【个人简介】 姓名 翟淑梅

性别 女

出生日期 1977-02-11

学历 博士

职称 讲师（硕导）

研究类别：分析化学

工作单位：分析化学所

办公室：老晶体所227室

电话：**

E-mail：smzhai@sdu.edu.cn
【学习及工作经历】 2005年12月毕业于山东大学生命科学学院，获理学博士学位。

2005/12–至今，山东大学，化学与化工学院，讲师

2007/03–2010/05，山东大学，药学院，博士后

2008/10–2009/10，美国Barbara Ann Karmanos 癌症研究中心，访问学者




【主讲课程】仪器分析实验

无机及分析实验

物理化学实验
【研究领域和兴趣】 小分子化合物抗癌活性及其机制分析； 纳米材料生物效应分析。
【主要论著】 1. Zhang CK#, Zhai SM#, Wu L, Bai YH, Jia JB, Zhang Y, Zhang B, Yan B* Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles. PLOS ONE，2015, 10(4): e**.

2. Li SH, Zhai SM, Liu Y, Zhou HY, Wu JM, Jiao Q, Zhang B, Zhu H*, Yan B**. Experimental Modulation and Computational Model of Nano-Hydrophobicity. Biomaterials. 2015, Vol 52, P312-317

3. Zhang CK#, Zhai SM#, Li XE, Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, Zhang SS, Su GX, Zhang B, Yan B*. Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death Dis., 2014, 5, e1138.

4. Jiang CJ, Jia JB, Zhai SM*. Mechanistic understanding of toxicity from nanocatalysts. Int. J. Mol. Sci., 2014, 15, 13967-13992.

5. Wu L, Zhang Y, Zhang CK, Cui XH, Zhai SM, Liu Y, Yan B*. Tuning Cell Autophagy by Diversifying Carbon Nanotube’s Surface Chemistry. ACS Nano, 2014, 8(3): 2087-2099.

6. Zhang RN, Pan XH, Li F, Lin Z, Zhai SM, Mu QX, Liu JF, Qu GB, Jiang GB, Yan B.* Cell Rescue by Nano-Sequestration: Reduced Cytotoxicity of An Environmental Remediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct. Environ. Sci. Technol., 2014, 48(3):1984-92

7. Liu AJ, Zhai SM, Zhang B, Yan B.* Analytical Strategies for Real-Time and Non-Invasive Tracking of Carbon Nanomaterials in vivo. TRAC-Trend Anal. Chem.,2013, 48, 1-13.

8. Zhou HY, ZhangY, Su GX, Zhai SM and Yan B*. Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation. RSC Adv.,2013, 3, 21596-21603.

9. Zhang Q, Zhai SM, Li LW, Li XE, Zhou HY , Liu AF, Su GX, Mu QX, Du YH , Yan B*. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochem. Pharmacol., 2013, 86: 351–360.

10. Zhai SM,Gao Q, LiuXX , Sui ZH, Zhang JR* .Overexpression of a Zea mays phospholipase C1 gene enhances drought tolerance in tobacco in part by maintaining stability in the membrane lipid composition, Plant Cell Tiss. Org., 2013, 115: 253-262.

11. Liu XX, Zhai S, Zhao YJ, Sun BC, Liu C, Yang AF, Zhang JR. Overexpression of the phosphatidylinositol synthase gene (ZmPIS) conferring drought stress tolerance by altering membrane lipid composition and increasing ABA synthesis in maize. Plant Cell Environ. 2013, 36(5):1037-55.

12. Zhai SM^#, Gao Q^#, Xue HW, Sui ZH, Yue GD, Yang AF, Zhang JR*. Overexpression of the phosphatidylinositol synthase gene from Zea mays in tobacco plants alters the membrane lipids composition and improves drought stress tolerance, Planta, 2012, 235(1), 69-84.

13. Wang F#, Zhai SM#, Liu XJ, Li LW, Wu S, Dou QP*, Yan, B.* A Novel Dithicarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Depentent Proteasome-Inhibitory and Apoptosis-Inducing Activity in Human Breast Cancer Cells. Cancer Lett., 2011, 300(1), 87-95.

14. Zhai SM, Yang L, Cui Q, Sun Y, Dou Q,* Yan, B.* Tumor Cellular Proteasome Inhibition and Growth Suppression by 8-Hydroxylquinoline and Clioquinol Requires Their Capabilities to Bind Copper and Transport Copper into Cells. J Biol. Inorg. Chem., 2010,15(2), 259-269

15. Zhou HY, Wu S, Zhai SM, Liu A, Sun Y, Li R, Zhang Y, Ekins, S., Swaan, PW, Fang B, Zhang B, Yan B* Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells,” J. Med.Chem., 2008, 51,1242-1251. Highlighted by Drug Discovery Today, 13, 1107-1108, 2008
【科研项目】 1,基于蛋白酶体为靶点的新型铜配体DiS衍生物库的筛选及其抗癌活性研究，国家自然科学基金青年基金，项目负责人，2010.01-2012.12

2，纳米银对非酒精性脂肪肝小鼠的肝脏毒性及相关机制的研究，山东省自然科学基金面上项目，项目负责人，2014.12-2017.12

3，目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价，科技部973子课题， 课题骨干，2010.01-2014.08


【科研成果】
【所获专利】

【联合培养情况】
【拟招收研究生情况】