教育背景
博士 起止时间：2004-2009毕业院校：山东大学 专业：发酵工程
硕士 起止时间：毕业院校：专业：
学士 起止时间：2000-2004毕业院校：山东大学 专业：生物技术

工作经历
起止时间 单位名称 专业技术职务
2010-2011 上海交通大学 博士后
2012至今 山东大学 教授
研究方向
微生物生理与代谢
生物催化
系统代谢工程
科研项目
1. 2020.01-2023.12，大肠杆菌中D-2-羟基戊二酸分解代谢机制研究，国家自然科学基金面上项目
2. 2019.01-2020.12，代谢工程改造产酸克雷伯氏菌高效生产丙酮酸，山东省重点研发计划
3. 2019.01-2023.12，山东大学齐鲁青年****学科建设经费
4. 2018.04-2021.06，微生物2-羟基羧酸分解代谢的应用基础研究，山东省****基金
5. 2015.01-2018.12，恶臭假单胞菌中一条新的戊二酸代谢途径，国家自然科学基金面上项目
6. 2014.07-2016.12，赖氨酸生物转化生产5-氨基戊酸，国家高技术研究发展计划
7 2013.01-2016.12，新型NAD非依赖性D-乳酸脱氢酶催化机理及应用基础研究，国家自然科学基金面上项目
8. 2012.11-2015.12，2-丁醇工程菌的基因组规模系统代谢育种，国家高技术研究发展计划
9. 2015.07-2020.06，铜绿假单胞菌L-乳酸代谢关键酶调控机制，山东大学青年****未来计划
代表性论文
1.Zhang Manman, Kang Zhaoqi, Guo Xiaoting, Guo Shiting, Xiao Dan, Liu Yidong, Ma Cuiqing, Xu Ping, Gao Chao*.Regulation of Glutarate Catabolism by GntR Family Regulator CsiR and LysR Family Regulator GcdR in Pseudomonas putida KT2440.mBio2019,10,e01570-19
2.Li Zhong, Yan Jinxin, Sun Jinkai, Xu Ping, Ma Cuiqing, Gao Chao*.Production of value-added chemicals from glycerol using in vitro enzymatic cascades.Communications Chemistry.2018, 1,71
3.Guo Xiaoting, Zhang Manman, Cao Menghao, Zhang Wen, Kang Zhaoqi, Xu Ping, Ma Cuiqing, Gao Chao*,D-2-Hydroxyglutarate dehydrogenase plays a dual role in L-serine biosynthesis and D-malate utilization in the bacterium Pseudomonas stutzeri. J. Biol. Chem. 2018, 293, 15513–15523
4.Zhang Manman, Gao Chao*, Guo Xiaoting, Guo Shiting, Kang Zhaoqi, Xiao Dan, Yan Jinxin, Zhang Wen, Tao Fei, Dong Wenyue, Liu Pan, Yang Chen, Ma Cuiqing, Xu Ping*, Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate. Nature Communications. 2018, 9,2114.
5. Zhang Wen, Zhang Manman, Gao Chao*, Zhang Yipeng, Ge Yongsheng, Guo Shiting, Guo Xiaoting, Zhou Zikang, Liu Qiuyuan, Zhang Yingxin, Ma Cuiqing, Tao Fei, Xu Ping*,Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L -serine synthesis.Proc Natl Acad Sci U S A. 2017, 114,E7574-E7582.
6.Jiang Tianyi, Guo Xiaoting, Yan Jinxin, Zhang Yingxin, Wang Yujiao, Zhang Manman, Sheng Binbin, Ma Cuiqing, Xu Ping, Gao Chao,A Bacterial Multidomain NAD-Independent d-Lactate Dehydrogenase Utilizes Flavin Adenine Dinucleotide and Fe-S Clusters as Cofactors and Quinone as an Electron Acceptor for d-Lactate Oxidization. J Bacteriol. 2017, 199, e00342-17.
7.Li Zhong, Zhang Manman, Jiang Tongtong, Sheng Binbin, Ma Cuiqing, Xu Ping, Gao Chao,Enzymatic Cascades for Efficient Biotransformation of Racemic Lactate Derived from Corn Steep Water.ACS Sustainable Chem. Eng. 2017, 5,3456?3464
8. Ge Yongsheng, Li Kun, Li Lixiang, Gao Chao*, Lijie Zhang, Ma Cuiqing*, Xu Ping, Contracted but effective: production of enantiopure 2,3-butanediol by thermophilic and GRAS Bacillus licheniformis. Green Chem, 2016, 18,4693-4703
9. Binbin Sheng, Jing Xu, Yongsheng Ge, Shuo Zhang, Danqi Wang, Chao Gao*, Cuiqing Ma, Ping Xu. Enzymatic Resolution by a d-Lactate Oxidase Catalyzed Reaction for (S)-2-Hydroxycarboxylic Acids. ChemCatChem 2016, 8, 2630– 2633
10. Gao Chao, Li Zhong, Zhang Lijie, Wang Chao, Li Kun, Ma Cuiqing*, Xu Ping, An artificial enzymatic reaction cascade for a cell-free bio-system based on glycerol, Green Chem, 2015, 17, 804-807
11. Gao Chao, Wang Yujiao, Zhang Yingxin, Lv Min, Dou Peipei, Xu Ping, Ma Cuiqing*, NAD-Independent L-lactate dehydrogenase required for L–lactate utilization in Pseudomonas stutzeri A1501. J. Bacteriol, 2015, 197, 2239–2247
12. Sheng Binbin, Xu Jing, Zhang Yingxin, Jiang Tianyi, Deng Sisi, Kong Jian, Gao Chao*, Ma Cuiqing, Xu Ping, Utilization of D-lactate as an energy source supports the growth of Gluconobacter oxydans, Appl Environ Microbiol. 2015, 81, 4098-4110

获奖情况
2015年山东大学青年****未来计划
2015年山东省暨山东大学优秀硕士学位论文指导教师
2018年山东省****科学基金
2019年山东大学齐鲁青年****
所获专利
一株重组大肠杆菌及其在生产2-丁醇中的应用，ZL8.9
一种加速5-氨基戊酸生物法生产的方法，ZL8.9
一种D-乳酸氧化酶及其在D-乳酸检测中的应用，ZL5.4
一株基因工程菌及其在生产(2R,3R)-2,3-丁二醇中的应用，ZL0.9
一种利用L-赖氨酸2-单加氧酶和δ-戊酰胺水解酶催化制备5-氨基戊酸方法，ZL9.4