侯桂革，男，博士，副教授，硕士生导师，药学院副院长，药物化学教研室负责人。烟台市药学会理事。主要从事医用抗菌材料的研究与开发、药物合成与活性评价等研究工作。目前，主持烟台市重点研发项目 1 项，主持并完成国家自然科学基金项目 1项，参与省部级课题 5 项。受邀 Eur J MedChem、Chem BiolDrug Des、
1 项和高等学校科研成果奖三等奖2 项。
2008 年 9 月至 2011 年 6 月，山东师范大学，物理化学专业，博士研究生
2005 年 9 月至 2008 年 6 月，山东师范大学，有机化学专业，硕士研究生
2001 年 9 月至2005 年 6 月，山东师范大学，化学专业，本科
2013 年 12 月至今，药学院，药物化学教研室，副教授
2011 年 7 月至2013 年 12 月，药学院，药物化学教研室，讲师
1.《药物化学》（药学本科、药学专升本必修课）
2.《药物合成反应》（药学本科、制药工程必修课）
1.医用抗菌材料的研究与开发
2.药物合成与活性评价
1.主持国家自然科学基金青年基金项目——“M2L2 型水溶性金属-药物配合物的定向合成与抗肿瘤活性研究”（No. **，2014年 1月－2017 年 12 月）。
2. 主持烟台市重点研发项目——“复合电纺纤维膜的研制与瘢痕修复性能开发”
（No. 2018XSCC048，2018 年1 月－2020 年12 月）
1.主持滨州医学院校级教学研究立项项目“药物合成系列课程实验理论一体化教学改革探索（No. JYKT201606，2016 年 1 月-2018 年 12月）
2.参与山东省本科高校教学改革研究项目“药学化学课程一体化教学模式的探索与实践”（面上项目，No. 2015M029， 2016 年 1月-2019 年 12 月）
(1)Ning Li, Wen-Yu Xin, Bin-Rong Yao, Chun-HuaWang, Wei Cong, Feng Zhao, Hong-Juan Li, Yun Hou, Qing-Guo Meng*, Gui-Ge Hou*. Novel asymmetric3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biologicalevaluation in vitro and in vivo. EuropeanJournal of MedicinalChemistry, 2018, 147,
21-33. (SCI 收录，影响因子 4.816)
(2)Ning Li, Wen-Yu Xin, Bin-Rong Yao, WeiCong, Chun-Hua Wang*,
2018, 155, 531-544. (SCI 收录，影响因子 4.816)
(3)Binrong Yao, Ning Li, Chunhua Wang,* GuigeHou,* Qingguo Meng and Ke Yan. Novelasymmetric 3,5-bis(arylidene)piperidin-4-one derivatives: synthesis, crystal
structures and cytotoxicity.Acta Cryst. 2018. C74, 659–665. (SCI 收录，影响因子
8.678)
(4)Ning Li, Binrong Yao, Chunhua Wang, Qingguo Meng and Guige Hou*. Synthesis, crystal structureand activity evaluation of novel 3,4-dihydro-1-benzoxepin-5(2H)-one derivativesas protein–tyrosine kinase (PTK) inhibitors. Acta Cryst. 2017. C73,
1003–1009. (SCI 收录，影响因子8.678)
(5) Xianrui Xie, Wei Cong, Feng Zhao, HongjuanLi, Wenyu Xin, ChunhuaWang*,
Gui-Ge Hou*, Synthesis, physiochemical propertyand antimicrobial activity of novel quaternary ammonium salts. J Enzyme InhibMed Chem. 2017, 33(1):98-105. (SCI 收
录，影响因子3.638)
(6)Chun-Hua Wang*, Xian-Rui Xie, Wen-ShuaiLiu, Gui-Ge Hou*,Ju-Feng Sun, Feng Zhao, Wei Cong,Hong-Juan Li, Wen-Yu Xin, Quaternaryammonium salts substituted by 5-phenyl-1,3,4-oxadiazole-2-thiol as novelantibacterial agents with
low cytotoxicity. Chemical Biology & Drug Design, 2017, 90(5),943-952. (SCI 收
录，影响因子2.328)
(7)Chun-Hua Wang*, Wen-Shuai Liu,Ju-Feng Sun, Gui-Ge Hou*,Qin Chen, Wei Cong, Feng Zhao,Non-toxic O-quaternized chitosan materials with better water solubility and antimicrobial function,International Journal of Biological
Macromolecules, 2016, 84, 418-427. (SCI 收录，影响因子3.671)
(8)Qin Chen, Yun Hou, Gui-Ge Hou*,Ning Li, Wei Cong, Feng Zhao,Hong-Juan Li, Chun-Hua Wang, Ju-FengSun Synthesis, anticancer activity and cytotoxicity of novel double Schiff-basecondensed α,β-unsaturated keto derivatives. Journal of Chemical
Research, 2016, 40(7): 400-403. (SCI 收录，影响因子0.668)
(9)Qin Chen, Yun Hou, Gui-Ge Hou*,Ju-Feng Sun, Ning Li, Wei Cong, FengZhao, Hong Juan Li, Chun-Hua Wang*. Design, synthesis, anticancer activity andcytotoxicity of novel 4-piperidone/cyclohexanone derivatives. Research on Chemical
Intermediates, 2016, 42(12): 8119-8130. (SCI 收录，影响因子1.369)
(10)Wen-Shuai Liu
Drug Design, 2015, 85(1), 91–97. (SCI 收录，影响因子 2.802)
(11)Hong-Juan Li, Lei Wang, Juan-Juan Zhao, Ju-Feng Sun,Ji-Liang Sun, Chun-Hua Wang,
2015, 1079, 414-422. (SCI 收录，影响因子 2.011)
(12)Ju-Feng Sun*, Shu-PingZhang, Chen Yu, Gui-Ge Hou*, Xiao-Fan Zhang, Ke-Ke Li, Feng Zhao.Design, Synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives ascytotoxic and antitumor
agents with fluorescent properties. Chem. Biol. Drug. Des. 2014, 83,392-400. (SCI收
录，影响因子2.802)
(13)Xian-Ping Dai, Gui-Ge Hou*, Ju-Feng Sun, Dong Lin, Jing-Tian Han*.Synthesis, structure and luminescence of novel 2D co-crystals based onasymmetric 5-substituted pyrimidines and isophthalic acid: Alternate arrangement and π-π interactions. J Mol
Struct, 2013, 1035, 203-208. (SCI 收录，影响因子2.011)
(14)Gui-GeHou*, Hui-Juan Zhao, Ju-Feng Sun, DongLin, Xian-Ping Dai, Jing-Tian Han, Hui Zhao. Synthesis, Structure andLuminescence of Co-crystals with Hexagonal Channels: Arranging Disposition andπ-π Interactions. CrystEngComm,
2013, 15, 577-585. (SCI 收录，影响因子 3.849)
(15)Gui-Ge Hou*, Chun-Hua Wang, Ju-FengSun, Mei-Zi Yang, Dong Lin,
Hong-Juan Li.Rhodamine-based “turn-on” fluorescent probe with high selectivity for
Fe2+ imaging in living cells. Biochem Biophys Res Co. 2013,439, 459-463. (SCI 收录，影响因子 2.559)
(16)Gui-GeHou*, Ju-Feng Sun, Chun-Hua Wang*, Feng Zhao, Xian-Ping Dai,Hong-Juan Li, Jing-Tian Han. Synthesis, structural characterization andluminescence studies of three novel complexesof asymmetric 5-(1-imidazolyl)pyrimidine ligand. J
Mol Struct, 2013, 1048, 295-300. (SCI 收录，影响因子2.011)
(17)Gui-GeHou, Yue Liu, Qi-KuiLiu, Jian-Ping Ma and Yu-Bin Dong*.NbO lattice MOFs based on octahedral M(II) and ditopic pyridyl substituteddiketonate ligands: structure, encapsulation and guest-driven luminescentproperty. Chemcomm. 2011, 47,
10731-10733. (SCI 收录，影响因子 6.29)
(18)
characterization and properties of Ag(I)-complexesbased on double-armed 1,3,4-oxadiazole bridging ligands.CrystEngComm, 2011, 13, 6850-6863. (SCI 收录，
影响因子3.849)
(19)Gui-GeHou, Jian-Ping Ma, Le Wang, PingWang, Yu-Bin Dong* and Ru-Qi Huang. Co-crystallization ofoxadiazole-bridged pyridyl-N-oxidebuilding modules with R-aromatics (R = -OH, -NH2 and -COOH). CrystEngComm, 2010, 12,
4287-4303. (SCI 收录，影响因子 3.849)
(20)Gui-GeHou, Jian-Ping Ma, Ting Sun, Yu-BinDong*, and Ru-Qi Huang. A binuclear CuIImetallacycle capable of discerning between pyrazine and its differentmethyl-substituted derivatives based on reversible intracage metal-ligand binding.
Chem. Eur. J., 2009, 15, 2261-2265. (SCI 收录，影响因子5.16)
(21)
-4-哌啶酮席夫碱衍生物及其制备方法，2018.02.13，中国，**4778.0
(22)
及其制备方法，2018.02.13，中国，CN**4780.8
(23)侯桂革，王春华，孙居锋，杨美子，林栋，一种检测亚铁离子的罗丹明荧光探针及其制备方法，2014.11.26，中国，CN**0477.6
(24)王春华, 侯桂革, 孙居锋, 刘文帅, 陈琴. 具有良好水溶性和抗菌活性的壳聚糖季铵盐衍生物及其制备方法，2017.06.30，中国，CN**06169
(25)王春华，
(1)王春华，孙居锋，徐艳岩，侯桂革，张静，王超云，王晓艳，刘永俊, O-长链烷基壳聚糖季铵盐抑菌材料的制备及其应用，烟台市科技局，科技进步奖，三等奖，2016
(2)刘启奎，马建平，
1.烟台市药学会理事
