【个人简介】 姓名: 刘磊

出生年月: 1981-11
职称: “齐鲁青年学者”特聘教授

单位: 有机化学研究所

研究方向: 有机合成方法、复杂天然产物全合成、药物化学

地址: 山东省济南市山大南路27号老数学楼113

电话: **

e-mail: leiliu@sdu.edu.cn

课题组主页: http://leiliugroup.com??

【学习及工作经历】 教育经历：

2006.08 -2011.03 美国匹兹堡大学 化学学院 有机化学 博士

2003.09 -2006.06 兰州大学 生命科学学院 生物化学 硕士

2006.08 -2011.03 兰州大学 生命科学学院 生物基地班 学士



工作经历：

2015.09- 山东大学 化学与化工学院 教授

2012.06-2015.09 山东大学 药学院 教授

2011.03 -2012.04 美国哈佛大学 化学与化学生物学学院 博士后



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【主讲课程】




【研究领域和兴趣】 （1）基于活性天然产物和药物骨架的、有机合成方法学的发展 (a) 选择性的氧化碳氢官能团化

(b) 不对称催化

(c) 简单烯烃的官能团化

（2）活性天然产物的全合成及构效关系研究

（3） 具有生物活性的小分子试剂的设计和发现研究（针对肿瘤、真菌及阿兹海默症）


【主要论著】 山东大学独立研究工作2015年

(16) Chen.J.; Wan, M.; Hua, J.; Sun, Y.; Lv, Z.; Li, W.*; Liu, L.* TBHP/TFA Mediated Oxidative Cross-Dehydrogenative Coupling of N-Heterocycles with Aldehydes. Org. Biomol. Chem. 2015, DOI: 10.1039/C5OB01763G.

(15) Wan, M.; Lou,H.; Liu, L.* C1-Benzyl and benzoyl isoquinoline synthesis throughdirect oxidative cross-dehydrogenative coupling with methyl arenes. Chem.Commun., 2015, 51, 13953.

(14) Sun, S.; Mao,Y.; Lou, H.; Liu, L.* Copper(II)/amine synergisticallycatalyzed enantioselective alkylation of cyclic N-acyl hemiaminals withaldehydes. Chem. Common., 2015, 51, 10691.

(13) Liu, X.; Sun,S.; Meng, Z.; Lou, H.; Liu, L.* Organocatalytic asymmetricC-H vinylation and arylation of N-acyl tetrahydroisoquinolines. Org.Lett. 2015, 17, 2396. (Top 20 most downloaded article for May2015)

(12) Li, F.; Meng,Z.; Hua, J.; Li, W.; Lou, H.; Liu, L.* Indium-catalyzedoxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls andaryl rings. Org. Biomol. Chem. 2015, 13, 5710.

(11) Sun, S.; Li,C.; Floreancig, P. E.; Lou, H.; Liu, L.* Highly enantioselectivecatalytic cross-dehydrogenative coupling of N-carbamoyl tetrahydro isoquino-lines and terminal alkynes. Org. Lett. 2015, 17, 1684.(Highlight by Synfacts)

(10) Liu, X.;Meng, Z.; Li, C.; Lou, H.; Liu, L.* OrganocatalyticEnantioselective Oxidative C-H Alkenylation and Arylation of N-CarbamoylTetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 2015, 54,6012. (Highlight by Synfacts)

2014年

(9) Chen, W.;Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverseα-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp³)-HFunctionalization. Org. Lett. 2014, 16, 5988.

(8) Sun, S.; Yang,J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-MemberedHeterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction.Tetrahedron Lett. 2014, 55, 6899.

(7) Wan, M.; Meng,Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalizationof Structurally Diverse Ethers. Angew. Chem. Int. Ed. 2014, 53,13845. (Selected as “hot paper” by Angew Chem)

(6)Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* Aneconomic and Environmentally Friendly Oxidative Biaryl Coupling Promoted byActivated MnO₂. Org. Biomol. Chem. 2014, 12,7774.

(5) Pan, X. H.;Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang,L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H.* Copper(II) CatalyzedCross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compoundsby Na₂S₂O₈. Tetrahedron 2014, 70,3447.

(4) Chen, W. F.;Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*;Lou, H.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinolineby Sodium Persulfate. Tetrahedron Lett. 2014, 55, 2879.

(3) Xie, Z. Y.; Liu,L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H.* PracticalMetal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-SubstitutedN-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 2014, 53,3904. (Highlight by Chinese J Org Chem)

(2)Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.*Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers withAldehydes. Angew. Chem. Int. Ed. 2014, 53, 543. (selectedas “Hot Paper” by Angew Chem/Highlightby Synfact, 2014, 341)

2013年

(1)Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H.X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct DehydrogenativeAlkylation of sp³ C–H Bonds Adjacent to A Heteroatom. J. Org.Chem. 2013, 78, 3104.




哈佛大学博士后研究工作 （2011-2012）

(21) Liu, L.;Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of alcoholsfrom m-Fluorophenylsulfones and Dialkylboranes: Application to theC14-C35 Building Block of E7389. Org. Lett. 2012, 14,2262.

匹兹堡大学攻读博士期间工作（2006-2011）
(20) Liu,L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethersthrough Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew.Chem. Int. Ed. 2010, 49, 5894. (Highlighted in SynFacts2010, 1152 and Synstory 2010, A101)

(19) Liu, L.;Floreancig, P. E. Structurally and Stereochemically Diverse TetrahydropyranSynthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew.Chem. Int. Ed. 2010, 49, 3069. (Selected as “Hot Paper” in Angew.Chem. Int. Ed.)

(18) Liu, L.;Floreancig, P. E. Stereoselective Heterocycles Synthesis through OxidativeCarbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010,13, 733.

(17) Liu, L.;Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO₂ as A StoichiometricOxidant. Org. Lett. 2010, 12, 4686.

(16) Liu, L.;Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl OxazolidinoneOxidation. Org. Lett. 2009, 11, 3152. (Highlightedin SynFacts 2009, 998)

(15) Tu, W.; Liu,L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis throughTransition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem.Int. Ed. 2008, 47, 4184.

(14) Zaware, N.;LaPorte, M. G.; Fraid, R.; Liu, L.; Wipf, P.; Floreancig, P. E. Diversity-OrientedSynthesis of a Library of Substituted Tetrahydropyrones using OxidativeCarbon–Hydrogen Bond Activation and Click Chemistry. Molecules 2011,16, 3648.

兰州大学攻读硕士期间工作（2003-2006）

(13) Liu, L.;Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition ofPhenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)–Copper(II)Complex. Synlett. 2006, 8, 1245.

(12) Liu, L.;Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.;Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic KetonesCatalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005,70, 1084.

(11) Liu, L.;Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. EnantioselectiveAlkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derivedβ-Amino Alcohol. Tetrahedron: Asymmetry 2004, 15, 3757.

(10) Kang, Y.-F.; Liu,L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation ofAromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth.Catal. 2005, 347, 243.

(9) Kang, Y.-F.; Liu,L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional CatalystSystems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron:Asymmetry 2004, 15, 3155.

(8) Kang, Y.-F.; Liu,L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzincto Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth.Commun. 2005, 35, 1819.

(7) Kang, Y.-F.;Wang, R.; Liu, L.; Da, C.-S.; Yan, W.-J.; Xu, Z.-Q.Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by New ChiralOxazolidine Ligands. Tetrahedron Lett. 2005, 46, 863.

(6) Chen, C.;Hong, L.; Xu, Z.-Q.; Liu, L.; Wang, R. Low Ligand Loading, HighlyEnantioselective Addition of Phenylacetylene to Aromatic Ketones Catalyzed by Schiff-BaseAmino Alcohols. Org. Lett. 2006, 8, 2277.

(5) Cai, H.-Q.;Chen, C.; Liu, L.; Ni, J.-M.; Wang, R. A New Type of LigandDerived from N-Terminal Protected Dipeptides in Enantioselective Addition ofPhenylacetylene to Aromatic Ketones at Room Temperature. J. Mol. Catal. A:Chem. 2006, 253, 86.

(4) Han, Z.-J.;Wang, R.; Zhou, Y.-F.; Liu, L. Simple Derivatives of NaturalAmino Acids as Chiral Ligands in the Catalytic Asymmetric Addition ofPhenylacetylene to Aldehydes. Eur. J. Org. Chem. 2005, 934.

(3) Ni, M.; Wang,R.; Han, Z.-J.; Mao, B.; Da, C.-S.; Liu, L.; Chen, C. Synthesisof New C₂-Symmetrical Bissulfonamide Ligands and Applicationin the Enantioselective Addition of Alkynylzinc to Aldehydes and Ketones. Adv.Synth. Catal. 2005, 347, 1659.

(2) Zhou, Y.-F.;Wang, R; Xu, Z.-Q.; Yan, W.-J.; Liu, L.; Kang, Y.-F.; Han, Z.-J.Highly Enantioselective Phenylacetylene Additions to Ketones Catalyzed by (S)-BINOL-TiComplex. Org. Lett. 2004, 6, 4147.

(1)Zhou, Y.-F.; Wang, R; Xu, Z.-Q.; Yan, W.-J.; Liu, L.; Gao, Y.-F.;Da, C.-S. Boc-L-proline as A New Chiral Ligand for EnantioselectivePhenylacetylene Addition to Aromatic Aldehydes. Tetrahedron: Asymmetry 2004,15, 589.




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【科研项目】


山东省自然科学基金“杰出青年基金” 2015-2017 主持

国家自然科学基金（面上项目） 2015-2018 主持

山东大学交叉学科培育基金 2015-2017 主持

教育部“新世纪优秀人才”支持计划 2014-2016 主持

国家自然科学基金(青年基金) 2013-2015 主持

山东省优秀中青年科学家科研奖励基金 2013-2015 主持

“齐鲁青年学者”特聘教授科研启动资金 2012-2016 主持






【科研成果】 ??
人才计划和获奖情况

Thieme Chemistry Journal Award ??(2016年)

山东省自然科学基金“杰出青年基金”??(2014年)

教育部“新世纪优秀人才”（2013年）

“齐鲁青年学者”（2012年）

国家优秀自费留学生奖学金（中国驻纽约总领事馆）（2010年）

中国科学院奖学金（2005年）






【所获专利】




【联合培养情况】 本课题组与美国匹兹堡大学化学学院Paul E. Floreancig教授课题组联合培养博士研究生??

【拟招收研究生情况】 ??
欢迎对有机化学感兴趣的本科生、硕士生和博士生加入本课题组