姓名：高雯


职称：
教授

专业：
细胞成像与环境毒理分析

博（硕）导：
博导

最终学历：
博士研究生

联系电话：
**

电子邮件：
gaowen@sdnu.edu.cn

简历及研究领域

个人简介：
本人自2012年10月进入山东师范大学工作至今，现任化学化工与材料科学学院教授，博士生导师，泰山****青年专家，山东省环境科学学会理事。长期从事环境相关细胞内重要活性分子的生化分析及生物效应研究，在高效原位化学标记、活性分子纳米探针的设计构建与成像检测、活性分子的毒性效应与致病机制以及相关疾病诊疗等方面取得了系列科研成果。先后在Nat. Commun., Biomaterials, Chem. Sci., Anal. Chem., Org. Lett., Chem. Comm.等国际知名学术期刊上发表SCI论文27篇，其中第一和通讯作者论文20篇，ESI高被引论文1篇，相关成果被Chem. Rev., Chem. Soc. Rev., Adv. Mater.等正面报道和评述。目前主持国家自然科学基金面上项目2项、山东省属高校优秀青年基金1项、中国博士后科学基金面上项目1项，主持完成国家自然科学基金青年项目1项，同时还作为主要完成人参与973、国家自然科学基金重大、重点以及山东省重大科技创新工程等多项国家级和省部级项目。

代表性论文

1) Wen Gao^#, Yuhui Sun^#, Michelle Cai, Yujie Zhao, Wenhua Cao, Zhenhua Liu, Guanwei Cui and Bo Tang*. Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis. Nat. Commun., 2018, 9, 231. (IF=11.878)
2) Wen Gao, Shuangshuang Li, Zhenhua Liu, Yuhui Sun, Wenhua Cao, Lili Tong, Guanwei Cui and Bo Tang*. Targeting and destroying tumor vasculature with a near-infrared laser-activated "nanobomb" for efficient tumor ablation. Biomaterials, 2017, 139, 1-11. (IF=10.273)
3) Wen Gao, Wenhua Cao, Yuhui Sun, Xueping Wei, Kehua Xu, Huaibin Zhang, Bo Tang*. AuNP flares-capped mesoporous silica nanoplatform for MTH1 detection and inhibition. Biomaterials, 2015, 69, 212-221. (IF=10.273)
4) Wen Gao, Lifei Ji, Lu Li, Guanwei Cui, Kehua Xu, Ping Li, Bo Tang*. Bifunctional combined Au-Fe₂O₃ nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging. Biomaterials, 2012, 33, 3710-3718. (IF=10.273)
5) Wen Gao^#, Yujie Zhao^#, Xiang Li, Yuhui Sun, Michelle Cai, Wenhua Cao, Zhenhua Liu, Lili Tong, Guanwei Cui and Bo Tang*. H₂O₂-responsive and plaque-penetrating nanoplatform for mTOR gene silencing with robust anti-atherosclerosis efficacy. Chem. Sci., 2018, 9, 439-445. (IF=9.556)
6) Yuhui Sun, Wen Gao*, Zhenhua Liu, Huazhen Yang, Wenhua Cao, Lili Tong and Bo Tang*. Luminescence-Resonance-Energy-Transfer-Based Luminescence Nanoprobe for In Situ Imaging of CD36 Activation and CD36?oxLDL Binding in Atherogenesis. Anal. Chem., 2019, 91, 9770-9776. (IF=6.350)
7) Wen Gao, Xiang Li, Zhenhua Liu*, Wei Fu, Yuhui Sun, Wenhua Cao, Lili Tong, and Bo Tang*. A Redox-Responsive Self-Assembled Nanoprobe for Photoacoustic Inflammation Imaging to Assess Atherosclerotic Plaque Vulnerability. Anal. Chem., 2019, 91, 1150-1156. (IF=6.350)
8) Yuhui Sun, Wen Gao*, Yujie Zhao, Wenhua Cao, Zhenhua Liu, Guanwei Cui, Lili Tong, Fengcai Lei, and Bo Tang*. Visualization and Inhibition of Mitochondria-Nuclear Translocation of Apoptosis Inducing Factor by a Graphene Oxide-DNA Nanosensor. Anal. Chem., 2017, 89, 4642-4647. (IF=6.350)
9) Wenhua Cao, Wen Gao*, Zhenhua Liu, Wenjing Hao, Xiang Li, Yuhui Sun, Lili Tong, and Bo Tang*. Visualizing miR-155 to monitor breast tumorigenesis and response to chemotherapeutic drugs by a self-assembled photoacoustic nanoprobe. Anal. Chem., 2018, 90, 9125-9131. (IF=6.350)
10) Lili Tong, Xiuxiu Wang, Wen Gao*, Zhenhua Liu, Zhenzhen Chen, Guiying Cheng, Wenhua Cao, Meiju Sui, and Bo Tang*. CeO₂ Nanowire-BODIPY-Adenosine Triphosphate Fluorescent Sensing Platform for Highly Specific and Sensitive Detection of Arsenate. Anal. Chem., 2018, 90, 14507-14513. (IF=6.350)
11) Zhenhua Liu, Zhihai Zhang, Guangyu Zhu, Yiqin Zhou, Lin Yang, Wen Gao*, Lili Tong and Bo Tang*. Copper-Catalyzed Aldol Reaction of Vinyl Azides with Trifluoromethyl Ketones. Org. Lett., 2019, 21, 7324-7328. (IF= 6.555)
12) Wen Gao*, Huazhen Yang, Xianghua Liu, Zhenhua Liu, Lili Tong, Yuhui Sun, Wenhua Cao, Yujie Cao and Bo Tang*. Reductively dissociable biomimetic nanoparticles for control of integrin-coupled inflammatory signaling to retard atherogenesis. Chem. Commun., 2019, 55, 11535-11538. (IF=6.164)
13) Zhenhua Liu^#, Huimin Ji^#, Wen Gao*, Guangyu Zhu, Lili Tong, Fengcai Lei and Bo Tang*. Copper(i)-mediated carboamination of vinyl azides by aryldiazonium salts: synthesis of N(2)-substituted 1,2,3-triazoles. Chem. Commun., 2017, 53, 6259-6262. (IF=6.164)
14) Wen Gao, Xueping Wei, Xuejun Wang, Guanwei Cui, Zhenhua Liu and Bo Tang*. A competitive coordination-based CeO2 nanowire-DNA nanosensor: fast and selective detection of hydrogen peroxide in living cells and in vivo. Chem. Commun., 2016, 52, 3643-3646. (IF=6.164)
15) Wen Gao, Wenhua Cao, Huaibin Zhang, Ping Li, Kehua Xu and Bo Tang*. Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au–ZnO hybrid nanoparticles. Chem. Commun., 2014, 50, 8117. (IF=6.164)
16) Zhenhua Liu^#, Wenjing Hao^#, Wen Gao*, Guangyu Zhu, Xiang Li, Lili Tong and Bo Tang *. Silver-catalyzed three-component reaction: synthesis of N2 -substituted 1,2,3-triazoles via direct benzylic amination. Sci. China Chem., 2019, 62, 1001-1006. (IF= 6.085)
17) Zhenhua Liu^#, Guangyu Zhu^#, Wen Gao*, Lin Yang, Huimin Ji, Lili Tong and Bo Tang*. Copper-catalyzed regioselective cyclization of vinyl azides by gem-difluoromethylene for trisubstituted pyridines. Org. Chem. Front., 2019, 6, 468-473. (IF= 5.076)
18) Zhenhua Liu*, Wenjing Hao, Zhixian Liu, Wen Gao*, Zhihai Zhang, Yanan Zhang, Xiang Li, Lili Tong and Bo Tang*. Bimetal-Catalyzed Cascade Reaction for Efficient Synthesis of N-isopropenyl 1,2,3-Triazoles via in situ Generated 2-Azidopropenes. Chem. Asian J., 2019, 14, 2149. (IF=3.698)
19) Wen Gao, Kehua Xu, Lifei Ji, Bo Tang*. Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation and apoptosis in HL7702 cells. Toxicol. Lett., 2011, 205, 86-95. (IF=3.499)
20) Wen Gao, Kehua Xu, Ping Li, Bo Tang*. Functional roles of superoxide and hydrogen peroxide generated by mitochondrial DNA mutation in regulating tumorigenicity of HepG2 cells. Cell Biochem. Funct., 2011, 29, 400-407. (IF=2.142)

研究课题

蛋白质氧化修饰在烟草烟雾致动脉粥样硬化中的作用机制研究 (**), 2020-01至2023-12, 主持, 在研
国家自然科学基金面上项目

高时空分辨的多模态纳米智能探针用于精准调控细胞自噬防治动脉粥样硬化研究 (**), 2018-01至2021-12, 主持, 在研
国家自然科学基金面上项目

多模态纳米探针用于动脉粥样硬化易损斑块标志物的高灵敏检测和高分辨成像 (ZR2018JL008), 2018-03至2020-12, 主持, 在研
山东省属高校优秀青年人才联合基金

智能纳米探针用于肝癌磁共振/超声分子影像诊断研究 (2019M650168), 2019-01至2021-12, 主持, 在研
中国博士后科学基金面上项目

金-金属氧化物功能纳米复合材料用于肝癌早期诊断、靶向治疗及可视化成像研究 (**), 2014-01至2016-12, 主持, 已结题
国家自然科学基金青年科学基金

荣誉称号

山东省泰山****青年专家
山东省人民政府
2019-01至2023-12

山东师范大学东岳****青年人才
山东师范大学
2018-01至2022-12