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李景新教授 博士生导师

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一、简历
1991.09 -1996.07 山东医科大学 学士
1996.09-1998.07 山东医科大学 助教
1998.09-2001.07 山东大学 硕士
2001.07-2005.06 山东大学 讲师
2006.07-2007.06 加拿大多伦多大学 博士后
2007.06-2008.09 山东大学 讲师
2008.09-2011.06 山东大学 博士
2011.07-2013.08 山东大学 副教授、硕导
2013.09-至今 山东大学 教授、硕导
2015年7月 山东大学 教授 博导
二、研究兴趣
1. 研究外周GABA-GABAARs 在消化道上皮干细胞增殖及分化及在肠炎 的作用。
2. Oxytocin信号系统在消化道上皮干细胞增殖及分化及在粘膜固有免疫中的作用3.小气体信号分子H2S在生殖中的作用特别是在早期胚胎转运及着床中的作用。
三、发表文章
1. Chen D, Zhao J, Wang H, An N, Zhou Y, Fan J, Luo J, Su W, Liu C, Li J. Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury. Sci Rep. 2015 Jul 10;5:11731. doi: 10.1038/srep11731（通讯作者）(IF: 5.597 5-year impact factor)
2. Nannan Ning, Jianchun Zhu, Yahui Du, Xiaolin Gao, Chuanyong Liu, Jingxin Li.
Dysregulation of hydrogen sulfide metabolism impairs oviductal transport of embryos. Nat Commun. 2014 Jun 10;5:4107. （通讯作者）（IF: 11. 9 5-year impact factor）
3. Li X, Fei J, Lei Z, Liu K, Wu J, Meng T, Yu J, Li J. Chloroquine impairs visual transduction via modulation of acid sensing ion channel 1a. Toxicol Lett. 2014 May 10;228(3):200-206.（通讯作者） （IF: 3. 666 5-year impact factor）
4. Zhao D, Ning?N, Lei Z, Sun H, Wei C, Chen D, Li J. Identification of a Novel Protein Complex Containing ASIC1a and GABAA Receptors and Their Interregulation. PLoS One. 2014 Jun 12;9(6):e99735. （IF: 4. 244 5-year impact factor）
5. Yang N, Lei Z, Li X, Zhao J, Liu T, Ning N, Xiao A, Xu L, Li J.Chloroquine stimulates Cl- secretion by Ca2+ activated Cl- channels in rat ileum. PLoS One. 2014 Jan 30;9(1):e87627（通讯作者）（IF: 4. 244 5-year impact factor）
6. Zhang D, Li X, Yao Z, Wei C, Ning N, Li J. GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation. Cancer Lett.2014 Jun 28;348(1-2):100-8.（（通讯作者）IF: 4. 544 5-year impact factor）
7. Gao X, Ning N, Kong B, Xu Y, Xu H, Zhou C, Li S, Shao Y, Qiu J, Li J. Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. Lipids. 2013 Oct;48(10):989-95（通讯作者）（IF: 2.526 5-year impact factor）
8. Jing F, Liu M, Yang N, Liu Y, Li X, Li J (2013) Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKca. J Pharm Pharmacol. 2013 Jun;65(6):847-54（通讯作者）(IF: 2.118 5-year impact factor）
9. Nannan Ning,Ying Wen, Yan Li, Jingxin Li. Meclofenamic acid blocks the gap junction communication between the retinal pigment epithelial cells. Hum Exp Toxicol. 2013 Nov;32(11):1164-9（通讯作者）(IF: 1.571 5-year impact factor）
10. Sun Hui. Retinal toxicity associated with high dose of meclofenamicacid. Drug Chem Toxicol. 2013 Oct;36(4):461-5 （通讯作者）(IF: 1.066 5-year impact factor）
11. Li Y, Zang Y, Fu S, Zhang H, Gao L, Li J. H(2) S Relaxes Vas Deferens Smooth Muscle by Modulating the Large Conductance Ca(2+) -Activated K(+) (BK(Ca) ) Channels via a Redox Mechanism. J Sex Med. 2012 Nov;9(11):2806-13(通讯作者) (IF: 3.077 5-year impact factor）
12. Li Y, Xiang YY, Lu WY, Liu C, Li J. A novel role of intestine epithelial GABAergic signaling in regulating intestinal fluid secretion. Am J PhysiolGastrointest Liver Physiol.2012 Aug;303(4):G453-60(通讯作者) (IF: 3.622 5-year impact factor）
13. Li Jingxin, Li Yan,Du Yahui,Mou Kun,Sun Hui,Zang Yuanwei,Liu Chuanyong. Endogenous hydrogen sulfide as a mediator of vas deferens smooth muscle relaxation. Fertil Steril. 2011 Apr;95(5):1833-5. Epub 2010 Dec 3 (第一兼通讯作者) (IF: 3.96 5-year impact factor）
14. Zhou Zhenzhong, Sun Hui, Li Xiaomei, Li Yan, Zhao Shigang, Zhang Deqing , Yao Ziming, and Li Jingxin. A local GABAergic system is functionally expressed in human fallopian tube. Biochem Biophys Res Commun. 2010 Jul 23;398(2):237-41. Epub 2010 Jun 19. (通讯作者) (IF: 2.5 5-year impact factor）
15. Li JX, Xiang YY, Ye Lin, Lap-Chee Tsui, John F MacDonald, Jim Hu and Lu WY. Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR. Eur Respir J 2008; 32: 334–343 (第一作者) (IF: 6.32 5-year impact factor）
16. Li JX, Zhang N, Ye B, Ju W, Orser BA, Manning Fox JE, Wheeler MB, Wang Q and Lu WY. Non-steroidal Anti-inflammatory Drugs Increase Insulin Release from Beta-Cells by Inhibiting ATP-Sensitive Potassium Channels. Br J Pharmacol. 2007 Jun;151(4):483-93. (第一作者) (IF: 4.898 5-year impact factor）
17. Xiang YY, Wang S, Liu M , Hirota JA, Li JX ,Ye B, Yang X and Lu WY. A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nat Med. 2007 Jul;13(7):862-7. (IF: 26.441 5-year impact factor）
18. Xiang YY, Dong H, Wan Y, Li JX, Yee A, Yang BB and Lu WY. Versican G3 domain regulates neurite growth and synaptic transmission of hippocampal neurons by activation of epidermal growth factor receptor. J BiolChem. 2006;281(28):19358-68. (IF: 5.023 5-year impact factor）

四、联系方式

本实验室每年招收硕士研究生1-2名，博士研究生1-2名。
联系方式 ljingxin@sdu.edu.cn 电话**或**





INSTITUTE of PHYSIOLOGY School of Medicine Shandong University Address:Baotu Spring campus of Shandong University Zip Code:250012