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山东大学病理学教研室
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师资力量>师资力量>刘志艳


刘志艳，女，病理学博士，副主任医师，副教授，硕士研究生导师。中华医学会病理学分会头颈部学组、呼吸学组委员。中国医疗保健国际交流促进会病理专业委员会委员、中国医疗保健国际交流促进委员会甲状腺疾病学会委员。美国甲状腺学会会员。研究方向为内分泌、皮肤及消化系统肿瘤。99年本科毕业于济宁医学院，02年于同济医科大学病理学专业硕士毕业并到本教研室任教。06年考取本教研室博士，2007.06-2011.03由国家留学基金委全额奖学金资助攻读日本/中国联合培养病理学博士。获日本Wakayama Medical University与山东大学双博士学位。师从周庚寅教授、觉道健一教授，专注于甲状腺肿瘤的诊断与分子生物学研究。留学期间获评2009年西日本地区优秀留学人员、2010年日本内分泌病理学会青年研究者。2011年10月获评中华病理学会首届吴秉铨基金青年学者奖。发表SCI论文多篇，作为第一位承担国家级、省部级基金多项。参与国家自然科学基金三项、省部级课题多项。曾在USCAP100周年年会、日本病理学99周年年会、中国病理学年会等会议，围绕“甲状腺恶性潜能未定的高分化肿瘤、高危甲状腺乳头状癌”发表10余次。



近期发表的论文:

1. Liu Zhiyan, Zhang Chunyan, Kakudo Kennichi, Cui Xiujie, Mu Kun, Zhou Chengjun,Wang Yan, Chen Shiming, Zhou Gengyin. Diagnostic pitfalls in pathologicaldiagnosis of infectious disease: patients with syphilitic lymphadenitis oftenpresent with inconspicuous history of infection. Pathol Int. 2016; 66:142-147.

2. Li Zhen, Zuo Xiu Li, Li ChangQing, Liu Zhi Yan, Ji Rui,Liu J, Guo J, Li Yan Qing. New Classification of gastric pit patterns and vesselarchitecture using probe-based Confocal Laser Endomicroscopy. J ClinGastroenterol. 2016;50(1):23-32.

3. Liu Zhiyan, Kakudo Kennichi, Zhang Chunyan, Cui Xiujie, Qi Mei, Han Bo. BiologicalBehavior of Thyroid Cancer in Indeterminate Category. JBasic Clinical Medicine. 2015;4:87-91.

4. Qi Mei, Liu Zhiyan, Shen Chengwu, Wang Lin,Zeng Jiping, Wang Chuni, Li Congcong, Fu Weiei, Sun Yi, Han Bo.Overexpression of ETV4 is associated with poor prognosis in prostate cancer:involvement of uPA/uPAR and MMPs. Tumour Biol. 2015; 36(5):3565-72. (Qi Mei and Liu Zhiyancontributed equally to the article).

5. Wang L, Song G, Chang X, Tan W, Pan J,Zhu X, Liu Z, Qi M, YuJ, Han B. The role of TXNDC5 in castration-resistant prostatecancer-involvement of androgen receptor signaling pathway. Oncogene. 2015, 3;34(36):4735-45.

6. Wakasa T, Li Yaqiong, BaiYanhua, Liu Zhiyan, OzakiTakahashi, Mori Ichiro, Miyauchi Akira, Kakudo Kennichi, Nakamura Misa.Up-regulation of urinary-type plasminogen activator correlates with high-riskpapillary thyroid carcinoma with BRAF (V600E) mutation and its possiblemolecular mechanism. Pathol Res Pract. 2014; 210(11):733-8.

7. Zhang Xiaoying, LiHiu Ming, Liu Zhiyan, Zhou Gengyin, ZhangQinghui, Zhang Tingguo, Zhang Jianping, ZhangCuijuan. Loss of heterozygosity and methylation of multiple tumor suppressorgenes on chromosome 3 in hepatocellular carcinoma. J Gastroenterol.2013;48(1):132-43.

8. Nishigami Keiko, Liu Zhiyan, Taniguchi K, OzakiTakahashi, Kakudo Kennichi. Cytological features of well-differentiated tumorsof uncertain malignant potential-Indeterminate cytology and WDT-UMP. EndocrineJ, 59(6):483-7. 2012.

9. Liu Zhiyan, Zhou Gengyin, Nakamura Misa,Koike E, Li Yaqiong, Ozaki Takahashi, Mori Ichiro, Taniguchi Emiko, KakudoKennichi. Encapsulated follicular thyroid tumor with equivocal nuclear changes,so-called well-differentiated tumor of uncertain malignant potential, amorphological, immunohistochemical, and molecular appraisal. Cancer Sci. 2011,102(1):288-94.

10. Liu Zhiyan, Zhou Gengyin, NakamuraM, Bai Yanhua, Li Yaqiong, Ozaki Takahashi, Mori Ichiro, Miyauchi Akira, KakudoKennichi. Retinoid X receptor γ up-regulation is correlated withdedifferentiation of tumor cells and lymph node metastasis in papillary thyroidcarcinoma. Pathol Int. 2011, 61(3):109-15.

11. Liu Zhiyan, Kakudo Kennichi, BaiYanhua, Li Yaqiong, Ozaki Takahashi, Miyauchi Akira, Taniguchi Emiko, Mori I.Loss of cellular polarity/cohesiveness in the invasive front of papillarythyroid carcinoma, a novel predictor for lymph node metastasis—possiblemorphological indicator of epithelial mesenchymal transition. J Clin Pathol. 2011, 64(4):325-9

12.Liu Zhiyan, Bai Yanhua, Li Yaqiong, Ohba K, Nakamura H, Ozaki Takahashi, TaniguchiEmiko, Mori Ichiro, Kakudo Kennichi. Non-solid type thyroid carcinoma: a casereport of moderately differentiated adenocarcinoma of the thyroid. Pathol Int.2010; 60(7):524-7.

13.Lu Ning, Lin T, Wang L, Qi Mei, Liu Zhiyan, Dong H, Zhang X,Zhai C, Wang Y, Liu L, Xiang L, Qi L, Han B, Li J. Association of SOX4 regulated by tumorsuppressor miR-30a with poor prognosis in low-grade chondrosarcoma. TumourBiol. 2015 36(5):3843-52.

14. Liu Zhiguo, Li J, Liu Zhiyan, Wang Qian, Famer P,Mehta A, Chalif D, Wang Y, Li JY. Supratentorial cortical ependymoma: caseseries and review of the literature. Neuropathology. 2014; 34(3):243-52.

15. Yao Shuzhe, Zhang J, Chen Haiyan,Sheng Y, Zhang Xiaofang, Liu Zhiyan,Zhang Cuijuan. Diagnostic value of immunohistochemical staining of GP73, GPC3,DCP, CD34, CD31, and reticulin staining in hepatocellular carcinoma.J HistochemCytochem. 2013;61(9):639-48.

16. Mu K, Li L, Yang Q, Zhang T, GaoP, Meng B, Liu Zhiyan,Wang Y, Zhou G. Detection of CHK1 and CCND1 gene copy number changes in breastcancer with dual-colour fluorescence in-situ hybridization. Histopathology.2011 Mar 14.

17. Bai Yanhua, Nakamura M, ZhouGengyin, Li Yaqiong, Liu Zhiyan, Ozaki Takahashi, Mori Ichiro, Kakudo Kennichi. Novel Isoforms ofPeriostin Expressed in the Human Thyroid. Japanese Clinical Medicine. 2010;1:13-20

18. Li Yaqiong, Bai Yanhua, Liu Zhiyan, Ozaki Takahashi, TaniguchiEmiko, Mori Ichiro, Nagayama K, Nakamura H, Kakudo Kennichi. Immunohistochemistryof IgG4 can help subclassify Hashimoto's autoimmune thyroiditis. Pathol Int.2009; 59(9):636-41.

19. Zhou CJ, Zhang QH, Zhang TG, SunSZ, Li H, Wang Y, Liu ZY. Expression of ER, Ki-67 and CyclinD1 in the pre-cancerous breastof Chinese Patients. Pathol Oncol Res. 2009; 15(2):153-8.

20. Bai Yanhua, Kakudo Kennichi,Nakamura M, Ozaki Takahashi, Li Yaqiong, Liu Zhiyan, Mori Ichiro, Miyauchi Akira, Zhou G. Loss of cellularpolarity/cohesiveness in the invasive front of papillary thyroid carcinoma andperiostin expression. Cancer Lett. 2009; 281(2):188-95.

21. Bai Yanhua, Kakudo Kennichi, LiYaqiong, Liu Zhiyan,Ozaki Takahashi, Ito Y, Kihara M, Miyauchi A. Subclassification ofnon-solid-type papillary thyroid carcinoma identification of high-risk group incommon type. Cancer Sci. 2008; 99(10):1908-15. Erratum in: Cancer Sci. 2008;99(12):2548.

22. Zhang XM, Yu D, Zhang HL, Dai Y,Bi D, Liu Zhiyan,Prince MR, Li C. 3D dynamic contrast-enhanced MRI of rectal carcinoma at 3T:correlation with microvascular density and vascular endothelial growth factormarkers of tumor angiogenesis. J Magn Reson Imaging. 2008; 27(6):1309-16.　

23. Gao Peng, Zhou Gengyin, Yin G,Liu Y, Liu Zhiyan,Zhang J, Hao Chunyan. Lymphatic vessel density as a prognostic indicator forpatients with stage I cervical carcinoma. Hum Pathol. 2006; 37(6):719-25.

24.蔡敏，孔香云，王妍，刘志艳，周志强，马榕，张庆慧。乳腺分叶状肿瘤EGFR、Ki67的表达和意义。中国现代普外科进展。2007; 12 (3): 247-250

25. 孙晔，张庆慧，周成军，王晓映，刘志艳，周志强，刘文君。CK5／6和CK34βE12在乳腺导管内增生性病变鉴别诊断中的价值。中国现代普外科进展。2007; 12(1): 40-44

26. 周成军，张庆慧，张廷国，李红，王妍，刘志艳。乳腺导管内增生性病变中ER、Ki-67和cyclinD1的表达。临床与实验病理学杂志，2006, 22(4): 454-457

27.刘志艳，周庚寅，张庆慧等。梅毒性淋巴结炎临床病理学诊断。临床与实验病理学杂志，2006,22(3): 277-280

28. 刘志艳，隋少峰，王志富等。吸烟对呼吸道上皮损伤机制的研究。中国公共卫生，2005,21(8): 897-899

29.高鹏，周庚寅，刘文军，刘志艳等。乳腺癌中细胞周期素D1基因改变和转录异常对其蛋白表达的影响，中国现代普外科进展，2004, 7(1):31-37

30. 隋少峰，刘志艳，张红，江媛媛。二氧化钛光降解饮用水中藻毒素的研究进展。中国公共卫生，2004, 20:875-876

31. 王志富，刘志艳，席海燕等。喉软骨肉瘤两例报告。山东大学学报(医学版)，2003, 41(1):102

32.刘志艳，吴人亮，李娜平等。γ连环素在小鼠气道上皮细胞中的表达。中华结核与呼吸杂志，2002,25(7): 440

33.刘志艳，吴人亮。γ连环素及其研究进展。国外医学（分子生物学分册），2002,24(2):127-129

34. 陈雁君，卢英华，刘君，黄丽静，刘志艳。水中丙溴磷的富集及气相色谱分析。分析化学，2000, 28(7), 887-889


出版著作：
1. Clinical management of thyroid cancer. Editor: Kennichi Kakudo, Zhiyan Liu Future Science Group (FSG) ISBN: 978-1-78084-305-6，2013
2. Molecular Mechanism and Morphology in Cancer. Editor: Misa Nakamura, vice editor: Kennichi Kakudo. Liu Z is one of the coauthors. eISBN: 978-1-60805-073-4 , 2010
3. 《诊断免疫组织化学》主编：周庚寅，张庆慧。本人参译。北京大学医学出版社。2008.09 ISBN 81071-750-2
4. 《西医综合考试点精要》主编：徐从高，李芳邻。本人副主编。北京大学医学出版社。2007.03 ISBN 7-81071-924-6
5. 《肾脏病理诊断图谱》主译：周庚寅。本人参译。北京大学医学出版社。2007.01 ISBN **71
6. 《组织病理学技术》主编：周庚寅，张庆慧，翟启辉。本人参编。北京大学医学出版社。2008.08 ISBN **85


科研课题
1. 上皮-间质转化（EMT）在甲状腺肿瘤浸润和转移中的作用及其机制 山东省自然基金第一位 编号：ZR2011HQ040
2. RXRγ调控上皮间叶转化参与甲状腺癌浸润转移的机制 中国博士后基金第52批面上项目第一位 编号：2012M521344
3. 酪氨酸激酶抑制剂genistein调控上皮-间质转化（EMT）参与甲状腺肿瘤发生、发展的机制 山东大学自主创新基金 第一位编号：2012TS121
4. EphBs/EphrinBs信号系统在肌筋膜疼痛扳机点中的表达及机制研究 国家自然基金 第三位编号：**
5. 乳腺癌非随机性抑癌基因的鉴定及特性分析的研究第四位 编号：**
6. 白杨黄素逆转耐药乳腺癌细胞中BCRP介导的多药耐药作用 山东省医药卫生项目 2008-2010 第一位编号：2007QZ003
7. 肝细胞癌抑制基因TMS1失活的表现遗传机制研究 国家自然基金青年基金 2009-2011 18万第6位 编号：**
8. 肝细胞癌抑制基因TMS1失活的表现遗传机制研究 教育部高等教师基金2009-2011 第6位 编号：**2
9. G47dnFGFR基因治疗恶性外周神经鞘瘤的实验研究 山东省科技攻关项目 2006-2008 第3位 编号：2006GG**
10. 携CT抗原启动子的新型靶向性MDR逆转载体的构建山东省科学技术发展计划重点项目第9位 2008-2010 编号：2008GG**
11. 乳腺癌特异性PLU-1启动子携多个反义核酶多靶性逆转乳腺癌多药 山东省自然基金 2010-2012 第9位 编号：20092RA01043
12. 乳腺癌激素受体及HER2检测标准化的研究 山东省医药卫生项目 2003-2005 第5位
13. 中药抗肿瘤生物分子作用的筛选与临床山东省中医药科技计划项目 2005-2007第5位


奖励
1. 中华病理学会吴秉铨基金优秀青年研究者参会奖 2011年10月
2. 国家留学基金委员会建设高水平大学全额奖学金 2007年4月-2010年3月
3. 国际妇女组织日本近畿地区分部优秀留学生奖学金 2010年4月
4. 日本大桑财团振兴会优秀留学生科研基金 2010年11月
5. 日本内分泌病理学会青年研究者奖 2010年10月
6. 中国驻大阪总领馆日本关西地区优秀留学人员 2008年10月
7. 华中科技大学同济医学院优秀硕士毕业生 2002年6月



学会发表

1. 2015.11.05~08 Zhiyan Liu, et al. How to define the well differentiated tumor with uncertain malignant potential of follicular thyroid lesions (Special lecture)? The 21^th Congress of Chinese Society of Pathology, Kunming, Yunnan, China

2. 2015.10.18-23 Zhiyan Liu. Genistein-a Potential Therapeutic Factor for High Risk Papillary Thyroid Carcinoma with BRAF^V600E Mutation (Oral presentation and poster). The 15^th international thyroid congress. Orlando, Florida, USA.

3. 2015.06.12-15 Zhiyan Liu. Loss of cellular polarity/cohesiveness in papillary thyroid carcinoma, a precursor lesion of hobnail feature and micro-papillae? Based on a case report and literature review (Oral presentation). The 3^rd Annual meeting of Chinese Cytopathology Association, Hefei, Anhui, China

4. 2014.11.14-16 Zhiyan Liu, et al. Diagnostic Pitfall in Surgical Pathology Unit- Four cases of cryptococcal infection of children diagnosed by lymph node biopsy (Oral presentation). The 20^th Congress of Chinese Society of Pathology, Chongqing, Sichuan, China

5. 2013.11.08-10 Zhiyan Liu. Borderline lesion of thyroid tumor, so-called well differentiated tumor of uncertain malignant potential and encapsulated follicular variant papillary thyroid carcinoma (Special lecture). The 19^th Congress of Chinese Society of Pathology, Guangzhou, Guangdong, China

6. 2011.2.25~3.04 Zhiyan Liu, et al. Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well differentiated tumor of uncertain malignant potential, a morphological immunohistochemical and molecular appraisal (Poster). 100th Annual meeting of United States and Canadian Academy of Pathology, San Antonio, TX, USA

7. 2010.11.20~22 Zhiyan Liu, et al. Cytopathological Features of Well Differentiated Tumor of Uncertain Malignant Potential (WDT-UMP), a Borderline Lesion of Thyroid Follicular Cell Tumor. The 49^th Fall meeting of Japanese society of Clinical Cytology, Kobe, Japan

8. 2010.10.29~30 Zhiyan Liu, et al. Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well differentiated tumor of uncertain malignant potential, a morphological immunohistochemical and molecular appraisal. The 14^th meeting of The Japanese Endocrine Pathology Society, Kyoto, Japan

9. 2010.10.14~16 Zhiyan Liu, et al. Retinoid X Receptor γ is a novel indicator of lymph node metastasis in papillary thyroid carcinoma. The 43th meeting of the Japanese Society of Thyroid surgery, Kurashiki, Japan

10. 2010.04.28~30 Zhiyan Liu, et al. Absence of BRAF^V600E mutation but occurrence of RET/PTC1 rearrangement in well differentiated tumor of uncertain malignant potential. The 99th Annual Meeting of the Japanese Society of Pathology, Tokyo, Japan

11. 2009.10.15~16 Zhiyan Liu, et al. Non-solid type thyroid carcinoma: a case report of moderately differentiated adenocarcinoma of the thyroid. The 42th meeting of the Japanese Society of Thyroid surgery, Nagoya, Japan

12. 2008.05.16~18 Zhiyan Liu, et al. Immunohistochemical analysis of thyroid tumor. The 97th Annual Meeting of the Japanese Society of Pathology, Tokyo, Japan