吴义丽，女，教授，医学博士，现任青岛大学公共卫生学院流行病与卫生统计学系副主任，硕士研究生导师，青岛大学****，山东预防医学会流行病学分会委员，山东省医学会临床流行病学与循证医学分会青年学组副组长，《中华疾病控制杂志》编委。
主要从事慢性非传染病流行病学、分子流行病学研究工作和卫生统计学教学工作。作为负责人主持国家自然科学基金面上项目、青年基金及中国博士后科学基金等科研项目7项。以第一或通讯作者身份，在《European Journal of Epidemiology》、《Journal of the American Geriatrics Society》等国际期刊发表论文20余篇，其中ESI 高被引论文1篇，中科院JCR一区论文2篇，web of science共计他引200余次。


一、主要研究方向
1. 肥胖的遗传病因学机制。基于青岛市双生子募集登记系统，将分子生物学技术和传统流行病学方法相结合，开展成人肥胖的遗传病因学研究，从基因序列变异和表观遗传修饰效应两个角度，全面探索肥胖的致病机制和疾病生物学通路。


2. 环境因素对慢性非传染病的影响。利用《青岛市糖尿病队列》、国内外公共数据库、以及Meta分析的方法，探索睡眠、体力活动、水果蔬菜摄入、微量元素摄入、镉暴露、高尿酸对肥胖、2型糖尿病、高血压、乳腺癌、躯体功能、认知功能、抑郁等疾病/表型的影响，为社区慢性病的防治工作及健康老龄化工作提供理论依据。


二、代表性科研成果
1）学术论文


第一作者

1. Wu Y^#, Duan H, Tian X, Xu C, Wang W, Jiang W, Pang Z, Zhang D, Tan Q. Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis. Front Genet. 2018 May; 9: 179.
2. Wu Y, Wang W, Liu T, Zhang D^#. Association of Grip Strength With Risk of All-Cause Mortality, Cardiovascular Disease, and Cancer in Community-Dwelling Populations: A Meta-analysis of Prospective Cohort Studies. J Am Med Dir Assoc. 2017 Jun; 18(6): 551.
3. Wu Y^#, Wang W, Jiang W, Yao J, Zhang D. An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing. Medicine(Baltimore). 2017 Feb;96(7):e6117.
4. Wu Y, Zhang D^#. Meta-analyses of etiologic studies should account for the underlying biologic mechanisms. Breast Cancer Res Treat. 2015 Feb;149(3):801-3.
5. Wu Y, Zhang D^#, Pang Z, Jiang W, Wang S, Li S, von Bornemann Hjelmborg J, Tan Q. Multivariate modeling of body mass index, pulse pressure, systolic and diastolic blood pressure in Chinese twins. Twin Res Hum Genet. 2015 Feb;18(1):73-8.
6. Wu Y, Zhang D^#, Jiang X, Jiang W. Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2015 Feb;25(2):140-7.
7. Wu Y^#, Zhai L, Zhang D. Sleep duration and obesity among adults: a meta-analysis of prospective studies. Sleep Med. 2014 Dec;15(12):1456-62.
8. Wu Y, Li S, Zhang D^#. Circulating 25-hydroxyvitamin D levels and hypertension risk. Eur J Epidemiol. 2013 Jul;28(7):611-6.
9. Wu Y, Zhang D^#, Kang S. Black tea, green tea and risk of breast cancer: an update. Springerplus. 2013 May 24;2(1):240.
10. Wu Y, Zhang D^#, Kang S. Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat. 2013 Feb;137(3):869-82.
11. Wu Y, Zhang D^#, Pang Z, Jiang W, Wang S, Tan Q. Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years. Geriatr Gerontol Int. 2013 Jul;13(3):672-7.
12. Wu Y, Zhang D^#, Pang Z, Oksuzyan A, Jiang W, Wang S, Li S, Kruse T, Christensen K, Tan Q. Gender-specific patterns in age-related decline in general health among Danish and Chinese: a cross-national comparative study. Geriatr Gerontol Int. 2012 Jul;12(3):431-9.
13. Wu Y, Pang Z^#, Zhang D^#, Jiang W, Wang S, Li S, Kruse TA, Christensen K, Tan Q.A cross-sectional analysis of age and sex patterns in grip strength, tooth loss, near vision and hearing levels in Chinese aged 50-74 years. Arch Gerontol Geriatr. 2012 Mar-Apr;54(2):e213-20.


通讯作者

1.Qiao H, Chen M, Li S, Li Y, Sun Y, Wu Y^#. Poor lung function accelerates cognitive decline in middle-aged and older adults: Evidence from the English Longitudinal Study of Ageing. Arch Gerontol Geriatr. 2020; 90: 104129.
2. Yin Z, Yang J, Huang C, Sun H, Wu Y^#. Eating and communication difficulties as mediators of the relationship between tooth loss and functional disability in middle-aged and older adults. J Dent. 2020; 96: 103331.
3. Chen M, Huang C, Feng W, Li Y, Wu Y^#. C-reactive protein mediates the association between leisure-time physical activity and lung function in middle-aged and older adults. BMC Public Health. 2020; 20 (1): 6.
4. Chen M, Li Y, Zhang D, Wu Y^#. Gender difference in the association between smoking and lung function: exploring the role of C-reactive protein as mediating factor. Public Health. 2020; 183: 88-93.
5. Chen M, Sun Y, Wu Y^#. Lower circulating zinc and selenium levels are associated with an increased risk of asthma: evidence from a meta-analysis. Public Health Nutr. 2020; 23(9): 1555-1562.
6. Wang T, Sun S, Li S, Sun Y, Sun Y, Zhang D, Wu Y^#. Alcohol consumption and functional limitations in older men: Does muscle strength mediate them?. J Am Geriatr Soc. 2019 Aug 2. doi: 10.1111/jgs.16082. [Epub ahead of print]
7. Huang C, Sun S, Wang W, Li Y, Feng W, Wu Y^#. Cognition mediates the relationship between sensory function and gait speed in older adults: Evidence from the English longitudinal study of ageing. J Alzheimers Dis. 2019;70(4):1153-1161.
8. Huang C, Sun S, Wang W, Li Y, Feng W, Wu Y^#. Age modify the associations of obesity, physical activity, vision and grip strength with functional mobility in Irish aged 50 and older. Arch Gerontol Geriatr. 2019 Sep-Oct; 84:103895.
9. Wang T, Feng W, Li S, Tan Q, Zhang D, Wu Y^#. Impact of obesity and physical inactivity on the long-term change in grip strength among middle-aged and older European adults. J Epidemiol Community Health. 2019 Jul; 73(7):619-624.
10. Wang T, Wu Y^#, Li W, Li S, Sun Y, Li S, Zhang D, Tan Q. Weak Grip Strength and Cognition Predict Functional Limitation in Older Europeans. J Am Geriatr Soc. 2019 Jan; 67(1):93-99.
11. Wang TY, Wu Y^#, Wang T, Li Y, Zhang D. A prospective study on the association of sleep duration with grip strength among middle-aged and older Chinese. Exp Gerontol. 2018 Mar; 103:88-93.
12. Li Y, Wu Y^#, Zhai L, Wang T, Sun Y, Zhang D, Longitudinal Association of Sleep Duration with Depressive Symptoms among Middle-aged and Older Chinse. Sci Rep. 2017; 7(1): 11794.
13. Wang T, Wu Y^#, Sun Y, Zhai L, Zhang D. A Prospective Study on the Association between Uric Acid and Cognitive Function among Middle-Aged and Older Chinese. J Alzheimers Dis. 2017; 58 (1): 79-86.
14. Li Y, Zhang Y, Wang W, Wu Y^#. Association of urinary cadmium with risk of diabetes: a meta-analysis. Environ Sci Pollut Res Int. 2017 Apr;24(11):10083-10090.


三、主要科研项目
1．基于表型不一致成年同卵双生子的肥胖全基因组甲基化谱和表达谱分析（**），国家自然科学基金面上项目，50万元，2018-2021，主持。
2．基于目标序列捕获测序技术的成人肥胖易感基因研究（2016M602102），中国博士后科学基金会，5万元，2016-2018，主持。
3．基于染色体7q36.3区域捕获测序的肥胖易感基因研究（**），青岛市博士后人员应用研究项目，5万元，2016-2018，主持。
4．染色体7q36.3区域遗传变异与成人肥胖表型的关联研究（**），国家自然科学基金青年基金，23万元，2014-2016，主持。
5．染色体7q36.3区域遗传变异与2型糖尿病的关联研究（BS2013SF002），山东省博士基金，5万元，2014-2016，主持。

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