【个人简介】 姓名：马晨，教授、博士生导师；

性别：男；籍贯：济南；

工作单位：有机化学研究所，山东大学化学与化工学院；

社会兼职：民革山东大学委员会委员，山东大学化学与化工学院学术委员会委员，山东省药物化学专业委员会委员；

联系方式：Tel: **; E-mail: chenma@sdu.edu.cn
【学习及工作经历】 学士：山东大学 (1985)

硕士：山东大学 (1990)

博士：韩国国立昌原大学 (2003)

博士后：香港科技大学 (2004)

访问教授：德国海德堡大学 (2005)


【主讲课程】 有机化学（本科双语）

药物化学（硕研）


【研究领域和兴趣】 1. 活性天然产物及活性中药单体及其类似物的全合成研究；

2. 活性杂环化合物高效及环境友好的合成方法学研究；

3. 活性杂环化合物组合合成、小分子库构建及活性筛选；


【主要论著】

1). Liu, H.; Duan, T.; Zhang, Z.;Xie, C.; Ma, C.*“One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction”

Org. Lett., 17, 2932-2935, 2015.

2). Zhang, Z.;Xie, C.; Tan, X.; Song, G.; Wen, L.; Gao, H.; Ma, C.* “I₂-Catalyzed One-pot Synthesis of Pyrrolo[1,2-a]quinoxaline and Imidazo[1,5-a]quinoxaline Derivatives via sp³ and sp² C-H Cross-Dehydrogenative Coupling”

Org. Chem. Front., 2, 942-946 , 2015.

3). Tan, X.; Du, Y.; Yang, B.; Ma, C.* “Novel type of AIE material as highly selective fluorenscent sensor for the detection of cysteine and glutathione”

RSC Advances, 5, 55165-55169, 2015.

4). Wang, W.; Peng, X.; Qin, X.; Zhao, X.; Ma, C.*; Tung, C.; Xu, Z.*“Synthesis of Quinolinones with Palladium-Catalyzed Oxidative Annulation between Acrylamides and Arynes”

J. Org. Chem., 80, 2835-2841, 2015.

5). Hu, F.; Xia, Y.; Ma, C.; Zhang, Y.; Wang, J.* “C–H bond functionalization based on metal carbene migratory insertion”

Chem. Comm, 51, 7986-7995, 2015.

6). Xie, C.; Zhang, Z.; Yang, B.; Song, G.; Gao, H.; Wen, L.; Ma, C.* “An efficient iodine–DMSO catalyzed synthesis of quinoxaline derivatives”

Tetrahedron, 71, 1831–1837, 2015.

7). Yang, B.; Tan, X.; Guo, R.; Chen, S.; Zhang, Z.; Chu, X.; Xie, C.; Zhang, D.*;Ma, C.* “A Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4H)-ones and Theoretical Study on S-N Type Smiles Rearrangement Process”

J. Org. Chem., 79, 8040-8048, 2014.

8). Fang, S.; Niu, X.; Zhang, Z.; Sun, Y.; Si, X.; Shan, S.; Wei, L.; Xu, A.; Feng, L.;Ma, C.* “A one-pot synthetic strategy for construction of the dibenzodiazepine skeletonviaa transition metal-free process”

Org. Biomol. Chem., 12, 6895-6900, 2014.

9). Hu, F.; Xia, Y.; Ma, C.*; Zhang, Y.; Wang, J.* “Cu(I)-Catalyzed Cross Coupling of Conjugated Ene-Yne-Ketones and Terminal Alkynes: Synthesis of Furan-Substituted Allenes”

Org. Lett., 16, 4082-4085, 2014.

10). Hu, F.; Xia, Y.; Liu, Z.; Ma, C.*; Zhang, Y.; Wang, J.* “Palladium-catalyzed three-component reaction of N-tosylhydrazone, norbornene and aryl halide”

Org. Biomol. Chem., 12, 3590–3593, 2014.

11). Fang, S.; Niu, X.; Yang, B.; Li, Y.; Si, X.; Feng, L.;Ma, C.* “One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]quinazoline Derivatives via Facile Transition-Metal-Free Tandem Process”

ACS Combinatorial Science, 16, 328–332, 2014.

12). Niu, X.; Yang, B.; Fang, S.; Li, Y.; Zhang, Z.; Jia, J.; Ma, C.* “An efficient one-pot synthesis of 1,2,4-triazoloquinoxalines”

Tetrahedron, 70, 4657–4660, 2014.

13). Huang, A.; Chen, Y.; Zhou, Y.; Guo, W.; Wu, X.; Ma, C.* “An Efficient One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]quinoxalines via Copper-Catalyzed Process”

Org. Lett., 15, 5480–5483, 2013.

14). Li, Y.; Yang, B.; Sun, Y.; Wang, H.; Li, H.; Fang, S.; Niu, X.;Ma, C.* “Metal-Free Tandem Cycloaddition Strategy for the Synthesis of Indolizines from Pyridine Derivatives and γ-Bromo-crotonates under Mild Conditions”

RSC Advances, 3, 21418–21423, 2013.3.708

15). Yang, B.; Huang, Z.; Guan, H.; Niu, X.; Liu, Y.; Fang, S.;Ma, C.* “New routes for the synthesis of fused pyrrole scaffolds through transition metal-free tandem reactions”

Tetrahedron Lett., 54, 5994–5997, 2013.2.391

16). Yang, B.; Niu, X.; Huang, Z.; Zhao, C.; Liu, Y.;Ma, C.* “A novel kind of dimmer (excimer)-induced-AIE compound 2-phenylisothiazolo[5,4-b]pyridin-3(2H)-one as high selective bisulfite anion probe”

Tetrahedron, 69, 8250–8254, 2013.

17). Huang, A.; Liu, H.; Ma, C.* “One-pot synthesis of 6H-benzo[b]benzo[4,5]imidazo[1,2-d][1,4]oxazines via copper-catalyzed process”

RSC Advances, 3, 13976–13982, 2013.

18). Niu, X.; Yang, B.; Li, Y.; Fang, S.; Huang, Z.; Xie, C.; Ma, C.* “A transition metal-free tandem process to pyridazinopyrido[3,2-f][1,4]thiazepine-diones via Smiles rearrangement”

Org. Biomol. Chem., 11, 4102–4108, 2013.

19).Zhao, Y.; Bai, Y.; Zhang, Q.; Chen, Z.; Dai, Q.; Ma, C.* “A Facile Method for the Synthesis of Pyridazino[4,5-b][1,4]thiazine-diones via Smiles Rearrangement”

Tetrahedron Lett., 54, 3253–3255, 2013.

20). Hu, F.; Zhao, X.; Li, Y.; Feng, L.; Ma, C.* “RegioselectiveSynthesis of Phenoxathiine Derivatives under Transition Metal-Free Conditions”

Synthesis, 45, 966–970, 2013.2.443

21). Huang, A.; Ma, C.* “Recent Progress in Biological Activities and Synthetic Methodologies of Pyrroloquinoxalines”

Mini-Reviews in Medicinal Chemistry,13 (4), 607–616, 2013.

22). Zhao, Y.; Dai, Q.; Chen, Z.; Zhang, Q.; Bai, Y.; Ma, C.* “One pot regioselective synthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via SmilesRearrangement”

ACS Combinatorial Science, 15, 130–134, 2013.

23). Li, Y.; Zhan, C.; Yang, B.; Cao, X.; Ma, C.* “A one-pot transition metal-free tandem process to 1,4-benzodiazepine scaffolds”

Synthesis,45, 111–117, 2013.

24). Huang, A.; Feng, L.; Qiao, Z.; Yu, W.; Zheng, Q.; Ma, C.* “Synthesis of pyrrolobenzoxazepinones by CuI/L-proline-catalyzed intramolecular coupling reactions”

Tetrahedron, 69, 642–646, 2013.

25). Liu, Y.; Zhang, X.; Ma, Y.; Ma, C.* “An Efficient C-C Bond Formation Reaction for the Synthesis of α-Arylated Ketones under Mild Conditions”

Tetrahedron Lett., 54, 402–405, 2013.

26). Zhao, Y.; Wu, Y.; Jia, J.; Zhang, D.*; Ma, C.* “A One-Pot Synthesis of Benzo[1,4]thiazin-3(4H)-ones and Theoretical Study on S-N Type Smiles Rearrangement Mechanism”

J. Org. Chem., 77, 8501–8506, 2012.

27). Zhang, X.; Jia, J.; Ma, C.* “A one-pot regioselective synthesis of benzo[d]imidazo[2,1-b]thiazoles”

Org. Biomol. Chem., 10, 7944–7948, 2012.

28). Zhan, C.; Jia, J.; Yang, B.; Huang, A.; Liu, Y.; Ma, C.* “A Tandem Coupling/Smiles Rearrangement/Cyclization Approach to 1,4-Benzooxazinones or 1,4-Pyridooxazinones under Mild Conditions”

RSC Advances, 2 (19), 7506–7512, 2012.

29). Liu, Y.; Ma, Y.; Zhan, C.; Huang, A.; Ma, C.* “One-Pot Synthesis of Fused Pyridazino[4,5-b][1,4]Oxazepiones via Smiles Rearrangement”

Synlett, 23, 255–258, 2012.2.463

30). Huang, A.; Qiao, Z.; Zhang, X.; Yu, W.; Zheng, Q.; Ma, Y.; Ma, C.* “A Transition metal-free Tandem Process to Pyrrolopyrazino[2,3-d]pyridazine-diones”

Tetrahedron, 68, 906–912, 2012.

31). Huang, A.; Liu, F.; Zhan, C.; Liu Y.; Ma, C.* “One-pot synthesis of pyrrolo[1,2-a]quinoxalines”

Org. Biomol. Chem., 9, 7351–7357, 2011.

32). Liu, Y.; Chu, C.; Huang, A.; Zhan, C.; Ma, Y.; Ma, C.* “Regioselective Synthesis of Fused Oxazepinone Scaffolds through One-Pot Smiles Rearrangement Tandem Reaction”

ACS Combinatorial Science, 13, 547–553, 2011.


【科研项目】

1.“惰性键活化的新型Smiles重排串联反应在杂环合成中的应用” (2016-2019)，国家自然科学基金。

2.“基于Smiles重排串联反应的并三环杂环体系的构建” (2012-2015)，国家自然科学基金。

3.“叶醇合成新工艺的开发” (2014-2015)，山东新和成药业有限公司 (横向)。

4.“几种异喹啉类天然产物及其类似物的合成及生物活性研究” (2010-2012)， 山东省自然科学基金重点项目。

5．“几种多药耐药逆转活性中药单体及其类似物的全合成及活性研究”（2009-2011），国家自然科学基金。

6．“抗寄生虫药吡喹酮的合成方法研究” (2008-2010)，山东省科技发展计划。

7.“噁嗪并异喹啉杂环有机分子的合成及生物活性研究” (2007-2009)，山东省自然科学基金重点项目。

8.“含异喹啉杂环化合物的设计, 合成及生物活性研究” (2006-2008)，山东省优秀中青年科学家科研奖励基金。

9.“哒嗪-1,4-噁嗪并异喹啉衍生物的设计, 合成及生物活性评价” (2005-2007), 教育部留学回国人员启动基金。


【科研成果】 【课题组】



硕士研究生：牛晓毅，房帅，段田田，谢彩霞，于小颖，范金皓，储向龙。

博士研究生：王曼琳，杨冰川，胡芳东，张泽远，刘欢欢。

已毕业学生：辛亮，万年星，罗丽，张宏志，张伟，赵鑫，周利，张群，丁锴，李靖，展春景，刘艳丽，赵永梅，张鑫海，黄爱萍，李艳秋。



【所获专利】

【联合培养情况】 本课题组与北京大学化学与分子工程学院有机所王剑波教授课题组联合培养博士研究生。


【拟招收研究生情况】 每年招收硕士、博士研究生各1-2名（包括工程硕士）。培养的研究生适合在高校、科研院所、企业等从事有机合成、药物合成方面的教学、科研及技术开发等工作。