曾涛
2015-11-26 15:58


曾涛，男，副教授，硕士研究生导师。

学术简历

2005年6月毕业于山东大学，获医学学士学位；同年7月推免为山东大学毒理学硕博连读研究生，2010年6月，获医学博士学位，并留校工作至今。其中，2010年7月—2012年7月，入山东大学药学博士后流动站从事博士后研究。

研究方向

1.肝脏毒理学：研究酒精、药物及其它化学毒物引起肝脏损伤的分子机制及干预

2.食品毒理学：研究各种天然活性物质对化学性肝损伤的保护作用

社会兼职

1.山东省预防医学会卫生毒理学分会委员

2.山东省自然科学基金结题评审专家库成员

3.Reviewer for“Toxicology”、“Food and Chemical Toxicology”、“Journal of Food Science”、“Hepatology International”等。

承担的主要研究课题

1.基于MAPK信号通路研究酒精性脂肪肝发病中PPAR-α抑制的分子机制（**）国家自然科学基金面上项目2015.1-2018.12

2.细胞色素P4502E1在酒精性脂肪肝发病中的作用及分子机制(**)国家自然科学基金青年基金2012.1-2014.12

3.PI3K/Akt信号通路在酒精性脂肪肝发病中的作用(**064）教育部博士点基金2011.12-2015.12

4.二烯丙基二硫化物拮抗酒精性肝损伤及Nrf2/HO-1介导的保护机制(ZR2011HQ026)山东省自然科学基金青年基金2011.7-2014.7

5.自噬溶酶体途径在酒精性脂肪肝发病中的作用(**)中国博士后基金特别资助(第四批)

6.酒精性肝损伤发病的分子机制及其干预研究(**)中国博士后基金面上项目(第48批)

7.细胞色素P4502E1活化在酒精性脂肪肝发病中的作用研究(**)山东省博士后创新项目基金

8.酒精性脂肪肝发病的分子机制及防治靶点的研究(2010GN045)山东大学自主创新基金

主要学术论文(2010年—至今)

1.Chen YY, Zhang CL, Zhao XL, XieKQ, Zeng T. Inhibition of cytochrome P4502E1 by chlormethiazole attenuatedacute ethanol-induced fatty liver.Chem BiolInteract.2014, 222C:18-26. (Corresponding author)

2.Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ.CMZ reversed chronicethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stressand PGC-1α acetylation, and activating the MAPK and GSK3β pathway.PLoS One. 2014, 9(6):e98658.

3.Zeng T, Zhang CL, Zhao XL, XieKQ. Pentoxifylline for the treatment of nonalcoholic fatty liver disease: ameta-analysis of randomized double-blind, placebo-controlled studies. Eur J Gastroenterol Hepatol. 2014, 26(6):646-53.

4.Zeng T, Zhang CL, Song FY, ZhaoXL, Yu LH, Zhu ZP, Xie KQ. The activation of HO-1/Nrf-2 contributes to theprotective effects of diallyl disulfide (DADS) against ethanol-inducedoxidative stress.Biochim Biophys Acta, 2013, 1830: 4848-4859.

5.Zeng T, Zhang CL, Zhao XL, XieKQ. The roles of garlic on the lipid parameters: a systematic review of theliterature.Crit Rev Food Sci Nutr, 2013,53: 215-230

6.Zeng T, Zhang CL, Han XY, ZhaoS, Xie KQ. Association between CD14-159C>T polymorphisms and the risk foralcoholic liver disease: a meta-analysis.Eur J Gastroenterol Hepatol,2013, 25, 1183-1189.

7.Zeng T, Li Y, Zhang CL, Yu LH,Zhu ZP, Zhao XL, Xie KQ. Garlic oil suppressed the hematological disordersinduced by chemotherapy and radiotherapy in tumor-bearing mice.J Food Sci,2013, 78: H936-942.

8.Zeng T, Guo FF, Zhang CL, SongFY, Zhao XL, Xie KQ. Roles of Cytochrome P4502E1 Gene Polymorphisms and theRisks of Alcoholic Liver Disease: A Meta-Analysis.PloS one, 2013,8:e54188.

9.Zeng T, Zhang CL, Song FY, ZhaoXL, Yu LH, Zhu ZP, Xie KQ. PI3K/Akt pathway activation was involved in acuteethanol-induced fatty liver in mice.Toxicology, 2012, 296:56-66.

10.Zeng T, Zhang CL, Song FY, ZhaoXL, Xie KQ. Garlic oil alleviated ethanol-induced fat accumulation viamodulation of SREBP-1, PPAR-alpha, and CYP2E1.Food Chem Toxicol, 2012,50:485-491

11.Zeng T, Guo FF, Zhang CL, SongFY, Zhao XL, Xie KQ. A meta-analysis of randomized, double-blind,placebo-controlled trials for the effects of garlic on serum lipid profiles.J Sci Food Agric, 2012, 92:1892-1902

12.Guo FF, Xie Q, An RF, Zeng T,Zhou W. The CD14--159C/T polymorphisms and the risks of tuberculosis: ameta-analysis.Infect Genet Evol. 2013, 18:277-83. (corresponding author)

13.ZengT, Xie KQ. The differential modulation on cytochrome P450 enzymes by garliccomponents.Food Reviews International.2010,26(4):353-363.

14.YinHY, Guo Y, Song FY, Zeng T, Xie KQ.Toxicokinetic study of pyrroleadducts and its potential application for biological monitoring of2,5-hexanedione subacute exposure.IntArch Occup Environ Health. 2014, 87(6):655-62.

15.ZhangCL, Zeng T, Zhao XL, Xie KQ.Garlic oil attenuatednitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolicactivation and detoxification enzymes.Int J Biol Sci. 2013, 9(3):237-45.

16.ChenJ, Zeng T, Zhao X, Xie K, Bi Y, Zhong Z, Zhao X. Docosahexaenoic acid (DHA) amelioratesparaquat-induced pulmonary fibrosis in rats possibly through up-regulation ofSmad 7 and SnoN.Food Chem Toxicol.2013, 57:330-7.

17.ZhongZ, Zeng T, Xie K, Zhang C, Chen J, Bi Y, Zhao X.Elevation of 4-hydroxynonenaland malondialdehyde modified protein levels in cerebral cortex with cognitivedysfunction in rats exposed to 1-bromopropane.Toxicology. 2013, 306:16-23.

18.SongF, Han X, Zeng T, Zhang C, Zou C, Xie K.Changes in beclin-1 and micro-calpainexpression in tri-ortho-cresyl phosphate-induced delayed neuropathy.Toxicol Lett. 2012, 210(3):276-84.

19.ZhangCL, Zeng T, Zhao XL, Yu LH, Zhu ZP, Xie KQ. Protective effects of garlic oil onhepatocarcinoma induced by N-nitrosodiethylamine in rats.Int J Biol Sci.2012, 8 (3):363-74.

20.XingX, Zeng T, Dou DD, Zhao S, Du JY, Pei JJ, Xie KQ, Zhao XL. Changes ofUltrastructures and Mitochondrial Membrane Permeability in nerve tissue of henstreated with tri-ortho-cresyl phosphate (TOCP).Hum Exp Toxicol. 2011,30(8): 1062-72.

代表性著作（章节）

重要奖项

1.2011年山东省毒理学会青年毒理学工作者一等奖

2.2011年山东省研究生优秀科技创新成果二等奖

2008年获得山东大学研究生校长奖学金

【