杨杰博士

Email:yangjie1110@163.com

教育背景
2006/09 - 2011/06，兰州大学，化学化工学院，硕、博士
2002/09 - 2006/06，潍坊学院，化学系，本科
工作经历
2014/08 - 至今，聊城大学，药学院，讲师
2012/08 - 2014/08，中国科学院上海有机化学研究所，生命有机化学国家重点实验室，博士后
2011/08 - 2012/08，上海药明康德新药开发有限公司，工艺研发部，高级研究员1
研究方向
主要研究领域是自由基化学、生物有机和药物化学。目前的研究兴趣和方向为：发展新的可见光引发的生物相容化学反应，新型的可见光诱导的有机荧光小分子的设计及其性能研究，以二苯乙烯类天然产物为导向的抗衰老和癌预防治疗药物分子的设计及其相关机制研究。
教研项目
1、聊城大学博士基金，“经济、便利的三氟甲基醚的合成及三氟甲氧基修饰生物活性分子的构效关系研究”，2015-2017，负责人。
2、国家自然科学基金，“光响应的小分子探针调控蛋白功能的新方法”（**）2013-2015，参与。
3、国家自然科学基金，“白藜芦醇导向的生物抗氧化剂合成及其作用机制和构效关系研究”（**）2010-2012，参与。
教研成果
1. Jie Yang, Jing Zhang, Li Qi, Chenchen Hu and Yiyun Chen*, Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions, Chem. Commun., Advance article, DOl: 10.1039/C4CC06344A, 2015.
2. Guo-Yun Liu, Jie Yang, Fang Dai*, Wen-Jing Yan, Qi Wang, Xiu-Zhuang Li, De-Jun Ding, Xiao-Yan Cao, Bo Zhou*, CuIIions and the stilbene-chroman hybrid with a catechol moiety synergistically induced DNA damage, and cell cycle arrest and apoptosis of HepG2 cells: an interesting acid/base-promotedprooxidant reaction, Chem. Eur. J., 18, 11100-11106, 2012.
3. Xiao-Yan Cao, Jie Yang, Fang Dai*, De-Jun Ding, Yan-Fei Kang, Fu Wang, Xiu-Zhuang Li, Guo-Yun Liu, Sha-Sha Yu, Xiao-Ling Jin, Bo Zhou*, Extraordinary radical-scavengers: 4-mercaptostilbenes, Chem. Eur. J., 18, 5898-5905, 2012.
4. Jie Yang, Guo-Yun Liu, Fang Dai*, Xiao-Yan Cao, Yan-fei Kang, Li-Mei Hu, Jiang-Jiang Tang, Xiu-Zhuang Li, Yan Li, Xiao-Ling Jin and Bo Zhou*, Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents, Bioorg. Med. Chem. Lett.,21, 6420-6425, 2011.
5. Jie Yang, Guo-Yun Liu, Dong-Liang Lu, Fang Dai*, Yi-Ping Qian, Xiao-Ling Jin and Bo Zhou*, Hybrid-increased radical-scavenging activity of resveratrol derivatives by incorporating a chroman moiety of vitamin E, Chem. Eur. J.,16, 12808–12813, 2010.
6. Li-Xia Cheng, Jiang Jiang Tang, Hui Luo, Xiao-Ling Jin, Fang Dai*, Jie Yang, Yi-Ping Qian, Xiu-Zhuang Li, Bo Zhou*, Antioxidant and antiproliferative activities of hydroxyl-substituted Schiff bases, Bioorg. Med. Chem. Lett.,20, 2417-2420. 2010.
7. Gui-Juan Fan, Xiao-Ling Jin, Yi-Ping Qian, Qi Wang, Ru-Ting Yang, Fang Dai*, Jiang-Jiang Tang, Ya-Jing Shang, Li-Xia Cheng, Jie Yang, and Bo Zhou*, Hydroxycinnamic acids as DNA-cleaving agents in the presence of CuII ions: Mechanism, structure-activity relationship and biological implication, Chem. Eur. J.,15, 12889-12899, 2009.
8. Qiang Liu*, Jing Li, Xiao-Xia Shen, Rui-Guang Xing, Jie Yang, Zhen-gang Liu, Bo Zhou*, Hydrogenation ofolefins using Hantzsch ester catalyzed by palladium on carbon, Tetrahedron Lett.,50, 1026-1028, 2009.