刘权焰 教授
硕士招生类型：学术型、专业型
硕士招生专业：外科学（普外科）
博士招生类型：学术型、专业型
博士招生专业：外科学（普外科）
所在院系：附属东方医院
联系方式：spss2005@126.com
课题组链接：
研究方向
主要任职
科研业绩

肝癌发生的表观遗传机制

Epigenetic mechanisms in hepatocellular carcinoma



同济大学东方医院肝胆胰外科主任
Directorof Hepatobiliary and Pancreatic Surgery, Dongfang Hospital of Tongji University




我目前重点研究集中在肝胆恶性肿瘤治疗效果的优化方案选择。同时，我的基础研究致力于发现HBV相关性肝癌发展的表观遗传分子机制。目前我已获得四个国家自然科学基金上面上项目的支持。
My key research, here at Dongfang hospital, has focused on investigating the optimizationof cancer treatment outcomes, in particular following hepatobiliary cancer surgery. And also, my researchworks toward discovering the epigenetic molecular mechanisms of HBV related hepatocellular Carcinoma development. I have presided four projects on the NationalNatural Science Foundation of China until now
Representative papers：
Guo T, Wang H, Liu P, Xiao Y, Wu P, Wang Y, Chen B, Zhao Q, Liu Z,LiuQ（通讯作者）. SNHG6 Actsas a Genome-Wide Hypomethylation Trigger via Coupling of miR-1297-MediatedS-Adenosylmethionine-Dependent Positive Feedback Loops. Cancer Res. 2018 Jul 15;78(14):3849-3864
Liu Q（通讯作者）.Upregulationof SNHG6 exhibits an oncogenic effect, regulating ZEB1 expression bycompetitively binding miR-101-3p and interacting with UPF1 in hepatocellularcarcinoma. Cancer Letters. 2016 Oct 1. pii: S0304-3835(16)30590-0. doi: 10.1016/j.canlet.2016.09.034
Bi Y, Yu G, Liu Q（通讯作者）. Glucocorticoid-induced S-adenosylmethionineEnhances the IFN Signaling Pathway by Restoring STAT1 Methylation in HepatitisB Virus Infected Cells. J Biol Chem. 2014Sep 30. pii: jbc.M114.589689

Liu Q, Liu L, Zhao Y, Zhang J, Wang D, Chen J, He Y, Wu J, ZhangZ, Liu Z Hypoxia inducesgenomic DNA demethylation through the activation of HIF-1{alpha} andtranscriptional up-regulation of MAT2A in hepatoma cells.Mol Cancer Ther; 2011; 10(6): 1113–23 PMID:**

Liu Q, Chen J, Liu L, Zhang J, Wang D, Ma L, He Y, Liu Y, Liu Z, WuJ.The X Protein ofHepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing theMethionine Adenosyltransferase 2A Gene Expression and ReducingS-Adenosylmethionine Production. J Biol Chem.2011 May 13;286(19):17168-80.