职称：副 教授
学院系所：生命科学学院，生物化学与分子生物学系
学科领域：微生物生物化学
联系电话： (Off)；** (Lab)
电子邮件：xhmo@qau.edu.cn; xhmo2013@163.com
通讯地址：山东省青岛市城阳区长城路700号
青岛农业大学生命科学学院/科技楼3032房间

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个人简介：
莫旭华，博士，副教授，硕士生导师。
青岛市生理学会理事。
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教学工作：
本科教育：主讲《基础生物化学》、《基础生物化学实验》。
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科研方向：
1、微生物新颖活性次生代谢产物的发现、鉴定及其生物合成机制的解析
2、甲基杆菌底盘微生物改造及合成生物学研究
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科研项目：
1、国家自然科学基金青年基金项目：丁香糖丝菌中诺卡霉素（nocamycins）的生物合成研究、2014/01-2016/12，主持人。
2、山东省自然科学基金项目：抗生素诺卡霉素（nocamycins）生物合成机制的研究、2013/12-2016/12，主持人。
3、国家自然科学基金青年基金项目：中国黄海近海水域产蛋白酶细菌的分类、多样性以及所产蛋白酶多样性研究、2014/01-2016/12，主要参与人。
4、国家自然科学基金面上项目：甲基杆菌异源一碳协作同化通道的构建及其强化甲醇转化，2018/01-2021/12，主要参与人。
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科研奖励：
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发明专利：
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代表性论文：(#共同一作，* 通讯作者)
1、Mo X*, Shi C, Gui C, Zhang Y, Ju J, Wang Q*, Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringaeNRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster.Microb. Cell Fact.,2017, 16:100.
2、Mo X^#,Zhang H^#,Wang T,Zhang C,Zhang C,Xing X,Yang S*.Establishment of CRISPR interference in Methylorubrum Extorquensand application of rapidly mining a new phytoene desaturase involved in carotenoid biosynthesis. Appl Microbiol Biotechnol.2020, 104(10):4515-4532
3、Mo X*, Gui C, Yang S. Cytochrome P450 oxidase SlgO1 catalyzes the biotransformation of tirandamycin C to a new tirandamycin derivative.3 Biotech.2019, 9(3):71.
4、Mo X*, Gui C, Wang Q, Elucidation of a carboxylate O-methyltransferase NcmP in nocamycin biosynthetic pathway. Bioorg. Med. Chem. Lett., 2017, 27(18): 4431-4435.
5、Shen XT^#,Mo XH^#,Zhu LP^#,Tan LL^#,Du FY,Wang QW,Zhou YM,Yuan XJ,Qiao B,Yang S.Unusual and highly bioactive sesterterpenes synthesized by Pleurotus ostreatus during coculture with Trametes robiniophilaMurr.Appl Environ Microbiol.2019, 85(14). pii: e00293-19.6、Gui C^#, Li Q^#, Mo X^#, Qin X, Ma J, Ju J.* Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis. Org. Lett., 2015, 17 (3):628-631.
7、Mo X, Li Q, Ju J.* Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity. RSC Adv., 2014, 4: 50566-50593.
8、Mo X, Ma J, Huang H, Wang B, Song Y, Zhang S, Zhang C, Ju J*. Δ11,12 -double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. J. Am. Chem. Soc.,2012，134 (6): 2844-2847. (Highlighted by Nature Chemical Biology, 2012, 8:320).
9、Mo X, Huang H, Ma J, Wang Z, Wang B, Zhang S, Zhang C, Ju J*. Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway.Org. Lett.,2011, 13: 2212-2215.
10、Mo X, Wang Z, Wang B, Ma J, Huang H, Tian X, Zhang S, Zhang C, Ju J*. Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomycessp. SCSIO1666. Biochem. Biophys. Res. Commun., 2011, 406: 341-347.
11、Gui C, Mo X, Gu Y, Ju J*. Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic Pathway. Org Lett.2017,19(20): 5617-5620.
12、Gui C, Chen J, Xie Q, Mo X, Zhang S, Zhang H, Ma J, Li Q, Gu YC, J Ju. CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces.Communications biology, 2019, 2 (1), 1-9.
13、Gui C, Yuan J, Mo X, Huang H, Zhang S, Gu YC, Ju J. Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces.J Nat Prod. 2018, 81(5):1278-1289.
14、Yang J, Zhang CT, Yuan XJ, Zhang M, Mo XH, Tan LL, Zhu LP, Chen WJ, Yao MD, Hu B, Yang S. Metabolic engineering of Methylobacterium extorquens AM1 for the production of butadiene precursor.Microb Cell Fact. 2018, 17(1):194.
15、Zhang M, Yuan X, Zhang C, Zhu L, Mo X, Chen W, Yang S. Bioconversion of methanol into value-added chemicals in native and synthetic Methylotrophs.Current issues in molecular biology, 2019, 33, 225-236.
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