张苑 副主任医师，副教授
硕士招生类型：专业型
硕士招生专业：内科学（呼吸内科学）
博士招生类型：无
博士招生专业：无
所在院系：附属肺科医院
联系方式：zhs0905@126.com
课题组链接：
研究方向
主要任职
科研业绩

间质性肺疾病，肺纤维化，结节病 intherstitial lung diseases（ILDs），pulmonary fibrosis，Sarcoidosis
上海市医学会呼吸分会青委委员， 成员 (Shanghai Medical Association respiratory medicine , Youth Committee)
课题/FUNDING: 上海市卫生健康委员会科研课题青年项目，特发性肺纤维化综合评分系统的建立与验证，2021/01-2023/12, 5万，在研，主持。
发表文章/Pulications:
1.Zhang Y#, Li N#, Li Q#, Zhou Y#, Zhang F, Chen T, Shen L, Su Y, Hu Y, Li H*. Analysis of the clinical characteristics of 176 patients with pathologically confirmed cryptogenic organizing pneumonia. Ann Transl Med 2020;8(12):763. doi: 10.21037/atm-20-4490；
2.Weng D#, Chen X#, Qiu H#, Zhang Y#, Li Q, Zhao M, Wu Q, Chen T, Hu Y, Wang L, Wei Y, Du Y, Chen S, Zhou Y, Zhang F, Shen L, Su Y, Kolb M, Li H*. The role of infection in acute exacerbation of Idiopathic Pulmonary Fibrosis. Mediators Inflamm. 2019 Jan 3;2019:**；
3.Liu Y, Fu Y, Hu X, Zhou Y, Zhang Y*. Caveolin-1 knockdown increases the therapeutic sensitivity of lung cancer to cisplatin-induced apoptosis by repressing Parkin-related mitophagy and activating the ROCK1 pathway. J Cell Physiol. 2020;235(2):1197–1208. doi:10.1002/jcp.29033 (Corresponding author)；
4.Yang J#, Zhang Y#, Sun X#, Gusdon AM, Song N, Chen L, Jiang G, Huang Y. The prognostic value of multiorgan metastases in patients with non-small cell lung cancer and its variants: a SEER-based study. J Cancer Res Clin Oncol. 2018 Jul 12；
5.Li QH, Zhang Y# , Zhao MM, et al. Simultaneous amplification and testing method for Mycobacterium tuberculosis rRNA to differentiate sputum-negative tuberculosis from sarcoidosis. Am J Physiol Lung Cell Mol Physiol. 2019;316(3):L519–L524. doi:10.1152/ajplung.00172.2018 ；
6.Zhang Y, Zhang SX, Trivedi J, et al. Pleural fluid secondary to pulmonary cryptococcal infection: a case report and review of the literature. BMC Infect Dis. 2019;19(1):710. Published 2019 Aug 12. doi:10.1186/s12879-019-4343-2；
7.Li N#, Weng D#, Wang SM#, Zhang Y#, Chen SS, Yin ZF, Zhai J, Scoble J, Williams CC, Chen T, Qiu H, Wu Q, Zhao MM, Lu LQ, Mulet X, Li HP*. Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury. Drug Deliv. 2017 Nov;24(1):**；
8.Zhang X#, Kuang Y#, Zhang Y#, He K, Lechtzin N, Zeng M, Yung RC, Xie C*. Shifted focus of bronchoalveolar lavage in patients with suspected thoracic malignancy: an analysis of 224 patients. J Thorac Dis. 2016 Nov;8(11):**；
9.Zhang Y#, Li N#, Zhang YX#, Li H*, Chen X, Wang S, Zhang X, Zhang R, Xu J, Shi J, Yung RC. Clinical analysis of 76 patients pathologically diagnosed with pulmonary cryptococcosis. Eur Respir J, 2012 40(5): 1191-1200；
10.Zhang Y#, Chen X#, Hu Y#, Du S#, Shen L, He Y, Zhang Y, Zhang X, Li H*, Yung RC. Preliminary characterizations of a serum biomarker for sarcoidosis by comparative proteomic approach with tandem-mass spectrometry in ethnic Han Chinese patients. Respir Res. 2013 Feb 11;14(1):18；
11.Zhang Y#, Wang KP*. Evolution of transbronchial needle aspiration - a hybrid method. J Thorac Dis. 2013 Jun;5(3):234-9；
12.Hallowell RW, Collins SL, Craig JM, Zhang Y, et al. mTORC2 signalling regulates M2 macrophage differentiation and response to helminth infection and adaptive thermogenesis. Nature Communications. 2017 Jan 27;8:14208.