李文军博士
男，1984年3月出生，青岛大学****，泰山****青年专家，硕士研究生导师，山东省优青。2006年本科毕业于郑州大学制药工程专业，获工学学士学位； 2011年研究生毕业于华东理工大学药物化学专业，获医学博士学位。 2012年01月至2015年06月分别在新加坡国立大学、南洋理工大学和清华大学从事博士后研究，博士及博士后期间主要从事有机小分子催化领域的研究。2015年7月受聘于青岛大学药学院，担任不对称催化与药物合成团队负责人。
迄今为止，李文军博士已在国际著名杂志Angew. Chem., Int. Ed., ACS Catal., Chem. Commun., Green Chem., Org. Lett.等发表SCI论文50余篇，其中第一作者或通讯作者40余篇，高倍引论文3篇，累计被引用1000余次，数篇被Angew. Chem., Int. Ed.和Synfacts作为亮点工作被重点评述或作为封面文章被亮点介绍。授权国家发明专利四项，独立工作之前参与多项国家自然科学基金、中组部青年****项目基金和海外基金。目前作为项目负责人主持国家自然科学基金，山东省自然科学基金和青岛大学高层次人才引进项目。
Ø研究方向
l有机合成化学：开展高选择性、高效经济、环境友好的合成方法学研究。
l药物合成化学：应用有机催化的方法合成活性药物分子并进行活性研究。
l过程化学：手性药物及中间体、天然药物的合成新方法研究及其过程化学开发。
Ø发表文章:
独立工作之后：
1.Chen Zhang, Yuyu Cheng, Fushuai Li, Yepeng Luan, Pengfei Li*, Wenjun Li*.Organocatalytic Enantioselective RegiodivergentC-H BondFunctionalization of 1-Naphthols with 1-Azadienes. Adv. Synth. Catal.2020, 362, 1286-1291. (IF = 5.45)
2.Huijun Yuan,Yao Li, Hanhui Zhao, Zhihong Yang, Xin Li*, Wenjun Li*. Asymmetric Synthesis of Atropisomeric Pyrazoleviaan Enantioselective Reaction ofAzonaphthalene with Pyrazolone. Chem. Commun., 2019, 55, 12715-12718. (IF = 6.16)
3.Chen Zhang, Xinye Shang, Yuyu Cheng, Fushuai Li, Hanhui Zhao,Pengfei Li*,Wenjun Li*. Enantioselective Construction of 3-Substituted3-amino-2-oxindoles Containing an N,N-ketalSkeleton via Organocatalyzed Aza-addition of IsatinImines. Org. Biomol. Chem., 2019, 17, 8374-8378. (IF = 3.49)
4.Lili Zhang, Yuzhe Han, Anqi Huang, Pei Zhang, Pengfei Li*,Wenjun Li*. Organocatalytic Remote Stereocontrolled 1,8-Additions ofThiazolones to Propargylic Aza?p?quinone Methides. Org. Lett., 2019, 21, 7415-7419. (IF = 6.56)
5.Hanhui Zhao, Huijun Yuan, Yanru Zhang, Rongshi Li*, Wenjun Li*. Enamine Catalytic Annulation of Azonaphthalenes: An Access toIndole Derivatives. Org. Lett., 2019, 21, 6557-6561. (IF = 6.56)
6.Yipeng Luan, Anqi Huang, Yuyu Cheng, Xiaohong Liu, Pengfei Li*,WenjunLi*. Organocatalytic Enantioselective Michael Addition ofOxazolones to 2-Enoylpyridine N-Oxides for Assembling ofPyridine N-Oxides Featuring Vicinal Oxygen-containingTetrasubstituted Stereocenters. Adv. Synth. Catal.2019, 361, 4208-4214. (IF = 5.45)
7.Wei Lin, Xiao Lin, Yuyu Cheng, Xiaoyong Chang, San Zhou, Pengfei Li*,Wenjun Li*. Organocatalytic Enantioselective Direct VinylogousMichael Addition of γ-Substituted DeconjugateButenolides to Azadienes. Org. Chem. Front., 2019,6, 2452-2456. (IF = 5.08)
8.Pei Zhang, Qiuhong Huang, Yuyu Cheng, Rongshi Li*, Pengfei Li*, Wenjun Li*. Remote Stereocontrolled Construction of Vicinal Axially Chiral Tetrasubstituted Allenes and Heteroatom-Functionalized Quaternary Carbon Stereocenters. Org. Lett., 2019, 21, 503-507. (高被引论文, IF = 6.49)
9.Pengfei Zhang, Xing Guo, Chang Liu, Wenjun Li*, Pengfei Li*. Enantioselective Construction of Pyridine N-Oxides Featuring 2,3-Dihydrofuran Motifs via Phosphine-Catalyzed [4 + 1]-Annulation of 2-Enoylpyridine N-Oxides with Morita-Baylis-Hillman Carbonates. Org. Lett., 2019, 21, 152-155. (IF = 6.49)
10.Anqi Huang, Lili Zhang, Dongmei Li, Yidong Liu*, Hailong Yan*, Wenjun Li*. Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes. Org. Lett., 2019, 21, 95-99. (IF = 6.49)
11.Wei Lin, Chen Zhang, Wen Xu, Yuyu Cheng, Pengfei Li*, Wenjun Li*.Organocatalytic Asymmetric Michael Addition of Rhodanines to Azadienes for Assembling of Sulfur-containing Tetrasubstituted Carbon Stereocenters. Adv. Synth. Catal.2019, 361, 476-480. (IF = 5.12)
12.Kun Liu, Xinye Shang, Yuyu Cheng, Xiaoyong Chang, Pengfei Li*, Wenjun Li*. Regioselective [3 + 2]-annulation of Hydrazonyl Chlorides with 1,3-Dicarbonyl Compounds for Assembling of Polysubstituted Pyrazoles. Org. Biomol. Chem., 2018, 16, 7811-7814. (IF = 3.42)
13.Qiuhong Huang, Yuyu Cheng, Huijun Yuan, Xiaoyong Chang, Pengfei Li*, Wenjun Li*.Organocatalytic Enantioselective Mannich-Type Addition of 5H-thiazol-4-ones to Isatin-derived Imines: Access to 3-Substituted 3-amino-2-oxindoles Featured by Vicinal Sulfur-containingTetrasubstituted Stereocenters. Org. Chem. Front., 2018, 5, 3226-3230. (IF = 5.45)
14.Yuyu Cheng, Zhiqiang Fang, Wenjun Li*, Pengfei Li*. Phosphine-mediated Enantioselective [4 + 1] Annulations between Ortho-quinone methides and Morita-Baylis-Hillman Carbonates.Org. Chem. Front., 2018, 5, 2728-2733. (IF = 5.45)
15.Lili Zhang, Huijun Yuan, Wei Lin, Yuyu Cheng, Pengfei Li*, Wenjun Li*. Catalyst-Controlled Diastereodivergent Construction of Vicinal Sulfur-Functionalized Quaternary and Tertiary Stereocenters. Org. Lett., 2018, 20, 4970-4974. (IF = 6.49)
16.Qiuhong Huang, Lili Zhang, Yuyu Cheng, Pengfei Li*, Wenjun Li*. Enantioselective Construction of Vicinal Sulfur-containing Tetrasubstituted Stereocenters via Organocatalyzed Mannich-Type Addition of Rhodanines to Isatin Imines. Adv. Synth. Catal.2018, 360, 3266-3270. (IF = 5.12)
17.Wenjun Li*, Xianhong. Xu, Pengfei. Zhang, Pengfei Li*. Recent Advances in Catalytic Enantioselective Reactions of para-Quinone Methides. Chem. Asian J. 2018, 13, 2350-2359. (IF = 3.69)
18.Wenjun Li*, Huijun Yuan, Zhantao Liu, Zhongyin Zhang, Yuyu Cheng, Pengfei Li*. NHC-catalyzed Enantioselective [4 + 3] Cycloaddition of ortho-Hydroxyphenyl Substituted para-Quinone Methides with Isatin-Derived Enals. Adv. Synth. Catal.2018, 360, 2460-2464. (高被引论文, IF = 5.12)
19.Wenjun Li*, Xianhong Xu, Yang Liu, Hua Gao, Yuyu Cheng, Pengfei Li*. Enantioselective Organocatalytic 1,6-Addition of Azlactones to para-Quinone Methides: An Access to α,α-Disubstituted and β,β-Diaryl-α-amino acid Esters. Org. Lett., 2018, 20, 1142-1145. (高被引论文, IF = 6.49)
20.Xinye Shang, Kun Liu, Zhongyin Zhang, Xianhong Xu, Pengfei Li*, Wenjun Li*. Direct Access to Spirobiisoxazoline via the Double 1,3-Dipolar Cycloaddition of Nitrile Oxide with Allenoate. Org. Biomol. Chem., 2018, 16, 895-898. (IF = 3.42)
21.Huijun Yuan, Hua Gao, Kun Liu, Zhantao Liu, Jian Wang*, Wenjun Li*. Cycloadduct Formation of α,β-Unsaturated Esters with Azides Catalyzed by NHC Systems. Org. Biomol. Chem., 2017, 15, 9066-9070. (IF = 3.42)
22.Lili Zhang, Yang Liu, Kun Liu, Zhantao Liu, Ningning He, Wenjun Li*. Asymmetric Synthesis of Dihydrocoumarins via the Organocatalytic Hetero-Diels-Alder Reaction of Ortho-quinone Methides. Org. Biomol. Chem., 2017, 15, 8743-8747. (IF = 3.42)
23.Lili Zhang, Xiao Zhou, Pengfei Li, Zhantao Liu, Yang Liu, Yong Sun, Wenjun Li*. Asymmetric Synthesis of Chromene Skeletons via Organocatalytic Domino Reactions of In situGenerated Ortho-quinone Methide with Malononitrile and Functionalized Ketone. RSC Adv.,2017, 7, 39216-39220. (IF = 2.94)
24.Huijun Yuan, Lili Zhang, Zhantao Liu, Yang Liu, Jian Wang*, Wenjun Li*. A NHC-catalyzed 1,3-Dipolar Cycloaddition Reaction of Allyl Ketones with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles. Org. Biomol. Chem., 2017, 15, 4286-4290. (IF = 3.42)
25.Zhenyan Shi, Wenjun Li*. Enamine-Mediated 1,3-Dipolar Cycloaddition Reaction of Curcumin Derivatives with Azides: Direct Access to 1,4,5-Trisubstituted 1,2,3-Triazoles. Synthesis, 2017, 49, 2081-2087. (IF = 2.65)
26.Wenjun Li*, Xiao Zhou, Zhenyan Shi, Yang Liu, Zhantao Liu, Hua Gao. Enolate-mediated 1,3-Dipolar Cycloaddition Reactions of Allyl Ketones with Nitrile Oxides: Direct Access to 3,5-Disubstituted Isoxazolines. Org. Biomol. Chem., 2016, 14, 9985-9988. (IF = 3.42)
27.Xianhong Xu, Zhenyan Shi, Wenjun Li*. Organocatalytic 1,3-Dipolar [3+3] Cycloaddition Reaction of 1,2-Cyclohexanedione with Azides: Direct Access to Highly Substituted 1,2,3-Triazoles. New J. Chem., 2016, 40, 6559-6563. (IF = 3.20)
28.Xiao Zhou, Xianhong Xu, Zhenyan Shi, Kun Liu, Hua Gao, Wenjun Li*. Enolate-mediated 1,3-Dipolar Cycloaddition Reaction of β-Functionalized Ketones with Nitrile Oxides: Direct Access to 3,4,5-Trisubstituted Isoxazoles. Org. Biomol. Chem., 2016, 14, 5246-5250. (IF = 3.42)
29.Xiao Zhou, Xianhong Xu, Kun Liu, Hua Gao, Wei Wang, Wenjun Li*. Organocatalytic 1,3-Dipolar Cycloaddition Reaction of β-Keto Amides with Azides: Direct Access to 1,4,5-Trisubstituted 4-Amide-1,2,3-Triazoles. Eur. J. Org.Chem., 2016, 1886-1890. (IF = 2.88)
30.Wenjun Li*, Xiao Zhou, Yepeng Luan, Jian Wang*. Direct Access to 1,4-Disubstituted 1,2,3-Triazoles through Organocatalytic 1,3-Dipolar Cycloaddition Reaction of α,β-Unsaturated Esters with Azides. RSC Adv.,2015, 5, 88816-88820. (IF = 2.94)
独立工作之前：
1.Wenjun Li,Jian Wang*. Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide-Zwitterion Cycloaddition. Angew. Chem., Int. Ed., 2014,53, 14186-14190. (IF = 12.10, This work has been highlightedinAngew. Chem., Int. Ed.)
2.Wenjun Li, Manjaly J. Ajitha, Ming Lang, Kuo-Wei Huang, Jian Wang*. Catalytic Intermolecular Cross-Couplings of Azides and LUMO Activated Unsaturated Acyl Azoliums. ACS Catal., 2017, 7, 2139-2144. (IF = 11.38)
3.Wenjun Li,Hui Liu, Xuefeng Jiang, Jian Wang*. Enantioselective Organocatalytic Conjugate Addition of Nitroalkanes to Electrophilic 2-Iminochromenes. ACS Catal.,2012,2, 1535-1538. (IF = 11.38)
4.Wenjun Li,Zhiyun Du, Jiayao Huang, Kun Zhang, Jian Wang*. Direct Access to 1,2,3-Triazoles through Organocatalytic 1,3-Dipolar Cycloaddition Reaction of Allyl Ketones with Azides. Green Chem., 2014, 16, 3003-3006. (IF = 8.59)
5.Wenjun Li,Zhiyun Du, Kun Zhang, Jian Wang*. Organocatalytic 1,3-Dipolar Cycloaddition Reaction of α, β-Unsaturated Ketones with Azides through Iminium Catalysis.Green Chem., 2015, 17, 781-784. (IF = 8.59)
6.Wenjun Li,Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Highly Diastereo- and Enantioselective One-pot Michael-Aldol Reactions of α,β-Unsaturated Aldehydes with Imidazole Derivatives. Chem. Commun., 2011,47, 8325-8327. (IF = 6.29, This work has been highlightedinSynfact)
7.Wenjun Li,Qianfa Jia, Zhiyun Du, Jian Wang*. Direct Access to Triazole-olefins through Catalytic Cycloaddition of Azides to Unsaturated Aldehydes. Chem. Commun., 2013, 49, 10187-10189. (IF = 6.29)
8.Wenjun Li,Qianfa Jia, Zhiyun Du, Kun Zhang, Jian Wang*. Amine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions ofAldehydes toC,N-Cyclic Azomethine Imines. Chem. Eur. J., 2014, 20, 4559-4562. (IF = 5.16)
9.Wenjun Li,Jia Wei, Qianfa Jia, Zhiyun Du, Kun Zhang, Jian Wang*. Asymmetric Synthesis of Tetrahydroquinolines by [3+2] Cycloaddition Controlled by Dienamine Catalysis. Chem. Eur. J., 2014, 20, 6592-6596. (IF = 5.16, Back Cover)
10.Wenjun Li,Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye*. Catalytic Asymmetric Michael Addition with Curcumin Derivative. Org. Biomol. Chem., 2011,9, 2505-2511. (IF = 3.42)
11.Wenjun Li,Jiayao Huang, Jian Wang*. Organocatalytic Conjugate Addition Promoted by Multi-hydrogen-bond Cooperation: Access to Chiral 2-Amino-3-nitrile-chromenes. Org. Biomol. Chem., 2013, 11, 400-406. (IF = 3.42)
12.Wenjun Li,Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*. Asymmetric Direct Michael Addition of Acetophenone to α,β-Unsaturated Aldehyde. Synthesis, 2011, 1085-1091. (IF = 2.65)
13.Wenjun Li,Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael/α-Alkylation Reaction of α,β-Unsaturated Aldehyde with Chloroacetophenone.Tetrahedron Lett., 2011,52, 2715-2718. (IF = 2.13)
14.Woon-Yew Siau, Wenjun Li, Fei Xue, Qiao Ren, Minghu Wu, Shaofa Sun, Haibing Guo, Xuefeng Jiang, Jian Wang*. Catalytic Enantioselective α-Functionalization of Oxindoles through Oxidative Reactions with Naphthoquinones. Chem. Eur. J., 2012, 18, 9491-9495. (IF = 5.16)
15.Juanjuan Yang, Wenjun Li,Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective Michael Reaction of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12, 5218-5221. (IF = 6.49)
16.Chunlin Wu, Wenjun Li,Juanjuan Yang, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael Addition of Anthrone to Enone. Org. Biomol. Chem., 2010, 8, 3244-3250. (IF = 3.42)
17.Zhichao Jin, Huicai Huang, Wenjun Li,Xiaoyan Luo, Xinmiao Liang, Jinxing Ye*. Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One-pot Cascade Reaction. Adv. Synth. Catal., 2011, 353, 343-348. (IF = 5.12)
18.Yufeng Zhou, Xin Li, Wenjun Li,Chunlin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Organocatalytic Michael Addition of α,β-Unsaturated Ketone with 1,2,4-Triazole. Synlett, 2010, 15, 2357-2360. (IF = 2.37)
19.Qiao Ren, Tao Gao, Wenjun Li,Li Wan, Yimin Hu, Yanhong Peng, Shaofa Sun, Liqing Hu, Minghu Wu, Haibing, Guo,Jian Wang*. A Highly Enantioselective Michael Reaction between α,β-Unsaturated Ketones and Malonic Acid Half-thioesters. New J. Chem., 2015, 39, 5100-5103. (IF = 3.20)
20.Qiao Ren, Shaofa Sun, Jiayao Huang, Wenjun Li,Minghu Wu, Haibing Guo, Jian Wang*. Enantioselective Cascade Reaction between α,β-Unsaturated Aldehydes and Malonic Half-thioesters: Rapid Access to Chiral δ-Lactones. Chem. Commun., 2014, 50, 6137-6140. (IF = 6.29)
21.Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li,Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric Vinylogous Michael Reaction of α,β-Unsaturated Ketones with γ-Butenolide under Multifunctional Catalysis. Chem. Commun., 2010,46, 5957-5959. (IF = 6.29)
22.Qiao Ren, Jiayao Huang, Lei Wang, Wenjun Li,Hui Liu, Xuefeng Jiang, Jian Wang*. Highly Efficient Assembly of 3-Hydroxy Oxindole Scaffold via a Catalytic Decarboxylative [1,2]-Addition Strategy. ACS Catal., 2012, 2, 2622-2625. (IF = 11.38)
Ø专利
1.叶金星，李文军，吴文彬，于峰，梁鑫淼，一种催化合成手性姜黄素类似物的方法。专利申请号：9.9（已授权）
2.姜雪峰，汪舰，刘会，李文军，3,3-二取代-2-氧化吲哚类化合物的不对称合成方法。专利申请号：5.9（已授权）
3.姜雪峰，汪舰，李一鸣，黄家尧，李文军，1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法。专利申请号：5.7（已授权）
4.姜雪峰，汪舰，李一鸣，黄家尧，李文军，吡咯稠环3-吲哚酮类化合物的合成方法。专利申请号：6.5（已授权）
5.李文军，石振燕，1,4,5-三取代-1,2,3-三氮唑类化合物的合成方法。专利申请号：6.8
邮箱：liwj@qdu.edu.cn; 联系电话：.