【个人简介】 姓名： 王建武
出生年月：1954年12月25日
地址： 山东大学化学院，济南，山大南路27号，山东，250100
电话： **(o); Moble. **
Email: jwwang@sdu.edu.cn


【学习及工作经历】 教育：
1994-1993: New York University,博士后；
1990-1984： 南开大学，硕士，博士；
1982-1978： 复旦大学，学士；

经历：
1999-今: 山东大学化学系，研究员。2001年起，博士生导师;
1999-1998: New York University, 访问教授；
1998-1997: 山东大学化学系, 副教授；
1994-1996: Peptosyn Inc. )研究科学家；
1993-1990: 天津轻工业化学研究所，高工。
【主讲课程】 有机化学（大本基础课,双语,泰山学堂，化基班）；
有机合成（大本专业课）；
理论有机化学（硕士生专业基础课）；
立体化学与手性合成（博士生专业基础课）；药物设计与合成（博士生专业选修课）。

【研究领域和兴趣】 有机合成：有机合成新反应及新方法。手性合成及功分子合成。天然化合物的全合成及结构修饰;
药物化学：新药物分子设计、合成及构效关系研究，开发新药。







【主要论著】
近5年主要论文：
1. Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles， Datong Zhang, Zongheng Wang, Weiren Xu, Fanggang Sun, Lida Tang, Jianwu Wang,， European Journal of Medicinal Chemistry，44 (2009) 2202- 2210
2. A NOVEL AND EFFICIENT APPROACH TO PYRAZOLO[1,5-a]- PYRIDINE DERIVATIVES VIA ONE-POT TANDEM REACTION, Yan-Qing Ge, Jiong Jia, Yan Li, Ling Yin, and Jianwu Wang* HETEROCYCLES, Vol 78, Issue 1, 2009, pp.197-206
3. A FACILE APPROACH TO INDOLIZINES VIA TANDEM REACTION, Yan-Qing Ge, Jiong Jia, He Yang, Gui-Long Zhao, Fu-Xu Zhan, and Jianwu Wang*，HETEROCYCLES, Vol. 78, No. 3, 2009, pp. 725 - 736.
4. Polyphosphoric Acid-Mediated, One-Pot, Novel Reactions to Build Polymethoxyarylnaphthalene Lignans，Guilong Zhao a; Fuxu Zhan b; Zhifeng Wang c; Weiren Xu a; Yuli Wang a; Wei Liu a; Lida Tang d;Jianwu Wang b，Synthetic Communications, 1, 40: 351–360, 2010
5. FACILE SYNTHESIS OF IMIDAZO[1,2-a]PYRIDINES VIA TANDEM REACTION，Jiong Jia,1,2 Yan-Qing Ge,2 Xu-Tang Tao,1*and Jian-Wu Wang2*，HETEROCYCLES, Vol. 81, No. 1, 2010, pp. 185 - 194.
6. Synthesis and antimicrobial activities of novel peptide deformylase inhibitors ，Ling Yin,a Wei-Ren Xu,b Zhi-Guo Wang,c Da-Tong Zhang,a Jiong Jia,a Yan-Qing Ge,aYan Li,a and Jian-Wu Wang a*，ARKIVOC 2010 (ix) 196-205
7. Synthesis and Preliminary Antibacterial Evaluation of 2-Butyl Succinate-based Hydroxamate Derivatives Containing Isoxazole Rings,Datong Zhang1,2, Jiong Jia1, Lijuan Meng1, Weiren Xu3, Lida Tang3, and Jianwu Wang1，Arch Pharm Res， 2010，0Vol 33, No 6, 831-842.

8. Design,Synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors, Y L Gao, G L Zhao, W Liu, H Shao, Y L Wang, W R Xu, L D Tang & J W Wang*, Indian Journal of Chemistry, Vol. 49b, November 2010,pp. 1499-1508.
9. The synthesis, characterization and optical properties of novel pyrido[1,2-a]benzimidazole derivatives，Yan Qing Ge a,c,1, Jiong Jia a,b,1, He Yang a, Xu Tang Tao b,*, Jian Wu Wang a,* Dyes and Pigments， 88 (2011)， 344-349
10. Synthesis and optical properties of novel pyrido[1,2-a]benzimidazole-containing 1,3,4-oxadiazole derivatives，He Yang, Yan-Qing Ge, Jiong Jia, Jian-Wu Wang* Journal of Luminescence，131(2011) 749-755
11. Synthesis, X-ray crystal structure and optical properties of novel 2,5-diaryl-1,3,4-oxadiazole derivatives containing substituted pyrazolo[1,5-a]pyridine units，He Yang, Jinglin Mu, Xia Chen, Lei Feng, Jiong Jia*, Jianwu Wang* Dyes and Pigments，Dyes and PigmentsVolume 91, Issue 3, December 2011, Pages 446-45
12. Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors,L Yina, J Jiaa, G L Zhaob, W R Xub, L D Tangb ＆ J W Wang*a，Indian Journal of chemistry,2011,50B may, pp695-703
13. Exquisite Synthesis of a Designed PAR-1 Antagonist, Hua-Ming Miaoa)b), Gui-Long Zhao*b), Lin-Shan Zhangc), Hua Shaob), and Jian-Wu Wang*a) Helvetica Chimica Acta – Vol. 94 (2011) pp 1981-1993
14. Design and Synthesis of Novel Pyrazole-based Lp-PLA2 Inhibitors Wang, Yia(王毅) Xu, Weirenb(徐为人) Shao, Huab(邵华) Xie, Yafeia(谢亚非) Wang, Jianwu*,a(王建武) Chin. J. Chem. 2011, 29, 2039—2048
15. The synthesis, characterization and opticalproperties of novel 1,3,4-oxadiazole containing
imidazo[1,5-a]pyridinederivatives， Yan Qing Ge a, BenQian Hao a, GuiYun Duan a,, JianWuWang b, Journal of Luminescence 131 (2011) 1070–1076
16． Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors. Zhao, Wen Jing; Shi, Yong Heng; Zhao, Gui Long; Wang, Yu Li; Shao, Hua; Li, Da Tang; Wang, Jian Wu. Chinese Chemical Letters (2011), 22(10), 1215-1218.
17． Synthesis and crystal structure ofethyl1-(2-bromoethyl)-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylate. Wang, Yi; Shao, Hua; Xu, Wei-Ren; Wang, Jian-Wu. Chinese Journal of Structural Chemistry (2012), 31(1), 110-114.
18. Synthesis, X-ray crystal structure and opticalproperties of novel 2-aryl-3-ethoxycarbonyl-4-
phenylpyrido[1,2-a]benzimidazoles, Xia Chen,a He Yang,a Yanqing Ge,c Lei Feng,a Jiong Jiaa,b* andJianwu Wanga* Luminescence (2012), 27(5), 382-389
19. 新型咖啡酸五环三萜酯的合成与保肝活性，贾炯, 孙学华, 邵腾飞, 金树根, 高月求, 王建武，有机化学 2012, 32 (04), pp 760-764
20. From Cyclopropenes to Tetrasubstituted Furans: Tandem Isomerization/Alkenylation Sequence with Cu/Pd Relay Catalysis，Chuanling Song, Lin Ju, Mingchao Wang, Pengcheng Liu, Yuanzhe Zhang, Jianwu Wang,* and Zhenghu Xu*[a]， Chem. Eur. J. 2013, 19, 3584 – 3589
21. A NEW METHOD FOR THE SYNTHESIS OF [1,2,4]TRIAZOLO[1,5-a]-PYRIDINE DERIVATIVES，Wei-Ming Zhao,a Yan-Qing Ge,b* Wei-Ren Xu,c Gui-Long Zhao,c Jiong Jia,a and Jian-Wu Wanga* HETEROCYCLES, Vol. 87, No. 4, 2013, pp. 869-876.
22. SYNTHESIS OF NITROGEN BRIDGEHEAD HETEROCYCLES WITH PHOSPHONATES VIA A NOVEL TANDEM PROCESS，Ya-Fei Xie,a Yan-Qing Ge,a,b Lei Feng,a Hua-Qiang Xu,a Song Meng,a Gui-Long Zhao,c Wei-Ren Xu,c Jiong Jia,a* and Jian-Wu Wanga* HETEROCYCLES, Vol. 87, No. 4, 2013, pp.815-826.
23. FACILE SYNTHESIS OF PYRIDO[1,2-a]BENZIMIDAZOLE DERIVATIVES VIA NOVEL TANDEM REACTION INVOLVING HORNER-EMMONS REACTION，Wen-Jing Zhao,a Ya-Fei Xie,a Yan-Qing Ge,b* Wei-Ren Xu,c Gui-Long Zhao,c and Jian-Wu Wanga*HETEROCYCLES, Vol. 87, No. 5, 2013, pp.1121-1126.
24. Design, synthesis and biological activity of cyclohexane-bearing C-glucoside derivatives as SGLT2 inhibitors, Zhang, Shuo; Wang, Yu-Li; Wei, Qun-Chao; Xu, Wei-Ren; Tang, Li-Da; Zhao, Gui-Long; Wang, Jian-Wu, Chinese Chemical Letters (2013), 24(5), 429-432.
25．Dimerization of cyclopropenes to bifurans using tandem metal relay catalysis? Chuanling Song, Di Sun, Xianglong Peng, Jing Bai, Rongyi Zhang, Shengzhen Hou, Jianwu Wang and Zhenghu Xu* Chem. Commun., 2013, 49, 9167—9169
26．Modular synthesis of all-substituted furans through oxidative carbonylation of cyclopropenes with tandem metal relay catalysis? Chuanling Song, Shuli Dong, Lei Feng, Xianglong Peng, Mingchao Wang,Jianwu Wang and Zhenghu Xu* Org. Biomol. Chem., 2013, 11, 6258–6262
27. Effect of the Substitution Pattern on the Intramolecular Charge-Transfer Emissions in Organoboron-Based Biphenyls, Diphenylacetylenes, and Stilbenes, Yi-Qiao Yan, Yan-Bang Li, Jian-Wu Wang,* and Cui-Hua Zhao*[a] Chem. Asian J. 2013, 8, 3164 – 3176
28. Discovery of 6-Deoxydapagliflozin as a Highly Potent Sodium-dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2Diabetes,Lingyu Zhang1,2, Yuli Wang2, Huaqiang Xu1,2, Yongheng Shi2,3, Bingni Liu2, Qunchao Wei2,Weiren Xu2,3, Lida Tang2,3, Jianwu Wang1* and Guilong Zhao2*Medicinal Chemistry, 2014, 10, 304-317
29.The synthesis, characterization and optical properties of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(3-butyl-1-chloroimidazo[1,5-a] pyridin-7-yl)-1,3,4-oxadiazole ，Yan Qing Ge a,b, Jiong Jia a, Teng Wanga, Hong Wei Sun c, Gui Yun Duan b, Jian Wu Wang a,?Spectrochimica Acta Part A: ,Molecular and Biomolecular Spectroscopy 123 (2014) 336–34130.Highly emissive dimesitylboryl-substituted 2,1,3-benzothiadiazole derivatives: photophysical properties and efficient fluorescent sensor for fluoride anions，Bin Wang, Hong Pan, Jiong Jia, Yan-Qing Ge, Wen-Qing Cai, Jian-Wu Wang *,Cui-Hua Zhao * Tetrahedron 70 (2014) 5488-5493

【科研项目】 1.国家重大基础研究973前期项目1个; PDF柔性模型及其抑制剂先导化合物的研究(2003CCA027).50万元;
2.山东省科技计划专项2个; a.新型抗生素-扑洛利福乐克星的合 成 2001 ,b.PDF柔性模型及其抑制剂先导化合物的 研究 (**),10万元;
3.山东省自然基金项目:“丙型肝炎病毒NS3/NS4A酶抑制剂的设计、合成及筛选”（Z2004C06）, 7万元;
4.山东省自然基金项目: 氮桥头芳性氮杂五环并吡啶衍生物的 合成与药物研究(Y2008B40) 5万元；
5.山东省科学技术发展计划项目：新型肽脱甲酰基酶抑制剂类抗生素的研究2009GG** 8万元；
6.与科研院所合作项目6个; 60万元;
7.与企业合作项目2个。20万元.

【科研成果】 科研成果：
发表科研论文160多篇；
承担项目１7个（国家级２个，省部级15个）；一项产品获部级奖。
发明专利15个;
医药及其医药中间体开发，十多个项目已应用于企业生产。
【所获专利】
发明专利：
1 . 一类非肽血管紧张素(AII)受体拮抗剂Jwsartan 化合物及其合成方法与用途，王建武 appl.ZL**.2 CN**, 2004-05-26

2. 一类PDF酶抑制剂- 异噁唑肟酸系列化合物及其合成方法与用途,王建武、徐为人、王平保、贾炯、任戎、郑晓平、郑洪艳、刘登科、冯勇、李炎、张士俊、任晓文、汤立达, appl. CN** ** ,CN **, 2006.06.21

3. 3-苯基异噁唑-5-甲酰胺基取代β-内酰胺类衍生物及其用途, 王建武 徐为人 王西照 张士俊 吴楠 汤立达,appl. **4, CN **A 2005.10.26

4．甘草次酸-30-酰胺类衍生物及其用途 王建武 徐为人 雍建平 汤立达 张士俊 刘利军 王玉丽 任晓文, appl. **1, CN**, 2009-05-20

5. GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF WANG JIANWU; XU WEIREN; YONG JIANPING; TANG LIDA; ZHANG SHIJUN; LIU LIJUN; WANG YULI; REN XIAOWEN ,WO**，2007-04-19

6. 含1，3二杂五元环的异羟肟酸类衍生物及其用途, 王建武、贾炯、徐为人、张大同、汤立达、张士俊、王玉丽、刘巍、李祎亮, appl. CN**1.8, 2007.6.19。CN**, 2008-12-24

7. 含1,3-二杂苯并五元环的异羟肟酸类衍生物、其制备方法和用途, 王建武;徐为人;贾 炯;张大同;汤立达;刘 巍;张士俊;王玉丽;刘冰妮, appl. CN**3.7, CN ** A ** ,

8. 含异噁唑环的五环三萜-28-羧酸酰胺衍生物、其制备方法和用途. 赵桂龙;王建武;徐为人;汤立达;张士俊;王玉丽;刘 巍 appl. CN**5.X , CN** 2010.02.17
　
9. 4-蝶啶氨类化合物及其制备和用途, 段崇刚;王建武;张兰英;宋海波;朱荣秀, appl. CN**5.0, CN**, 2009.09.30

10. 酰胺基噻唑衍生物、其制备方法和用途, 赵桂龙、徐为人、李祎亮、邹美香、战付旭、王玉丽、刘巍、张士俊、汤立达、王建武, appl. **4 CN ** 2009-06-03

11. Glycyrrhetinic Acid-30-Amide Derivatives and Their Use WANG JIANWU; XU WEIREN; YONG JIANPING; TANG LIDA; ZHANG SHIJUN; LIU LIJUN US** (A1), 2008-09-04

12. 苯基-3-取代吡唑并[1，5-a] 吡啶(Ⅱ)类衍生物及其制备方法和用途，刘默，刘登科，徐为人，汤立达等， CN **6

13. 3-o-caffeoyloleane type pentacyclic triterpenoid ester derivative, and preparation method and application thereof. Gao, Yueqiu; Wang, Jianwu; Jia, Jiong; Sun, Xuehua; Jin, Shugen. . Faming Zhuanli Shenqing (2012), 34pp. CN **

14. Preparation of heterocycles useful as antitumor agents and anticoagulants. Xu, Weiren; Wang, Jianwu; Zhao, Guilong; Zhang, Datong; Tang, Lida; Zhang, Shijun; Wang, Yuli; Liu, Wei; Tan, Chubing; Ren, Xiaowen. Faming Zhuanli Shenqing (2010), 22pp. CN **

15. Preparation of heterocycles as antitumor agents and anticoagulants. Xu, Weiren; Wang, Jianwu; Zhao, Guilong; Zhang, Datong; Tang, Lida; Zhang, Shijun; Wang, Yuli; Liu, Wei; Tan, Chubing; Ren, Xiaowen. Faming Zhuanli Shenqing (2010), 16pp. CN **



【联合培养情况】
【拟招收研究生情况】 招收研究生情况:
硕士研究生培养 :1997-2014： 共34人,毕业30人;
博士研究生培养: 2003-2014： 共20人,毕业15人;

每年拟招收硕士生1-2人、博士研究生1-2人;

本人培养的研究生适合从事工作领域:
研究型: 进行有机合成及药物合成研究;
教学型: 进行有机化学及药物化学教学;
开发型: 进行有机化合物合成及药物中间体合成开发;