教育背景
博士1988.10.－1992.10.丹麦奥胡斯大学 分子生物学
硕士1982.9.－1985.10.中国南京农业大学 农业微生物学
本科1978.9.－1982.7.中国华中农业大学 农业微生物学


人才基金及学术兼职
2019年：Frontiers in Microbiology，Biology of Archaea，副主编
2019年：BMC Molecular and Cell Biology，副主编
2003年：丹麦国家科学技术研究基金会青年领军人才基金获得者（丹麦国家****）


工作经历
2018.11.山东大学****
2011–2018 丹麦哥本哈根大学古菌研究中心主任
2005–2019 丹麦哥本哈根大学生物系终身副教授
2000–2004丹麦哥本哈根大学分子生物学研究院生物化学系科研副教授
1996–1999丹麦哥本哈根大学分子生物学研究院生物化学系科研助理教授
1992–1995丹麦科技大学微生物研究中心 博士后
1985–1988中国农业科学院油料作物研究所（武汉） 研究助理


科研方向
1. CRISPR-Cas防御体系的多样性和作用机理
2.新型CRISPR技术的开发和利用：包括病毒和病原菌的检测，基因组编辑以及开发靶向CRIPSR基因治疗
3.古菌病毒及其与宿主相互作用的分子机制
4.古菌DNA复制机制和细胞周期的调控机理
5.古菌DNA损伤应答及其介导的细胞程序性死亡分子机制


在研课题
1. 2018.11-2023.10：山东大学****启动基金，700万
2. 2018.1-2021.12：国家自然科学基金面上项目（**）60万（佘群新主持）
3. 2018.1-2019.12： 国际合作网络基金、Strategy of genome integrity maintenance in Archaea, the third domain of life丹麦科技部科学与高等教育局 （SFU）28.8万丹麦克朗（佘群新主持）
4. 2015.7-2019.9，FFR重点基金、Diverse CRISPR adaptive immune systems of Sulfolobus: Molecular mechanisms and application to studying novel archaeal virus-host interactions,丹麦自然科学基金会（FFR/FNU）619.3万丹麦克朗（佘群新主持）


重要论文（2015年–2019年）
1. X. Feng, Q. Huang, andQ. She*.2019. Crenarchaeal 3D genome: A prototypical chromosome architecture for eukaryotes.Cell179,56-58. doi: 10.1016/j.cell.2019.08.045
2. M. S. Donia,Q. She,J.A. Huber and H. Jia. 2019.Editorial--Leading edge Voices: Creating a Unique Culture.Cell177,1368-1369. doi: 10.1016/j.cell.2019.05.014 (Voice piece by QS “Empathy as a solution”)
3.Q. She.2019. Antiviral defense mechanisms in Archaea. InEncyclopedia of Virology4th edition. Editors in Chief: Dennis Bamford and Mark Zuckerman. Vol. 3, “Archaeal viruses”, Elsevier Publisher (in press)
4. R. Molina#, S. Stella#, M. Feng, N#. Sofos, V. Jauniskis, I. Pozdnyakova, B. López-Méndez,Q. She,G. Montoya*. 2019. Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.Nat Commun.2019 Sep 20;10(1):4302. doi: 10.1038/s41467-019-12244-z. (# Equal contribution)
5. T. Guo, W. Han*,Q. She*.2019. Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus.RNA Biol16,549-556. doi: 10.1080/**.2018.**.
6. W. Han, S. Stella, Y. Zhang, T. Guo, K. Sulek, L. Lundgren, G. Montoya,Q. She*.2018. A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding.Nucleic Acids Res.46,10319-10330.
7. M. Sun, X. Feng, Z. Liu, W. Han, Y. X. Liang*,Q. She*.2018.An Orc1/Cdc6 ortholog functions as a key regulator in the regulatory network of DNA damage response in an archaeon.Nucleic Acids Res.46,6697-6711.
8. X. Feng, M. Sun, W. Han, Y. X. Liang,Q. She*.2018.A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea.Nucleic Acids Res.46,7085-7096.
9. W. Han, S. Pan, B. López-Méndez, G. Montoya andQ. She*.2017. Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail.Nucleic Acids Res.45,10740-10750.
10. Y. Li, Y. Zhang, J. Lin, S. Pan, W. Han, N. Peng, Y. X. Liang,Q. She*.2017. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA.Nucleic Acids Res.45,11305-11314.
11. T. Liu, Z. Liu, Q. Ye, S. Pan, X. Wang, W. Peng, Y. Li, X. Y. Liang,Q. She, N. Peng. 2017. Coupling transcriptional activation of CRISPR-Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus.Nucleic Acids Res.45,8978-8992.
12. W. Han, Y. Xu, X. Feng, Y. X. Liang, L. Huang, Y. Shen.Q. She*.2017. NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus.Front Microbiol.doi:10.3389/fmicb.2017.01480
13. N. Peng, W. Han, Y. Li, Y. X. Liang,Q. She*. 2017.Genetic technologies for extremely thermophilic microorganisms of Sulfolobus, the only genetically tractable genus of crenarchaea.Sci China Life Sci.60,370-385.
14. W. Han, L. Deng, M. Feng, W. Peng, S. Hallstrøm, Y. X. Liang, M. F. White,Q. She*. 2017. A type III-B CRISPR–Cas effector complex mediating massive target DNA destruction by modulating the cognate RNA cleavage.Nucleic Acids Res.28,1983-1993.
15. F. He, G. Vestergaard, W. Peng,Q. She,X. Peng. 2017. CRISPR-Cas type I-A Cascade complex couples viral infection surveillance to host transcriptional regulation.Nucleic Acids Res.45,1902-1913.
16.Q. She*,X. Feng and W. Han. 2017. Archaeal DNA damage repair. In Communication of Archaea, (G. Witzany, ed. 2017) pp305-318. Springer Publisher
17. Y. Li, S. Pan, Y. Zhang, M. Ren, M. Feng, N. Peng, L. Chen, Y. X. Liang*,Q. She*.2016. Harnessing Type I and Type III CRISPR-Cas systems for genome editing.Nucleic Acids Res.44,e34.
18. H. Wang, N. Peng, S. A. Shah, L. Huang*,Q. She*.2015. Archaeal Extrachromosomal Genetic Elements.Microbiol. Mol. Biol. Rev.79,117-152. doi: 10.1128/MMBR.00042-14.
19. W. Peng, M. Feng, X. Feng, X. Y. Liang,Q. She*.2015. An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference.Nucleic Acids Res.43,406-417.
20. T. Liu, Y. Li, X. Wang, Q. Ye, H. Li, Y. X. Liang,Q. She,N. Peng. 2015. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition.Nucleic Acids Res.43,1044-1055.
21. S. Fusco S,Q. She,G. Fiorentino, S. Bartolucci, P. Contursi. 2015. Unravelling the role of the F55 regulator in the transition from lysogeny to UV induction of Sulfolobus spindle-shaped virus 1.J. Virol.89,6453-6461.
22. Q. Huang, L. Liu, J. Liu, J. Ni,Q. She*,Y. Shen*. 2015. Efficient 5′-3′DNA end resection by HerA and NurA is essential for cell viability in the crenarchaeon Sulfolobus islandicus.BMC Mol. Biol.2015,16:2(14 February 2015). doi: 10.1186/s12867-015-0030-z.