姓名：张毅
性别：女
出生日期：1988-12-28
邮箱: yizhang@sdnu.edu.cn
教育经历:
2013.3–2017.1, 中国科学院大学, 遗传学, 博士
2010.9–2013.3, 中国科学院大学, 遗传学, 硕士
2006.9–2010.6, 山东师范大学, 生物技术, 学士
工作经历：
2019.7-2021.7，哥本哈根大学，博士后
2017.5-至今, 山东师范大学, 生命科学学院, 讲师
研究领域：
主要从事植物基因组编辑相关研究，能够熟练掌握水稻及苜蓿的遗传转化工作。研究生期间在小麦中建立了一种高效安全的基因组编辑技术体系，并对小麦中产量相关的基因进行了较为深入的研究，研究成果分别以第一作者发表在Nature Communications及The Plant Journal杂志上，同时以共同作者的身份参与了多篇基因组编辑相关的国际顶尖论文的工作及发表。现阶段正在山东师范大学进行小麦基因定点插入相关的研究工作，期间以第一作者在Genome Biology杂志上发表植物基因编辑相关的综述性文章。2019年7月开始在丹麦哥本哈根大学进修博士后，主要工作为利用基因编辑工具对苜蓿进行遗传改良，期间以第一作者在Nature Food杂志上发表植物基因编辑相关的评论性文章。
正在承担的与本项目相关的科研项目情况：
国家自然科学基金青年科学基金项目，编号：**，基因定点插入技术体系在小麦中的建立及应用，2019年01月至2021年12月，25万。
山东省自然科学基金博士基金项目，编号：ZR2018BC016，基因定点插入技术体系在小麦中的建立及应用，2018年03月至2020年12月，9万。
发表的学术论文:
1. Zhang Y, Pribil M, Palmgren M*, Gao C*. (2020). A CRISPR way for accelerating improvement of food crops. Nature Food, 1, 200-205.
2. Zhang Y, Palmgren M*. (2020). Gene-editing in plants no longer requires tissue culture. Frontiers of Agricultural Science & Engineering, 7, 229-230.
3. Zhang Y, Massel K, Godwin I D, Gao C*. (2018). Applications and potential of genome editing in crop improvement. Genome Biology, 19, 210.
4. Zhang Y¹, Li D¹, Zhang D, Zhao X, Cao X, Dong L, Liu J, Chen K, Zhang H, Gao C*, Wang D*. (2018). Analysis of the functions of TaGW2 homoeologs in wheat grain weight and protein content traits. Plant Journal, 94, 857-866.
5. Zhang Y, Gao C*. (2017). Recent advances in DNA-free editing and precise base editing in plants. Emerging Topics in Life Sciences, 1, 161-168.
6. Zhang Y¹, Liang Z¹, Zong Y¹, Wang Y, Liu J, Chen K, Qiu J, Gao C*. (2016). Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA. Nature Communications, 7, 12617.
7. Zhang Y, Li J, Gao C*. (2016). Generation of stable transgenic rice (Oryza sativa L.) by Agrobacterium-mediated transformation. Current Protocols in Plant Biology, 1, 235-246.
8. Ji X¹, Si X¹, Zhang Y, Zhang H, Zhang F, Gao C*. (2018) Conferring DNA virus resistance with high specificity in plants using virus-inducible genome-editing system. Genome Biology, 19, 197.
9. Liang Z, Chen K, Yan Y, Zhang Y, Gao C*. (2018). Genotyping genome-edited mutations in plants using CRISPR ribonucleoprotein complexes. Plant Biotechnology Journal, 16, 2053-2062.
10. Liang Z¹, Chen K¹, Zhang Y, Liu J, Yin K, Qiu J, Gao C^*. (2018). Genome editing of bread wheat using biolistic delivery of CRISPR/Cas9 in vitro transcripts or ribonucleoproteins. Nature Protocols, 13, 413-430.
11. Meng X¹, Yu H¹, Zhang Y, Zhuang F, Song X, Gao S, Gao C*, Li J*. (2017). Construction of a genome-wide mutant library in rice using CRISPR/Cas9. Molecular Plant, 10, 1238-1241.
12. Liang Z¹, Chen K¹, Li T, Zhang Y, Wang Y, Zhao Q, Liu J, Zhang H, Liu C, Ran Y, Gao C^*. (2017). Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes. Nature Communications, 8, 14261.
13. Shan Q, Zhang Y, Chen K, Zhang K, Gao C*. (2015). Creation of fragrant rice by targeted knockout of the OsBADH2 gene using TALEN technology. Plant Biotechnology Journal, 13, 791-800.
14. Ji X¹, Zhang H¹, Zhang Y, Wang Y, Gao C*. (2015). Establishing a CRISPR-Cas-like immue system conferring DNA virus resistance in plants. Nature Plants, 1, 15144.
15. Zhang K¹, Liu J¹, Zhang Y, Yang Z, Gao, C*. (2015). Biolistic genetic transformation of a wide range of Chinese elite wheat (Triticum aestivum L.) varieties. Journal of Genetics and Genomics, 42, 39-42.
16. Wang S, Li S, Liu Q, Wu K, Zhang J, Wang S, Wang Y, Chen X, Zhang Y, Gao C, Wang F, Huang H, Fu X*. (2015). The OsSPL16-GW7 regulatory module determines grain shape and simultaneously improves rice yield and grain quality. Nature Genetics, doi:10.1038/ng.3352.
17. Wang Y¹, Cheng X¹, Shan Q, Zhang Y, Liu J, Gao C*, Qiu J*. (2014) Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nature Biotechnology, 32, 947-951.
授权专利情况：
1. 一种提高小麦产量的方法，专利号：CNB, 发明人：高彩霞，张毅（已授权）。
2. A method for site-directed modification of whole plant through gene transient expression. 专利号：PCT/CN2016/072352. 发明人：Caixia Gao, Yi Zhang, Zhongyi Wu, Kang Zhang (published in many counties and granted in Australia).
3. A method for precise modification of plant via transient gene expression. 专利号：PCT/CN2016/071352. 发明人：Caixia Gao, Yanpeng Wang, Yi Zhang, Jinxing Liu, Kang Zhang (published in many counties and not yet granted).