教育背景
博士 2004-2009 山东大学 微生物学
学士 2000-2004 山东大学 生物技术


工作经历
起止时间 单位名称 专业技术职务
2009-2015 山东大学 讲师
2015-至今 山东大学 教授
2017.12-2018.12 东北大学（美国） 访问****
研究方向
1.微生物生理和生物化学
2.基因组学和生物信息学
3.海洋微生物资源、环境适应与进化
科研项目
1. 2018-2021， 假交替单胞菌多糖利用能力的分化及其基因组基础，国家自然基金面上项目
2. 2016-2021， 海洋特有细菌属Pseudoalteromonas的进化和适应， 山东大学青年****未来计划
3. 2015-2016， 北极海冰假交替单胞菌属细菌的多样性、系统分类及生态适应的遗传与生理基础，国家自然基金面上项目
4. 2014-2017， 评价嗜高压细菌在南海深部碳循环中的作用,国家自然基金重点项目子课题
5. 2011-2014， 新型海洋弹性蛋白酶的中试研究，863计划子课题
6. 2011-2013， 新型深海弹性蛋白酶Pseudoalterin对弹性蛋白的降解机制和适冷机制研究，国家自然科学基金青年科学基金项目
7. 2010-2013， 新型深海弹性蛋白酶Pseudoalterin的结构和功能研究，山东省中青年科学家科研奖励基金（博士基金）
8. 2011-2013， 一种新型深海弹性蛋白酶的结构和功能研究，高等学校博士学科点专项
9. 2010-2011， 蛋白质分子内相互作用网络的进化的研究，山东省博士后创新项目
10. 2010-2011， 蛋白质共进化的方法学研究及其应用，山东大学自主创新基金
代表性论文
(*corresponding author)
1. Li, P. Y., Zhang, Y. (Co-first author), Xie, B. B.*, Zhang, Y. Q., Hao, J., Wang, Y., Wang, P., Li, C. Y., Qin, Q. L., Zhang, X. Y., Su, H. N., Shi, M., Zhang, Y. Z., Chen, X. L* (2017) Structural and mechanistic insights into the improvement of the halotolerance of a marine microbial esterase by increasing intra- and interdomain hydrophobic interactions.Appl Environ Microbiol 83, e01286-17.
2. Su, H. N., Wang, Q. M. (Co-first author), Li, C. Y., Li, K., Luo, W., Chen, B., Zhang, X. Y., Qin, Q. L., Zhou, B. C., Chen, X. L., Zhang, Y. Z., and Xie, B. B.* (2017) Structural insights into the cold adaptation of the photosynthetic pigment-protein C-phycocyanin from an Arctic cyanobacterium.Biochim Biophys Acta 1858, 325-335.
3. Chen XL, Dong S (Co-first author), Xu F, Dong F, Li PY, Zhang XY, Zhou BC, Zhang YZ, Xie BB*. 2016. Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase fromPseudoalteromonas sp. SM0524.Front Microbiol.7:1120.
4. Rong JC, Liu M, Li Y, Sun TY, Pang XH, Qin QL, Chen XL, Xie BB*. 2016. Complete genome sequence of a marine bacterium with two chromosomes,Pseudoalteromonas translucida KMM 520(T).Mar Genomics.26:17-20.
5. Xie BB, Li D, Shi WL, Qin QL, Wang XW, Rong JC, Sun CY, Huang F, Zhang XY, Dong XW, Chen XL, Zhou BC, Zhang YZ*, Song XY*. 2015. Deep RNA sequencing reveals a high frequency of alternative splicing events in the fungusTrichoderma longibrachiatum.BMC Genomics.16:54.
6. Li H, Zhang XY (Co-first author), Liu C, Liu A, Qin QL, Su HN, Shi M, Zhou BC, Chen XL, Zhang YZ, Xie BB*. 2015.Bizionia arctica sp. nov., isolated from Arctic fjord seawater, and emended description of the genusBizionia.Int J Syst Evol Microbiol.65:2925-30.
7. Lin CY, Zhang XY (Co-first author), Liu A, Liu C, Song XY, Su HN, Qin QL, Xie BB*, Zhang YZ. 2015.Marivirga atlantica sp. nov., isolated from seawater and emended description of the genusMarivirga.Int J Syst Evol Microbiol.65:1515-9.
8. Xie, B. B., Q. L. Qin, M. Shi, L. L. Chen, Y. L. Shu, Y. Luo, X. W. Wang, J. C. Rong, Z. T. Gong, D. Li, C. Y. Sun, G. M. Liu, X. W. Dong, X. H. Pang, F. Huang, W. Liu, X. L. Chen, B. C. Zhou, Y. Z. Zhang*, and X. Y. Song*. 2014. Comparative genomics provide insights into evolution ofTrichoderma nutrition style.Genome Biol Evol 6:379-90.
9. Sun, M. L., S. B. Liu, L. P. Qiao, X. L. Chen, X. Pang, M. Shi, X. Y. Zhang, Q. L. Qin, B. C. Zhou, Y. Z. Zhang, and B. B. Xie*. 2014. A novel exopolysaccharide from deep-sea bacteriumZunongwangia profunda SM-A87: low-cost fermentation, moisture retention, and antioxidant activities.Appl Microbiol Biotechnol.98:7437-45.
10. Su, H. N., L. Y. Ran, Z. H. Chen, Q. L. Qin, M. Shi, X. Y. Song, X. L. Chen, Y. Z. Zhang, and B. B. Xie*. 2014. The ultrastructure of type I collagen at nanoscale: large or small D-spacing distribution?Nanoscale 6:8134-9.
11. Zhao, H. L., J. Yang, X. L. Chen, H. N. Su, X. Y. Zhang, F. Huang, B. C. Zhou, and B. B. Xie*. 2014. Optimization of fermentation conditions for the production of the M23 protease Pseudoalterin by deep-seaPseudoalteromonas sp. CF6-2 with artery powder as an inducer.Molecules 19:4779-90.
12. Qin QL, Xie BB*, Yu Y, Shu YL, Rong JC, Zhang YJ, Zhao DL, Chen XL, Zhang XY, Chen B, Zhou BC, Zhang YZ*. 2014. Comparative genomics of the marine bacterial genusGlaciecola reveals the high degree of genomic diversity and genomic characteristic for cold adaptation.Environ Microbiol 16:1642-53.
13. Li PY, Xie BB*, Zhang XY, Qin QL, Dang HY, Wang XM, Chen XL, Yu J, Zhang YZ*. 2012. Genetic structure of three fosmid-fragments encoding 16S rRNA genes of the Miscellaneous Crenarchaeotic Group (MCG): implications for physiology and evolution of marine sedimentary archaea.Environ Microbiol 14:467-79.
14. Xie, B. B., Y. L. Shu, Q. L. Qin, J. C. Rong, X. Y. Zhang, X. L. Chen, M. Shi, H. L. He, B. C. Zhou, and Y. Z. Zhang*. 2012. Genome sequences of type strains of seven species of the marine bacteriumPseudoalteromonas.J Bacteriol 194:2746-7.
15. Xie, B. B., Y. L. Shu, Q. L. Qin, J. C. Rong, X. Y. Zhang, X. L. Chen, B. C. Zhou, and Y. Z. Zhang*. 2012. Genome sequence of the cycloprodigiosin-producing bacterial strainPseudoalteromonas rubra ATCC 29570^T.J Bacteriol 194:1637-8.
16. Bian, F., B. B. Xie(Co-first author), Q. L. Qin, Y. L. Shu, X. Y. Zhang, Y. Yu, B. Chen, X. L. Chen, B. C. Zhou, and Y. Z. Zhang*. 2012. Genome sequences of sixPseudoalteromonas strains isolated from Arctic sea ice.J Bacteriol 194:908-9.
17. Xie BB, Bian F(Co-first author), Chen XL, He HL, Guo J, Gao X, Zeng YX, Chen B, Zhou BC, Zhang YZ*. 2009. Cold adaptation of zinc metalloproteases in the thermolysin family from deep sea and arctic sea ice bacteria revealed by catalytic and structural properties and molecular dynamics: new insights into relationship between conformational flexibility and hydrogen bonding.J Biol Chem.284:9257-69.
18. Xie BB, Chen XL, Zhang XY, He HL, Zhang YZ*, Zhou BC. 2008. Predicting protein interaction interfaces from protein sequences: case studies of subtilisin and phycocyanin.Proteins.71:1461-74.
获奖情况
2016年，入选“山东大学青年****未来计划”（2016-2021）