盛文龙个人信息
姓 名
盛文龙
性 别
男


籍 贯
山东莒县
出生年月
1988.12

职 称
副研究员
政治面貌
中共党员

专 业
生物与医药
职 务
无

导师类别
硕导
学历、学位
研究生、博士

课 题 组
药物筛选研究室

工作信息
手机：**； 邮箱：shengwenlong@sdas.org

隶属单位
山东省科学院生物研究所

通讯地点
济南市历城区经十东路28789号

学习、工作简历：
2020.01至今 齐鲁工业大学（山东省科学院）生物研究所 药物筛选研究室 副研究员
2019.03至今 山东省科技厅科技合作处（借调）
2016.08~2019.03 山东省科学院生物研究所 药物筛选研究室 助理研究员
2011.09~2016.06 复旦大学 生命科学学院 神经生物学 硕博连读 导师：杨雄里院士
2007.09~2011.07 山东轻工业学院 食品与生物工程学院 生物技术

主要研究方向：1. 视网膜信息处理的神经机制及分子生物学基础；2. 荧光探针应用研究

课题：
褪黑素受体在昼行动物斑马鱼视网膜中的表达及对自感光神经节细胞光反应的调制，省自然科学基金，主持，5万元，2018.03-2020.06；
人才专项-优秀博士引进，省科学院，主持，30万，2018.01-2020.12；
褪黑素受体在昼行动物斑马鱼和鸽子视网膜中的细胞学定位，省科学院青年科学基金，主持，20万，2019.01-2020.12；
山东省科学院科技发展基金项目，省科学院，主持，3万，2019.01-2019.12；
EPS1120P/EPS1121P/EPS1122P三种蛋白样品抑制血管生成活性研究，技术服务合同（工程科研项目）；共同主持，2万元，2018.01-2019.12。
论文：
1.A coumarin-based fluorescent probe for Hg2+ and its application in living cells and zebrafish. Luminescence. 2020;1-6.（IF=1.691, 共同通讯作者）
2.A new phenylsulfonamide-based Golgi-targeting fluorescent probe for H2S and its bioimaging applications in living cells and zebrafish. Chemical Communications. 2020, 56, 4086-4089.（IF=6.164, 共同通讯作者）
3.A simple p-methylaminophenylether-based fluorescent probe for detecting native hypochlorous acid in live cells and zebrafish. Dyes and Pigments. 177 (2020) 108310. （IF=4.018, 共同通讯作者）
4.A novel highly selective ratiometric fluorescent probe with large emission shift for detecting mercury ions in living cells and zebrafish. Dyes and Pigments. 177 (2020) 108290. （IF=4.018, 共同通讯作者）
5.A Simple Long-wavelength Fluorescent Probe for Simultaneous Discrimination of Cysteine/Homocysteine and Glutathione/Hydrogen Sulfide with Two Separated Fluorescence Emission Channels by Single Wavelength Excitation. Anal Sci. 2020 Feb 10;36(2):255-262. （IF=1.618, 共同通讯作者）
6.A highly specific Golgi-targetable fluorescent probe for tracking cysteine generation during the Golgi stress response. Sensors & Actuators: B. Chemical 310 (2020) 127820. （IF=6.393, 共同通讯作者）
7.Visualization of cysteine level during Golgi stress with a novel targeting highly specific fluorescent probe. Chemical Communications. 2020, 56, 1807-1810（IF=6.164, 共同通讯作者）
8.Rational Design of a Targetable Fluorescent Probe for Visualizing H2S Production under Golgi Stress Response Elicited by Monensin. Anal. Chem. 2020, 92, 1883?1889.（IF=6.350, 共同通讯作者）
9.A novel Pd2+-free highly selective and ultrasensitive fluorescent probe for detecting CO-releasing molecule-2 in live cells and zebrafish. Dyes and Pigments 174 (2020) 108040. （IF=4.018, 共同通讯作者）
10.A highly sensitive rapid-response fluorescent probe for specifically tracking endogenous labile Fe2+ living cells and zebrafish. Dyes and Pigments 174 (2020) 108065. （IF=4.018, 共同通讯作者）
11.Development of a ratiometric fluorescent probe with a large emission shift for imaging ONOO- in live cells and zebrafish. Dyes and Pigments 173 (2020) 107942. （IF=4.018, 共同通讯作者）
12.A novel highly selective fluorescent probe for imaging endogenous hypobromous acid in living cells and zebrafish. Sensors & Actuators: B. Chemical 305 (2020) 127460. （IF=6.393, 共同通讯作者）
13.Cellular localization of melatonin receptor Mel1b in pigeon retina. Neuropeptides 78 (2019) 101974. （IF=2.407, 第一作者、通讯作者.）
14.Rational design of a hepatoma-specific fluorescent probe for HOCl and its bioimaging applications in living HepG2 cells. Anal. Chem., 2019, 91, 2163?2168.（IF=6.350, 共同通讯作者）
15.A carbonothioate-based far-red fluorescent probe for the specific detection of mercury ions in living cells and zebrafish. Analyst, 2019, 144, 1426–1432.（IF=4.019, 共同通讯作者）
16.Dichlororesorufin-Based Colorimetric and Fluorescent Probe for Ultrasensitive Detection of Mercury Ions in Living Cells and Zebrafish. Ind. Eng. Chem. Res., 2019, 58, 11?17.（IF=3.375, 共同通讯作者）
17.A metal-free near-infrared fluorescent probe for tracking the glucose-induced fluctuations of carbon monoxide in living cells and zebrafish. Sensors & Actuators: B. Chemical 291 (2019) 329–336. （IF=6.393, 共同通讯作者）
18.A long-wavelength ultrasensitive colorimetric fluorescent probe for carbon monoxide detection in living cells. Photochem. Photobiol. Sci., 2019, 18, 1851–1857. （IF=2.408, 共同通讯作者）
19.A highly specific and ultrasensitive p-aminophenylether-based fluorescent probe for imaging native HOCl in live cells and zebrafish. Analytica Chimica Acta, 2019, 1052, 131-136. （IF=5.256, 共同通讯作者）
20.Dicyanoisophorone-Derived Near-Infrared Fluorescent Probe for Ultrasensitive Detection of Peroxynitrite in Living Cells and Zebrafish. Ind. Eng. Chem. Res. 2019, 58, 19778?19784. （IF=3.375, 共同通讯作者）
21.Chemical constituents from Alismatis Rhizoma and their anti-inflammatory activities in vitro and in vivo. Bioorganic Chemistry 92 (2019) 103226. （IF=3.926, 共同第一作者）
22.A novel hepatoma-specific fluorescent probe for imaging endogenous peroxynitrite in live HepG2 cells. Sensors & Actuators: B. Chemical 289 (2019) 124–130. （IF=6.393, 共同通讯作者）
23.A water-soluble and highly specific fluorescent probe with large stokes shift for imaging basal HOCl in living cells and zebrafish. Sensors & Actuators: B. Chemical. 291 (2019) 243–249. （IF=6.393, 共同通讯作者）
24.Novel Dimethylhydrazine-Derived Spirolactam Fluorescent Chemodosimeter for Tracing Basal Peroxynitrite in Live Cells and Zebrafish. J. Agric. Food Chem. 2019, 67, 6407?6413. （IF=3.571, 共同通讯作者）
25.Development of a concise rhodamine-formylhydrazine type fluorescent probe for highly specific and ultrasensitive tracing of basal HOCl in live cells and zebrafish. ACS Sens. 2019 4(8):2156-2163. （IF=6.944, 共同通讯作者）
26.A highly selective and sensitive red-emitting fluorescent probe for visualization of endogenous peroxynitrite in living cells and zebrafish. Analyst. 2019, 144, 3442–3449. （IF=4.019, 共同通讯作者）
27.A water-soluble and highly specific fluorescent probe for imaging thiophenols in living cells and zebrafish. New J. Chem., 2019, 43, 6746—6752. （IF=3.069, 共同通讯作者）
28.A novel water-soluble fluorescent probe with ultra-sensitivity over a wider pH range and its application for differentiating cancer cells from normal cells. Analyst, 2019, 144, 6975. （IF=4.019, 共同通讯作者）
29.A novel ratiometric fluorescent probe for highly sensitive and selective detection of peroxynitrite and its application for tracing endogenous peroxynitrite in live cells. Anal.Methods, 2019, 11, 5699. （IF=2.378, 共同通讯作者）
30.A simple highly specific fluorescent probe for simultaneous discrimination of cysteine/homocysteine and glutathione/hydrogen sulfide in living cells and zebrafish using two separated fluorescence channels under single wavelength excitation. Analyst, 2019, 144, 4258–4265. （IF=4.019, 共同通讯作者）
31.A novel highly sensitive fluorescent probe for bioimaging biothiols and its applications in distinguishing cancer cells from normal cells. Analyst, 2019, 144, 7010. （IF=4.019, 共同通讯作者）
32.A novel hexahydropyridazin-modified rhodamine fluorescent probe for tracing endogenous/exogenous peroxynitrite in live cells and zebrafish. Dyes and Pigments 170 (2019) 107573. （IF=4.018, 共同通讯作者）
33.Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation. Med. Chem. Commun., 2019, 10, 598. （IF=2.394, 共同第一作者）
34.Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells. PLoS One (2015) 10:e**. （IF=2.776, 第一作者）
35.Two novel non-holostane type glycosides from the viscera of sea cucumber Apostichopus japonicas. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 2019.**. （IF=1.170，第3/8位）
36.TWO NOVEL HOLOSTANE-TYPE GLYCOSIDES FROM THE VISCERA OF SEA CUCUMBER APOSTICHOPUS JAPONICUS WITH ANTITUMOR ACTIVITIES. Rev. Roum. Chim., 2019, 64(4), 353-359. （IF=0.395，第3/8位）
37.Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish and Shellfish Immunology 83 (2018) 26–36. （IF=3.298，第2/6位）
38. Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish. Ecotoxicology and Environmental Safety 172 (2019) 460–470. （IF=4.527，第4/6位）
39.A highly specific and sensitive ratiometric fluorescent probe for carbon monoxide and its bioimaging applications. New J.Chem., 2018, 42, 14417. （IF=3.069，第4/8位）
40.Temporal Neuromodulation of Retinal Ganglion Cells by Low-Frequency Focused Ultrasound Stimulation. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, (2018) 26 (5). （IF=3.478，第4/12位）
41.RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. MBoC (2015) 26 3671-3678. （IF=3.905，第5/9位）
42.Signalling mechanism for somatostatin receptor 5-mediated suppression of AMPA responses in rat retinal ganglion cells. Neuropharmacology 107 (2016) 215e226. （IF=4.367，第2/6位）
43.Orexin-A differentially modulates AMPA-preferring responses of ganglion cells and amacrine cells in rat retina. Neuropharmacology 93 (2015) 80-93. （IF=4.367，第6/9位）
44.Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae. 2020, Fish Physiol Biochem. （第4/8位）
专利：
1. 一种非海参烷型海参皂苷及其制备方法与应用，ZL8.4，第8/8位。
2. 一种三氮唑糖修饰的小檗碱盐衍生物及其制备方法和用途，ZL4.9，第4/5位。
3. 利用鳕鱼内脏制备高纯度海产多不饱和脂肪酸磷脂的方法，ZL20**，第10/10位。
4. 一种用于冷冻组织切片中固定斑马鱼体位的装置，ZL9.7，第7/7位。
5. 一种斑马鱼老年疾呆模型的建立方法及应用，ZL 0.4，第6/8位。

获奖：
无

人才称号和荣誉：
2019年度山东省科学院生物研究所所嘉奖
2018年度山东省科学院院嘉奖
2017年度山东省科学院院嘉奖

社会兼职：济宁医学院兼职讲师