贺晓丽^1,2, 秦松^2,3, 李文军^2,3, 唐志红¹
1.烟台大学 生命科学学院, 山东 烟台 264005;2.中国科学院烟台海岸带研究所, 山东 烟台 264003;3.中国科学院海洋大科学研究中心, 山东 青岛 266071

摘要:
海洋生物功能肽是从海洋生物中获得的一类具有多种生理活性、在体内担负着重要调节功能的肽类化合物。目前已经从海洋生物中分离出两千多种功能肽，这些功能肽具有抗肿瘤、抗菌、抗氧化、降血压等多种生理活性，且来源广泛、毒性小、特异性强。海洋生物功能肽现已成为医药、食品、化妆品等领域研究的热点，国内外有许多公司和机构致力于海洋生物功能肽类新型药物的研究，大批海洋生物功能肽已经进入医药市场或临床研究阶段。功能肽的结构是其活性的基础，研究它们的构效关系有利于对海洋生物功能肽进行结构改造和修饰，对推进海洋生物资源的开发具有重要意义。本文对近年来国内外在海洋生物功能肽构效关系研究中所取得的主要进展进行综述，为海洋活性物质的开发和应用提供参考。
关键词:海洋生物功能肽生理活性构效关系
DOI：10.11759/hykx20200313002
分类号:Q-1
基金项目:烟台市重点研发项目（2019XDHZ101，2020MSGY084）

Research progress on structure-activity relationship of marine biological functional peptides
HE Xiao-li^1,2, QIN Song^2,3, LI Wen-jun^2,3, TANG Zhi-hong¹
1.College of Life Sciences, Yintai University, Yantai 264005, China;2.Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China;3.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
Abstract:
Marine functional peptides are peptides obtained from marine organisms. They have a variety of physiological activities and play important regulatory roles in vivo. More than 2 000 kinds of functional peptides have been isolated from marine organisms. These functional peptides have many physiological activities, such as anti-tumor, antibacterial, antioxidant, and anti-hypertensive activities. Marine functional peptides have become a research hotspot in the medicine, food, cosmetics, and other fields. Many companies and institutions in China and abroad are committed to research new marine functional peptide drugs. A large number of marine functional peptides have entered the pharmaceutical market or are in the clinical research stage. The structures of the functional peptides are the basis of their activity. A study of their structure-activity relationships is conducive to transforming and modifying marine functional peptides to promote the development of marine resources. This article provides a critical review on recent advances in structure-activity relationships of marine biological peptides and will act as a reference for the development and application of marine bioactive substances.
Key words:marine organismfunctional peptidesphysiological activitystructure-activity relationship





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