张玉忠 教授
　　博士生导师
　　Tel：**
　　E-mail:zhangyz@sdu.edu.cn
　　
　　教育背景
　　学习和工作经历:
　　1985年9月—1989年7月，山东师范大学生物系，学士学位；
　　1989年9月—1992年7月，南京农业大学农学系，硕士学位；
　　1992年9月—1995年10月，中国科学院海洋研究所，博士学位；
　　1995年10月—1998年6月，山东大学微生物技术国家重点实验室，博士后；
　　1998年6月—至今，山东大学微生物技术国家重点实验室 工作。
　　2005年5月—2005年9月，美国威斯康星州立大学高级访问学者；并先后访问俄亥俄州立大学、UCLA、夏威夷大学、华盛顿大学西雅图分校。
　　2005年10月—2005年12月，荷兰莱顿大学，高级访问学者；
　　2007年9月—2008年10，德国马普学会生物物理研究所，高级访问学者；
　　2005年至今，一直与荷兰莱顿大学、美国俄亥俄州立大学、夏威夷大学、德国马普学会生物物理研究所保持良好的合作关系。
　　
　　学术兼职
　　中国微生物学会海洋微生物专业委员会副主任委员、中国微生物学会农业微生物专业委员会委员。
　　
　　研究方向
　　一、海洋微生物学与海洋微生物技术
　　1.深、远海微生物资源的多样性、重要的生命过程与环境响应。
　　主要研究内容包括：深海、极地等极端环境下微生物资源的多样性、生命过程及其对低温、寡营养等极端环境的生态适应机制；微生物参与的深海、极地等极端环境下有机氮、有机碳的降解机制及生物地球化学循环过程；深海、极地极端微生物资源及其基因资源的开发利用。
　　2.海洋蓝藻（蓝细菌）和单细胞红藻光合作用机理与调节
　　近来主要研究内容：蓝藻和红藻光合作用捕光复合物—藻胆蛋白、连接蛋白的结构、功能与进化；藻胆体的三维结构、藻胆蛋白与连接蛋白的相互作用及藻胆体自组装的分子机制；藻胆体¬-类囊体膜光合作用光系统的天然超分子结构，包括藻胆体在类能体膜上的二维排列、藻胆体与光系统的相互作用、能量吸收传递过程及其对光强的生态适应机制。藻类生物能源的研究与开发。
　　二、农业微生物学与农业微生物技术
　　主要研究内容：木霉属真菌与植物的相互作用，包括促进植物生长、诱导植物抗病性的机制；木霉属真菌与土壤中其它微生物的相互作用；木霉属真菌对植物土传病害的生物防治及其机制；木霉属真菌微生物技术、微生物农药、微生物肥料的研究与开发。
　　
　　承担课题
　　近年来，主持承担国家自然科学基金、国家863计划课题、973前期专项课题、科技部国家合作重点项目、以及省部级课题等多项课题，研究经费充足。
　　
　　研究成果及发表论文
　　近年来发表的代表性论文（*通讯作者）:
　　1.Yu-Kai Wang, Hai-Lun He, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang*, Bai-Cheng Zhou，Production of novel Angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM 605，Applied Microbiology and Biotechnology, 2008, in press.
　　2.Hai-Lun He, Hao Wu, Xiu-Lan Chen, Mei Shi, Xi-Ying Zhang, Cai-Yun Sun, Yu-Zhong Zhang*, Bai-Cheng Zhou, Pilot and plant scaled production of ACE inhibitory hydrolysates from Acetes chinensis and its in vivo antihypertensive effect，Bioresource Technology, 2008, 99 (2008) 5956–5959
　　3.Bin-Bin Xie, Xiu-Lan Chen, Xi-Ying Zhang, Yu-Zhong Zhang*, and Bai-Cheng Zhou, Predicting Intra- and Inter-protein Interaction Interfaces from Protein Sequences: Case Studies of Subtilisin and Phycocyanin, PROTEINS: Structure, Function, and Bioinformatics, 2008; 71:1461–1474.
　　4.Hao Wu, Hai-Lun He, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang*, Bai-Cheng Zhou, Purification and Identification of Novel angiotensin-I-converting Enzyme Inhibitory Peptides from Shark Meat Hydrolysate, Process Biochemistry, 2008, 43, 457–461
　　5.Arteni AA, Liu LN, Aartsma TJ, Zhang YZ, Zhou BC, Boekema EJ.Structure and organization of phycobilisomes on membranes of the red alga Porphyridium cruentum. Photosynth Res. 2008， 95, 169–174
　　6.Zhao Dianli, Chen Xiulan*, He Hailun, Shi Mei, Zhang Yuzhong, Gene Cloning and Sequence Analysis of the Cold-adapted Chaperones DnaK and DnaJ from Deep-sea psychrotrophic bacterium Pseudoalteromonas sp. SM9913, Acta Oceanologica Sinica, 2007, 26(6),1-10
　　7.Hailun He, Xiulan Chen, Caiyun Sun, Yuzhong Zhang*, Baicheng Zhou, High throughput and rapid Screening of marine protein hydrolysates enriched in peptides with angiotensin-I-converting enzyme inhibitory activity by CE, Bioresource Technology, 2007, 98, 3499–3505
　　8.Xiao-Yan Song, Shu-Tao Xie, Xiu-Lan Chen, Cai-Yun Sun, Mei Shi, Yuzhong Zhang*, Solid state fermentation for Trichokonins production from Trichoderma koningii SMF2 and preparative purification of Trichokonin VI by a simple protocol, Journal of Biotechnology, 2007, 131, 209–215.
　　9.Xiu-Lan Chen, Yuzhong Zhang*, Jing-Tao Lu, Bin-Bin Xie, Cai-Yun Sun, Bing Guo，Autolysis of a novel multidomain subtilase—Cold-adapted deseasin MCP-01 is pH-dependent and the surface loops in its catalytic domain, the linker, and the P-proprotein domain are susceptible to proteolytic attack，Biochem. Biophys. Res. Commun., 2007, 358(3): 704-709.
　　10.Xiu-Lan Chen, Bin-Bin Xie, Jing-Tao Lu, Hai-Lun He, Yu-Zhong Zhang*，（2007），A novel type of subtilase from the psychrotolerant bacterium Pseudoalteromonas sp. SM9913: catalytic and structural properties of deseasin MCP-01，Microbiology-SGM，153: 2116-2125.
　　11.Guokui Qin, Lizhi Zhu, Xiulan Chen, Peng George Wang, and Yuzhong Zhang*, Structural characterization and ecological roles of a novel exopolysaccharide from the deep-sea psychrotrophic bacterium Pseudoalteromonas sp. SM9913, Microbiology-SGM, 2007, 153: 1566-1572.
　　12.Qin QL, Zhao DL, Wang J, Chen XL, Dang HY, Li TG, Zhang YZ*, Gao PJ. Wangia profundagen. nov., sp. nov., a novel marine bacterium of the family Flavobacteriaceae isolated from southern Okinawa Trough deep-sea sediment . FEMS Microbiology Letters,2007, 271(1): 53-58.
　　13.Song Xiao-Yan, Shen Qing-Tao, Xie Shu-Tao, Chen Xiu-Lan, Sun Cai-Yun & Zhang Yu-Zhong*, (2006) Broad-spectrum antimicrobial activityand high stability of Trichokonins from Trichoderma koningiiSMF2 against plant pathogens, FEMS Microbiol Lett 260, 119–125
　　14.Hailun He, Xiulan Chen, Caiyun Sun, Yuzhong Zhang*, Baicheng Zhou (2006) Analysis of novel angiotensin-I-converting inhibitory Peptides from protease-hydrolyzed marine shrimp Acetes chinensis, Journal of Peptide Science, 2006, 12: 726-733.
　　15.Hailun He, Xiulan Chen, Caiyun Sun, Yuzhong Zhang*, Baicheng Zhou (2006), Preparation of oligopeptide-enriching hydrolysate from shrimp (Acetes chinensis) with the protease produced from Bacillus sp. SM98011 and its function eva luation, Bioresource Technology, 97, 385-390.
　　16.Lu-Shan Wang, Yu-Zhong Zhang, Pei-Ji Gao, Dong-Xia Shi, Liu-Hong Wen and Hong-Jun Gao, (2006), Changes in the structural properties and rate hydrolysis of cotton fibers during extended enzymatic hydrolysis, Biotechnology and Bioengineering, 93(3), 443-456.
　　17.Zhan-Ping Zhou, L-N Liu, X-L Chen, Y-Z Zhang* & B-C Zhou (2005), Factors Effecting Antioxidant Activity of C-phycocyanin from Spirulina platensis, Journal of Food Biochemistry, 29, 313-322.
　　18.Lu-Ning Liu, Xiu-Lan Chen, Yu-Zhong Zhang*, Bai-Cheng Zhou, (2005), Characterization, structure and function of Linker polypeptides in phycobilisomes of Cyanobacteria and Red algae: an overview, Biochimica et Biophysica Acta, - Bioenergetics, 1708, 133 – 142
　　19.Jun Pan, Xiu-Lan Chen, Cai-Yun Shun, Hai-Lun He, Yu-Zhong Zhang*, (2005), Stabilization of cold-adapted protease MCP-01 promoted by trehalose: Prevention of the autolysis, Protein and Peptide Letters, 12(4): 375-378
　　20.Lu-Ning Liu, Xiu-Lan Chen, Xi-Ying Zhang, Yu-Zhong Zhang*, Bai-Cheng Zhou (2005) One-step chromatography method for efficient separation and purification of R-phycoerythrin from marine red alga Polysiphonia urceolata, J. of Biotechnology, 116, 91-100.
　　21.LIU, Y.Q., Y.Z. ZHANG*, P.J. GAO (2004) Bactericidal pharmacodynamics: a novel approach to in vitro estimation of bactericidal potency of antibiotics using a concentration-killing curve method, Antimicrob. Agents Chemother. 2004, 42(10), 1195-1203
　　22.Qing-Tao Shen, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang*, (2004) Dissecting and exploiting nonribosomal peptide synthetase, , Acta Biochimica et Biophysica Sinica, 36(4), 243-249.
　　23.Wang L.S., Zhang Y.Z., Yang H., Gao P.J.,(2004) Quantitative estimate of the effect of cellulase components during degradation of cotton fibers. Carbohydrate Research. 339, 819-824.
　　24.Hailun He, Xiulan Chen, Jianwei Li, Yuzhong Zhang* and Peiji Gao,(2004) Taste improvement of refrigerated meat treated with cold-adapted protease, Food Chemistry, 84(2), 307-311
　　25.Wang L.S., Liu J., Zhang Y. Z., Zhao Y., Gao P.J.,(2003) Comparison of domains function between cellobiohydrolase I and endoglucanase I from Trichoderma pseudokoningii S-38 by limited proteolysis. J. of Mol. Catalysis. B, Enzymatic. 24-25C, 27-28.
　　26.Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang*, and Pei-Ji Gao, (2003) Rapid monitoring of autolysis process of proteases by capillary electrophoresis, Biotechnology Letters, 25, 1763-1767.
　　27.Xiu-Lan Chen, Yu-Zhong Zhang*, Pei-Ji Gao, Xi-Wu Luan (2003) Two different proteases produced by a deep-sea psychrotrophic bacterial strain, Pseudoaltermonas sp. SM9913, Marine Biology, 143, 989-993.

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