蒋凡
教授，博士生导师
Email：fjiang@sdu.edu.cn
研究方向
血管生物学；细胞的应激与保护机制
教育经历
1995/02-1999/05，澳大利亚RMIT大学，Department of Medical Laboratory Sciences, 博士(药理专业)，导师：Professor Michael Rand and Dr. Chunguang Li，论文题目：Nitrergic Mechanisms in Cerebral Arteries (脑动脉中的一氧化氮能神经传递机制)
1987/09-1993/09，北京医科大学，医学学士
工作经历
2016/03 – 今：山东大学医学院生理与病理生理学系，教授，博士生导师；山东大学（教育部卫生部）心血管重构与功能研究重点实验室PI（兼）
2009/09 – 2016/03：山东大学（教育部卫生部）心血管重构与功能研究重点实验室，教授，博士生导师；
2005/03 – 2009/07：O’Brien Institute，University of Melbourne （澳大利亚墨尔本大学），Senior Research Officer，心血管药理实验室主管(Team leader)；
1999 /05– 2005/02：Howard Florey Institute ，University of Melbourne (澳大利亚墨尔本大学，博士后
科研项目
蒋凡曾以第一PI 身份独立承担三项由澳大利亚National Heart Foundation of Australia（NHF）资助的科研项目，两项（第二PI）由澳大利亚National Health and Medical Research Council (NHMRC) 的资助项目，两项（Co-PI）国际合作资助项目（新加坡心脏研究中心和北京天坛医院）。
回国后获得项目资助
1. 国家自然科学基金重大研究计划（培育项目），**，死亡受体与血管炎症稳态，2016/01- 2018/12，78万元，在研，主持
2．国家自然科学基金面上项目，**，剪切力对内皮细胞自噬反应的影响及意义，2015/01-2018/12，80万元，在研，主持
3．国家自然科学基金面上项目，**，脑出血病人血浆中 microRNA 水平的变化及其对血管细胞再生修复功能的影响，2013/01-2016/12，49万元，已结题，主持
4．国家自然科学基金面上项目，**，NOX4介导的氧化还原信号通路促进毛细血管新生及抑制内皮细胞凋亡的生物学机制，2011/01 -2013/12，30万元，已结题，主持
5．973项目子课题，2010CB732605，心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究（子课题名称：三维血流流场成像与斑块破裂的力学机制)，2010/01-2014/12，440万元，已结题，主持
学术兼职
中国病理生理学会理事；国际动脉硬化学会中国分会理事；山东省病理生理学会副理事长；Front Pharmacol（IF 4.41）杂志编委；每年为多个SCI杂志审稿5-10篇；香港中文大学，澳大利亚Monash大学博士毕业论文评审人；近几年应编辑部邀请在J Cardiovasc Pharmacol，Clin Exp Pharmacol Physiol，Arch Toxicol等SCI杂志上发表特邀综述文章3篇，述评文章1篇。
Publications
已发表SCI论文77篇，特邀Book chapter 2 篇，非SCI论文10余篇。
近五年发表的论文
1. Xiao Ting Lu, Yun Fang Liu, Li Zhao, Wen Jing Li, Rui Xue Yang, Fang Fang Yan, Yu Xia Zhao, Fan Jiang. (2013) Chronic psychological stress induces vascular inflammation in rabbits. Stress 2013;16(1):87-98.
2. Masayoshi Higuchi, Gregory J. Dusting, Hitesh Peshavariya, Fan Jiang, Sarah Tzu-Feng Hsiao, Elsa C. Chan, Guei-Sheung Liu. Differentiation of Human Adipose-Derived Stem Cells into Fat involves Reactive Oxygen Species and Forkhead Box O1 Mediated Upregulation of Antioxidant Enzymes. Stem Cells Dev. 2013 Mar 15;22(6):878-88.
3. Elsa Chan, Hitesh Peshavariya, Guei-Sheung Liu, Fan Jiang, Shiang-Yong Lim, Gregory Dusting. Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro. Biochem Biophys Res Commun. 2013 Jan 18;430(3):918-25.
4. Liu J, Wu X, Wang X, Zhang Y, Bu P, Zhang Q, Jiang F. Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress. Int J Mol Sci. 2013 Mar 11;14(3):5633-49.
5. Peshavariya HM, Taylor CJ, Goh C, Liu G-S, Jiang F, Elsa C. Chan, Gregory J. Dusting. (2013) Annexin Peptide Ac2-26 Suppresses TNFa-Induced Inflammatory Responses via Inhibition of Rac1-Dependent NADPH Oxidase in Human Endothelial Cells. PLoS ONE 8(4): e60790.
6. Dong Guo, Junni Liu, Weihua Wang, Fang Hao, Xuedong Sun, Xiao Wu, Peili Bu, Yun Zhang, Yu Liu, Fengqing Liu, Qunye Zhang, Fan Jiang. Alteration in abundance and compartmentalization of inflammation-related miRNAs in plasma after intracerebral hemorrhage. Stroke, 2013; 44(6):1739-1742.
7. Elsa C. Chan, Peter van Wijngaarden, Guei-Sheung Liu, Fan Jiang, Hitesh Peshavariya, Gregory J. Dusting. Involvement of Nox2 NADPH oxidase in retinal neovascularization. Invest Ophthalmol Vis Sci, 2013 Oct 29;54(10):7061-7.
8. Xiao-Ting Lu, Yu-Xia Zhao, Yun Zhang, Fan Jiang. Psychological stress, vascular inflammation and atherogenesis: potential roles of circulating cytokines. Journal of Cardiovascular Pharmacology 2013, 62(1): 6-12.
9. Fan Jiang. How Bad Moods Make Blood Vessels Blue? International Atherosclerosis Society (IAS) Commentaries, 2013 October: http://www.athero.org/commentaries/comm1152.asp#
10. Elsa C. Chan, Ming-Hong Tai, Pei-Chang Wu, Hsiao-Mei Kuo, Fan Jiang, Richard Tee, Wayne A. Morrison, Gregory J. Dusting, Guei-Sheung Liu. Expression of the proangiogenic protein hepatoma-derived growth factor in neovessels in an arterial venous loop-based tissue engineering chamber. Biomedical Engineering Applications, Basis and Communications, 2013, 25(5): **.
11. Wang Y, Li Y, Jiang C, Wu Z, Jiang F, Meng H, Siddiqui AH, Yang X. Could the types of paraclinoid aneurysm be used as a criterion in choosing endovascular treatment? Neuro-radiologists' view. Acta Neurochir (Wien), 2013 Nov;155(11):2019-27.
12. Feng Yan, Yuan Wang, Xiao Wu, Hitesh M. Peshavariya, Gregory J. Dusting, Mei Zhang, and Fan Jiang. Nox4 and redox signaling mediate TGF-beta-induced endothelial cell apoptosis and phenotypic switch. Cell Death & Disease, 2014 Jan 23;5:e1010.
13. Fang Fang Liu, Xiao Wu, Yun Zhang, Yan Wang*, Fan Jiang*. TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression. PLoS One, 2014 Jan 22;9(1):e87059.
14. Fan Jiang*, Guei-Sheung Liu, Gregory J. Dusting, Elsa C. Chan*. NADPH oxidase-dependent redox signaling in TGF-b-mediated fibrotic responses. Redox Biol. 2014 Jan 20;2:267-272.
15. Fan Jiang, Jianmin Yang, Yongtao Zhang, Mei Dong, Shuangxi Wang, Qunye Zhang, Fang Fang Liu, Kai Zhang and Cheng Zhang. Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets. Nature Reviews Cardiology, 2014 Jul;11(7):413-26.
16. Pengxiang Li, Qunye Zhang, Xiao Wu, Xinjian Yang, Yun Zhang, Youxiang Li*, Fan Jiang*. Circulating microRNAs serve as novel biological markers for intracranial aneurysms. J Am Heart Assoc, 2014; 3(5): e000972.
17. Dehua Liu, Liang Han, Xiao Wu, Xinjian Yang, Qunye Zhang*, Fan Jiang*. Genome-wide microRNA changes in human intracranial aneurysms. BMC Neurology, 2014 Oct 10; 14(1):188.
18. Hitesh M. Peshavariya, Guei-Sheung Liu, Catherine W. T. Chang, Fan Jiang, Elsa C. Chan, Gregory J. Dusting. Prostacyclin signalling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis. Antioxidants & Redox Signaling, 2014 Jun 10;20(17):2710-25.
19. Hitesh M Peshavariya, Elsa C Chan, Guei Sheung Liu, Fan Jiang*, Gregory J Dusting*. Transforming Growth Factor-β1 Requires NADPH Oxidase 4 for Angiogenesis In Vitro and In Vivo. Journal of Cellular and Molecular Medicine, 2014 Jun;18(6):1172-83.
20. Elsa C. Chan, Gregory J. Dusting, Guei-Sheung Liu, Fan Jiang. Redox mechanisms of the beneficial effects of heme oxygenase in hypertension. Journal of Hypertension, 2014 Jul;32(7):1379-86.
21. Wen Cheng, Yuxia Zhao, Shuangxi Wang, Fan Jiang*. Tumor necrosis factor-related apoptosis-inducing ligand in vascular inflammation and atherosclerosis: a protector or culprit? Vascular Pharmacology, 2014 Dec;63(3):135-144.
22. Xiao Meng, Jianmin Yang, Kai Zhang, Guipeng An, Jing Kong, Fan Jiang, Yun Zhang, Cheng Zhang. Regulatory T Cells Prevent Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E Knockout Mice. Hypertension, 2014 Oct;64(4):875-82.
23. Hao PP, Jiang F, Chen YG, Yang J, Zhang K, Zhang MX, Zhang C, Zhao YX, Zhang Y. Traditional Chinese medication for cardiovascular disease. Nat Rev Cardiol. 2015 Feb;12(2):115-122.
24. Zhang Yongtao, Bi Xiaolei, Jiang Fan. Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death. Arch Toxicol. 2015 Jul;89(7):991-1006.
25. 张勇涛, 蒋凡. 生理性和病理性心肌肥厚的信号传导机制. 中华心血管病杂志 Chin J Cardiol, 2015年3月，43(3): 277-280.
26. Xiaoling Liu, Mei Ni, Lianyue Ma, Jianmin Yang, Lin Wang, Fangfang Liu, Mei Dong, Xiaoyan Yang, Mei Zhang, Huixia Lu, Jingjing Wang, Cheng Zhang, Fan Jiang* and Yun Zhang*. Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization. Sci Rep. 2015 May 11;5:10225.
27. Yuanyuan Zhang, Shasha Wang, Chunyan Chen, Xiao Wu, Qunye Zhang*, Fan Jiang*. Arsenic primes human bone marrow CD34+ cells for erythroid differentiation. Bioinorg Chem Appl. 2015;2015:751013.
28. Xu Z, Han Y, Liu J, Jiang F, Hu H, Wang Y, Liu Q, Gong Y, Li X. MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C. Sci Rep. 2015 Jul 17;5:12276.
29. Liu J, Bi X, Chen T, Zhang Q, Wang SX, Chiu JJ, Liu GS, Zhang Y, Bu P*, Jiang F*. Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression. Cell Death Dis. 2015 Jul 16; 6: e1827.
30. Zhang Y, Fang Liu F, Bi X, Wang S, Wu X, Jiang F*. The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction. Sci Rep. 2015 Aug 11; 5: 13005.
31. Cheng W, Liu F, Wang Z, Zhang Y, Zhao YX*, Zhang Q, Jiang F*. Soluble TRAIL Concentration in Serum Is Elevated in People with Hypercholesterolemia. PLoS One, 2015 Dec 3; 10(12): e**.
32. Fan Jiang*. The expanding list of redox-sensing transcription factors in mammalian cells. J Cell Signal, 2015; 1(1): e101.
33. Hakami NY, Wong H, Shah MH, Dusting GJ, Jiang F, Peshavariya HM. Smad-independent pathway involved in transforming growth factor β1-induced Nox4 expression and proliferation of endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2015 Mar;388(3):319-26.
34. Sun M, Ji J, Guo X, Liu W, Wang Y, Ma S, Hu W, Wang J, Jiang F. Early adventitial activation characterized by NADPH oxidase expression and neovascularization in an aortic transplantation model. Exp Mol Pathol. 2016 Dec 3; 100(1): 67-73.
35. Jiang F*. Search for magic patches that heal the broken heart. Clin Exp Pharmacol Physiol. 2016 Mar; 43(3):290-3.
36. Yanjun Li, Jingxiao Xu, Fan Jiang, Zimu Jiang, Chuanyong Liu, Li Li, Yang Luo, Ruihui Lu, Yongrun Mu, Yugang Liu, Bing Xue. G protein-coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57BL/6 female mice. Neurogastroenterol Motil. 2016 Mar;28(3):432-42.
37. Guei-Sheung Liu*, Hitesh Peshavariya, Masayoshi Higuchi, Elsa C. Chan, Gregory J. Dusting, Fan Jiang*. Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine. J Tissue Eng Regen Med. 2016 Mar; 10(3):E167-76.
38. Fangfang Liu#, Wen Cheng#, Xiaolei Bi, Yun Zhang, Yuxia Zhao, Fan Jiang*. Stage-dependent effects of exogenous TRAIL on atherogenesis: role of ER stress-mediated sensitization of macrophage apoptosis. Clin Exp Pharmacol Physiol. 2016 May; 43(5):543-51.
39. Yuan Wang, Feng Yan, Qing Ye, Xiao Wu & Fan Jiang*. PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway. Sci Rep. 2016 Apr 7; 6:24111.
40. Fan Jiang*. Autophagy in vascular endothelial cells. Clin Exp Pharmacol Physiol. 2016 Nov; 43(11):1021-1028.
41. Li P#, Yin YL#, Guo T#, Sun XY, Ma H, Zhu ML, Zhao FR, Xu P, Chen Y, Wan GR, Jiang F, Peng QS, Liu C, Liu LY, Wang SX*. Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in vivo. Circulation. 2016 Nov 29;134(22):1752-1765.
42. Xiao Wu, Fan Jiang*. MicroRNA-365 is a negative regulator of endothelial cell proliferation. J. Mol. Biochem. 2016, 5: 78-86.
43. Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G*, Miao J*, Zhao B*. Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget. 2017 Jan 31;8(5): 7625-7636.
44. Ye Q, Pang S, Zhang W, Guo X, Wang J, Zhang Y, Liu Y, Wu X, Jiang F*. Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol. 2017 Mar;37(3): 476-484.
45. Xiaotong Guo, Mengyao Sun, Chaochao Dai, Xun Zhang, Qihui Yin, Xiao Wu, Fan Jiang, Jianli Wang. Macrophage-stimulated microRNA expression in mural cells promotes transplantation-induced neointima formation. Oncotarget. 2017; 8:30100-30111.
Book chapters
1. Elsa C. Chan, Hitesh Peshavariya, Srinivasa Raju Datla, Gregory J. Dusting, Fan Jiang. Redox regulation of angiogenesis: NADPH oxidase as a drug target. In: Anti-Angiogenesis-Drug Discovery and Development, pp86-115. ed. ATTA-UR-RAHMAN & CHOUDHARY. Bentham Science Publishers, 2010. (Invited)
2. Jiang F. Pharmacology of polyphenols in cardiac remodeling. In: Watson RR, Preedy VR, Zibadi S, eds. Polyphenols in human health and disease. Elsevier; 2013:945-956. (Invited)
参编教材
《Pathophysiology》（十三五规划教材），人民卫生出版社，2017 （编委）
专利
（1）颜凤、蒋凡；专利名称：主动脉三维培养单细胞分离器；专利号：ZL7.1
（2）蒋凡、叶青、仵霄；专利名称：一种高通量筛选具有Nrf2激活活性的化合物的方法；专利号： 7.5
（3）蒋凡、叶青；专利名称：RNA聚合酶I的抑制剂在抑制血管损伤后再狭窄的应用；专利号： 2.7