副教授 硕士生导师
研究方向：鱼类分子遗传学
邮箱：yanhe@ouc.edu.cn
电话：
地址：青岛市鱼山路5号中国海洋大学海洋生命学院化学馆322
教育背景
2012.4-2012.7 法国Caen大学，交流学生
2007.9-2012.6 中国海洋大学，海洋生物专业，博士
2009.12-2011.10 美国罗格斯大学Haskin贝类研究室，交流学生
2003．9-2007.6 中国海洋大学，生物技术专业，本科
工作经历
2016.1-至今 中国海洋大学，副教授
2013.6-2015.12 中国海洋大学，讲师
2013.4-2013.7 法国Caen大学，博士后
科研方向
鱼类功能基因组学及分子遗传育种。发掘鱼类生长相关基因，并对其功能进行解析，从而探索鱼类个体间生长差异的分子机制。
科研项目
1. 国家自然基金：外显子测序解析半滑舌鳎生长及雌雄生长差异关键调控基因（**，2015-2017，主持）
2. 国家博士后基金面上项目：利用外显子捕获测序筛查半滑舌鳎生长相关的基因标记（2014M551960，2014-2015，主持）
3. 中央高校基本科研业务费：利用外显子捕获测序筛选长牡蛎抗疱疹病毒的基因标记（，2014-2015，主持）
代表性论文（*通讯作者）
1. Niu, Jingjing, Jian Guan, Rui Li, Xuemei Li, Jieming Zhai, Jie Qi and Yan He*. Cynoglossus Semilaevis Rspo3 Regulates Embryo Development by Inhibiting the Wnt/Β-Catenin Signaling Pathway. International Journal of Molecular Sciences 19, no. 7 (2018): 1915.
2. Riviere, Guillaume, Yan He, Samuele Tecchio, Elizabeth Crowell, Micha?l Gras, Pascal Sourdaine, Ximing Guo and Pascal Favrel. Dynamics of DNA Methylomes Underlie Oyster Development. Plos Genetics 13, no. 6 (2017): e**.
3. Liu, Jinxiang, Wei Zhang, Xinxin Du, Jiajun Jiang, Chunli Wang, Xubo Wang, Quanqi Zhang and Yan He*. Molecular Characterization and Functional Analysis of the Gata4 in Tongue Sole (Cynoglossus Semilaevis). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology193, (2016): 1-8.
4. Zhang, Wei, Yuezhong Liu, Haiyang Yu, Xinxin Du, Quanqi Zhang, Xubo Wang* and Yan He*. Transcriptome Analysis of the Gonads of Olive Flounder (Paralichthys Olivaceus). Fish Physiology & Biochemistry42, no. 6 (2016): 1-14.
5. He, Yan, Aude Jouaux, Susan E Ford, Christophe Lelong, Pascal Sourdaine, Michel Mathieu and Ximing Guo. Transcriptome Analysis Reveals Strong and Complex Antiviral Response in a Mollusc. Fish & shellfish immunology46, no. 1 (2015): 131-44.
6. Yuan, Junqing, Jiajun Jiang, Liming Jiang, Fang Yang, Yan Chen, Yan He*and Quanqi Zhang. Insights into Trx1, Trp14, and Prx1 Homologs of Paralichthys Olivaceus: Molecular Profiles and Transcriptional Responses to Immune Stimulations. Fish physiology and biochemistry, (2015): 1-15.
7. Niu, Jingjing, Conghui Liu, Fang Yang, Zhenwei Wang, Bo Wang, Quanqi Zhang, Yan He* and Jie Qi*. Characterization and Genomic Structure of Dnah9, and Its Roles in Nodal Signaling Pathways in the Japanese Flounder (Paralichthys olivaceus). Fish Physiology and Biochemistry10.1007/s10695-015-0127-9, (2015).
8. Liu, Tiantian, Jie Cheng, Chunli Wang, Jingjing Niu, Bo Wang, Jieming Zhai, Muhammad Shafi, Quanqi Zhang, Jie Qi and Yan He*. Genetic Characteristic and Evolution of Pitx2 in Sinistral Tongue Sole, Cynoglossus Semilaevis and Dextral Stone Flounder, Kareius Bicoloratus. Pakistan Journal of Zoology47, no. 5 (2015).
9. Guo, Ximing, Yan He, Linlin Zhang, Christophe Lelong and Aude Jouaux. Immune and Stress Responses in Oysters with Insights on Adaptation. Fish & shellfish immunology46, no. 1 (2015): 107-19.
10. Lian, Shanshan, Yan He, Xue Li, Bosong Zhao, Rui Hou, Xiaoli Hu, Lingling Zhang and Zhenmin Bao. Changes in Global DNA Methylation Intensity and Dnmt1 Transcription During the Aging Process of Scallop Chlamys Farreri. Journal of Ocean University of China14, no. 4 (2015): 685-690.
11. Gómez-Chiarri, Marta, Ximing Guo, Arnaud Tanguy, Yan Heand Dina Proestou. The Use of–Omic Tools in the Study of Disease Processes in Marine Bivalve Mollusks. Journal of Invertebrate Pathologydoi: 10.1016/j.jip.2015.05.007, (2015).
12. Song, Huayu, Yan He, Liman Ma, Xiaosu Zhou, Xiumei Liu, Jie Qi and Quanqi Zhang. Characterisation of Kisspeptin System Genes in an Ovoviviparous Teleost: Sebastes Schlegeli. General and comparative endocrinology214, (2014): 114-125.
13. He, Yan, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Lingling Zhang, Shi Wang, Jingjie Hu and Xiaoli Hu. Molecular Cloning and Characterization of Soxb2 Gene from Zhikong Scallop Chlamys Farreri. Chinese Journal of Oceanology and Limnology31, (2013): 1216-1225.
14. Lv, Jia, Liying Feng, Zhenmin Bao, Huihui Guo, Yueyue Zhang, Wenqian Jiao, Lingling Zhang, Shi Wang, Yan He*and Xiaoli Hu*. Molecular Characterization of Rxr (Retinoid X Receptor) Gene Isoforms from the Bivalve Species Chlamys Farreri. PloS one8, no. 9 (2013): e74290.
15. He, Yan, Susan E Ford, David Bushek, Eric N Powell, Zhenmin Bao and Ximing Guo. Effective Population Sizes of Eastern Oyster Crassostrea Virginica(Gmelin) Populations in Delaware Bay, USA. Journal of Marine Research70, no. 2-3 (2012): 2-3.
16. He, Yan, Haiyang Yu, Zhenmin Bao, Quanqi Zhang and Ximing Guo. Mutation in Promoter Region of a Serine Protease Inhibitor Confers Perkinsus MarinusResistance in the Eastern Oyster (Crassostrea Virginica). Fish & shellfish immunology33, no. 2 (2012): 411-417.
17. Zhang, Guofan, Xiaodong Fang, Ximing Guo, Li Li, Ruibang Luo, Fei Xu, Pengcheng Yang, Linlin Zhang, Xiaotong Wang and Haigang Qi, …. Yan He (第53位). The Oyster Genome Reveals Stress Adaptation and Complexity of Shell Formation. Nature490, no. 7418 (2012): 49-54.