修冰 副主任医师，副教授
硕士招生类型：专业型
硕士招生专业：内科学（血液病）
博士招生类型：无
博士招生专业：无
所在院系：附属同济医院
联系方式：Xiubing1233@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩


1. 淋巴瘤的发生发展机制研究。
2. 淋巴瘤的肿瘤微环境。
3. 淋巴瘤的免疫治疗。
1. The pathogenesisand progression of lymphoma.
2. The tumormicroenvironment of lymphoma.
3. The immunotherapy of lymphoma.



同济大学附属同济医院血液科副主任医师、讲师，美国mayo clinic血液中心访问研究员。现任中国抗癌协会血液学转化医学委员会青年委员，中华医学会上海分会血液学会秘书，上海市女医师协会血液学专业委员会委员，上海市医学会血液学专科分会第十届委员会淋巴瘤及骨髓瘤学组成员，上海市抗癌协会肿瘤科普和人文专业委员会会员，国家医师资格考试上海考区考官。


Associate chief physician of department ofHematology, lecturer，TongjiHospital, Tongji University, Visiting research fellow of mayo clinic.
Member of Shanghai Society of Hematology,Member of Shanghai Society of Hematology physicians.
Youth Member of Hematological ConversionMedical Committee of China Anti-cancer Association；
Secretary of Shanghai Society of Hematology ofChinese Medical Association；
Member of lymphoma and myeloma group of 10thcommittee of Shanghai Society of Hematology;
Member of tumor science and humanitiescommittee of Shanghai anti-cancer association;
National examiner of examination of doctors
主持及参与课题:
1. 国家自然基金青年科学基金项目**《活化T细胞核因子（NFAT）诱导PD-1/TIM-3调控淋巴瘤T细胞耗竭的机制研究》, 2017.01-2019.12,18万元，主持。
2. 上海市卫生局青年科研项目20124Y124《Tregs 细胞与PD-L1 在非霍奇金淋巴瘤中的作用》，2013.12-2015.12，2万元，主持。
3. 同济医院优秀学科杰出人才计划HBRC1802，2018.12-2020.12,20万元，主持。
4. 国家自然基金科学基金**《SENP1 介导的去类泛素化作用在淋巴瘤细胞白血病（LMCL）发病机制中的作用》，2010.1-2013.12，34万元，课题主要参与者。
5. 美国NIH LymphomaSpecialized Program of Research Excellence (SPORE)，P50CA097274-11CDA1，The role of Galectin-9in IL-12/TIM-3 -mediated T-cell exhaustion in B-cell non-Hodgkin lymphoma，07/01/2012- 06/30/2013，5万美金，课题主要参与者。
科技奖励：
1. 科研成果“附红细胞体病诊疗和研究体系的创新与应用”获2014年度上海市科技进步奖二等奖。
2. 科研成果“双相培养体系及分子标志物检测在正常核型急性白血病诊治中的作用”获2011年度教育部科技进步二等奖。
Grants:
1. The National Natural Science Fund, No.**, T cell exhaustionregulated by Nuclear Factor of Activated T cells via inducing PD-1 and TIM-3expression in lymphoma，2017.01-2019.12, RMB 180,000, Role: PI.
2. The Scientific Research Funds forYoung Scholars from Shanghai Municipal Public Health Bureau, 20124Y124,2013.12-2015.12, RMB 20,000,Role: PI.
3. Talent plan for excellent reservetalented person of Tongji hospital, HBRC1802，2018.12-2020.12, RMB 200,000, Role: PI.
4. The National Natural Science Fund, No.**, 2012/01-2014/12, RMB 340,000,The role of SENP1-mediatedubiquitination in the pathogenesis of lymphomacell leukemia (LMCL). 2010.1-2013.12, RMB340,000, Role: Participant.
5. NIH Lymphoma Specialized Program ofResearch Excellence (SPORE), P50CA097274-11CDA1,The role of Galectin-9in IL-12/TIM-3 -mediated T-cell exhaustion in B-cell non-Hodgkin lymphoma,07/01/2012- 06/30/2013,$50,000, Role:Participant.
Scientific Awards:
1. Theinnovation and application for the diagnosis and treatment and research systemfor Eperythrozoon disease, Shanghai scientific and technological progress,second prize, 2014
2. Roleof establishment of a biphase culture system and detection of moleculargenetics alterations in the diagnosis and treatment in acute leukemia patientswith normal karotype. The ministry of education of science and technologyprogress, second prize, 2010
代表论文（Publications，Full length, peer-reviewed, original articles）：
1. B Xiu, Y Lin, DM Grote, S C Ziesmer, M P Gustafson, M L Maas,Z Zhang, A B Dietz, L F Porrata, A J Novak, A-B Liang,Z-Z Yang,S M Ansell. IL-10 induces the development ofimmunosuppressive CD14+HLA-DRlow/? monocytes in B-cell non-Hodgkin lymphoma. BloodCancer Journal, (2015) 5, e328。
2. FangX^#, Xiu B^#, Yang Z, Qiu W, Zhang L, Zhang S, Wu Y,Zhu X, Chen X, Xie S, Yi X, Liang A, Zeng Y,The expression and clinicalrelevance of PD-1, PD-L1, and TP63in patients with diffuse large B-cell lymphoma,Medicine (Baltimore). 2017，96(15):e6398.
3. Xiu, Bing，Zhang, Wenjun，Huang,Binbin，Chen, Jingde，Lu, Huina，Fu, Jianfei，Xiong, Hong，Liang,Aibin，Genetic inhibition of vascularendothelial growth factor receptor-1 significantly inhibits the migration andproliferation of leukemia cells and increases their sensitivity to chemotherapy，ONCOLOGY REPORTS，2013，29（5）：2030-2038。
4. Zhi-ZhangYang，Deanna Grote，Bing Xiu，Steven C. Ziesmer，Tammy L. Price-Troska，Lucy S.Hodge，Danielle M. Yates，Anne J. Novak，Stephen Ansell.TGF-β upregulates CD70 expression and induces exhaustion of effectormemory T cells in B-cell non-Hodgkin