药学院(葡萄酒学院)教师个人情况登记表
个人简介:
张加余,男,中共党员,博士后,博士,教授,硕士生导师,云南中医药大学兼职硕导,中药执业药师。入选北京市科技新星与领军人才培养专项计划,中华中医药学会中青年创新人才,北京中医药大学杰青培育人才计划等。迄今共发表学术论文 120 余篇,第一/通讯作者 SCI/EI 论文 49 篇,第一/通讯作者中文核心论文 30 篇。主持国家自然基金、北京市自然基金、省重点实验室开放课题、博士
后基金等课题 10 余项;参与国自然重点、面上项目等近 30 项;获北京市科技进
步一等奖、中国药学会自然科学技术一等奖等2 项省部级奖励;参编卫计委——
十三五规划研究生教材 2 部(《中药分析学专论》、《中药代谢化学》);申请
国内发明专利14 项,获得授权6 项。培养或协助培养博士、硕士研究生18 名。
学习经历:
2008 年09 月至2011 年07 月,北京大学,生药学专业,博士研究生
2005 年09 月至2008 年07 月,山东中医药大学,中药学专业,硕士研究生
2001 年09 月至2005 年07 月,山东中医药大学,制药工程专业,本科
工作经历:
2019 年06 月至今,滨州医学院,中药学专业,教授
2014 年10 月至2019 年05 月,北京中医药大学,中药学专业,副研究员
2013 年09 月至2014 年10 月,北京中医药大学,中药学专业,助理研究员
2012 年03 月至2012 年09 月,北京市药品检验所,所长助理
2011 年 09月至 2013 年09 月,北京中医药大学中药学专业 博士后
研究方向:
1.中药复杂体系系统分析
2.中药体内代谢全表征
3.整合组学分析方法以及基于肠道微生态的发酵中药产品开发研究
科研项目:
1、基于肠道微生态阐明麦冬甾体皂苷干预炎-癌转化过程的抗肿瘤作用机制; Z****;北京市科技新星与领军人才计划
2、麦冬多糖修复荷瘤大鼠肠道菌群结构谱促进甾体皂苷体内吸收的机制研究;
**;国家自然科学基金;2014.1- 2016.12
3、基于 mTOR 信号通路的麦冬甾体皂苷干预结直肠炎-癌转变的作用机制研究;
** ;北京市自然科学基金;2017.1- 2018.6
4、多甲氧基黄酮电喷雾串联质谱在线精确结构鉴定与预测;2013M530563;中国博士后科学基金面上资助项目;2012.10-2013.6
5、基于肠道功能菌组的苦丁茶皂苷降血脂效应成分及作用机制研究;**; 国家自然科学基金地区基金,2016.1-2019.12
教材专著:
1.国家卫生和计划生育委员会“十三五”规划教材、全国高等中医药院校研究生教材《中药分析学专论》,人民卫生出版社,编委,2017 年
2.全国高等院校药学中药学类专业十三五规划教材《中药代谢化学》,北京科学技术出版社,编委,2017 年
代表性论文及专利:
代表专利:
1.刘国飞, 孙志强, 张加余. 一种用于治疗缺血性中风的中药组合物及其制备方法和用途,2014.10.22,中国,**1205.7,已授权
2.张加余,李西秦. 一种治疗过敏性紫癜的中药组合物及其制备方法和用途,
2014.8.20, 中国,**6723.2,已授权
3.李西秦, 张加余. 一种治疗慢性咳嗽的中药组合物及其制备方法和用途,
2014.4.16,中国,**6711.X,已授权
4.李西秦, 张加余, 吴捷. 一种药物组合物的新用途,2013.7.10, 中国,
**9019.4,已授权
5.代龙, 张加余, 贾世伟, 高鹏, 赵德峰. 一种从中药提取液中分离总生物碱的方法,2013.4.17, 中国,**4331.0,已授权
6.欧阳文竹,张加余,聂鹏. 治疗亚急性肝坏死的中药组合物及其制备方法和用途,2016.10.17,中国,**1535.0,已授权
代表论文:
(1)Jia-Yu Zhang, FangWang, Hong Zhang, Jian-Qiu Lu*, Yan-Jiang Qiao*. Rapid identification ofpolymethoxylated flavonoids in traditional Chinese medicines with a practicalstrategy of stepwise mass defect filtering coupled to diagnostic product ionsanalysis based on a hybrid LTQ-Orbitrap massspectrometer[J]. Phytochemical Analysis, 2014,25(5): 405-414. 入选扩展板高被引 ESI 论文 Top3%
(2)Jia-Yu Zhang, Zi-Jian Wang,Yun Li, Ying Liu, WeiCai, Chen Li, Jian-Qiu Lu*,
Yan-Jiang Qiao*. A strategy for comprehensiveidentification of sequential constituents using ultra-high-performance liquidchromatography coupled with linear ion trap-Orbitrap mass spectrometer,application study on chlorogenic acids in Flos Lonicerae Japonicae[J]. Talanta,2016, 147: 16-27.
(3)Jia-Yu Zhang,Zi-Jian Wang, Qian Zhang, Fang Wang, Qun Ma, Zhao-Zhou Lin, Jian-Qiu Lu*,Yan-Jiang Qiao*. Rapid screening andidentification of target constituents using full scan-parent ions list-dynamicexclusion acquisition coupled to diagnostic product ions analysis on a hybrid LTQ-Orbitrap mass spectrometer[J]. Talanta, 2014, 124: 111-122.
(4)Jia-Yu Zhang, QianZhang, Ning Li, Zi-Jian Wang, Jian-QiuLu*, Yan-Jiang Qiao*. Diagnosticfragment-ion-based and extension strategy coupled to DFIs intensity analysisfor identification of chlorogenic acids isomers in Flos LoniceraeJaponicae by HPLC-ESI-MSn [J]. Talanta, 2013, 104: 1-9.
(5)Jia-Yu Zhang, QianZhang, Hong-Xia Zhang, Qun Ma, Jian-Qiu Lu*, Yan-JiangQiao*. Characterization ofpolymethoxylated flavonoids (PMFs) inthe peels of ―Shatangju‖mandarin (Citrus reticulata Blanco) by online high-performance liquidchromatography coupled to photodiode array detection and electrospray tandemmass spectrometry[J]. Journal of Agricultural and Food Chemistry, 2012, 60(36):9023-9034.
(6)Jia-Yu Zhang,Shi-Feng Wang, Lu-Lu Xu, Qiao Zhang,Zhan-Peng Shang, Yan-Ling Zhang,Qing-Hua Wu, Shi-You Li, Yan-jiang Qiao. Multiple Perspectives ofQingkailing Injection-Fraction-Single Compound in Revealing the Hepatotoxicityof Baicalin and Hyodeoxycholic Acid[J]. Journal of Ethnopharmacology, 2017,215:147-155.
(7)Jia-Yu Zhang, ChenLi, Yan-yun Che, Zi-Jian Wang, WeiCai, Yun Li, Zhi-Guo Ma*,Peng-Fei Tu*. LTQ-Orbitrap-basedstrategy for traditional Chinese medicine targeted class discovery,identification and herbomics research: a case study on phenylethanoidglycosides in three different species of Herba Cistanche[J]. RSC Advances,2015, 5(98): 80816-80828.
(8) Wei Cai#, Jia-Yu Zhang#, Lu-Yan Dong, Pei-Hua Yin, Chun-Guo Wang,
Jian-Qiu Lu*, Hong-Gui Zhang*. Identificationof the metabolites of Ixerin Z from Ixeris sonchifolia Hance in rats byHPLC-LTQ-Orbitrap mass spectrometry[J]. Journal of Pharmaceutical andBiomedical Analysis, 2015, 107: 290-297.
(9)Jia-Yu Zhang, NingLi, Yan-Yun Che, Yun Zhang, Shen-Xuan Liang, Ming-Bo Zhao, Yong Jiang, Peng-Fei Tu*. Characterization of seventy polymethoxylated
flavonoids (PMFs) in the leaves of Murrayapaniculata by on-line high-performance liquid chromatography coupled tophotodiode array detection and electrospray tandem mass spectrometry[J].Journal of Pharmaceutical and Biomedical Analysis, 2011, 56: 950-961.
(10)Jia-Yu Zhang#, Wei Cai#, Yuan Zhou, Ying Liu,Xiao-Dan Wu, Yun Li, Jian-Qiu Lu*, Yan-JiangQiao*. Profiling and identification of the metabolites of baicalin andstudy on their tissue distribution in rats by ultra-high-performance liquidchromatography with linear ion trap-Orbitrap mass spectrometer[J]. Journal ofChromatography B, 2015, 985: 91-102.
(11)Jia-Yu Zhang,Jian-Qiu Lu, Fang Wang, Guang-ShangGao, Peng-Fei Tu*, Yan-Jiang Qiao*. A strategy of EIC-MScoupled with diagnostic product ions analysis for efficient discovery of newhydroxylated polymethoxyflavonoid glycosides from the leaves of Murrayapaniculata L. using HPLC-DAD-MS/MS[J]. Analytical Methods, 2013, 5(11): 2880-2891.
(12)Wei Cai#, Jia-Yu Zhang#, Ying Liu, Xiu-Ping Zhang, Siyi Liu, Jian-Qiu Lu*, Hong-GuiZhang*. Metabolic profiles of 11, 13α-dihydroixerinZ in rats using high performance liquid chromatography-LTQ-Orbitrap massspectrometry[J]. Analytical Methods, 2016, 8(4): 854-861.
(13)Jia-Yu Zhang, NingLi, Yuan Zhou, Yong Jiang, Peng-Fei Tu*. Simultaneous qualitative andquantitative determination of major polymethoxylated flavonoids in the leaves of Murraya paniculata byRRLC-DAD-ESI-MSn.Analytical Methods, 2012, 4: 3399-3406.
(14)Jia-Yu Zhang,Jian-Qiu Lu, Xiao-Yan Gao, QianZhang, Ning Li, Peng-Fei Tu, Yan-JiangQiao. Characterization of thirty-nine polymethoxylated flavonoid (PMFs)in the branches of Murraya paniculataby HPLC-DAD-ESI-MS/MS[J]. Chinese Journalof Natural Medicines, 2013, 11(1):63-70.
(15)Jia-Yu Zhang*,Fang Wang, Wei Cai, Qian Zhang, Ying Liu,Yun Li, Rong-Rong Liu andGuang-Shang Cao. Identification of metabolites of gardenin A in rats bycombination of high‐performanceliquid chromatography with linear ion trap–Orbitrap mass spectrometer based onmultiple data processing techniques[J]. Biomedical Chromatography, 2015, 29(3): 379-387.
(16)Jia-Yu Zhang,Jian-Qiu Lu, Qian Zhang, Long Dai, Ying Liu,Peng-Fei Tu*, Yan-JiangQiao*. Simultaneous Screening and Identifying Four Categories ofParticular Flavonoids in the Leaves of Murraya exotica L. byHPLC–DAD–ESI-MS-MS[J]. Journal of chromatographic science, 2014, 52(2):103-114.
(17)Jia-Yu Zhang, QianZhang, Ying Liu, Wei Cai, Fang Wang, Lu-Yan Dong, Pei-Hua Yin,Peng-Fei Tu*. HPLC-LTQ-orbitrap MS nanalysis of multiple chemicalconstituents in a chinese herbal preparation Shuang-Huang-Lian injection[J].WIT Transactions on Biomedicine and Health, 2013, 18: 621-629.
(18)Jia-Yu Zhang, NingLi, Kua Hu, Peng-Fei Tu*. Chemicalconstituents from processed seeds of Strychnos nux-vomica[J]. Journal ofChinese Pharmaceutical Sciences, 2012, 21(2):187-191.
(19)Sheng-Yun Dai,Zhan-Peng Shang, Fei Wang, Yan-Feng Cao,Xin-Yuan Shi, Zhao-Zhou Lin, Zhi-Bin Wang, Ning Li, Jian-Qiu Lu, Yan-JiangQiao*, Jia-Yu Zhang*. Noveltyapplication of multi-omics correlation in the discrimination ofsulfur-fumigation and non-sulfur-fumigation Ophiopogonis Radix[J]. ScientificReports, 2017, 7(1):9971.
(20)Sheng-Yun Dai, Zhao-Zhou Lin, Bing Xua, Yu-Qi Wang, Xin-Yuan Shi, Yan-JiangQiao*, Jia-Yu Zhang*.Metabolomics data fusion between near infrared spectroscopy and high-resolutionmass spectrometry: a synergetic approach to boost performance or induceconfusion[J]. Talanta, 2018, 189:641-648.
(21)Zhan-Peng Shang, Fei Wang,Sheng-Yun Dai, Jian-Qiu Lu,Xiao-Dan Wu, Jia-Yu Zhang*. Profiling and identification of (-)-epicatechinmetabolites in rats using ultra-high performance liquid chromatography coupledwith linear trap-Orbitrap mass spectrometer[J]. Drug Testing and Analysis, 2017, 9(8):1224-1235.
(22)Si-Yi Liu, Yan-Yun Che, Fei Wang, Zhan-Peng Shang, Jian-Qiu Lu, Sheng-Yun Dai, Jia-Yu Zhang*,Wei Cai*. Identification ofmetabolites of 6'-hydroxy-3, 4, 5, 2', 4'-pentamythoxychalcone in rats bycombination of ultra–high–performance liquid chromatography with linear iontrap–Orbitrap mass spectrometer based on multiple data processing techniques[J]. Molecules, 2016, 21, 1266.
(23)Lu-Lu Xu, Jing-Jing Xu, Kun-Rui Zhong, Zhan-PengShang, Fei Wang, Ru-Feng Wang, Le Zhang, Jia-Yu Zhang*, Bin Liu*. Analysis of Non-Volatile Chemical Constituents of Menthae Haplocalycis Herbaby Ultra-High Performance Liquid Chromatography-High Resolution MassSpectrometry[J]. Molecules, 2017, 22(10): E1756.
(24)Yan-Yun Che,Zhi-Bin Wang, Zhi-Yun Zhu, Yang-Yang Ma, Ya-Qiong Zhang, Wen Gu,Jia-Yu Zhang*, Gao-Xiong Rao*.Simultaneous Qualitation andQuantitation of Chlorogenic Acids in Kuding Tea UsingUltra-High-Performance Liquid Chromatography–Diode ArrayDetection Coupled with Linear Ion Trap–Orbitrap Mass Spectrometer[J].Molecules, 2016, 21(12): E1728.
(25)Wen-Jing Zhao,Zhan-Peng Shang, Qin-Qing Li, Mo-Ran Huang, Wen-BinHe, Zhi-Bin Wang*, Jia-Yu Zhang*. Rapid Screening andIdentification of Daidzein Metabolites in Rats Based on UHPLC-LTQ-Orbitrap MassSpectrometry Coupled with Data-Mining Technologies[J]. Molecules, 2018, 23(1): E151.
(26)Zhan-Peng Shang, WeiCai, Yan-Feng Cao, Fei Wang, Zhi-Bin Wang, Jian-Qiu Lu*, Jia-Yu Zhang*.An integrated strategy for rapid discovery and identification of the sequentialpiperine metabolites in rats using ultrahigh-performance liquid
chromatography/high resolution massspectrometery[J]. Journal of Pharmaceutical and BiomedicalAnalysis, 2017, 146:387-401.
(27)Zhan-Peng Shang, Qi-Qi Xin, Wen-Jing Zhao, Zhi-Bin Wang,Qin-Qing Li, Jia-Yu Zhang, Wei-Hong Cong. Rapid Profiling andIdentification of Puerarin Metabolites in Rat Urine and Plasma after OralAdministration by UHPLC-LTQ-Orbitrap Mass Spectrometer[J]. Journal ofChromatography B, 2017, 1068-1069: 180-192
(28)Yun Li, Ying Liu, Rong-Rong Liu, Si-Yi Liu, Xiu-Ping Zhang, Zi-Jian Wang, Jia-Yu Zhang* and Jian-Qiu Lu*.HPLC-LTQ-Orbitrap MS profiling method to comprehensively characterize multiplechemical constituents in Xiao-er-qing-jie granules[J]. Analytical Methods,2015, 7(18): 7511-7526.
(29)Zhan-Peng Shang, Fei Wang, Jia-YuZhang*, Zi-Jian Wang, Jian-Qiu Lu, Huai-You Wang, NingLi*. The genus Liriope: Phytochemistry and pharmacology[J]. Chinese Journal ofNatural Medicines, 2017, 15(11): 801-815.
(30)Si-Yi Liu, Wei Cai, Fei Wang, Ying Liu, Zhan-PengShang, Xiu-Ping Zhang, Zi-Jian Wang, Jian-QiuLu*, Jia-Yu Zhang*.UHPLC-LTQ-Orbitrap-based metabolomics coupled with metabolomics pathwayanalysis method for exploring the protection mechanism of Kudiezi injection ina rat anti-ischemic cerebral reperfusion damage model[J]. Chinese Journal ofNatural Medicines 2017, 15(12):955-960.
(31)Si-Yi Liu, Wei Cai, Xiu-Ping Zhang, Ying Liu, Zi-Jian Wang, Zhan-Peng Shang,Fei Wang,Jia-Yu Zhang*, Jian-Qiu Lu*.UHPLC−LTQ−Orbitrap−based metabolomicscoupled with metabolomics pathway analysis method for exploring the protectionmechanism in anti−ischemiccerebral reperfusion damage of Kudiezi injection [J].Chinese Journal of Natural Medicines, 2017, 15(12):955-960.
(32)Rong-Rong Liu, Xiu-Ping Zhang, Fang Wang, Zhan-Peng Shang, Fei Wang, Ying Liu, Jian-Qiu Lu, Jia-Yu Zhang.Rapid screening and dentification of sesquiterpene
lactones in Kudiezi injection based onhigh-performance liquid chromatography coupled with linear ion trap-orbitrapmass spectrometry[J]. Chinese Journal of Natural Medicines, 2018,16(2):150-160.
(33)Xiao-Dan Mei, Yan-Feng Cao, Yan-YunChe, Jing Li, Zhan-Peng Shang, Wen-JingZhao, Yan-Jiang Qiao, Jia-Yu Zhang. Danshen: a phytochemical andpharmacological overview[J]. Chinese Journal of Natural Medicines, 2019, 17(1): 59.
(34)Fei Wang, Zhan-PengShang, Lu-Lu Xu, Zhi-Bin Wang, Wen-Jing Zhao, Xiao-Dan Mei, Jian-Qiu Lu, Jiang-YuZhang. Profiling and identification of chlorogenic acid metabolites inrats by ultra-high-performance liquid chromatography coupled with linear iontrap-Orbitrap mass spectrometer[J]. Xenobiotica, 2017:1-30.
(35)Yun Li, Wei Cai, Qian Cai, Yan-Yun Che, Bao-Sheng Zhao*, Jia-YuZhang*. Comprehensive characterization of the in vitro and in vivometabolites of geniposide in rats using ultra-high-performance liquidchromatography coupled with linear ion trap–Orbitrap mass spectrometer[J].Xenobiotica, 2015: 1-12.
(36)Fei Wang, Guang-ShangCao, Yun Li, Lu-Lu Xu, Zhi-Bin Wang, Ying Liu, Jian-Qiu Lu, Jia-Yu Zhang. Characterization ofForsythoside A Metabolites in Rats by a Combination of UHPLC-LTQ-Orbitrap MassSpectrometer with Multiple Data Processing Techniques[J]. BiomedicalChromatography, 2018, 32(5): e4164.
(37)王子健, 刘颖, 刘思燚, 李宁, 卢建秋*, 张加余*.UPLC-HRMSn 结合高能诱导裂解快速鉴定麦冬中高异黄酮类成分[J].质谱学报, 2016, 37(06):481-491. 2016 年《质谱学报》重点推荐论文,2017 年高被引论文 Top6.
(38)张加余, 屠鹏飞*.天然产物液相色谱-质谱-数据库(LC-MS-DS) 的建立应用. 药学学报, 2012, 47(9): 1187-1192.《药学学报》优秀研究论文
荣誉获奖:
1.中药生产过程控制可靠性工程理论与关键技术应用,北京市人民政府,自然科学,省部一等奖, 2017 年
2.基于大数据的中药注射剂上市后再评价及方法学研究,中国药学会,自然科学,中国药学会科学技术奖一等奖,2018 年
3.中华中医药学会中青年创新人才,2018,中华中医药学会
4.北京市科技新星与领军人才,2017 年,北京市科学技术委员会
5.亚临床代谢组学,北京中医药大学杰出青年人才,2018 年,北京中医药大学
6.卫生部国际交流与合作中心第一三共医药学奖学金,2011 年,卫生部国际交流与合作 中心
7.北京中医药大学中药学院 2018 年度学生工作突出贡献奖
8.北京中医药大学 2018年度就业工作先进个人
9.北京中医药大学 2016年度先进共产党员
10.北京中医药大学 2016年度机关党委先进共产党员
社会兼职:
1. 中国药理学会药检药理专业委员会 副主任委员
2. 中国合格评定国家认可委员会(CNAS) 评审专家
3. 世界中医药联合会中药系统科学与工程专业委员会 常务理事
4. 中国中西医结合学会中药专业委员会 青年委员
5. 中国医药教育协会中药制剂专业委员会 常务委员
6. 中国中医药研究促进会骨质疏松分会 理事
7. 中国民族医药学会信息与大数据分会 理事
8. 中华中医药学会中药分析分会 委员
9. 中华中医药学会中药化学分会 委员
10. 国家自然科学基金委员会 通讯审评专家
11. 北京市自然科学基金委员会 通讯审评专家
12. Sci Rep/JPBA/JCB/JSS、中国中药杂志/中草药 审稿专家