张慧珍讲师/博士
研究领域: 生物有机药物化学
联系邮箱: zhanghuizhen@lyu.edu.cn


个人简历
女，临沂大学药学院讲师。主要从事唑类化合物的设计合成及其生物活性与相关作用机理研究。参与并主持国家自然科学基金、山东省自然科学基金等多项科研项目。在国内外学术杂志发表多篇论文，申请多项国家发明专利，并作为编委参与了E-BOOK《Advances in Anticancer Agents in Medicinal Chemistry》和著作《基础药物化学》的编写。
主要研究领域
1.唑类活性小分子的设计与合成
2.以结构为基础的药物设计与合成以及构效关系研究
代表性论文
1.Hui-Zhen Zhang*, Zhi-Long Zhao, Cheng-He Zhou. Recent advance in oxazole-based medicinal chemistry[J]. European Journal of Medicinal Chemistry, 2018, 144: 444-492.
2.Hui-Zhen Zhang, Shi-Chao He, Yan-Jun Peng, Hai-Juan Zhang, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu, Lin-Ling Gan, Cheng-He Zhou*. Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues[J]. European Journal of Medicinal Chemistry, 2017, 136: 165-183.
3.刘庆龙, 房鹏金, 赵志龙, 张慧珍^*, 周成合. 新型磺胺1,2,4-三唑类化合物的设计合成、抗微生物活性及与小牛胸腺DNA相互作用研究[J].有机化学, 2017, 37(12): 3146-3154.
4.Hui-Zhen Zhang*, Lin-Ling Gan, Hui Wang, Cheng-He Zhou*. New progress in azole compounds as antimicrobial agents[J]. Mini-Reviews in Medicinal Chemistry, 2017, 17(2): 122-166.
5.何世超, Ponmani Jeyakkumar, Avula Srinivasa Rao, 王宪龙, 张慧珍*, 周成合*. 磺胺类药物化学研究新进展[J].中国科学: 化学, 2016, 46(9): 823–847.
6.Hui-Zhen Zhang, Ponmani Jeyakkumar, Kannekanti Vijaya Kumar, Cheng-He Zhou*. Synthesis of novel sulfonamide azoles viaC-N cleavage of sulfonamides by azole ring and relational antimicrobial study[J].New Journal of Chemistry, 2015, 39(7): 5776-5796.
7.Hui-Zhen Zhang, Jin-Jian Wei, Kannekanti Vijaya Kumar, Syed Rasheed, Cheng-He Zhou*. Synthesis and biological evaluation of novel D-glucose-derived 1,2,3-triazoles as potential antibacterial and antifungal agents[J].Medicinal Chemistry Research, 2015, 24(1): 182-196.
8.Hui-Zhen Zhang, Sheng-Feng Cui, Gui-Xin Cai, Cheng-He Zhou*. A unique one-pot reaction viaC?C cleavage from aminomethylene benzimidazoles to access benzimidazolones with wide potentiality[J].Tetrahedron Letters, 2014, 55(30): 4105-4109.
9.Hui-Zhen Zhang, Jian-Mei Lin, Syed Rasheed, Cheng-He Zhou*. Design, synthesis, and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs[J]. Science China Chemistry, 2014, 57(6): 807-822.
10.Hui-Zhen Zhang, Damu Guri Lakishmi Vasantha, Gui-Xin Cai, Cheng-He Zhou *. Current developments in the syntheses of 1,2,4-triazole compounds[J].Current Organic Chemistry, 2014, 18(3): 359-406.
11.Hui-Zhen Zhang, Damu Guri Lakishmi Vasantha, Gui-Xin Cai, Cheng-He Zhou *. Design, synthesis and antimicrobial evaluation of novel benzimidazole type of fluconazole analogues and their synergistic effects with chloromycin, norfloxacin and fluconazole[J]. European Journal of Medicinal Chemistry, 2013, 64: 329-344.
12.Damu Guri Lakishmi Vasantha, Qing-Peng Wang, Hui-Zhen Zhang(并列第一作者), Yi-Yi Zhang, Jing-Song Lv, Cheng-He Zhou*. A series of naphthalimide azoles: design, synthesis and bioactive evaluation as potential antimicrobial agents[J]. Science China Chemistry (中国科学化学分册英文版), 2013, 56(7): 952-969.
13.张慧珍, 王慧, 刘凤志, 双苯并咪唑胺类化合物在制备抗微生物药物中的用途, 中国发明专利, 申请号: CN2.8, 申请日：2015年11月25日.
14.张慧珍, 刘凤志, 王慧, 一种双苯并咪唑胺类化合物及其制备方法, 中国发明专利, 申请号: CN8.1, 申请日：2015年11月25日.