物技术国家重点实验室(教授，博士生导师)。研究领域聚焦微生物次级代谢产物及合成生物学，发展和利用生物技术的开展沉默生物合成基因簇的挖掘和高值天然产物的高效微生物合成及组合生物合成研究。在Nature Biotechnology、Proc Natl Acad Sci U S A等刊物发表论文30余篇；被Science、Nature Biotechnology、Nature Microbiology等期刊论文他引400余次，H指数为15 (Web of Science)。应邀在国际、国内学术会议做大会报告及分会场主旨报告多次，研究成果获Nature Biotechnology、Nature Methods和Natural Product Reports等推荐点评。担任Frontiers in Microbiology和ACS Chemical Biology等多个期刊审稿人和国家自然科学基金函评专家。获授权美国专利1件，申请国内专利三项。曾获得美国生药学会颁发的Journal of Natural Products期刊年度最佳论文奖(Arthur E. Schwarting Award)，应邀参加第54届美国生药学会年会并领取奖牌。主持国家自然科学基金、山东省自然科学基金重大基础项目及杰出青年基金、国家重点研发计划课题等项目多项。 Web of Science ResearcherIDA-7007-2015
ORCID0000-0002-1356-3211教育经历Education Background 工作经历Work Experience
2008.102013.3
德国萨尔大学药物生物技术博士2005.92008.6
西北农林科技大学植物资源利用农学硕士学位2001.92005.7
西北农林科技大学植物保护农学学士学位 2015.7至今
山东大学State Key Laboratory of Microbial TechnologyProfessor2014.102015.6
山东大学State Key Laboratory of Microbial TechnologyScientist2013.22014.9
德国亥姆霍兹萨尔药物研究所微生物天然产物研究组博士后研究方向Research Focus 社会兼职Social Affiliations
微生物天然产物生物合成与生物合成工程基因组编辑技术用于基因组挖掘发现新天然产物微生物天然产物异源表达
中国生物工程学会终身会员
中国微生物学会终身会员
中国化学会会员 2014-2018

版权所有?山东大学　地址：中国山东省济南市山大南路27号　邮编：250100　
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发表论文

2020
Ouyang Q, Wang X, Zhang N, Zhong L, Liu J, Ding X, Zhang Y,Bian X*. Promoter screening facilitates heterologous production of complex secondary metabolites in Burkholderiales strains.ACS Synth. Biol.2020 Feb 21;9(2):457-460. doi: 10.1021/acssynbio.9b00459
Chen H^#, Zhou H^#, Sun T, Xu J, Tu Q, Yang J, Zhang Y,Bian X*. Identification of holrhizins E-Q reveals the diversity of nonribosomal lipopeptides in Paraburkholderia rhizoxinica.J Nat Prod.2020, Feb 28; 83(2):537-541. doi:10.1021/acs.jnatprod.9b00927
Wang ZJ, Zhou H, Zhong G, Huo L, Tang YJ, Zhang Y*,Bian X*. Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Org Lett. 2020 Feb 7; 22(3):939-943. doi: 10.1021/acs.orglett.9b04490.
Zheng W^#, Wang X^#, Zhou H, Zhang Y*, Li A*,Bian X*.Establishment of recombineering genome editing system in Paraburkholderia megapolitanaempowers activation of silent biosynthetic gene clusters.Microb Biotechnol.2020 Mar;13(2):397-405. doi: 10.1111/1751-7915.13535
Abbasi MN, Fu J,Bian X, Wang H*, Zhang Y*, Li A*. Recombineering for Genetic Engineering of Natural Product Biosynthetic Pathways.Trends Biotechnol.2020 Jan 20. doi: 10.1016/j.tibtech.2019.12.018.
Wang M^#, Bian Z^#, Shi J, Wu Y, Yu X, Yang Y, Ni H, Chen H,Bian X, Li T, Zhang Y, Jiang L*, Tu Q*.Effect of the nitrogen-fixing bacteriumPseudomonas protegensCHA0-ΔretS-nif on garlic growth under different field conditions.Ind Crop Prod. 2020, 145: 111982. doi: 10.1016/j.indcrop.2019.111982
Jing X^#, Cui Q^#, Li X, Yin J, Ravichandran V, Pan D, Fu J, Tu Q, Wang H*,Bian X*, Zhang Y*.EngineeringPseudomonas protegensPf-5 to improve its antifungal activity and nitrogen fixation.Microb Biotechnol.2020,13(1):118-133. doi: 10.1111/1751-7915.13335

2019
Huo L, Hug JJ, Fu C,Bian X*, Zhang Y*, Müller R*. Heterologous expression of bacterial natural product biosynthetic pathways.Nat Prod Rep.2019 Oct 16;36(10):1412-1436. doi: 10.1039/c8np00091c.ESI Hot Paper and Highly Cited Paper
Tang B, Yu Y, Liang J, Zhang Y,Bian X, Zhi X, Ding X. Reclassification of “Polyangium brachysporum” DSM 7029 as Schlegelella brevitalea sp. nov.Int J Syst Evol Microbiol.2019 Sep;69(9):2877-2883. doi: 10.1099/ijsem.0.003571
Chen H, Bian Z, Ravichandran V, Li R, Sun Y, Huo L, Fu J,Bian X, Xia L, Tu Q, Zhang Y . Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales.Crit Rev Microbiol.2019 Mar;45(2):162-181. doi: 10.1080/1040841X.2018.1514365.
Yu F, Jing X, Li X, Wang H, Chen H, Zhong L, Yin J, Pan D, Yin Y, Fu J, Xia L,Bian X, Tu Q*, Zhang Y*. Recombineering Pseudomonas protegens CHA0: An innovative approach that improves nitrogen fixation with impressive bactericidal potency.Microbiol Res. 2019 Jan;218:58-65

Li R^#, Helbig L^#, Fu J,Bian X, Herrmann J, Baumann M, Stewart AF, Müller R, Li A*, Zips D*, Zhang Y*. Expressing Cytotoxic Compounds in Escherichia coli Nissle 1917 for Tumor-targeting Therapy.Res Microbiol. 2019 Mar;170(2):74-79. doi: 10.1016/j.resmic.2018.11.001.
2018
Chen H, Fang Q, Tu Q, Liu C, Yin J, Yin Y, Xia L,Bian X*, Zhang Y*.Identification of a contact-dependent growth inhibition system in the probiotic Escherichia coli Nissle 1917.FEMS Microbiol Lett.2018 Jun 1;365(11): fny102. doi: 10.1093/femsle/fny102.
Wang X^#, Zhou H^#, Chen H^#, Jing X, Zheng W, Li R, Sun T, Liu J, Fu J, Huo L, Li YZ, Shen Y, Ding X, Müller R,Bian X*, Zhang Y*.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proc Natl Acad Sci U S A. 2018 May 1,115 (18): E4255-E4263.pii: **. doi: 10.1073/pnas.**.
Xu X, Zhou H, Liu Y, Liu X, Fu J, Li A, Li YZ, Shen Y,Bian X*, Zhang Y*.Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic.J Nat Prod.2018 Apr 27;81(4):1060-1064. doi: 10.1021/acs.jnatprod.7b00835. Epub 2018 Mar 22.

Liu C, Yu F, Liu Q,Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q, Zhang Y.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiol Lett.2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

2017
郑文韬，张友明*，卞小莹*。Red/ET同源重组技术及在微生物基因组挖掘中的应用进展。微生物学报(Acta Microbiologica Sinica), 2017; 57(11): 1735-1746

Bian X^#, Tang B^#, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao G, Ding X, Müller R, Zhang Y*.Heterologous production and yields improvement of epothilones in the Burkholderiales strain DSM 7029.ACS Chem Biol.2017; 12 (7): 1805-1812. doi: 10.1021/acschembio.7b00097. Highlight in Hot off the Press of Natural Product Reports (Nat. Prod. Rep., 2017, 34, 1180-1184).

Yin J,Wang H,Li R,Ravichandran V,Bian X,Li A,Tu Q,Francis Stewart A,Fu J,Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.Curr Top Microbiol Immunol.2017; 402:195-213. doi: 10.1007/82_2016_57.

2016

Liu Q#, Shen Q#,Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W, Li D, Zhang Y*.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.Sci Rep.2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J,Bian X, Li A, Müller R, Stewart AF, Fu J, Zhang Y*.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.Nat Protoc.2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R,Bian X, Zhang Y, Müller R.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

2015

Yin J, Hoffmann M,Bian X, Tu Q, Yan F, Xia L, Ding X, Stewart AF, Müller R, Fu J, Zhang Y*.Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2).Sci Rep. 2015 Oct 13;5:15081. doi: 10.1038/srep15081.

Bian X, Plaza A, Zhang Y, Müller R. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chemical Science2015, 6(5): 3154-3160,

Bian X, Plaza A, Yan F, Zhang Y, Müller R.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. Epub 2015 Mar 2.

2014

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M,Bian X, Müller R, Fu J, Stewart AF, Zhang Y*.A new recombineering system for Photorhabdus and Xenorhabdus.Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. Epub 2014 Dec 24.

Bian X, Huang F, Wang H, Klefisch T, Müller R, Zhang Y.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.**. Epub 2014 Aug 21.

Wang H,Bian X, Xia L, Ding X, Müller R, Zhang Y, Fu J, Stewart AF*.Improved seamless mutagenesis by recombineering using ccdB for counterselection.Nucleic Acids Res.2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. Epub 2013 Dec 24.

2013

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y, Müller R. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery.Planta Medica79(10): 834, 2013

Ongley SE#,Bian X#, Neilan BA, Müller R.Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5. Review.

2013 Q3 Top ten most accessed Natural Product Reports articles (2nd); BABS 'Paper of the Month' award in July 2013, UNSW.

Ongley SE,Bian X, Zhang Y, Chau R, Gerwick WH, Müller R, Neilan BA.High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium.ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. Epub 2013 Jun 17.

BABS 'Paper of the Month' award in June 2013, UNSW.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y, Müller R.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.**. Epub 2013 Jun 6.

2012

Bian X, Plaza A, Zhang Y, Müller R.Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012 Sep 28;75(9):1652-5. Epub 2012 Aug 21.

2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y, Müller R.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.**. Epub 2012 Jul 31.

Fu J#,Bian X#, Hu S, Wang H, Huang F, Seibert PM, Plaza A, Xia L, Müller R, Stewart AF, Zhang Y*.Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.Nat Biotechnol. 2012 May;30(5):440-6. doi: 10.1038/nbt.2183. Highlighted in ‘Cover Paper’ and ‘News and Views’ ofNature Biotechnology, and Research Highlighted in Nature Methods; HZI 'Paper of the Month' award in July 2012.

研究领域

1. 微生物天然产物（医药或农药）的生物合成, 异源表达以及组合生物合成
2. 基因组挖掘发现新型微生物天然产物（医药或农药）
3. Red/ET同源重组工程技术与天然产物合成生物学

论文成果More>>

周海波,涂强,张友明and陈汉娜.Identification of Holrhizins E-Q Reveals the Diversity of Nonribosomal Lipopeptides in Paraburkholderia rhizoxinica.ACC: PROCEEDINGS OF THE 2005 AMERICAN CONTROL CONFERENCE, VOLS 1-7,83,537,2020.王宗杰.Genome Mining and BiosynthesiS of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Organic Letters,22,939,2020.王海龙.Recombineering for Genetic Engineering of Natural Product Biosynthetic Pathways.Trends in biotechnology,2020.王海龙.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.NATURE PROTOCOLS,2020.霍刘杰,卞小莹and张友明.Heterologous expression of bacterial natural product biosynthetic pathways.36,1412,2020.李瑞娟,张友明,符军,卞小莹and李爱英.Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy.RESEARCH IN MICROBIOLOGY,170,74,2019.

专利

一组伯克氏菌同源重组酶及其表达载体与应用创新霉素生物合成基因簇及其应用

科研项目More>>

深海微生物代谢产物结构和生物功能研究, 2019/12/01-2024/12/31新天然与人工产物的定向挖掘和高效合成的平台技术, 2020/01/01-2024/12/31天然产物“暗物质”定向挖掘的平台技术, 2020/01/16-2024/03/31杀线虫根际靶向生防工程菌的人工构建, 2018/06/22-2020/12/31创新霉素生物合成途径的阐释和异源表达, 2015/08/17-2018/12/31一个用于表达黏细菌天然产物的底盘菌的优化及应用, 2016/08/17-2020/12/31 版权所有?山东大学　地址：中国山东省济南市山大南路27号　邮编：250100　
查号台：（86）-**
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卞小莹

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发表论文

当前位置：卞小莹>>科学研究>>发表论文

Liu C, Yu F, Liu Q,Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q, Zhang Y.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiol Lett.2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

2017
郑文韬，张友明*，卞小莹*。Red/ET同源重组技术及在微生物基因组挖掘中的应用进展。微生物学报(Acta Microbiologica Sinica), 2017; 57(11): 1735-1746

Bian X^#, Tang B^#, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao G, Ding X, Müller R, Zhang Y*.Heterologous production and yields improvement of epothilones in the Burkholderiales strain DSM 7029.ACS Chem Biol.2017; 12 (7): 1805-1812. doi: 10.1021/acschembio.7b00097. Highlight in Hot off the Press of Natural Product Reports (Nat. Prod. Rep., 2017, 34, 1180-1184).

Yin J,Wang H,Li R,Ravichandran V,Bian X,Li A,Tu Q,Francis Stewart A,Fu J,Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.Curr Top Microbiol Immunol.2017; 402:195-213. doi: 10.1007/82_2016_57.

2016

Liu Q#, Shen Q#,Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W, Li D, Zhang Y*.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.Sci Rep.2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J,Bian X, Li A, Müller R, Stewart AF, Fu J, Zhang Y*.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.Nat Protoc.2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R,Bian X, Zhang Y, Müller R.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

2015

Yin J, Hoffmann M,Bian X, Tu Q, Yan F, Xia L, Ding X, Stewart AF, Müller R, Fu J, Zhang Y*.Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2).Sci Rep. 2015 Oct 13;5:15081. doi: 10.1038/srep15081.

Bian X, Plaza A, Zhang Y, Müller R. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chemical Science2015, 6(5): 3154-3160,

Bian X, Plaza A, Yan F, Zhang Y, Müller R.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. Epub 2015 Mar 2.

2014

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M,Bian X, Müller R, Fu J, Stewart AF, Zhang Y*.A new recombineering system for Photorhabdus and Xenorhabdus.Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. Epub 2014 Dec 24.

Bian X, Huang F, Wang H, Klefisch T, Müller R, Zhang Y.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.**. Epub 2014 Aug 21.

Wang H,Bian X, Xia L, Ding X, Müller R, Zhang Y, Fu J, Stewart AF*.Improved seamless mutagenesis by recombineering using ccdB for counterselection.Nucleic Acids Res.2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. Epub 2013 Dec 24.

2013

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y, Müller R. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery.Planta Medica79(10): 834, 2013

Ongley SE#,Bian X#, Neilan BA, Müller R.Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5. Review.

2013 Q3 Top ten most accessed Natural Product Reports articles (2nd); BABS 'Paper of the Month' award in July 2013, UNSW.

Ongley SE,Bian X, Zhang Y, Chau R, Gerwick WH, Müller R, Neilan BA.High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium.ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. Epub 2013 Jun 17.

BABS 'Paper of the Month' award in June 2013, UNSW.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y, Müller R.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.**. Epub 2013 Jun 6.

2012

Bian X, Plaza A, Zhang Y, Müller R.Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012 Sep 28;75(9):1652-5. Epub 2012 Aug 21.

2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y, Müller R.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.**. Epub 2012 Jul 31.

Fu J#,Bian X#, Hu S, Wang H, Huang F, Seibert PM, Plaza A, Xia L, Müller R, Stewart AF, Zhang Y*.Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.Nat Biotechnol. 2012 May;30(5):440-6. doi: 10.1038/nbt.2183. Highlighted in ‘Cover Paper’ and ‘News and Views’ ofNature Biotechnology, and Research Highlighted in Nature Methods; HZI 'Paper of the Month' award in July 2012.

版权所有?山东大学　地址：中国山东省济南市山大南路27号　邮编：250100　
查号台：（86）-**
值班电话：（86）-**　建设维护：山东大学信息化工作办公室?　　
技术支持qq群：**
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1. 微生物天然产物（医药或农药）的生物合成, 异源表达以及组合生物合成
2. 基因组挖掘发现新型微生物天然产物（医药或农药）
3. Red/ET同源重组工程技术与天然产物合成生物学

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[1]周海波,涂强,张友明and陈汉娜.Identification of Holrhizins E-Q Reveals the Diversity of Nonribosomal Lipopeptides in Paraburkholderia rhizoxinica.ACC: PROCEEDINGS OF THE 2005 AMERICAN CONTROL CONFERENCE, VOLS 1-7, 83,537, 2020.[2]王宗杰.Genome Mining and BiosynthesiS of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Organic Letters, 22,939, 2020.[3]王海龙.Recombineering for Genetic Engineering of Natural Product Biosynthetic Pathways.Trends in biotechnology, 2020.[4]王海龙.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.NATURE PROTOCOLS, 2016.[5]霍刘杰,卞小莹and张友明.Heterologous expression of bacterial natural product biosynthetic pathways. 36,1412, 2019.[6]李瑞娟,张友明,符军,卞小莹and李爱英.Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy.RESEARCH IN MICROBIOLOGY, 170,74, 2019.[7]王雪,李越中,沈月毛,张友明,卞小莹,霍刘杰,周海波,荆晓姝,李瑞娟and符军.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America, 115,E4255, 2018.[8]王雪,李越中,沈月毛,张友明,卞小莹,霍刘杰,周海波,荆晓姝,李瑞娟and符军.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America, 115,E4255, 2018.[9]王雪,李越中,沈月毛,张友明,卞小莹,霍刘杰,周海波,荆晓姝,李瑞娟and符军.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America, 115,E4255, 2018.[10]王雪,李越中,沈月毛,张友明,卞小莹,霍刘杰,周海波,荆晓姝,李瑞娟and符军.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America, 115,E4255, 2018.[11]张友明,周海波,符军,李爱英,李越中,沈月毛,卞小莹and许晓坤.Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic.Journal of Natural Products, 81,1060, 2018.[12]符军,张友明,卞小莹,涂强,颜富and尹佳.Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2).Scientific Reports, 5, 2015.[13]王雪,李越中,沈月毛,张友明,卞小莹,霍刘杰,周海波,荆晓姝,李瑞娟and符军.Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proceedings of the National Academy of Sciences of the United States of America, 115,E4255, 2018.[14]符军,张友明,卞小莹,涂强,颜富and尹佳.Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2).Scientific Reports, 5, 2015.[15]张友明,李瑞娟,卞小莹,李爱英and符军.Expressing Cytotoxic Compounds in Escherichia coli Nissle 1917 for Tumor-targeting Therapy.RESEARCH IN MICROBIOLOGY, 2018.[16]卞小莹,涂强,张友明,王海龙and符军.Recombineering Pseudomonas protegens CHA0: An innovative approach that improves nitrogen fixation with impressive bactericidal potency.Microbiological Research, 2019.[17]卞小莹,涂强,张友明,王海龙and符军.Recombineering Pseudomonas protegens CHA0: An innovative approach that improves nitrogen fixation with impressive bactericidal potency.Microbiological Research, 2019.[18]卞小莹,张友明,李越中,涂强,王海龙,李爱英,符军and沈月毛.Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029.ACS Chemical Biology, 12,1805, 2017.[19]卞小莹,张友明,李越中,涂强,王海龙,李爱英,符军and沈月毛.Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029.ACS Chemical Biology, 12,1805, 2017.[20]张友明,涂强,卞小莹,李越中,沈月毛andLiu, Chenlang.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiology Letters, 365, 2018.共134条1/7 首页上页下页尾页页
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一组伯克氏菌同源重组酶及其表达载体与应用创新霉素生物合成基因簇及其应用共2条1/1 首页上页下页尾页
版权所有?山东大学　地址：中国山东省济南市山大南路27号　邮编：250100　
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深海微生物代谢产物结构和生物功能研究,2019/12/01,2024/12/31,新天然与人工产物的定向挖掘和高效合成的平台技术,2020/01/01,2024/12/31,天然产物“暗物质”定向挖掘的平台技术,2020/01/16,2024/03/31,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,创新霉素生物合成途径的阐释和异源表达,2015/08/17,2018/12/31,一个用于表达黏细菌天然产物的底盘菌的优化及应用,2016/08/17,2020/12/31,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,创新霉素生物合成途径的阐释和异源表达,2015/08/17,2018/12/31,一个用于表达黏细菌天然产物的底盘菌的优化及应用,2016/08/17,2020/12/31,一个用于表达黏细菌天然产物的底盘菌的优化及应用,2016/08/17,2020/12/31,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,微生物次级代谢,2019/04/26,2022/06/30,杀线虫根际靶向生防工程菌的人工构建,2018/06/22,2020/12/31,新型农药双丙环虫酯的合成生物学与组合生物合成研究,2017/07/01,2020/12/31,兼具生物固氮/杀虫抑菌功能的根际细胞工厂的构建,2017/08/01,2019/07/31,一个用于表达黏细菌天然产物的底盘菌的优化及应用,2016/08/17,2020/12/31,K-微生物技术国家重点实验室自主课题,2016/03/29,2017/12/31,共21条1/2 首页上页下页尾页页
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Liu C, Yu F, Liu Q,Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q*, Zhang Y*.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiol Lett.2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

Yin J,Wang H,Li R,Ravichandran V,Bian X,Li A,Tu Q,Francis Stewart A*,Fu J*,Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.Curr Top Microbiol Immunol.2017; 402:195-213. doi: 10.1007/82_2016_57.

Liu Q#, Shen Q#,Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W*, Li D*, Zhang Y*.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.Sci Rep.2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J,Bian X, Li A, Müller R, Stewart AF*, Fu J*, Zhang Y*.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.Nat Protoc.2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R,Bian X, Zhang Y*, Müller R*.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

Bian X, Plaza A, Zhang Y*, Müller R*. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chemical Science2015, 6(5): 3154-3160,

Bian X, Plaza A, Yan F, Zhang Y*, Müller R*.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. Epub 2015 Mar 2.

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M,Bian X, Müller R, Fu J*, Stewart AF*, Zhang Y*.A new recombineering system for Photorhabdus and Xenorhabdus.Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. Epub 2014 Dec 24.

Bian X, Huang F, Wang H, Klefisch T, Müller R*, Zhang Y*.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.**. Epub 2014 Aug 21.

Wang H,Bian X, Xia L, Ding X, Müller R, Zhang Y*, Fu J*, Stewart AF*.Improved seamless mutagenesis by recombineering using ccdB for counterselection.Nucleic Acids Res.2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. Epub 2013 Dec 24.

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y*, Müller R*. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery.Planta Medica79(10): 834, 2013

Ongley SE#,Bian X#, Neilan BA*, Müller R*.Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5. Review.

2013 Q3 Top ten most accessed Natural Product Reports articles (2nd); BABS 'Paper of the Month' award in July 2013, UNSW.

Ongley SE,Bian X, Zhang Y, Chau R, Gerwick WH, Müller R*, Neilan BA*.High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium.ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. Epub 2013 Jun 17.

BABS 'Paper of the Month' award in June 2013, UNSW.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y*, Müller R*.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.**. Epub 2013 Jun 6.

Bian X, Plaza A, Zhang Y*, Müller R*.Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012 Sep 28;75(9):1652-5. Epub 2012 Aug 21.

2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y*, Müller R*.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.**. Epub 2012 Jul 31.

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Liu C, Yu F, Liu Q,Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q*, Zhang Y*.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiol Lett.2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

Yin J,Wang H,Li R,Ravichandran V,Bian X,Li A,Tu Q,Francis Stewart A*,Fu J*,Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.Curr Top Microbiol Immunol.2017; 402:195-213. doi: 10.1007/82_2016_57.

Liu Q#, Shen Q#,Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W*, Li D*, Zhang Y*.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.Sci Rep.2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J,Bian X, Li A, Müller R, Stewart AF*, Fu J*, Zhang Y*.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.Nat Protoc.2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R,Bian X, Zhang Y*, Müller R*.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

Bian X, Plaza A, Zhang Y*, Müller R*. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chemical Science2015, 6(5): 3154-3160,

Bian X, Plaza A, Yan F, Zhang Y*, Müller R*.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. Epub 2015 Mar 2.

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M,Bian X, Müller R, Fu J*, Stewart AF*, Zhang Y*.A new recombineering system for Photorhabdus and Xenorhabdus.Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. Epub 2014 Dec 24.

Bian X, Huang F, Wang H, Klefisch T, Müller R*, Zhang Y*.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.**. Epub 2014 Aug 21.

Wang H,Bian X, Xia L, Ding X, Müller R, Zhang Y*, Fu J*, Stewart AF*.Improved seamless mutagenesis by recombineering using ccdB for counterselection.Nucleic Acids Res.2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. Epub 2013 Dec 24.

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y*, Müller R*. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery.Planta Medica79(10): 834, 2013

Ongley SE#,Bian X#, Neilan BA*, Müller R*.Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5. Review.

2013 Q3 Top ten most accessed Natural Product Reports articles (2nd); BABS 'Paper of the Month' award in July 2013, UNSW.

Ongley SE,Bian X, Zhang Y, Chau R, Gerwick WH, Müller R*, Neilan BA*.High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium.ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. Epub 2013 Jun 17.

BABS 'Paper of the Month' award in June 2013, UNSW.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y*, Müller R*.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.**. Epub 2013 Jun 6.

Bian X, Plaza A, Zhang Y*, Müller R*.Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012 Sep 28;75(9):1652-5. Epub 2012 Aug 21.

2012 Arthur E. Schwarting Award for Best Paper in the Journal of Natural Products

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y*, Müller R*.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.**. Epub 2012 Jul 31.

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Liu C, Yu F, Liu Q,Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q, Zhang Y.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiol Lett.2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

Yin J,Wang H,Li R,Ravichandran V,Bian X,Li A,Tu Q,Francis Stewart A,Fu J,Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.Curr Top Microbiol Immunol.2017; 402:195-213. doi: 10.1007/82_2016_57.

Liu Q#, Shen Q#,Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W, Li D, Zhang Y*.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.Sci Rep.2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J,Bian X, Li A, Müller R, Stewart AF, Fu J, Zhang Y*.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.Nat Protoc.2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R,Bian X, Zhang Y, Müller R.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

Bian X, Plaza A, Zhang Y, Müller R. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chemical Science2015, 6(5): 3154-3160,

Bian X, Plaza A, Yan F, Zhang Y, Müller R.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. Epub 2015 Mar 2.

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M,Bian X, Müller R, Fu J, Stewart AF, Zhang Y*.A new recombineering system for Photorhabdus and Xenorhabdus.Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. Epub 2014 Dec 24.

Bian X, Huang F, Wang H, Klefisch T, Müller R, Zhang Y.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.**. Epub 2014 Aug 21.

Wang H,Bian X, Xia L, Ding X, Müller R, Zhang Y, Fu J, Stewart AF*.Improved seamless mutagenesis by recombineering using ccdB for counterselection.Nucleic Acids Res.2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. Epub 2013 Dec 24.

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y, Müller R. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery.Planta Medica79(10): 834, 2013

Ongley SE#,Bian X#, Neilan BA, Müller R.Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5. Review.

Ongley SE,Bian X, Zhang Y, Chau R, Gerwick WH, Müller R, Neilan BA.High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium.ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. Epub 2013 Jun 17.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y, Müller R.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.**. Epub 2013 Jun 6.

Bian X, Plaza A, Zhang Y, Müller R.Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012 Sep 28;75(9):1652-5. Epub 2012 Aug 21.

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y, Müller R.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.**. Epub 2012 Jul 31.

Liu C, Yu F, Liu Q,Bian X, Hu S, Yang H, Yin Y, Li Y, Shen Y, Xia L, Tu Q, Zhang Y.Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering.FEMS Microbiol Lett.2018 May 1; 365(9): fny045. doi: 10.1093/femsle/fny045.

Yin J,Wang H,Li R,Ravichandran V,Bian X,Li A,Tu Q,Francis Stewart A,Fu J,Zhang Y*. A Practical Guide to Recombineering in Photorhabdus and Xenorhabdus.Curr Top Microbiol Immunol.2017; 402:195-213. doi: 10.1007/82_2016_57.

Liu Q#, Shen Q#,Bian X, Chen H, Fu J, Wang H, Lei P, Guo Z, Chen W, Li D, Zhang Y*.Simple and rapid direct cloning and heterologous expression of natural product biosynthetic gene cluster in Bacillus subtilis via Red/ET recombineering.Sci Rep.2016 Sep 30;6:34623. doi: 10.1038/srep34623.

Wang H#, Li Z#, Jia R, Hou Y, Yin J,Bian X, Li A, Müller R, Stewart AF, Fu J, Zhang Y*.RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression.Nat Protoc.2016 Jul;11(7):1175-90.

Tu Q, Herrmann J, Hu S, Raju R,Bian X, Zhang Y, Müller R.Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering.Sci Rep. 2016 Feb 15;6:21066. doi: 10.1038/srep21066.

Bian X, Plaza A, Zhang Y, Müller R. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chemical Science2015, 6(5): 3154-3160,

Bian X, Plaza A, Yan F, Zhang Y, Müller R.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-53. doi: 10.1002/bit.25560. Epub 2015 Mar 2.

Yin J, Zhu H, Xia L, Ding X, Hoffmann T, Hoffmann M,Bian X, Müller R, Fu J, Stewart AF, Zhang Y*.A new recombineering system for Photorhabdus and Xenorhabdus.Nucleic Acids Res. 2015 Mar 31;43(6):e36. doi: 10.1093/nar/gku1336. Epub 2014 Dec 24.

Bian X, Huang F, Wang H, Klefisch T, Müller R, Zhang Y.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014 Oct 13;15(15):2221-4. doi: 10.1002/cbic.**. Epub 2014 Aug 21.

Wang H,Bian X, Xia L, Ding X, Müller R, Zhang Y, Fu J, Stewart AF*.Improved seamless mutagenesis by recombineering using ccdB for counterselection.Nucleic Acids Res.2014 Mar;42(5):e37. doi: 10.1093/nar/gkt1339. Epub 2013 Dec 24.

Bian X, Fu J, Plaza A, Stewart AF, Zhang Y, Müller R. Novel Recombineering Method Facilitates Cryptic Natural Product Discovery.Planta Medica79(10): 834, 2013

Ongley SE#,Bian X#, Neilan BA, Müller R.Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013 Aug;30(8):1121-38. doi: 10.1039/c3np70034h. Epub 2013 Jul 5. Review.

Ongley SE,Bian X, Zhang Y, Chau R, Gerwick WH, Müller R, Neilan BA.High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium.ACS Chem Biol. 2013 Sep 20;8(9):1888-93. doi: 10.1021/cb400189j. Epub 2013 Jun 17.

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y, Müller R.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013 Jul 8;14(10):1194-7. doi: 10.1002/cbic.**. Epub 2013 Jun 6.

Bian X, Plaza A, Zhang Y, Müller R.Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli.J Nat Prod. 2012 Sep 28;75(9):1652-5. Epub 2012 Aug 21.

Bian X#, Huang F#, Stewart FA, Xia L, Zhang Y, Müller R.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.ChemBioChem. 2012 Sep 3;13(13):1946-52. doi: 10.1002/cbic.**. Epub 2012 Jul 31.