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山东师范大学生命科学学院导师教师师资介绍简介-丁乃峥(校内)

本站小编 Free考研考试/2020-12-01



简介丁乃峥,女,博士,教授,动物学专业和学科教学(生物)专业硕士生导师,动物学专业博士生导师。山东师范大学生命科学学院动物生殖发育与疾病团队负责人。迄今已发表研究论文50余篇。主持完成国家自然科学基金面上项目3项,山东省科技厅项目2项。获国家级科研奖励1项和省级科研奖励4项;
教育经历1992-1996东北农业大学生物技术专业,学士
1996-1999东北农业大学预防兽医学专业,硕士
1999-2002东北农业大学基础兽医学专业,博士
工作经历2002-2006北京大学生命科学学院,博士后
2006-2011中南大学生物科学与技术学院,副教授
2011-至今:山东师范大学,教授
研究方向:本实验室主要研究哺乳动物生殖发育及其相关疾病的发生机理。包括哺乳动物胚胎早期发育、胚胎着床和蜕膜化、子宫发育、附睾在精子成熟中的作用、卵巢功能等的分子调节机理和相关疾病的发生机理。主要利用基因敲除小鼠模型,研究重要基因和信号通路在哺乳动物生殖发育和相关疾病中的作用。这些工作对于推动哺乳动物生殖与发育生物学的基础研究,治疗不孕不育等生殖疾病具有重要的理论指导作用。另外,本实验室还利用生物信息学和分子生物学手段,研究动物病毒进化的分子机制,及其对动物生殖的影响。
开设课程:本科:生物信息学(山东省一流本科课程,网址:https://coursehome.zhihuishu.com/courseHome/**#teachTeam)
硕士研究生:生殖生物学实验方法和技术、动物胚胎工程
博士研究生:生殖生理学、生物信息学
主持的科研项目 主持山东省重点研发计划(公益类)项目:2019-2020,《构建BVDV的干酪乳杆菌口服疫苗》(2019GSF107020)
主持国家自然科学基金面上项目的研究工作:2018-2019年,《RNA连接酶RtcB在小鼠卵母细胞发育和减数分裂过程中的功能研究》(**)
主持国家自然科学基金面上项目:2013-2016年,《FAAP 在小鼠附睾中的功能和作用的分子机制研究》(**)
主持国家自然科学基金面上项目:2005-2007年,《一个新基因p55与小鼠胚胎着床和蜕膜化的关系》(**)
主持山东省高等学校科技计划项目:2012-2015年,《细胞朊蛋白在雌性生殖中的作用》(JRLE06)
获得的科研奖励 获得国家教育部科技进步二等奖:2004年,《胚胎着床分子机理的研究》(第5完成人)
获山东高校优秀科研成果二等奖:2008年,《同源重组导致我省出现新基因型鸡贫血病毒》(第2完成人);
获山东高校优秀科研成果一等奖:2009年,《同源重组导致我省出现新基因型鸡贫血病毒》(第2完成人);
获山东高校优秀科研成果二等奖:2010年,《RNA病毒遗传多样性分子机制》(第2完成人)
获山东高校优秀科研成果三等奖:2013年,《发热伴血小板综合征等RNA病毒的同源重组证据》(第1完成人)
主持的教学研究课题: 湖南省普通高等学校教学改革项目:《以创新意识和动手能力培养为导向的发育生物学实验教学改革与实践》,湖南省教育厅,2009年
中南大学研究生教育创新计划项目,《发育生物学硕士研究生创新能力培养研究与实践》,中南大学,2009年
山东师范大学混合式课程建设立项:本科生必修课《生物信息学》,2015年
山东师范大学生命科学学院优质核心课程建设立项:本科生必修课《生物信息学》,2015年
山东师范大学教学改革项目:《以创新和实践能力培养为导向的混合式生物信息学课程改革与实践》,(2016JG41),2017年
山东师范大学“在线开放课程”A类课程立项:本科生必修课《生物信息学》,2018年
山东师范大学混合式“金课”建设项目立项:本科生选修课《生物信息学》,(2019JK84),2019年

发表的教学研究论文: 丁乃峥,刘艳平,李善妮,刘新发.创新型生命科学人才培养的实践与探索. 医学教育探索.2010,9(12):1606-1607
丁乃峥,李善妮. 浅谈发育生物学实验教学改革及创新能力培养,生物学杂志,2011,28(3):103-105

发表科研论文(*为通讯作者) Yu HN, Li XM, Kong LL, Ren J, Wu H, Bu LG, Ding NZ, Ni H.Connective tissue growth factor gene expression in goat endometrium during estrous cycle and early pregnancy.Theriogenology. 2020 Sep 1;153:85-90.
He M, Qin CX, Wang X, Ding NZ*. Plant Unsaturated Fatty Acids: Biosynthesis and Regulation.Front Plant Sci. 2020 Apr 23;11:390.
He QL, Wei XY, Han XY, Zhou Q, Wang HQ, Ding NZ, Meng XQ, Schatten H, Sun QY, Liu SZ. Effects of 2,3',4,4'5-pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring's oocytes in mice. Arch Toxicol. 2019 Sep;93(9):2575-2592.
He M, Zhou D, Ding NZ, Teng CB, Yan XC, Liang Y.Common Carp mef2 Genes: Evolution and Expression.Genes (Basel). Genes (Basel). 2019 Aug 1;10(8).
He CQ, He M, He HB, Wang HM, Ding NZ*. The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses. Transbound Emerg Dis. 2019 Sep;66(5):2188-2195.
He M, He CQ, Ding NZ*Abiotic Stresses: General Defenses of Land Plants and Chances for Engineering Multistress Tolerance. Front Plant Sci. 2018 Dec 7;9:1771.
Ding NZ, Wang XM, Jiao XW, Li R, Zeng C, Li SN, Guo HS, Wang ZY, Huang Z, He CQ. Cellular prion protein is involved in decidualization of mouse uterus. Biol Reprod. 2018 Aug 1;99(2):319-325. doi: 10.1093/biolre/ioy065
Ding NZ, Qi QR, Gu XW, Zuo RJ, Liu J, Yang ZM.De novo synthesis of sphingolipids is essential for decidualization in mice. Theriogenology. 2018 Jan 15;106:227-236
Ding NZ, Xu DS, Sun YY, He HB, He CQ. A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination. Sci Rep. 2017 Mar 21; 7(1):289.
He CQ, Liu YX, Wang HM, Hou PL, He HB, Ding NZ*.New genetic mechanism, origin and population dynamic of bovine ephemeral fever virus.Vet Microbiol. 2016;182:50-6.
Ji W, Guo Z, Ding NZ, He CQ. Studying classical swine fever virus: making the best of a bad virus. Virus Res. 2015 Feb 2;197:35-47.
Ji W, Niu DD, Si HL, Ding NZ, He CQ.Vaccination influences the evolution of classical swine fever virus.Infect Genet Evol. 2014 Jul;25:69-77.
Ding NZ, Luo ZF, Niu DD, Ji W, Kang XH, Cai SS, Xu DS, Wang QW, He CQ.Identification of two severe fever with thrombocytopenia syndrome virus strains originating from reassortment.Virus Res. 2013 Dec 26;178(2):543-6.
He M, Ding NZ, He CQ, Yan XC, Teng CB.Dating the divergence of the infectious hematopoietic necrosis virus.Infect Genet Evol. 2013 Aug;18:145-50.
He CQ, Meng SL, Yan HY, Ding NZ, He HB, Yan JX, Xu GL. Isolation and identification of a novel rabies virus lineage in China with natural recombinant nucleoprotein gene.PLoS One. 2012;7(12):e49992.
He CQ, Ding NZ. Discovery of severe fever with thrombocytopenia syndrome bunyavirus strains originating from intragenic recombination.J Virol. 2012 Nov;86(22):12426-30.
He CQ, Ding NZ, Mou X, Xie ZX, Si HL, Qiu R, Ni S, Zhao H, Lu Y, Yan HY, Gao YX, Chen LL, Shen XH, Cao RN. Identification of three H1N1 influenza virus groups with natural recombinant genes circulating from 1918 to 2009.Virology. 2012 May 25;427(1):60-6. PMID: ** Free Article
Ding NZ, He M, He CQ, Hu JS, Teng JL, Chen J.Yin yang-1 regulates the characterized murine focal adhesion-associated protein promoter. DNA Cell Biol. 2012 Apr;31(4):496-503.9.
He M, He CQ, Ding NZ* .Natural recombination between tobacco and tomato mosaic viruses.Virus Res. 2012 Jan;163(1):374-9.
Zhao J, Ju X, Zhang L, An Y, Zhang Z, Sun Z, Ding N*, Teng CB*. Spatiotemporal expression of D10Wsu52e in the developing mouse pancreas. Front Biosci (Elite Ed). 2011, 3:355-363.
Ding NZ, He M, He CQ, Hu JS, Teng J, Chen J. Expression and regulation of FAAP in the mouse epididymis. Endocrine. 2010 Oct;38(2):188-93.
He CQ, Ding NZ*, He M, Li SN, Wang XM, He HB, Liu XF, Guo HS. Intragenic recombination as a mechanism of genetic diversity in bluetongue virus. J Virol. 2010 Nov;84(21):11487-95.
Ding NZ*, Wang XM, Sun SW, Song Q, Li SN, He CQ. Appearance of mosaic enterovirus 71 in the 2008 outbreak of China. Virus Res. 2009 Oct;145(1):157-61. PMID: **
胡劲松、丁乃峥、滕俊林、陈建国,小鼠FAAP蛋白对细胞黏附的影响,生物化学与生物物理进展,2009,36(1):88-94.
He CQ, Ma LY, Wang D, Li GR, Ding NZ*. Homologous recombination is apparent in infectious bursal disease virus. Virology. 2009 Feb 5;384(1):51-8.
He CQ, Han GZ, Wang D, Liu W, Li GR, Liu XP, Ding NZ*. Homologous recombination evidence in human and swine influenza A viruses. Virology. 2008 Oct 10;380(1):12-20.
Han GZ, He CQ, Ding NZ*, Ma LY. Identification of a natural multi-recombinant of Newcastle disease virus. Virology. 2008 Feb 5;371(1):54-60.
He CQ, Ding NZ*, Fan W. YY1 repressing peroxisome proliferator-activated receptor delta promoter. Mol Cell Biochem. 2008 Jan;308(1-2):247-52.
He CQ, Ding NZ*, Kang J. Germ cell nuclear factor directly represses the transcription of peroxisome proliferator-activated receptor delta gene. Acta Biochim Biophys Sin. 2008, 40: 253-260. (通讯作者, SCI IF 1.547 4区)
Hu J, Teng J, Ding N, He M, Sun Y, Yu AC, Chen J.FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association. Front Biosci. 2008 May 1;13:7123-31. (SCI IF 3.52 3区)
He CQ, Ding NZ*, Fan W, Wu YH, Li JP, Li YL. Identification of chicken anemia virus putative intergenotype recombinants. Virology. 2007 Sep 15;366(1):1-7.
He CQ, Ding NZ, Chen JG, Li YL. Evidence of natural recombination in classical swine fever virus.Virus Res. 2007 Jun;126(1-2):179-85(共同第一作者)
Feng Q, Yu H, Liu YY, He CQ, Hu JS, Sang HC, Ding NZ, Ding MX, Fung YW, Lau LT, Yu AC, Chen J. Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains. Biochem Biophys Res Commun. 2004,323:254-263(SCI IF 2.595)名字拼写错误ding neizheng
Ding NZ, Teng CB, Ma H, Ni H, Ma XH, Xu LB, Yang ZM. Peroxisome proliferator-activated receptor delta expression and regulation in mouse uterus during embryo implantation and decidualization.Mol Reprod Dev. 2003 Nov;66(3):218-24.
Ding NZ, Ma XH, Diao HL, Xu LB, Yang ZM. Differential expression of peroxisome proliferator-activated receptor delta at implantation sites and in decidual cells of rat uterus.Reproduction. 2003 Jun;125(6):817-25.
Ding NZ, He CQ, Yang ZM.Quantification of basigin mRNA in mouse oocytes and preimplantation embryos by competitive RT-PCR.Zygote. 2002 Aug;10(3):239-43.
Xiao LJ, Chang H, Ding NZ, Ni H, Kadomatsu K, Yang ZM. Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period. Mol Reprod Dev. 2002 Sep;63(1):47-54.
Ni H, Ding NZ, Harper MJ, Yang ZM. Expression of leukemia inhibitory factor receptor and gp130 in mouse uterus during early pregnancy.Mol Reprod Dev. 2002 Oct;63(2):143-50.
Xiao LJ, Diao HL, Ma XH, Ding NZ, Kadomatsu K, Muramatsu T, Yang ZM.Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period. Reproduction. 2002 Aug;124(2):219-25.
Ni H, Sun T, Ding NZ, Ma XH, Yang ZM. Differential expression of microsomal prostaglandin e synthase at implantation sites and in decidual cells of mouse uterus. Biol Reprod. 2002 Jul;67(1):351-8.



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