李延伟

??博士副教授 博/硕士生导师


通讯地址：山东省青岛市即墨滨海路72号

办公电话：

E-mail：lyw@sdu.edu.cn



Publons: https://publons.com/researcher/**/yanwei-li/
工作经历

2017/09-至今，山东大学，环境研究院，副教授
2015/11-2016/11，加州大学洛杉矶分校，化学与生物化学系，访问****，合作导师：Kendall Houk教授
2014/07-2017/09，山东大学，环境研究院，助理研究员
教育背景
2009/09-2014/06，山东大学，环境研究院，博士，导师：张庆竹教授
2005/09-2009/06，山东大学，化学与化工学院，学士


学术兼职:
Applied Catalysis B: Environmental, Environmental Microbiology, Science of the Total Environment, Chemosphere, Frontiers of Environmental Science and Engineering, Journal of Physical Chemistry, ACS Omega等期刊审稿人。
研究方向:

环境污染物的酶催化降解机理
环境污染物的酶催化转化与毒性效应
酶的定向进化与理性设计

毕业学生:
鲍雷（2016级），去向：中国科学院大学，读博
王小丹（2016级），去向：安徽节源环保科技公司，工作




主持承担的科研项目:



1.国家科技重大专项课题(子任务)，项目编号：2017ZX07202-002，子任务负责人

2.国家自然科学基金重点项目专项(子课题)，项目编号：**，子课题负责人
3.山东大学青年****未来计划，项目编号：2018WLJH54，负责人
??4.国家自然科学基金青年项目，项目编号：**，负责人(已结题)

5.山东省自然科学基金培育基金，项目编号：ZR2015PB002，负责人(已结题)
6.山东大学基本科研业务费资助项目，项目编号：2015GN007，负责人(已结题)
代表性论文与著作(^#共同第一，*通讯作者):


(1) Yue Yue, Jinfeng Chen, Lei Bao, Junjie Wang, Yanwei Li*, Qingzhu Zhang. Fluoroacetate dehalogenase catalyzed dehalogenation of halogenated carboxylic acids: A QM/MM approach. Chemosphere, 2020, 254, 126803.
(2) Hongxia Zhang^#, Shaixiao Tian^#, Yue Yue, Min Li, Wei Tong, Guangyu Xu, Bo Chen, Ming Ma, Yanwei Li*, and Jian-bo Wang*. Semirational design of fluoroacetate dehalogenase RPA1163 for kinetic resolution of α?fluorocarboxylic acids on a gram scale. ACS Catalysis, 2020, 10, 3143?3151.
(3) Pijun Duan, Yuanfeng Qi, Shanshan Feng, Xiaoming Pengd Wei Wang, Yue Yue,Yanan Shang, Yanwei Li*, Baoyu Gao, Xing Xu*. Enhanced degradation of clothianidin in peroxymonosulfate/catalyst system via core-shell FeMn @ N-C and phosphate surrounding. Applied Catalysis B: Environmental, 2020, 267, 118717.
(4) Yanwei Li*, Yue Yue, Hongxia Zhang, Zhongyue Yang, Hui Wang, Shaixiao Tian, Jian-bo Wang*, Qingzhu Zhang*, Wenxing Wang. Harnessing fluoroacetate dehalogenase for defluorination of fluorocarboxylic acids: in silico and in vitro approach. Environment International, 2019, 131, 104999.
(5) Xiaodan Wang, Jinfeng Chen, Xiaowen Tang, Junjie Wang, Ledong Zhu, Weixin Zhang, Hui Wang, Yanwei Li*, Qingzhu Zhang. Biodegradation mechanism of polyesters by hydrolase from Rhodopseudomonas palustris: An in silico approach. Chemosphere, 2019, 221, 11?20.
(6) Pijun Duan, Tengfei Ma, Yue Yue, Yanwei Li*, Xue Zhang, Yanan Shang, Baoyu Gao, Qingzhu Zhang, Qinyan Yue and Xing Xu*. Fe/Mn nanoparticles encapsulated in nitrogen-doped carbon nanotubes as a peroxymonosulfate activator for acetamiprid degradation. Environmental Science: Nano, 2019, 6, 1799?1811.（ES:Nano Best Papers Collection）
(7) Jianxin Guan^#, Chuancheng Jia^#, Yanwei Li^#, Zitong Liu^#, Jinying Wang, Zhongyue Yang, Chunhui Gu, Dingkai Su, Kendall N. Houk*, Deqing Zhang*, and Xuefeng Guo*, Direct single-molecule dynamic detection of chemical reactions. Science Advances, 2018, 4, eaar2177. (Highlighted by C&EN)
(8) Zhongyue Yang^#, Song Yang^#, Peiyuan Yu^#, Yanwei Li^#, Charles Doubleday, Jiyong Park, Ashay Patel, Byung-sun Jeon, William K. Russell, Hung-wen Liu, David H. Russell, and Kendall N. Houk*, Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115, E848?E855.
(9) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, Catalytic mechanism of C-F bond cleavage: insights from QM/MM analysis of fluoroacetate dehalogenase, Catalysis Science & Technology, 2016, 6(1): 73?80. (Outside Front Cover)
(10) Yanwei Li, Xiangli Shi , Qingzhu Zhang*, Jingtian Hu, Jianmin Chen, and Wenxing Wang, Computational Evidence for the Detoxifying Mechanism of Epsilon Class Glutathione Transferase Toward the Insecticide DDT, Environmental Science & Technology, 2014, 48 (9): 5008?5016.