【个人简介】

姓名: 闫兵

性别: 男

学历: 博士

职称：教授（博导）

学术身份：****

学术团体兼职：美国化学会"J Comb Chem"编委（1999-2005）及副主编（2005-2011）Elsevier 新期刊 NanoImpact 副主编（2016年至今）

研究类别：分析化学

工作单位：分析化学研究所

电话：**

传真：**

E-mail：drbingyan@yahoo.com


【学习及工作经历】 闫兵教授，****，山东大学特聘教授，化学与化工学院博士生导师，现从事纳米材料化学生物学和纳米毒理学的研究。1982年毕业于山东大学化学系获学士学位，1990年获美国哥伦比亚大学化学系博士学位。1990年至1993年先后在英国剑桥大学生理学系和美国德克萨斯大学医学院微生物和分子基因系从事博士后研究工作。1993年至2004年期间先后就职于制药公司Novartis、DPI和Bristol-Myers Squibb。1999至2011年任美国化学会"ACS Combinatorial Science （曾用名Journal of Combinatorial Chemistry）"编委和副主编，曾担任"Current Medicinal Chemistry"，"Current Pharmceutical Design"，"Molecula Diversity"， " Combinatorial Chemistry and High-Throughput Screening"和"International Journal of Molecular Sciences"特邀专刊主编。

早期研究人类视觉信号的分子机理，以光敏感微生物为模型发现了配体异构化以及引起蛋白构象变化对于视觉传导的必要性，发现了细胞受体传导视觉信号的活性构象，并在动物模型中证明了小分子配体缺少是造成幼鼠视觉敏感度下降的唯一原因。这些重要发现于1991年相继发表在Nature 和 Proc. Natl. Acad. Sci. U.S.A.等杂志上。随后在组合化学高通量固相合成、纯化和分析及用于早期药物开发的高通量筛选领域的研究作出了突出贡献，其成果概括于他发表在Accounts in Chemical Research和Current Opinion in Chemical Biology的两篇综述中。自2005年以来的研究中首创了纳米材料组合化学系统研究方法，并应用这种方法进行纳米药物和纳米毒理的开拓性研究。前期结果已在 Nature Nanotechnology, Chemical Reviews, Chemical Society Review, 三篇 J. Am. Chem. Soc. 论文, 三篇Nano Letters论文和三篇ACS Nano等论文中报道。

闫兵教授撰写或编辑英文专著10部，在Nature, Nature Nanotechnology, Proc. Natl. Acad. Sci. U.S.A., Chem. Rev., Chem. Soc. Rev., J. Am. Chem. Soc., Angew. Chem., Curr. Opin. Chem. Biol., Acc. Chem. Res., Nano Letters, ACS Nano等杂志上发表论文212篇，发表论文被引用3000多次。课题组网站为： http://www.yanlab.net.


【主讲课程】

每学年第一学期：Analytical Techniques in ChemicalBiology


【研究领域和兴趣】

我们课题组现有25人，由硕士及博士研究生、博士后、讲师、副教授和教授组成。利用团队协同攻关、与国内外学者合作和学科交叉的优势，我们致力于纳米材料和化学小分子在体内、体外的化学生物学研究。研究成果将有助于人类对纳米毒理和纳米材料安全性的认知与调控，以及新型抗癌药物和纳米药物的研发。毕业生去向包括在国内外大学及研究所从事科学研究和教学工作，以及在药物研发和生物科技公司以及商检、质检、药监、环保等企事业单位任职。


【主要论著】
Representative publications (from 212 publications):

90. Yan Mu, Yongjin Liu, Jinbao Xiang, Qiu Zhang, Shumei Zhai, Daniel P. Russo, Hao Zhu and Xu Bai and Bing Yan*
. From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor. Cell Death and Disease. 2016, in press




89. Daniel J Klionsky*... Bing Yan, etc.al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12(1): 1-222.


88. Peifu Jiao,Mario Otto, Qiaohong Geng, Chencan Li, Faming Li, Elizabeth R. Butch, Scott E. Snyder, Hongyu Zhoua* and Bing Yan*.Enhancing both CT imaging and natural killer cell-mediated cancer cell killing by a GD2-targeting nanoconstruct. Journal of Materials Chemistry B, 2016, Vol 4, 513-520.

87.Yi Zhang, Yabin Wang, Aijuan Liu, Sherry Li Xu, Bin Zhao, Yi Zhang, Hanfa Zou, Wenyi Wang,Hao Zhu and Bing Yan*. Modulation of Carbon Nanotube's Perturbation to the Metabolic Activity of CYP3A4 in the Liver. Advanced Functional Materials, 2016, Vol 26, 980. JOURNAL COVER

86. Tu C. Le, Bing Yan,, and David A. Winkler. Robust Prediction of Personalized Cell Recognition from a Cancer Population by a Dual Targeting Nanoparticle Library", Advanced Functional Materials, 2015, Vol 25, 6927-6935.

85. Fourches, Denis; Pu, Dongqiuye; Li, Liwen; Zhou, Hongyu; Mu, Qingxin; Su, Gaoxing; Yan, Bing*; and Tropsha, Alexander*. Computer-Aided Design of Carbon Nanotubes with the Desired Bioactivity and Safety Profiles, Nanotoxicology, 2015 Nov 2:1-10.

84. Long, Yan-Min; Zhao, Xingchen; Clermont, Allen C.; Zhou, Qun fang; Liu, Qian; Feener, Edward P; Yan, Bing; Jiang, Gui bin. Negatively Charged Silver Nanoparticles Cause Retinal Vascular Permeability by Activating Plasma Contact System and Disrupting Adherens Junction. Nanotoxicology 2015, Sep 23: 1-11.

83. Guangshu Zhai, Sarah Gutowski, Katherine Walters, Bing Yan, Jerald Schnoor. Charge, Size and Celluar Selectivity for Multi-wall Carbon Nanotubes by Maize and Soybean. Environmental Science & Technology. 2015 Jun 16;49(12):7380-90.

82. Shuhuan Li, Shumei Zhai, Yin Liu, Hongyu Zhou, Jinmei Wu, Qing Jiao, Bin Zhang, Hao Zhu*, Bing Yan**. Experimental Modulation and Computational Model of Nano-Hydrophobicity. Biomaterials. 2015, Vol 52, P312-317.

81. Zhiping Wang, Chunhui Li, Yan Mu, Zhang Lin, Anji Yi, Qiu Zhang, Bing Yan*. Nanoadduct Relieves: Alleviation of Developmental Toxicity of Cr(VI) Due to Its Spontaneous Adsorption to Mg(OH)2 Nanoflakes. Journal of hazardous materials. 2015, Vol 287, P296-305.

80. Yin Liu, Fei Li, Ling Wu, Wenyi Wang, Hao Zhu, Qiu Zhang, Hongyu Zhou,Bing Yan*.Improving Both Aqueous Solubility and Anti-Cancer Activity by Assessing Progressive Lead Optimization Libraries. Bioorganic & Medicinal Chemistry Letters. 2015, Vol 25, P1971-1975.

79. Chengke Zhang, Shumei Zhai, Ling Wu, Yuhong Bai, Jianbo Jia, Yi Zhang,Bin Zhang, Bing Yan*, Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles. PLOS ONE. 2015, 10(4): e**.

78. Yan Mu, Yin Liu, Liwen Li, Cong Tian, Hongyu Zhou, Qiu Zhang*, Bing Yan*, The Novel Tubulin Polymerization Inhibitor MHPT Exhibits Selective Anti-tumor Activity against Rhabdomyosarcoma in vitro and in vivo. PLOS ONE. 2015, 10(3): e**.

77. Mu QX, Jiang GBi, Chen LX, Zhou HY, Fourches, Denis, Tropsha, Alexander, Yan B*, Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems. Chemical Reviews, 2014; 114(15):7740-7781.

76. Zhang Y, Bai YHi, Jian JB, Gao NN, Li Y, Zhang RN, Jiang GB, Yan B*, Perturbation of Physiological Systems by Nanoparticles. Chemical Society Review, 2014, 43, 3762-3809.

75. Wu L, Zhang CK, Cui XH, Zhai SM, Liu Y, Li CL, Zhu H, Qu GB, Jiang GB, Yan B *, Tuning Cell Autophagy by Diversifying Carbon Nanotube’s Surface Chemistry. ACS Nano, 2014 Mar25; 8(3):2087-99.

74. Zhang CK, Zhai SM, Li XE, Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, ZhangSS, Su GX, Zhang B, Yan B.* Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death & Disease, 2014 Mar. 20, 5: 1138.

73. Li LW, Liu Y, Zhang Q, Zhou HY, Zhang Y, Yan B*. Comparison of Microtubule Damage-Triggered Cancer Cell Survival after Turning Kinase Dyrk1BOn and Off. ACS Chemical Biology, 2014 Mar 21, 9(3):731-42.

72. Zhang RN, Pan XH, Li F, Lin Z, Zhai SM, Mu QX, Liu JF, Qu GB, Jiang GB, Yan B.*Cell Rescue by Nano-Sequestration: Reduced Cytotoxicity of An EnvironmentalRemediation Residue, Mg(OH)2 Nanoflake/Cr(VI) Adduct. Environmental Science & Technology, 2014 Feb 4, 48(3): 1984-92.

71. Wang YQ, Yan B, Chen LX. SERS Tags: Novel Optical Nanoprobes for Bioanalysis. Chemical Reviews, 2013,113(3), 1391-1428.

70. Zhang Q, Zhai SM, Li LW, Li XE, Zhou HY, Liu AF, Su GX, Mu QX, Du YH, Yan B.*Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor innon-small cell lung cancer models. Biochemical Pharmacology, 2013, 86(3): 351-360.

69. Yan B. Therapy at the Nano Dimension. Current Pharmaceutical Design, 2013,Vol. 19.

68. Zhang CK, Zhang Q, Zhang Y, Yan B.* Toward a Better Understanding of Pharmacokinetics of Nanomaterials. Current Pharmaceutical Design, 2013, 19(37): 6667-6680

67. Liu AJ, Zhai SM, Zhang B, Yan B.* Analytical Strategies for Real-Time andNon-Invasive Tracking of Carbon Nanomaterials in vivo.Trendsin Analytical Chemistry, 2013,48, 1-13.

66. Zhang Y, Tekobo S, Tu Y, Zhou QF, Jin XL, Dergunov S,Pinkhassik E, Yan B.* Permission to Enter Cell by Shape: Nanodisk vs.Nanosphere. ACS Applied Materials & Interfaces, 2012, 4(8), 4099-4105. Highlighted by Chemical &Engineering News, 2012, Aug. 7.

65. Zhang B, Pai Panandiker AS, Yan B.* A Nano-CombinatorialApproach to Developing Cancer Diagnostics. Nanomedicine (U.K.),2012, 7(7), 937-940.

64. Zhang Y, Mu QX, Zhou HY, Karen Vrijens, Martine F. Roussel, Jiang GB and Yan B* Binding of Carbon Nanotube to BMPReceptor 2 Enhances Cell Differentiation and Inhibits Apoptosis via RegulatingbHLH Transcription Factors. Cell Death and Disease, 2012, 3, e308.

63. Mu QX, Su GX, Li LW, Gilbertson B, Yu L, Zhang Q, Sun Y-P, YanB.* Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets. ACS Applied Materials & Interfaces, 2012, 4(4), 2259-2266.

62. Zhou HY, Su GX, Jiao PF, Yan B.* Accelerating the Multifunctionalization of Theranostic Nanoparticles Using a Multicomponent Reaction. Chemistry - A European Journal, 2012,18(18), 5501-5505.

61. Su GX, Zhou HY, Mu QX, Zhang Y, Li LW, Jiao PF, Jiang GB, YanB.* Effective Surface Charge Density Determines the Electrostatic Attraction between Nanoparticles and Cells. Journal of Physical Chemistry C, 2012, 116(8),4993-4998.

60. Jiao PF, Zhou HY, Otto M, Mu QX, Li LW, Su GX, Zhang Y, Butch E, Snyder S,Jiang GB, Yan B.* Leading Neuroblastoma Cells to Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct. Journal of American Chemistry Society, 2011, 133(35), 13918-13921.

59. Gao NN, Zhang Q, Mu QX, Bai, YH, Li LW, Zhou HY, Butch, E, Powell, T, Snyder,S, Jiang, G, Yan, B*, Steering Carbon Nanotubes to Scavenger ReceptorRecognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity. ACS Nano, 2011, 5(6), 4581-4591.

58. Wang F, Zhai SM, Liu XJ, Li LW, Wu S, Dou QP*, Yan, B.* A Novel Dithicarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Depentent Proteasome-Inhibitory and Apoptosis-Inducing Activity in Human Breast Cancer Cells. Cancer Letters, 2011, 300(1), 87-95.

57. Li X, Zhou HY, Yang L, Du GQ, Pai-Panandiker A, Huang XF, and Yan B.*Enhancement of Cell Recognition in vitro by Dual-Ligand Cancer Targeting Gold Naoparticles. Biomaterials, 2011, 232, 2540-2545.

56. Jiao PF, Zhou HY, Chen L, Yan B.* Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy. Current Medicinal Chemistry, 2011,18, 2086-2102.

55. Yan B. Impacts of Nanotechnology on Medicinal Chemistry and Drug Discovery. Current Medicinal Chemistry, 2011, 18(14), 2044.

54. Wu L and Yan B.* Discovery of Small Molecules that Target Autophagy for Cancer Treatment. Current Medicinal Chemistry, 2011, 18, 1866-1873.

53. Zhou QF, Dergunov SA, Zhang Y, Li X, Mu QX, Zhang Q, Jiang GB, Pinkhassik F,Yan B.* Safety profile and cellular uptake of biotemplated nanocapsules withnanometer-thin walls. Nanoscale, 2011,136,872-877.

52. Li LW, Zhang Q, Liu AF, Li, XE,Zhou HY,Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of aCancer-killing Molecule. Journal of American Chemistry Society, 2011, 133(18),6886-6889.

51. Zhou HY, Jiao PF, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. Journal of American Chemistry Society, 2010, 133(4),680-682.

50. Bai YH, Zhang Y, Zhang JP, Mu QX, Zhang WD, Butch E, Snyder S,Yan B.* Repeated carbon nanotube administrations in male mice cause reversibletestis damage without affecting fertility. Nature Nanotechnology, 2010, 5(9),683-689.
Highlighted by Nature China, RSC Chemistry World, NanoWerk, Institute of Nanotechnology, Meridian Institute, Softpedia, 北京科技报，香港文汇报 and more than 50 websites.

49. Zhang Y, Bai Y, Yan B.* Functionalized Carbon Nanotubes for Potential Medicinal Applications. Drug Discovery Today, 2010, 15(11-12), 428-435.

48. Yan B, Zhang B. Analyticalmethods in combinatorial chemistry, Second Edition by Francis and Taylor Group, 2010

47. Mu QX, Yang L, Davis JC, Vankayala R, Hwang KC, Zhao JC, YanB.* Biocompatibility of Polymer Grafted Core/Shell Iron/Carbon Nanoparticles. Biomaterials, 2010, 31(19), 5083-5090.

46. Wang F, Jiao PF, Qi MH, Frezza, M., Dou QP.*, Yan, B.* Turning Tumor-Promoting Copper into anAnti-Cancer Weapon via High-Throughput chemistry. Current Medicinal Chemistry, 2010,17(25), 2685-2698.

45. Zhang Q, Zhou, H.Y., Zhai,S.M., Yan, B.* Natural Product–Inspired Synthesis of Thiazolidine andThiazolidinone Compounds and Their Anticancer Activities. Current Medicinal Chemistry, 2010, 16(16), 1826-1842.

44. Zhai SM, Yang L., Cui QZC., Sun Y, Dou, Q.P.*, Yan, B.* Tumor Cellular Proteasome Inhibition and Growth Suppression by 8-Hydroxylquinoline and Clioquinol Requires Their Capabilities to Bind Copper and Transport Copper into Cells. Journal of Biological Inorganic Chemistry, 2010, 15(2), 259-269.

43. Mu QX, Broughton DL, Yan B.*Endosomal leakage and Nuclear Translocation of Multiwalled Carbon Nanotubes: Developing a Model for Cell Uptake. Nano Letters, 2009, 9(12), 4370-4375.

42. Mu QX, Du GQ, Chen, TS, Zhang B, Yan B* Suppression of Human Bone Mophorgenetic Protein (BMP) Signaling by Carboxylated Single-Walled Carbon Nanotubes. ACS Nano, 2009,3,(5), 1139-1144.

41. Zhang B, Xing YH, Zhou HY, Li ZW, Mu QX, Yan B.* Functionalized Carbon Nanotubes Specifically Bind to Chymotrypsin Catalytic Site and Regulate its Enzymatic Function. Nano Letters, 2009,9(6), 2280–2284.

40. Yan B, and Czarnik, AW, Series Editors, Critical Review in Combinatorial Chemistry Volume 5. Chen, T. High-Throughput Screening Technologies by Francis and Taylor Group, 2009

39. Qu GB, Bai YH, Zhang Y, Jia Q, Zhang WD, Yan B*, The effect of multiwalled carbon nanotube agglomeration on theiraccumulation in and damage to organs in mice. Carbon, 2009,47(8), 2060-2069.

38. Mu QX, Li, Li X, Sanjay R. Mishra, Zhang B, Si ZK, Yang L, Jiang W, Yan B*. Characterization of Protein Clusters of Diverse Magnetic Nanoparticles and Their Dynamic Interactions with Human Cells. Journal of Physical Chemistry C, 2009, 113 (14),5390-5395.

37. Du FF, Zhou HY, Chen LX, Zhang B, Yan B*, Structure Elucidation of Nanoparticle-Bound Organic Molecules by 1HNMR. Trends in Analytical Chemistry, 2009,28(1),88-95.

36. Zhou HY, Du FF, Li X, Zhang B, Li W, Yan B.* Characterization of Organic Molecules Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning 1H NMR. Journal of Physical Chemistry C, 2008, 112 (49) 19360-19366.

35. Zhou HY, Mu QX, Gao NN, Liu A, Xing Y, Gao SL, Zhang Q, Qu GB, Chen Y, Liu G, Zhang B, Yan B*, A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity and Immune Response, Nano Letters, 2008,8 (3), 859-865.

34. Zhou HY, Wu S, Zhai SM, Liu A, Sun Y, Li R, Zhang Y, Ekins, S., Swaan, PW, Fang B, Zhang B, Yan B* Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells,” Journal of Medicinal Chemistry, 2008, 51,1242-1251.
Highlighted by Drug Discovery Today, 13, 1107-1108, 2008

33. Yan, B. and A. W. Czarnik, Series Editors, Critical Review in Combinatorial Chemistry Volume 3. Tushar A. Kshirsagar Editor, High-Throughput Lead Optimization in Drug Discovery. by Francis and Taylor Group, 2008

32. Yan, B. and A. W. Czarnik, Series Editors, Critical Review in Combinatorial Chemistry Volume 4. Wang, P. High-Throughput Analysis in Pharmaceutical Industry by Francis and Taylor Group, 2008

31. Mu, Q.; Liu, W.; Xing, Y.; Zhou, H.; Li, Z.; Zhang, Y.; Ji, L.;Wang, F.; Si, Z.; Zhang, B.; Yan, B.* Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter, Journal of Physical Chemistry C, 2008, 112 (9), 3300-3307.

30. Yan, B.* Zhao,J., Leopold, K., Zhang, B.,Jiang, G. The Structure Dependent Response of Chemiluminescence Nitrogen Detector (CLND) for Organic Compounds with Adjacent Nitrogen Atoms Connected by a Single Bond, Analytical Chemistry, 2007, 79 (2) 718-726.

29. Yan, B. and A.W. Czarnik, Series Editors, Critical Review in Combinatorial Chemistry Volume 1. Radislav A. Potyrailo, Wilhelm Maier. Editors, Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials by Francis and Taylor Group, 2005.

28. Yan, B. and A. W. Czarnik, Series Editors, Critical Review in Combinatorial Chemistry Volume 2. Armen M. Boldi, Editor, Combinatorial Synthesis of NaturalProduct Based Libraries. by Francis and Taylor Group, 2005

27. Yan, B. Editor, Chemical Analysis – A Series ofMonographs on Analytical Chemistry and Its Applications Volume 163 “Analytical and purification methods in Combinatorial Chemistry” by John Wiley and Sons, Inc., 2003

Highlighted by: Journal of Natural Products, 2004, Vol. 67, No. 6, 1076. Angew.Chem. Int. Ed. 2004, 43, 4552 – 4553. Drug Development And Industrial Pharmacy,2004, Vol. 30, No. 7, p. 793.

26. Yan, B.* Single bead analysis in combinatorial chemistry, Current Opinion in Chemical Biology, 2002, 6, 328-332.

25. Fang,L., Demee, M., Sierra, T., Kshirsagar, T., Celebi, A., Yan, B.* Kinetic Studyof Amine Cleavage Reactions of Various Resin-Bound Thiophenol Esters from Marshall Linker, Journal of Combinatorial Chemistry, 2002, 4, 362-368.

24. Yan, B. and Czarnik, A.Editors, Optimization of solid-phase combinatorial synthesis by Marcel Dekker, New York, 2001
Highlighted by J. AM. CHEM. SOC. 9 VOL. 124, NO. 26, 2002 7875

23. Gremlich, H. U. and Yan, B. Editors, Biological FTIR and Raman Spectroscopy by Marcel Dekker, New York, 2000
Highlighted by J. A. C. S., Vol. 123, No. 42, 2001 10427

22. Yan, B.*, Nguyen, N., Liu, L., Holland, G., Raju, B. Kinetic Comparison of Trifluoroacetic Acid Cleavage Reactions of Resin-Bound Carbamates, Ureas, Secondary Amides, and Sulfonamides from Benzyl-, Benzhydryl-, and Indole-Based Linkers, Journal of Combinatorial Chemistry, 2000, 2(1) 66-74.

21. Yan, B., Analytical methods incombinatorial chemistry by CRC Press (former Technomics), 1999
Highlighted by Journal of Medicinal Chemistry, 2001, Vol. 44, No. 20,3334.

20. Yan, B.*, Liu, L., Astor, C. A., Tang, Q. Determination of the Absolute Amount of Resin-Bound Hydroxyl or Carboxyl Groups for the Optimization of Solid-Phase Combinatorialand Parallel Organic Synthesis, Analyical Chemistry, 1999, 71(20) 4564-4571.

19. Yan,B.*, Martin,P. C., Lee, J. Single Bead Fluorescence Microspectroscopy: Detection of Self-Quenching in Fluorescence-Labeled Resin Beads, Journal of Combinatorial Chemistry, 1999, 1, 78-81.

18. Yan,B.*, Gremlich, H.-U., Moss, S., Coppola,G. M., Sun, Q., Liu, L. A comparison of various FTIR and FT raman methods: applications in the reaction optimization stage of combinatorial chemistry, Journal of Combinatorial Chemistry, 1999, 1, 46-54.

17. Yan, B.*, Monitoring the progress and the yield of solid-phase organic reactions directly on resin supports, Accounts of Chemical Research, 1998, 31, 621-630.

16. Yan, B.*, Jewell, Jr. C. F., Myers, S. W., Quantitatively monitoring of solid-phase organic synthesis by combustion elemental analysis, Tetrahedron, 1998, 54, 11755-11766.

15. Li, W. and Yan, B.*, Effects of Polymer Supports on the Kinetics of Solid-Phase Organic Reactions: A Comparison of Polystyrene- and Tenta Gel-Based Resins, Journal of Organic Chemistry, 1998, 63,4092-4097.

14. Sun, Q. and Yan, B.*, Single bead IR monitoring a novel benzimidazolesynthesis. Bioorganic Medicinal Chemistry Letters, 1998, 8, 361-364.

13. Yan,B.* and Sun, Q., Crucial factors regulating site-interactions in resin supports determined by single bead IR,” Journal of Organic Chemistry, 1998, 63, 55-58.

12. Yan,B.* and Li, W., Rapid fluorescence determination of the absolute amount of aldehyde and ketone groups on resin supports, Journal of Organic Chemistry, 1997, 62,9354-9357.

11. Yan,B., Spudich, E. N., Sheves, M. and Spudich, J. L., Complexation of the signal transducing protein HtrI tosensory rhodopsin I and its effect on thermodynamics of signaling statedeactivation, Journal of Physical Chemistry B, 1997, 101, 109-113.

10. Yan,B.*, Sun, Q., Wareing, J. R. and Jewell, C. F. Real-time Monitoring of the Catalytic Oxidation of Alcohols on Resin Supports by Single Bead FTIR Microspectroscopy, Journal of Organic Chemistry, 1996, 61,8765-8770.

9. Yan,B.*, Fell, J. B. and Kumaravel, G. Progression of organic reactions on resin supports monitored by single bead FTIR microspectroscopy, Journal of Organic Chemistry, 1996, 61, 7467-7472.
Highlighted by CHEMTRACTS-ORGANIC CHEMISTRY 10:822-827, 1997.

8. Yan,B.*, Spudich, J. L., Mazur, P., Vunnam, S., Derguini, F. and Nakanishi, K., Spectral tuning in bacteriorhodopsin in the absence of counterion and coplanarization effects, Journal of Biological Chemistry, 1995, 270, 29668-29670.

7. Yan,B.*, Kumaravel, G., Anjaria, H., Wu, A., Petter, R. C., Jewell, C. F. and Wareing, J., Infrared spectrum of a single resin bead for real-time monitoring of solid-phase reactions, Journal of Organic Chemistry, 1995, 60,5736-5738.
Selected asBio-Rad Application Note in 1996.Received 145 citations.

6. Yan,B., Xie, A., Nienhaus, G. U., Katsuta, Y. & Spudich, J. L. Steric con-straints in the retinal binding pocket ofsensory rhodopsin I, Biochemistry, 1993, 32, 10224-10232.

5. Ratto,G.M., D.W.Robinson, B.Yan & P.A.Mc Naughton, Develop-ment of the light response in neonatal mammalianrods, Nature (Lon-don), 1991,351, 654-657.

4. Yan,B., K.Nakanishi & J.L.Spudich., Mechanism of activa-tion of sen-sory rho-dopsin I: evidence for a steric trigger, Proc. Nat. Acad. Sci. U.S.A. 1991, 88, 9412-9416.

3. Yan, B., T.Takahashi, Johnson, R. & J.L.Spudich., Identifica-tion of sig-naling states of a sensoryreceptor by modulation of lifetimes of stim-ulus-in-duced conformations: thecase of sensory rhodopsin II, Biochemistry, 1991, 30,10686-10692.

2. Yan,B., T.Takahashi, D.A.McCain, V.J.Rao, K.Nakanishi & J.L.Spudich., Ef-fects of modifications of the retinalb-ionone ring on archaebacterial sensory rhodopsin I, Biophysical Journal, 1990, 57, 477-483.

1. Yan,B., T.Takahashi, R.Johnson, F.Derguini, K.Nakanishi, J.L.Spudich. All-trans/13-cis isomerization of retinal is required for phototaxis signaling by sensory rhodopsins in halobacterium halobium, Biophysical Journal, 1990,57, 807-814.


【科研项目】


1. 国家自然科学基金重大研究计划重点项目：“细颗粒物与生物界面作用机制的系统探索”（项目编号：**，2016-2019年）

2. 中国科学院B类战略性先导科技专项：“典型污染物的环境暴露与健康危害机制”，协作课题“细颗粒物引起细胞氧化应激及免疫毒性的机制及健康效应关联”（项目编号：XDB**，2014-2019年）

3. 国家重大基础研究（973）课题：“目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价”（项目编号：2010CB933504，2010-2014年）

4. 国家自然科学基金重点项目：“典型纳米材料的生物毒性效应及调控研究”（项目编号：**，2012-2016年）

5. 国家自然科学基金面上项目：“环境中碳纳米管生物毒性的分子机制与调控研究”（项目编号：**，2011-2013年）

6. 国家自然科学基金重大研究计划培育项目：“选择性治疗耐药性肺癌的噻唑烷酮类小分子探针化合物的设计、合成及其体内外抗癌活性研究与机制探讨”（项目编号：**，2010-2012年）



【科研成果】
【所获专利】 1. 一种抗肺癌的药物组合物。申请号：**6.X；公开公告号：CN**A；授权公告日期：2011年11月16日；专利号：ZL 2010 1 **.X

2. 2-苯醚基亚氨基-5-(2-羟基-苯甲基)-1, 3-噻唑-4-酮在制备抗脑癌药物中的应用。申请号：**4.0；公开公告号：CN**A；授权公告日期：2011年11月9日；专利号：ZL 2010 1 **.0

3. 噻唑烷酮衍生物及其在制备抗肿瘤药物中的应用。申请号：CN**7.9；公开公告号：CN**

4. 表面化学基团修饰的碳纳米管化合物及其应用。 申请号：CN**5.6；公开公告号：CN**

5. 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法。申请号：**9.7；公开公告号：CN**A；授权公告日期：2013年7月17日；专利号：ZL 2011 1 **.7

6 . 一种表面电荷密度连续变化的金纳米颗粒阵列。申请号：**2.0；申请日：2012年2月20日

7. 噻唑烷酮衍生物及其在制备抗肺癌药物中的应用。申请号：CN**3.7；申请日：2012年6月20日

8. 2-苯亚胺基-5-(4-二甲氨基苯亚甲基)-4-噻唑烷酮在制备抗乳腺癌药物中的应用。申请号：**2.6；申请日：2012年10月15日

9. 2-(4-羟基苯亚胺基)-5-(3-甲氧基-4-羟基苯亚甲基)-4-噻唑烷酮的制抗肿瘤药应用。申请号：**3.X；申请日：2012年11月6日

10. 一种噻唑烷酮衍生物在制备广谱抗癌药物中的应用。申请号：**6.7；申请日：2013年1月16日

11. 一种具有协同抗肿瘤作用的金纳米药物载体。申请号：**4.3；申请日：2013年4月12日

12. 一种噻唑烷酮衍生物在制备抗横纹肌肉瘤药物中的应用。申请号：**0.9；申请日：2013年11月7日

13. 一种噻唑烷酮衍生物在制备抗结肠癌药物中的应用。申请号：**7.8；申请日：2013年11月7日

14. 一种定量表征功能化金纳米颗粒疏水性强度的分析方法。申请号：**0.9；申请日：2013年11月27日


【联合培养情况】

课题组现在有五名毕业生在美国从事博士后研究，先后有七名博士研究生在美国和加拿大参与联合培养项目。




【拟招收研究生情况】 2016年拟招收博士研究生2名（纳米化学生物学)，硕士生（含推免生）3-5名．招收博士后研究人员2-3人 (工资、住房等福利待遇参见山东大学的相关管理规定)。除化学专业毕业生外，生物专业考生初试科目可选择政治、英语、细胞生物学和生物化学。欢迎有生物学专业背景、对化学生物学研究领域感兴趣的同学加入我们的团队。