姓名：解希雷


职称：
副教授

专业：
应用化学

博(硕)导：
硕士生导师

最终学历：
博士研究生

联系电话：


电子邮件：
xiexilei@sdnu.edu.cn

简历及研究领域

学习工作经历：
2008年7月于山东大学获理学学士学位，药学专业；
2014年7月于北京协和医学院（清华大学医学部）药物研究所获博士学位，药物化学专业；
2014年9月至今于山东师范大学化学化工与材料科学学院工作。
研究领域：
应用化学、分析化学；
新型荧光染料及分子诊疗试剂的设计合成与生物应用。
招生信息：
每年在应用化学专业招收硕士研究生1-2名。

代表性论文

(17) Yong Li^#, Yingzheng Shu^#, Xu Wang^*, Xiaoyun Jiao, Xilei Xie, Jian Zhang, Bo Tang^*, An H₂S-activated ratiometric CO photoreleaser enabled by excimer/monomer conversion, Chemical Communications, 2019, 55(44): 6301-6304
(16) Jian Zhang^#, Muwen Liang^#, Xu Wang^*, Yong Li, Xiaoyun Jiao, Xilei Xie, Bo Tang^*, Visualizing peroxynitrite fluxes in myocardial cells using a new fluorescent probe reveals the protective effect of estrogen, Chemical Communications, 2019, 55(47): 6719-6722
(15) Xilei Xie^{*, #}, Guangzhao Liu^#, Xingxing Su, Yong Li, Yawen Liu, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, A facile, versatile, and highly efficient strategy for peroxynitrite bioimaging enabled by formamide deformylation, Analytical Chemistry, 2019, 91(10): 6872-6879
(14) Yong Li^#, Zhiwen Zhao^#, Yongsheng Xiao, Xu Wang^*, Xiaoyun Jiao, Xilei Xie, Jian Zhang, Bo Tang^*, Reactivity modulation of benzopyran-coumarin platform by introducing electron-withdrawing groups: specific detection of biothiols and peroxynitrite, Analytical Chemistry, 2019, 91(9): 6097-6102
(13)Xilei Xie^#, Tianhong Wu^#, Xu Wang^*, Yong Li, Kaiye Wang, Zhiwen Zhao, Xiaoyun Jiao, Bo Tang^*, A two-photon fluorescent probe for ratiometric visualization of hypochlorous acid in live cells and animals based on a selenide oxidation/elimination tandem reaction, Chemical Communications, 2018, 54(84): 11965-11968
(12) Yong Li, Yingzheng Shu, Muwen Liang,Xilei Xie, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, A two-photon H₂O₂-activated CO photoreleaser, Angewandte Chemie International Edition, 2018, 57(38): 12415-12419
(11)Xilei Xie^{*, #}, Fuyan Tang^#, Guangzhao Liu, Yong Li, Xingxing Su, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, Mitochondrial peroxynitrite mediation of anthracycline-induced cardiotoxicity as visualized by a two-photon near-infrared fluorescent probe, Analytical Chemistry, 2018, 90(19): 11629-11635
(10) Xiaoyun Jiao^#, Yongsheng Xiao^#, Yong Li, Muwen Liang,Xilei Xie, Xu Wang^*, Bo Tang^*, Evaluating drug-induced liver injury and its remission via discrimination and imaging of HClO and H₂S with a two-photon fluorescent probe, Analytical Chemistry, 2018, 90(12): 7510-7516
(9) Xiaoyun Jiao, Yong Li, Jinye Niu, Xilei Xie, Xu Wang^*, Bo Tang^*, Small-molecule fluorescent probes for imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems, Analytical Chemistry, 2018, 90(1): 533-555
(8) Xilei Xie^#, Jilin Fan^#, Muwen Liang, Yong Li, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, A two-photon excitable and ratiometric fluorogenic nitric oxide photoreleaser and its biological applications, Chemical Communications, 2017, 53(87): 11941-11944
(7) Xilei Xie^#, Fuyan Tang^#, Xiaoyan Shangguan, Shiyi Che, Jinye Niu, Yongsheng Xiao, Xu Wang^*, Bo Tang^*, Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe, Chemical Communications, 2017, 53(48): 6520-6523
(6) Yong Li^#, Xilei Xie^#, Xiue Yang, Mengmeng Li, Xiaoyun Jiao, Yuhui Sun, Xu Wang^*, Bo Tang^*, Two-photon fluorescent probe for revealing drug-induced hepatotoxicity via mapping fluctuation of peroxynitrite, Chemical Science, 2017, 8(5): 4006-4011
(5) Xilei Xie, Mengmeng Li, Fuyan Tang, Yong Li, Leilei Zhang, Xiaoyun Jiao, Xu Wang^*, Bo Tang^*, Combinatorial strategy to identify fluorescent probes for biothiol and thiophenol based on diversified pyrimidine moieties and their biological applications, Analytical Chemistry, 2017, 89(5): 3015-3020
(4) Jinye Niu, Jilin Fan, Xu Wang^*, Yongsheng Xiao, Xilei Xie, Xiaoyun Jiao, Chuanzhi Sun, Bo Tang^*, Simultaneous Fluorescence and Chemiluminescence Turned on by Aggregation-Induced Emission for Real-time Monitoring of Endogenous Superoxide Anion in Live Cells,Analytical Chemistry, 2017, 89(13): 7210-7215
(3) Yong Li, Xu Wang^*, Jie Yang, Xilei Xie, Mengmeng Li, Jinye Niu, Lili Tong, Bo Tang^*, Fluorescent probe based on azobenzene-cyclopalladium for the selective imaging of endogenous carbon monoxide under hypoxia conditions, Analytical Chemistry, 2016, 88(22): 11154-11159
(2) Xilei Xie, Xiue Yang, Tianhong Wu, Yong Li, Mengmeng Li, Qi Tan, Xu Wang^*, Bo Tang^*, Rational design of an α?ketoamide-based near-infrared fluorescent probe specific for hydrogen peroxide in living systems, Analytical Chemistry, 2016, 88(16): 8019-8025
(1) Xilei Xie, Yu Yan, Ning Zhu, Gang Liu^*, Benzothiazoles exhibit broad-spectrum antitumor activity: their potency, structure–activity and structure–metabolism relationships, European Journal of Medicinal Chemistry, 2014, 76: 67-78

研究课题

国家自然科学基金面上项目
项目负责人，2019.01--2022.12

国家自然科学基金青年基金项目
项目负责人，2016.01--2018.12

山东省优秀中青年科学家科研奖励基金
项目负责人，2015.01--2016.12