宋利格 副主任医师，副教授
硕士招生类型：学术型；专业型
硕士招生专业：内科学（内分泌内科学）
博士招生类型：专业型
博士招生专业：内科学（内分泌内科学）
所在院系：附属同济医院
联系方式：6songlige@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

1. 骨质疏松的发生机制
2. 成骨细胞调节能量代谢的机制
3. 维生素D与胰岛素抵抗

1. Mechanisms of Osteoporosis
2. Mechanisms of osteoblasts on regulating energy homeostasis
3. Vitamin D and insulin resistance




中华医学会骨质疏松和骨矿盐疾病分会 青年委员
上海市医学会骨质疏松分会 青年委员兼秘书
上海市医学会内分泌分会 青年委员
美国骨矿盐学会 会员
国际华人骨矿盐学会 会员

Youth Committee member of Chinese Society of Osteoporosis and Bone Mineral Research
Youth Committee member and Secretary of Shanghai Osteoporosis Society
Youth Committee member of Shanghai Medical Association
Member of American Society of Bone and Mineral Research (ASBMR)
Member of International Chinese Musculoskeletal Research Society (ICMRS)




本科、硕士和博士毕业于同济大学，在哈佛医学院/麻省总医院内分泌科完成博士后和访问****学习，期间针对骨质疏松的发生机理、成骨细胞的内分泌作用及维生素D与胰岛素抵抗开展科研工作。相继获得国家自然科学基金、上海市自然科学基金、教育部博士点基金、同济大学青年英才计划及同济大学附属同济医院“甘泉新星”等多项基金和人才计划的支持，多次应邀在国际和国内学术会议上做口头报告。已在国际和国内高水平期刊发表科研论文20余篇。
M.D and Ph.D: Tongji University School of Medicine, Tongji University
Postdoctor and Visiting scholar: Harvard Medical School and Massachusetts General Hospital
Research focuses on Mechanisms of Osteoporosis, Mechanisms of osteoblasts on regulating glucose and lipid homeostasis, and The regulation of vitamin D on insulin resistance. Grants include National Natural Science Foundation of China, Shanghai Natural Science Foundation, Doctoral Fund of Ministry of Education of China), and other grants supported by Tongji University and Tongji Hospital.
Selected publications:
1) Zhu X, Shan C, Zhu Q, Song L, Zhou Y, Liu J, Zhang K. Clinical value of calcium load test in differential diagnosis of different types of hyperparathyroidism. Int J Clin Exp Med. 2014;7(12):5445-52.
2) Zhu Q, Wang L, Zuo Y, Shan C, Yu J, Song L, Zhang K. Adipocytes exert lipotoxic effects on osteoblast through activating hypoxia signaling pathway in vitro. Am J Transl Res. 2015;7(12):2694-705.
3) Song L, Liang X, Zhou Y. Estrogen-mimicking isoflavone genistein prevents bone loss in a rat model of obstructive sleep apnea-hypopnea syndrome. Int J Clin Exp Pathol. 2014;7(4):168:7-94.
4) Zhang W, Zhang K, Song L,et al.The phenotype and genotype of fibrodysplasia ossificans progressiva in China: a report of 72 cases. Bone. 2013;57(2):386-91.
5) Song L, Zhao J, Zhang X,et al. Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation. Eur J Pharmacol. 2013;714(1-3):15-22.
6) Guo J, Song L, Liu M, et al. Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice. Endocrinology. 2013;154(5):1680-9.
7) Guo J, Song L, Liu M, et al. Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation. Biochim Biophys Acta. 2012;1823(12):2243-53.
8) Song L, Liu M, Ono N, et al. Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes. J Bone Miner Res. 2012;27(11):2344-58.
9) Song L, Zhang X, Zhou Y. A synergetic role of 1,25-dihydroxyvitamin D(3) in 17β-estradial induced-proliferation and differentiation of osteoblastic MC3T3-E1 cells. Eur J Pharmacol. 2011;659(2-3):273-80.