周蓉 主任医师，副教授
硕士招生类型：专业型
硕士招生专业：内科学（肾内科学）
博士招生类型：无
博士招生专业：无
所在院系：附属杨浦医院
联系方式：zhourong@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

糖尿病肾病 (Diabetic Nephropathy）
中毒性肾病（Toxic nephropathy）
血液净化（Hemodialysis）
同济大学附属杨浦医院肾内科行政主任兼内科系主任Director of the Department of Nephrology of Yangpu Hospital Tongji University
上海市医学会肾脏病分会委员Committee member of Society of Nephrology, Shanghai Medical Association
上海市医师协会肾内科医师分会委员 Committee member of Society of Nephrology, Shanghai Medical Doctor Association
上海市中西医结合学会肾病专业委员会委员 Committee member of Society of Nephrology, Shanghai Association of Chinese Integrative Medicine
中国药理学会肾脏病分会委员Committee member of Society of Nephrology, Chinese Pharmacological Society
擅长各类各类原发性及继发性肾病及疑难危重肾脏病的诊治。科研聚焦中毒性肾病、糖尿病肾病、血液净化，主持各级课题，发现铅可通过Smad、TGF-β介导的炎症反应诱导间质纤维化的作用；尿kim-1可作为铅致肾损伤的早期预测指标等科研结果。
Specialized in the diagnosis and treatment of primary or secondary kidney diseases that are intractable and severe. Being in charge of various research projects including toxic nephrology, diabetic nephrology and hemodialysis. We have reported it for the first time that Smad/TGF-βpathways contribute to the renal tubule-interstitial fibrosis by the upregulated inflammation status. In addition, we also found that urinary KIM-1 could be the biomarker of the early stage of renal injury induced by lead.
承担上海市科委科研项目1项：In charge of 1 research project of Shanghai Science and Technology Commision:
《聚醚砜血液透析器上市后临床性能评价》（16DZ**,2016.09-2019.09）
《The evaluation of safety and clinical performance of post-marketing polyether sulfone blood dialyzer》（16DZ**,2016.09-2019.09）
承担及指导上海市卫生局科研项目5项:
In charge of 5 scientific research projects of Shanghai Health Bureau:1.《肾损伤分子-1和中性粒细胞明胶酶相关脂质运载蛋白在职业性铅接触人群肾损伤早期诊断中的应用研究》（**，2012.01-2.015.01）
《The application of KIM-1 and NGAL in the early diagnosis of kidney injury in the occupational people exposed to lead》（**，2012.01-2.015.01）
2.《自噬在醋酸铅致肾小管上皮细胞损伤中的作用及机制研究》（，2018.01-2020.12）
《The mechanism of autophagy of renal epithelial injury in the environment of lead》（，2018.01-2020.12）
3.《醋酸铅对NRK-49F细胞转分化的影响》（20134y091,2014.01-2017.01）
《The effect of trans-differentiation of NRK-49F cells induced by lead》（20134y091, 2014.01-2017.01）
4.《社区成年人镉蓄积及镉致肾损伤效应研究》（ 2014.01-2017.12）
《The subsequent effect of kidney injury of community residents exposed to cadmium in a long term observation》（ 2014.01-2017.12）
5.《肾小球系膜细胞/内皮细胞间Ang/Tie2通路调控糖尿病肾病血管新生的机制研究》（20144y0224 2014.1-2017.12）
《The mechanism of crosstalk between endothelial and mesangial cells through the Ang/Tie2 signaling in the prevention of progress of diabetic nephrology》（20144y0224 2014.1-2017.12）
承担同济大学基础研究能力提升计划项目1项：In charge of 1 scientific capability elevated project of Tongji University in basic science:
《HO-1对自噬的调控在铅致肾损伤氧化应激中的作用及其机制研究》（2017.01-2017.08）
《The effect of autophagy in the kidney injury induced by lead through the regulation of excessive oxidative stress regulated by HO-1 pathway》（2017.01-2017.08）
指导及参加上海市杨浦区中心医院院级课题4项：
Directed the 4 college research projects of Shanghai Yangpu central hospital:
1.《慢性肾脏病患者重金属（铅、镉）水平流行病学调查》 （Se**，2014.01-2015.12）
《The epidemiological survey of the level of heavy metals such as lead and cadmium in the chronic kidney disease patients》（Se**，2014.01-2015.12）
2. 《细胞自噬在汞、铅中毒性肾病初步探讨》（Se**,2014.01-2015.12）
《The effect of autophagy in the progress of toxic nephrology induced by lead and mercury》（Se**,2014.01-2015.12）
3. 《镉对肾小管上皮细胞转分化的影响及机制研究》（Se**,2015.01-2016.12）
《The mechanism of trans-differentiation of renal epithelial cells induced by cadmium》（Se**,2015.01-2016.12）
4. 《血液透析联合血液灌流对终末期肾衰竭患者营养指标的影响》（Se**,2015.01-2016.12）
《The influence of combination of hemodialysis and hemoperfusion on the nutritional indexes of the end-stage renal diseases patients》（Se**,2015.01-2016.12）
参加上海卫生系统先进适宜技术推广项目1项：
Participated in 1 research project of advanced and appropriate technology of Shanghai health system:
《系统性血管炎标准化筛查与诊断在基层医院的应用》（2013SY017，2014.01-2016.12）
《The application of standard screening and diagnosis of systemic vasculitis in grass-roots hospitals》（2013SY017，2014.01-2016.12）
参加国家科技部重大新药创制项目（分中心负责人）1项：
participated in 1 research project of significant drug discovery initiative of Ministry of Science and Technology (chair of sub-center)
《肾炎康复片治疗慢性肾脏病的安全性和有效性临床研究》（2014ZX**，2015.10-2016.12）
《The clinical safety and effectiveness of Shenyankangfu Tablet in the treatment of chronic kidney diseases》
参加国家十二五支撑项目（分中心负责人）1项
Participated in 1 research project of China’s 12th five-year support program (chair of sub-center) 《高血压肾损害及缺血性肾脏病的研究》（2011BAI10B06 ，2012.01-2015.12.31）
《The study of hypertensive renal damage and ischemic kidney disease》（2011BAI10B06 ，2012.01-2015.12.31）
近五年发表论文（第一或通讯作者）：
Papers published in the past five years(first author or corresponding author)
1.Rong Zhou, Yahong Xu, Jie Shen. Urinary KIM-1: a novel biomarkerfor evaluation of occupational exposure to lead. Sci Rep. 2016 Dec 14;6:38930. doi: 10.1038/srep38930.（IF5.228）
2.Zhou R, Kuang X, Tang B. Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics.Life Sci. 2016 Feb 1;146:73-80 . （IF2.702）
3.Lin Han,Rong Zhou,Xingya Kuang. Study on lead-induced activation of rat renal interstitial fibroblasts and the related mechanisms.Toxicol Mech Methods,2014 ,Dec;24(9):713-8 （IF1.517）
4.陈闽东，徐雅虹，沈杰，韩琳，蒋茜，陈希，王雅楠，周蓉.重视腹膜透析患者的呋塞米相关性横纹肌溶解症.中国中西医结合肾病杂志.2017，18（01）：71-72.
5.MinDong Chen, Yahong Xu, Jie Shen, Lin Han, Qian Jiang, Xi Chen, Yanan Wang, Rong Zhou. To pay attention to the rhabdomyolysis induced by diuretic drugs in peritoneal dialysis patients. Journal of Chinese traditional Chinese and western medicine combined with nephropathy. 2017，18（01）：71-72. (Chinese core periodicals)
6.蒋茜，周蓉，刘迎，沈杰，王雅楠，冯雪芳，徐雅虹.糖尿病肾病患者心血管疾病患病率及其影响因素分析.中国全科医学,2017,20（29）:3590-3595.
7.Qian Jiang, Rong Zhou, Yin Liu, Jie Shen, Yanan Wang, Xuefang Feng,Yahong Xu. The prevalence and influence factors of cardiovascular disease in diabetic nephrology patients. Journal of Chinese General practice. 2017,20（29）:3590-3595. (Chinese core periodicals)
8.曾洋，周蓉，徐雅虹，蒋茜，崔克勤.不同分期2型糖尿病肾病患者的血浆同型半胱氨酸水平及其临床意义.广西医学，2017,39（12）:1791-1793.
9.Yang Zeng, Rong Zhou, Yahong Xu, Qian Jiang, Keqing Cui. The clinical value of plasma homocysteine in different stages of diabetic nephrology related with type 2 diabetic disease. GuangXi Medicine. 2017,39（12）:1791-1793. (Chinese core periodicals)
10.徐雅虹，蒋茜，关雪晶， 陈闽东，韩琳，周蓉.Ang-Tie2通路在早期糖尿病肾病血管新生中的作用.山西医药杂志,2017,46（23）：2875-2877.
11.Yahong Xu, Qian Jiang, Xuejing Guan, Mindong Chen, Lin Han, Rong Zhou. The effect of Ang/Tie2 pathway in the regulation of angiogenesis in the progress of early stage of diabetic nephrology. Shanxi drug medicine. 2017,46（23）：2875-2877. (Chinese core periodicals)
12.徐雅虹，蒋茜，王雅楠，曾洋，沈杰，周蓉.血清白细胞介素-6水平在慢性肾脏病病人中的变化及与糖尿病的相关性研究.蚌埠医学院学报，2017，42（6）:725-727.
13.Yahong Xu, Qian Jiang, Yanan Wang, Yang Zeng, Rong Zhou. The level of IL-6 in the patients of chronic kidney disease and its relationship with diabetic disease. BenBu medical college. 2017，42（6）:725-727. (Chinese core periodicals)
14.周蓉，陈希，徐雅虹.老年慢性肾病非血透患者骨代谢相关指标调查分析。中华老年医学杂志，2016,35(7):723-727.
15.Rong Zhou, Xi Chen, Yahong Xu. The investigation of metabolism of bone in the elder patients of chronic kidney disease without hemodialysis.Chinese Journal of Geriatrics. 2016,35(7):723-727. (Chinese core periodicals)
16.周蓉，徐雅虹，陈闽东等.N-乙酰半胱氨酸对醋酸铅致肾小管上皮细胞损伤的保护作用.中国中西医结合急救，2016,23(1):52-56 .
17.Rong Zhou, Yahong Xu, Mindong Chen. The prospective effect of NAC on the renal epithelial cells in the environment of lead. Chinese traditional Chinese and western medicine combined with first aid.2016,23(1):52-56. (Chinese core periodicals)
18.周蓉，陈希，徐雅虹等.泌尿道感染病原菌构成及其耐药性变迁.同济大学学报，2016.37(5):102-106
19.Rong Zhou, Xi Chen, Yahong. The spectrum of bacteria and drug resistance of urinary infection. Journal of Tongji University. 2016.37(5):102-106 (Chinese core periodicals)
20.冯雪芳，周蓉，徐雅虹等.两种血液净化方式治疗急性炎症反应综合征合并急性肾损伤.临床肾脏病杂志，2016,16（7）,427-431 .
21.Xuefang Feng, Rong Zhou , Yahong. The value of two ways of hemodialysis in the treatment of kidney injury induced by SIRS. Clinic Kidney Disease. 2016,16（7）,427-431 . (Chinese core periodicals)
22.沈杰，周蓉，徐雅虹.职业性铅接触人群肾损伤调查分析.上海预防医学，2016,82（11）：783-786
23.Jie Shen, Rong Zhou ,Yahong Xu. The investigation of kidney injury in the occupational people exposed to lead. Shanghai preventive medicine. 2016,82（11）：783-786 (Chinese core periodicals)
24.陈希，周蓉，陈闽东等.短期高频血液灌流联合血液透析对规律性血透患者皮肤瘙痒的疗效观察.中国血液净化，2015,14(2):97-99.
25.Xi Chen, Rong Zhou ,Mindong Chen. The clinical value of the new therapy of the combination of blood perfusion and hemodialysis on the treatment of pruritus of maintenance hemodialysis patients. Chinese Journal of Blood Purification.2015,14(2):97-99. (Chinese core periodicals)
26.沈杰，周蓉，蒋茜等.非布司他治疗慢性肾脏病4-5期合并高尿酸血症的有效性及安全性观察.世界临床药物，2015,36(11):763-7660.
27.Jie Shen, Rong Zhou, Qian Jiang. The safety and effectiveness of Febuxostat in the treatment of hyperuricemia of patients of chronic kidney disease stage 4-5. World Clinical Drugs.2015,36(11):763-7660. (Chinese core periodicals)
28.韩琳，周蓉，陈闽东等.血液透析患者临时中心静脉导管置管感染的相关因素分析.中国血液净化，2014,13(1):46-48.
29.Lin Han, Rong Zhou, Mindong. The analysis of influence factors of temporary central venous catheter infection in the hemodialysis patients. Chinese Journal of Blood Purification. 2014,13(1):46-48. (Chinese core periodicals)
参编专著2本：
Participated in 2 monograph:
《现代肾脏生理与临床》 林善炎主编
《Modern kidney physiology and clinical practice》 editorial director: Shanyan Lin
《全科医师临床诊断思路》 于德华主编
《The clinical thinking of general practioners》editorial director: Dehua Yu