?个人简介
工作职位：药物制剂教研室，副教授（特聘）
办公地址：青岛科技大学四方校区精细化工楼105室（青岛市市北区郑州路53号）
工作邮箱：gcl_cpu@126.com
2019年获中国科学院海洋研究所海洋生物学专业博士学位，2013年6月至2016年6月，任职于山东省眼科研究所。2019年7月–至今，任职于青岛科技大学化工学院药物制剂教研室。主要从事新型抗肿瘤药物研制与开发、活性化合物筛选及作用机制研究。作为项目负责人，主持山东省自然科学基金1项，参与国家自然科学基金项目3项。近五年，发表SCI论文20余篇，其中第一作者发表SCI论文14篇，作为主要参与人授权国家发明专利4项。
?教学情况
体内药物分析：32学时，研究生，约15人。
临床药学：32学时，本科，约60人。
生物化学与分子生物学：80学时，本科，约60人。
?论文与专利
1、主要论文
[1]Chuanlong Guo, Yuzhen Hou, Xuemin Yu, Fan Zhang, Xiaochen Wu, Xianggen Wu and Lijun Wang. The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell deathin vitroandin vivo.Food and Chemical Toxicology, 137 (2020) 111158.
[2]Chuanlong Guo, Fan Zhang, Xiaochen Wu, Xuemin Yu, Xianggen Wu, Dayong Shi and Lijun Wang. BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activitiesin vitroandin vivo. International Journal of Biological Macromolecules, 150 (2020) 238–245.
[3] Lijun Wang, Shuhong Zhang, Xuemin Yu andChuanlong Guo*. Novel Poly(ADP-ribose) Polymerase?1 Inhibitor DDHCB Inhibits Proliferation of BRCA Mutant Breast Cancer Cell In Vitro and In Vivo through a Synthetic Lethal Mechanism. Chem. Res. Toxicol. 2020, 33, 1874?1881.
[4] Jun Wang, Lijun Wang, Shuhong Zhang, Junting Fan, Hui Yang, Qiqi Li andChuanlong Guo*.Novel eIF4E/eIF4G protein-protein interaction inhibitors DDH-1 exhibits anti-cancer activity in vivo and in vitro. International Journal of Biological Macromolecules 160 (2020) 496–505.
[5]Chuanlong Guo¹, Lijun Wang¹, Xiuxue Li, Shuaiyu Wang, Xuemin Yu, Kuo Xu, Yue Zhao, Jiao Luo, Xiangqian Li, Bo Jiang, Dayong Shi. Discovery of novel bromophenol – thiosemicarbazone hybrids as potent selectve inhibitors of poly(ADPribose) polymerase-1 (PARP-1) for use in cancer. Journal of Medicinal Chemistry. 2019, 62, 3051?3067.
[6] Lijun Wang¹,Chuanlong Guo¹,Xiuxue Li, Xuemin Yu, Xiangqian Li, Kuo Xu, Bo Jiang, Xiaoling Jia, Chao Li, Dayong Shi.Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment. European Journal of Medicinal Chemistry. 2019, 177:153-170.
[7]Chuan-Long Guo¹Li-Jun Wang¹, Yue Zhao, Hua Liu, Xiang-Qian Li，Bo Jiang, Jiao Luo, Shu-Ju Guo, Ning Wu, Da-Yong Shi. A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway. Mar. Drugs. 2018, 16, 43.
[8]Kuo Xu¹,Chuanlong Guo¹, Jie Meng, Haiying Tian, Shuju Guo, Dayong Shi.Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents Through ROS-mediated Apoptotic Pathway. Mar. Drugs. 2019, 17, 207
[9]Li-Jun Wang¹,Chuan-Long Guo¹,Xiang-Qian Li, Shuai-Yu Wang, Bo Jiang, Yue Zhao, Jiao Luo, Kuo Xu, Hua Liu, Shu-Ju Guo, Ning Wu, Da-Yong Shi. Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation. Mar. Drugs. 2017, 15, 34.
[10]Chuanlong Guo¹, Mengshuang Li^1,Xia Qi, Guiming Lin, Fenghua Cui, Fengjie Li, Xianggen Wu. Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice. Sci Rep. 2016, 6: 29753.
[11]Chuanlong Guo, Fenghua Cui, Mengshuang Li, Fengjie Li, Xianggen Wu. Enhanced corneal permeation of coumarin-6 using nanoliposomes containing dipotassium glycyrrhizinate:in vitromechanism andin vivopermeation evaluation. RSC Adv. 2015, 5, 75636.
[12]Chuanlong Guo¹, Yan Zhang¹, Zhao Yang, Mengshuang Li, Fengjie Li, Fenghua Cui, Ting Liu, Weiyun Shi, Xianggen Wu. Nanomicelle formulation for topical delivery of cyclosporine A into the cornea:in vitromechanism andin vivopermeation evaluation. Sci Rep. 2015, 5: 12968.
[13]Yue Zhao¹,Chuanlong Guo¹, Lijun Wang, Shuaiyu Wang, Xiangqian Li, Bo Jiang, Ning Wu, Shuju Guo, Renshuai Zhang, Kun Liu, Dayong Shi. A novel fluorinated thiosemicarbazone derivative- 2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondriadependent pathway. Biochemical and Biophysical Research Communications. 2017, 491:65-71.
[14]Hua Liu¹,Chuanlong Guo¹, Shuju Guo, Lijun Wang, Dayong Shi. Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells. Molecules. 2019,24, 375.(IF: 3.098)
[15]Guo Chuanlong¹, Wang Lijun¹, Jiang Bo, Shi Dayonng. Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1α/VEGF/Akt signaling pathway in human umbilical vein endothelial cells. Anti-Cancer Drugs. 2018, 29(10):965-974.
[16]Chuanlong Guo¹, Lijun Wang¹, Yue Zhao, Bo Jiang, Jiao Luo, Dayong Shi. BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3K/Akt/mTOR and MAPK signaling pathway. Experimental and Therapeutic Medicine. 2019,17: 3848-3858.
2、授权专利
[1]吴祥根，郭传龙，李梦双，史伟云。一种33G针头注射用雷珠单抗眼玻璃体腔内缓释药物.2019,中国,授权专利号: ZL 4.5
[2]吴祥根，郭传龙，李梦双，史伟云。一种姜黄素胶束滴眼液及其制备方法. 2018,中国,授权专利号: ZL 6.9
[3]吴祥根，郭传龙，李梦双，史伟云。一种姜黄素胶束鼻腔给药用溶液及其制备方法. 2017,中国,授权专利号: ZL 4.9
[4]史大永，王 立军，郭传龙，江波，王帅玉，赵越。一类新型溴酚氨基硫脲类化合物及其制备和药物与用途。2019,中国,授权专利号: ZL 7.6
?承担的科研项目
[1] 2019.9-2024.8抗肿瘤先导化合物筛选及作用机制研究。青岛科技大学高层次人才启动经费。主持，在研。
[1]2015.7-2016.12姜黄素纳米胶束经鼻腔粘膜-三叉神经节-角膜神经通路治疗糖尿病性角膜病变及其机制研究。山东省自然科学基金，项目编号：ZR2015PH06。主持，已结题。
[2]2016.1-2018.12增溶型环孢素A滴眼液的临床前开发研究。山东省科技攻关计划。结题，项目参与人。
[3]2016.1-2018.12糖尿病引起血视网膜内屏障ABC转运蛋白表达/功能改变的机制及其作为干预靶点防治糖尿病视网膜病变的研究。国家自然科学基金青年基金。在研，项目参与人。
[4]2018.1-2021.12基于分子杂合和多样性导向合成策略构建新型海洋溴酚杂合体库及靶向eIF4E抗肿瘤活性研究。国家自然科学基金面上项目。在研，项目参与人。


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