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王向东 教授
王向东 博士

山东大学医学院教授 博士生导师

山东大学医学院细胞生物学系 系主任

学历
1985年于山东师范大学生物学系获 科学学士学位（BS）
1990年于第二军医大学生化与分子生物学系获 科学硕士学位（MS）
1997年于北京医科大学生化与分子生物学系获 博士学位（PhD）


工作经历
1985-87 于山东师范大学任助教
1990-91于北京军区总医院任检验技师
1991-94于北京军区总医院任主管技师
1997-98 La Jolla Institute for allergy and immunology ，博士后
1998-2000 NCI of NIH，博士后
2000-2002，University of Alabama at Birmingham，博士后
2003-2006，University of Alabama at Birmingham， 科研讲师（Research Instructor)
2006-2008 University of Alabama at Birmingham，助教授 (Assistant Professor)
2009- 山东大学医学院 细胞生物研究所所长，山东大学关键岗教授


工作简介
曾从师于我们国家著名的生化、分子生物学专家、北京大学教授、中国科学院院士童坦君先生。在蛋白质的表达、分离纯化与鉴定等技术方法方面有丰富经验。对adenovirus, retrovirus and lentivirus三大实验所用病毒的构建与应用有亲身经验，已掌握有各种类型的病毒载体。曾在国内获得过全军科技进步二等奖、三等奖各一次， 在国际内分泌年会上曾获得过两次奖（Travel Award by the Endocrine Society 及Quest Diagnostics Travel Grant Award）。在以往的十几年中，在内分泌研究领域里，一直从事细胞与分子生物学及分子内分泌学的研究，先后发表SCI影响因子在5.0以上的文章22篇。现在从事肥胖与2型糖尿病分子机理研究。现在有国家自然基金支持。还有山东省自然基金、山东大学的重大培育计划基金及教育部博士点基金的支持。


科研获奖记录：
1992,12 全军科技进步二等奖（关于疟原虫与其红细胞膜受体识别机制研究）
2000, 12 全军科技进步三等奖(关于肺癌相关抗原的研究)
2002, 6 Travel Award by the Endocrine Society (about TACE cleavage site in rbGHR)
2005, 6 Quest Diagnostics Travel Grant Award. The abstract was selected for the travel grant because is it one of the 12 highest scored abstracts submitted for ENDO.

发表的文章（SCI，selected):
1. Sung-Oh Kim, Kimberly Loesch, Xiangdong Wang, Jing Jiang, Lin Mei, Jess M. Cunnick, Jie Wu and Stuart J. Frank A Role for Grb2-associted binder(Gab)-1 in Growth Hormone Signaling. Endocrinology, 2002;143(12):4856-4867
2. Xiangdong Wang, Kai He, Mary Gerhart, Yao Huang, Jing Jiang,Raymond J. Paxton, Shaohua Yang， Chunxia Lu, Ram K. Menon, Roy A. Black, Gerhard Baumann and Stuart J. Frank Metalloprotease- mediated GH Receptor Proteolysis and GHBP Shedding: Determination of Extracellular Domain Stem Region Cleavage Site. J Biol Chem. 2002;277(52):50510- 50519
3. Anne-Marie Hansen, Hansj?rg Lehnherr, Xiandong Wang, Victoria Mobley, Ding Jun Jin Escherichia coli SspA is a Transcription Factor for Bacteriophage P1 Late Genes. Molecular Microbiology 2003, Jun;48(6);1621-31
4. Xiangdong Wang, Kai He, Mary Gerhart, Jing Jiang, Raymond J. Paxton, Ram K. Menon, Roy A. Black, Gerhard Baumann and Stuart J. Frank Reduced Rabbit GHR Proteolysis Substituted with Mouse GHR Cleavage Site. Molecular Endocrinology 2003,17(10):1931-1943
5. Huijun Zhi§, Xiangdong Wang§, Julio E. Cabrera, Reid C. Johnson and Ding Jun Jin Fis stabilizes the interaction between RNA polymerase and the ribosomal promoter rrnBP1, leading to transcriptional activation. J Biol Chem. 2003 Nov21;278(47):47340-9
6. Kai He, Xiangdong Wang, Jing Jiang, Ran Guan, Kenneth E. Bernstein, Peter P. Sayeski and Stuart J. Frank. Janus Kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol Endocrinol. 2003 Nov:17(11):2211-27
7. Yao Huang, Yongchang Chang, Xiangdong Wang, Jing Jiang and Stuart J. Frank Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 2T3F442A cells. Endocrinology. 2004 Jul;145(7);3297-306.
8. Jing Jiang§, Xiangdong Wang§, Kai He, Xin Li, Changmin Chen, Peter P. Sayeski, Michael J. Waters and Stuart J. Frank. A conformationally sensitive GHR[growth hormone(GH) receptor]antibody: impact on GH signaling and GHR proteolysis. Mol Endocrinol. 2004 Dec;18(12):2981-96
9. Jon W. Cowan§, Xiangdong Wang§, Ran Guan, Kai He, Jing Jiang, Gerhard Baumann, Roy A. Black, Michael S. Wolfe and Stuart J. Frank Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. J Biol Chem. 2005 May 13;280(19):19331-42
10. Kai He, Kimberly Loesch, Jon W. Cowan, Xin Li, Luqin Deng, Xiangdong Wang, Jing Jiang and Stuart J. Frank Janus kinase 2 enhances the stability of the mature growth hormone receptor. Endocrinology. 2005 Nov;146(11):4755-65
11. Kimberly Loesch, Luqin Deng, Jon W. Cowan, Xiangdong Wang, Kai He, Jing Jiang, Roy A. Black and Stuart J. Frank JAK2 influences growth hormone receptor metalloproteolysis. Endocrinology. 2006 Jun;147(6):2839-49
12. Peng Fang, Eric M. Kofoed, Brian M. Little, Xiangdong Wang, Richard J. M. Ross, Stuart J. Frank, Vivian Hwa and Ron G. Rosenfeld A mutant STAT5b , associated with growth hormone insensitivity and IGF-1 Deficiency, cannot function as signal transducer or transcription factor. J Clin Endocrinol Metab. 2006 Apr;91(4):1526-34
13. Stuart J. Frank§, Xiangdong Wang§, Kai He, Ning Yang, Peng Fang, Ron G. Rosenfeld, Vivian Hwa, Tandra R. Chaudhuri, Luqin Deng and Kurt R. Zinn In vivo Imaging of hepatic growth hormone signaling Mol Endocrinol 2006 November, 20(11):2819-2830
14. Luqin Deng, Kai He, Xiangdong Wang, Ning Yang, Chellappagounder Thangavel, Jing Jiang, Serge Y. Fuchs and Stuart J. Frank Determinants of Growth Hormone Receptor Downregulation Mol Endocrinol. 2007 Jul;21(7):1537-51.
15. Kimberly Loesch, Luqin Deng, Xiangdong Wang, Kai He, Jing Jiang and Stuart J. Frank. Endoplasmic reticulum- associated degradation of growth hormone receptor in Janus kinase 2- deficient cells. Endocrinology. 2007 Dec;148(12):5955- 65.
16 Ning Yang, John F. Langenheim, Xiangdong Wang, Jing Jiang, Wen Y. Chen and Stuart J. Frank Activation of Growth Hormone Receptors by Growth Hormone and Growth Hormone Antagonist Dimers: Insights into Receptor Triggering. Mol Endocrinol. 2008 ；20; 22 (4): 978-988
17 . Ning Yang, Xiangdong Wang, Jing Jiang and Stuart J. Frank Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation. Mol Endocrinol. 2007 Jul;21(7):1642-55.
18. Kurt R. Zinn, Tandra R. Chaudhuri, April Adams Szafran, Darrell O’Quinn, Casey Weaver, Kari Dugger, Dale Lamar, Robert A. Kesterson, Xiangdong Wang, and Stuart J. Frank Noninvasive bioluminescence imaging in small animals. ILAR J. 2008;49(1):103-15.
19. Xiangdong Wang, Jing Jiang§, Jason Warram, Gerhard Baumann, Yujun Gan, Ram K. Menon, Lee A. Denson, Kurt R. Zinn and Stuart J. Frank. Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity. Mol Endocrinol. 2008 Jun;22(6):1427-37
20. Xiangdong Wang§, Ning Yang§, Luqin Deng, Xin Li, Jing Jiang, Yujun Gan
and Stuart J.Frank .Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1. Mol Endocrinol. 2009 Apr;23(4):486-96. Epub 2009 Jan 22.
21. Ning Yang, Jing Jiang, Luqin Deng, Michael J. Waters, Xiangdong Wang and Stuart J. Frank Growth hormone receptor targeting to lipid rafts requires extracellular subdomain 2. Biochem Biophys Res Commun. 2010 Jan 1;391(1):414-8.
22. Yujun Gan, Yue Zhang, Douglas J. DiGirolamo, Jing Jiang, Xiangdong Wang, Xuemei Cao, Kurt R. Zinn, David P. Carbone, Thomas L. Clemens, and Stuart J. Frank Deletion of IGF-I Receptor (IGF-IR) in Primary Osteoblasts Reduces GH-Induced STAT5 Signaling. Mol Endocrinol. 2010 ；24(3):644-56.
23. Xiangdong Wang, Jon Cowan, et al. γ-Secretase-mediated growth hormone receptor proteolysis: Mapping of the intramembranous cleavage site. Biochem Biophys Res Commun. 2011 May 13;408(3):432-6
24. Luo N, Wang X, Chung BH, Lee MH, Klein RL, Garvey WT, Fu Y. Effects of macrophage-specific adiponectin expression on lipid metabolism in vivo.
Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E180-6. Epub 2011 Apr 19
25. Jiang J§, Wan Y§, Wang X§, Xu J,Harris JM, Lobie PE, Zhang Y, Zinn KR, Waters MJ, Frank SJ. Inhibitory GH Receptor Extracellular Domain Monoclonal Antibodies:Three-dimensional Epitope Mapping Endocrinology 2011 Dec;152（12）：4777-88
26. Lu S, Guan Q, Liu Y, Wang H, Wu W, Li X, Fu Y, Gao L, Zhao J, Wang X Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity Lipids health Dis. 2012 Jan30;11(1)17.
（§These authors are equal contributors to the paper.）

科研基金的情况

Past:
1. “Tumor Marker Research” Clinic Research Grant ( funded by the General Hospital of Bejing Military Region ) 1991-93 , P.I.
2. “Isotope imaging method in detecting malignant tumor” Clinic Research Grant (funded by the General Hospital of Bejing Military Region ) 1992-94, P.I.
3. “Lung Cancer Associate Antigen Purification, Characterization and Detection” Young Researcher Funding Grant (funded by the Chinese military) 1992-1996, P.I.

4. “Effect of curcumin on in vitro and in vivo JAK-STAT signaling” NIH Pilot Grant from UAB Center for Nutrient-Gene Interaction (CNGI) in Cancer Prevention, July 2006 to June 2007 - P.I.

5.国家自然科学基金（项目批准号**），生长激素受体的膜上酶解及其对信号转导的调节，2009.01—2011.12，项目负责人
Active

1.山东省自然科学基金（项目批准号2009ZRB02545），脂肪细胞上促甲状腺素受体（TSHR3）的表达与肥胖的相关性研究，2009.09—2012.09，项目负责人

2.国家教育部博士点基金， 生长激素信号相关分子通过STAT5途径影响
肥胖 2010，01-2013，12 项目负责人

3.山东大学重大导向培育项目：一类心血管‘生物清洗、保护剂’的研制与药效分析2010，06-2012，12 项目负责人

4.国家自然科学基金（项目批准号**），生长激素降低与肥胖发生的分子机制研究，2012-2015， 项目负责人


【上 一 篇】：课程简介【下 一 篇】：李相芝 教授
友情链接山东大学
版权所有? 2012 山东大学医学院细胞生物学系

地址：山东省济南市文化西路４４号：山东大学医学院6＃细胞生物学系

联系电话：0086-**
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