【个人简介】姓名 张晓丽性别 女

出生年月 1961-11

学历 研究生

职称 教授

研究类别 分析化学

工作单位 分析化学研究所

电话 **

地址 山东大学化学与化工学院

E-mail zhangxl@sdu.edu.cn
【学习及工作经历】 1979-1983 山东大学化学系，获理学学士学位

1983-1986 山东大学化学系，获理学硕士学位

1986-1989 山东大学化学系助教

1989-1994 山东大学化学系讲师

1994-2001 山东大学化学院副教授

2001-至今 山东大学化学与化工学院教授
【主讲课程】 《分析化学》山东省精品课程，网址：http://course.sdu.edu.cn/G2S/Template/View.aspx?action=view&courseType=0&courseId=162

《仪器分析》,《仪器分析实验》

《电化学分析》,《分析化学实验技术》，《光电分析》
【研究领域和兴趣】 1 基于微纳米球介导酶联技术的生物单分子电化学检测

2 电化学技术的拉曼成像及环境分析

3 传感界面的构筑和电化学传感器

4 电化学发光共振能量转移技术及生物应用
【主要论著】 主编出版的教材

1.《基础化学实验》--(I) 山东大学出版社，2000年。

2.山东省高校化学实验新体系立体化系列教材《基础化学实验》化学工业出版社，2003年

3.普通高等教育“十一、五”国家级规划教材《仪器分析实验》化学工业出版社，2007年

发表的研究论文

1. Non-enzymatic glucose biosensor based on copper oxide-reduced grapheme oxide nanocomposites synthesized from water-isopropanol solution Electrochimica Acta 2014, 130, 253-260

2. Electrochemical sensor for endocrine disruptor bisphenol A based on a glassy carbon electrode modified with silica and nanocomposite prepared from reduced graphene oxide and gold nanoparticles Analytical Methods 2014,6,8604-8612
3. Electrodeposited apatite coating for solid-phase microextraction and sensitive indirect voltammetric determination of fluoride ions Talanta 2013, 115, 500-505

4. Electrochemical co-reduction synthesis of graphene/nano-goldcomposites and its application to electrochemical glucose biosensor Electrochimica Acta 2013, 112, 774-782
5. Electrogenerated chemiluminescence sensor for glutathione with Ru(bpy)₃²⁺-doped silica nanoparticles Journal of Solid State Electrochemistry 2013, 17(3), 795-803
6. Applications of electrochemiluminescence resonance energy transfer between CdSe/ZnS quantum dots and cyanine dye (Cy5) molecules in evaluating interactions and conformational changes of DNA molecules Electrochimica Acta 2013, 94, 367-373
7. A method based on electrodeposition of reduced graphene oxide on glassy carbon electrode for sensitive detection of theophylline Journal of Solid StateElectrochemistry 2013, 17(1), 167-173
8. Ultrasensitive Immunoassay Based on Anodic Near-Infrared Electrochemiluminescence from Dual-Stabilizer-Capped CdTe Nanocrystals Anal.Chem. 2012, 84, 10645-10649
9. Nanocomposite of graphene based sensor for paraquat: synergetic effect of nano-gold and ionic liquids on electrocatalysisAnalytical Methods 2012, 4(12), 3974-3980
10. Nanocomposite of electrochemically reduced graphene oxide and gold nanoparticles enhanced electrochemilunescence of peroxydisulfate and its immunosensing abililty towards human IgG J.Electroanal.Chem. 2012, 686, 25-31
11. Signal amplification based on DNA hybridization-dehybridization reaction on the surface of magnet submicrobeads for ultrasensitive DNA detectionAnalyst 2012,137(20),4849- 4854
12. Measuring interactions and conformational changes of DNA molecules using electrochemiluminescence resonance energy transfer in the conjugates consisting of luminol, DNA and quantum dot Electrochimica Acta 2012, 80, 171-179
13. Electrogenerated chemiluminescence sensor for formaldehyde based on Ru(bpy)₃²⁺-doped silica nanoparticles modified Au electrode Material science & Engineering C 2012, 32, 2169-2174
14. Electrodeposition of CdSe quantum dots and its application to an electrochemiluminescence immunoassay for α-fetoproteinMicrochemica Acta 2012, 178(3), 323-330
15. Electrochemical sensor for epinephrine based on a glassy carbon electrode modified with graphene /gold nanocomposites J.Electroanal.Chem. 2012, 669, 35-41
16. Heterogeneous electrochemiluminescence spectrometry of Ru(bpy)₃²⁺ for determination of trace DNA and its application in measurement of gene expression level Talanta 2012,89, 427- 432
17. Electrochemiluminescence DNA Sensor Based on Ru(bpy)₃²⁺-doped silica nanoparticles labeling and proximity-dependent surface hybridization assay Journal of Solid StateElectrochemistry 2012, 16（1）247-252
18. Electrochemical detection of chloride at the multilayer nano-silver modified indium-tin oxide thin electrodes J.Electroanal.Chem. 2012, 665, 26-32
19. Electrochemiluminescence DNA sensor based on hairpin structure DNA as recognition element and Ru(bpy)₃²⁺-doped silica nanoparticles as signal-producing compound Electroanalysis 2011, 23(11), 2693-2698
20. Ultrasensitive electrochemiluminescence method for determination of DNA using Ru(bpy)₃²⁺-coated magnetic submicrobeads wrapped with carbon nanotubes Electrochem. Comm.2011, 13，1499-1501
21. DNA microspot assay using sigle-molecule detection and requiring 1.8nL samples only Microchemica Acta 2011,174, 201-206
22. Electrochemiluminescence resonance energy transfer between an emitter electrochemically generated by luminol as the donor and luminescent quantum dots as the acceptor and its biological application Chem.Commun.,2011,47, 8292-8294
23. Determination of dopamine with improved sensitivity by exploiting an accumulation effect at a nano-gold electrode modified with poly(sulfosalicylic acid) Microchemica Acta 2011,174,345-352
24. Electrochemical simultaneous determination of nitrophenol isomers at nano-gold modified glassy carbon electrode Microchemica Acta 2011, 172, 285-290
25. Electrochemical simultaneous determination of nitrophenol isomers at nano-gold modified glassy carbon electrode J.Appl.Electrochem.,2011, 41, 687-694
26. Single-molecule-counting protein microarray with nanoliter samples and its application in the dynamic protein expression of living cells Biosensors & Bioelectronics 2011, 26, 3688-3691
27. Determination of pentachlorophenol at carbon nanotubes modified electrode incorporated withβ-cyclodextrin J.Nanoscience & Nanotechnology 2010, 10, 7654-7657
28. Ultrasensitive electrogenerated chemiluminescence immunoassay by magnetic nanobead amplification Electroanalysis 2010, 22, 333-337
29. Electrochemiluminescence of CdTe quantum dots as labels at nanoporous gold lea f electrode for ultrasensitive DNAanalysis Talanta, 2010,80, 1737-1743
30. Ultrasensitive electrochemical immunoassay based on counting single magnetic nanobead by a combination of nanobead amplification and enzyme amplification Electrochem. Comm. 2009,11, 1457-1459
31. Electrochemistry of thio-capped CdTe quantum dots and its sensing application J.Electroanal.Chem. 2009, 625, 88-91
32. Ultrasensitive electrochemical DNA assay based on counting of single magnetic nanobeads by a combination of DNA amplification and enzyme amplication Anal.Chem. 2009,81,1826-1832
33. Simultaneous voltammetry determination of dihydroxybenzene isomers by Nano-gold modified electrode Electroanalysis 2009,21,124-129
34. Quantitative counting of single fluoreacent molecules by combined electrochemicail adsorption accumulation and totel internal reflection fluorescence microscopy Anal.Chem. 2008,80,3999-4006
35. Accurately measuring respiratory activity of single living cells by scanning electrochemical microscopy Talanta, 2008,77, 804-808
36. Fabrication of active horseradish peroxidase micropatterns with a high resolution by scanning electrochemical microscopy Electroanalysis, 2007, 19, 1734-1740
37. Scanning electrochemical microscopy coupled with intracellular standard addition for quantification of enzyme activity in single intact cells Analyst, 2007, 132, 1139-1146
38. A simple approach for fabrication of dual-disk electrodes with a nanometer-radius electrode and a micrometer-radius electrode Talanta, 2007, 73, 589-593
39. High-throughput determination of glutathione and reactive oxygen species in single cells based on fluorescence images in a microchannel Electrophoresis, 2007, 28, 3966-3975
40. Micropatterning of active enzyme with a high-resolution by scanning electrochemical microscopy coupled with a nanometer-sized carbon fiber disk tip Electrochimica Acta 2007, 53, 2016-2024
41. Quantitative determination of enzyme activity in single cells by scanning microelectrode coupled with a nitrocellulose film-covered microreactor by means of a scanning electrochemical microscope Anal.Chem. 2007,79, 1256-1261
42. High-throughput single-cell analysis for enzyme activity without cytolysis，Anal.Chem. 2006,78, 3213-3220













【科研项目】 1.国家自然科学基金 电化学发光共振能量转移技术及应用 2010- 2012 负责人 2.家自然科学基金 扫描电化学显微术单细胞分析 2007- 2009 负责人

3.山东省自然科学基金 基于分子自组装技术的压电生物传感器 2000- 2002. 负责人

4.山东省自然科学基金 单分子及活细胞表面酶的纳米分辨的SECM成像 2004- 2006 负责人

5.山东省自然科学基金 基于微纳米球介导酶联技术的DNA单分子电化学检测 2009-2011 负责人

6.中科院长春应化所开放课题，生物物质的扫描电化学显微镜成像及定量测定 2005 -2006 负责人

7.国家自然科学基金重点项目单细胞分析化学方法研究，2003-2006 主要参加者

8.国家自然科学基金 非石英晶体压电传感检测研究 2003-2005 主要参加者

9. 国家自然科学基金压电传感器应用于超薄分子膜特性的研究 1996-1998 主要参加者


【科研成果】
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【联合培养情况】
【拟招收研究生情况】