翁东 副研究员-高研院
硕士招生类型：学术型
硕士招生专业：内科学（呼吸内科学）
博士招生类型：无
博士招生专业：无
所在院系：附属肺科医院
联系方式：wengdong@tongji.edu.cn; **(微信同号)
课题组链接：
研究方向
主要任职
科研业绩

呼吸系统疾病特别是肺部感染、损伤、纤维化的免疫调控机制。 Mechanism of immune regulation in respiratory diseases, especially pulmonary infection, injury and fibrosis.
同济大学附属上海市肺科医院呼吸病实验室副研究员，同济大学医学高等研究院副研究员，硕士研究生导师。 He is an associate researcher of the Respiratory Laboratory of Shanghai Pulmonary Hospital Affiliated to Tongji University, an associate researcher of the Institute of Advanced Medical Research, Tongji University, and a master
已发表ERJ、Autophagy、Theranostics、Chest等SCI论文46篇，以第一或通讯作者发表22篇 （IF＞5的7篇）JCR一区13篇，累计被引用次数超过350。主持完成国家自然基金面上及青年项目2项，完成中国博士后科学基金1项；作为学术骨干参与国家重点研发计划、国家自然科学基金重大研究计划等课题多项。
近三年代表性论文（第一或通讯，*通讯作者,#同等贡献）：
1.Li C, Lu YP, Du ST, Li SY, Zhang YT, Liu FW, Chen Y, Weng D*, Chen J*. Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis In Mice. Theranostics. 2017; 7(17):4255-4275. (IF=8.579) (Corresponding author)；
2.Li C, Du ST, Lu YP, Lu XW, Liu FW, Chen Y, Weng D*, Chen J*. Blocking the 4-1BB Pathway Ameliorates Crystalline silica-induced Lung Inflammation and Fibrosis in Mice. Theranostics. 2016 Sep 9;6(12):2052-2067. (IF=8.579) (Corresponding author)；
3.Zhao M#, Song J#, Du S#, Zhang Y#, Zhou Y, Li Q, Weng D*, Li H*. Serum IL-35 levels are Associated with Activity and Progression of Sarcoidosis. Front. Immunol. 2020 May 19; 11:977. (IF=5.085) (Corresponding author)；
4.Qiu H#, Weng D#, Chen T#, Shen L#, Chen S, Wei Y, Wu Q, Zhao M, Li Q, Hu Y, Zhang Y, Zhou Y, Su Y, Zhang F, Lu L, Zhou N, Li S, Zhang L, Wang C*, Li H*. Stimulator of Interferon Genes Deficiency in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Front. Immunol. 2017; 8:1756. (IF=5.085) (Co-first author)；
5.Song J#, Zhao M#, Li Q#, Lu L, Zhou Y, Zhang Y, Chen T, Tang D, Zhou N, Yin C, Weng D* and Li H* (2019) IL-17A Can Promote Propionibacterium acnes-Induced Sarcoidosis-Like Granulomatosis in Mice. Front. Immunol. 2019 Aug 14; 10:1923. (IF=5.085) (Corresponding author)；
6.Weng D#, Chen J#, Li H, Liu F, Zhou L, Liu H, Zheng R, Jiang Y, Liu Z, Ge B*. 2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis. Cell Death Discov. 2018 Feb 13; 4:17. (IF=4.114)；
7.Weng D#, Chen X#, Qiu H#, Zhang Y#, Li Q, Zhao M, Wu Q, Chen T, Hu Y, Wang L, Wei Y, Du Y, Chen S, Zhou Y, Zhang F, Shen L, Su Y, Kolb M, Li H*. The Role of Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators Inflamm. 2019 Jan 3; 2019:**. (IF= 3.758)；
8.Weng D#, Wu Q#, Chen X#, Du Y#, Chen T#, Li H, Tang D, Li Q, Zhang Y, Lu L, Zhou N, Song J, Wang C*, Li H*. Azithromycin treats diffuse panbronchiolitis by targeting T cells via inhibition of mTOR pathway. Biomed Pharmacother. 2019 Feb; 110: 440-448. (IF= 4.545)；
9.Zhang F#, Weng D#, Su Y#, Yin C#, Shen L, Zhang Y, Zhou Y, Li Q, Hu Y, Li H*. Therapeutic effect of subcutaneous injection of low dose recombinant human granulocyte-macrophage colony-stimulating factor on pulmonary alveolar proteinosis. Respiratory Research 2020 Jan 2;21(1):1. (IF=3.924) (Co-first author)；
10.Li N#, Weng D#, Wang S#, Zhang Y#, Chen S, Yin Z, Zhai J, Scoble J, Williams C, Chen T, Qiu H, Wu Q, Zhao M, Lu L, Mulet X*, Li H*. Surfactant Protein-A Nanobody-conjugated Liposomes Loaded with Methylprednisolone increases lung-targeting specificity and therapeutic effect for Acute Lung Injury. Drug Deliv. 2017 Nov;24(1):1770-1781. (IF=4.902) (Co-first author)；
11.Liu F, Lu X, Dai W, Lu Y, Li C, Du S, Chen Y, Weng D*, Chen J*. IL-10-Producing B Cells Regulate T Helper Cell Immune Responses during 1,3-β-Glucan-Induced Lung Inflammation. Front. Immunol. 2017 Apr 6; 8: 414. (IF=5.085) (Corresponding author)；
12.Chen Y, Li C, Lu YP, Zhuang HY, Gu WJ, Liu B, Liu FW, Sun JK, Yan B, Weng D*, Chen J*. IL-10-producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients. Front Immunol. 2017 Feb 13; 8: 110. (IF=5.085) (Corresponding author) ；
13.Chen T, Qiu H, Zhao M, Chen S, Wu Q, Zhou N, Lu L, Song J, Tang D, Weng D*, Li H*. IL-17A contributes to HSV1 infection-induced acute exacerbation of lung fibrosis in mice. J Cell Mol Med. 2019 Feb;23(2):908-919. (IF=4.486) (Corresponding author)