权明 讲师，主治医师
硕士招生类型：学术型
硕士招生专业：肿瘤学
博士招生类型：无
博士招生专业：无
所在院系：附属东方医院
联系方式：mquan@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

消化道肿瘤的基础、转化及临床研究The basic, transformation and clinical study of digestive tract tumor
/
承担课题:1.2020.01~2023.12 濒死细胞通过Caspases调控Hippo信号通路促进胰腺癌放化疗后再增殖的机制研究（国家自然科学基金面上项目，项目批准号：**，资助额度：55万）在研，主持
2.2016.01 ~ 2018.12 Merlin/FoxM1 信号轴在PanIN恶性转化中的作用及机制（国家自然科学基金青年项目，项目批准号：**，资助额度：18万）已结题，主持
3.2019.07~2022.06 MSI1-Hippo信号轴调控胃癌干性特征的机制研究 （上海市自然科学基金，项目批准号：19ZR**，资助额度：20万）在研，主持
4.2019年入选上海市医苑新星青年医学人才培养计划，项目批准号：yyxx201901，10万，在研，主持
Grant:1.National Natural Science Foundation of China, No.**, machanism of Dying cells stimulate repopulation of pancreatic cancer cells via Caspases regulating Hippo pathway during Radiotherapy and chemotherapy, 2020.01~2023.12, 550000.
2.National Natural Science Foundation of China, No.**, The Critical Role and Mechanism of Merlin/FoxM1 during the Malignant Transformation from PanIN to Pancreatic Cancer, 2016.01 ~ 2018.12, 180000.
3.Shanghai natural science fund, No. 19ZR**, The mechanism of MSI1-Hippo signal axis regulating the Stem cell properties of gastric cancer, 2019.07~2022.06, 200000.
4.Shanghai “Rising Stars of Medical Talent” Youth Development Program, No.yyxx201901, 202001~202212. 100000.
发表论文（published paper）1.Liu S, Huang M, Chen Z, Chen J, Chao Q, Yin X, Quan M（Corresponding author/通讯作者）. FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13. Exp Cell Res. 2020 Feb 6:111894. doi: 10.1016/j.yexcr.2020.111894. [Epub ahead of print]（IF：3.383）
2.Quan M, Chen Z, Jiao F, Xiao X, Xia Q, Chen J, Chao Q, Li Y, Gao Y, Yang H, Wang L, Cui J. Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression. J Exp Clin Cancer Res. 2020 Jan 15;39(1):13. doi: 10.1186/s13046-019-1489-0.（IF：7.068）
3.Xie D, Yu S, Li L, Quan M（Co-Corresponding author/通讯作者）, Gao Y. The FOXM1/ATX signaling contributes to pancreatic cancer development. Am J Transl Res. 2020 Aug 15;12(8):4478-4487. eCollection 2020. （IF：3.375）
4.Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, Quan M（Co-Corresponding author/通讯作者）, Wang L.RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. Med Oncol. 2020 Aug 11;37(9):84. doi: 10.1007/s12032-020-01384-8. （IF：2.834）
5.Chen J, Quan M(Co-First author/共同第一作者), Chen Z, Zeng T, Li Y, Zhou Y, Hai Y, Gao Y. Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial. J Cancer Res Clin Oncol. 2020 Oct;146(10):2651-2657. doi: 10.1007/s00432-020-03251-5. Epub 2020 Jul 4. （IF：3.656）
6.Cui J, Quan M(Co-First/Corresponding author/共同第一/通讯作者), Xie D, Gao Y, Guha S, Fallon MB, Chen J, Xie K. A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Oncogene. 2020 Jan;39(5):1140-1151. doi: 10.1038/s41388-019-1051-8. Epub 2019 Oct 22. （IF：7.971）
7.Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, Wang L, Chen J, Quan M(Corresponding author/通讯作者). MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Mol Cancer Res. 2019 Jun;17(6):1316-1325. doi: 10.1158/1541-7786.MCR-18-0910. Epub 2019 Feb 22.（IF：4.63）
8.Guo K, Cui J, Quan M(Co-First author/共同第一作者),Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K.A novel KLF4-MSI2 signaling pathway regulates growth and metastasis of pancreatic cancer.Clin Cancer Res. 2017 Feb 1;23(3):687-696. (IF: 10.107)
9.Ming Quan,Jiu-jie Cui, Xiao Feng, Qian Huang. The Critical Role and Potential Target of the ATX/LPA Axis in Pancreatic Cancer. Tumor Biology2017 Mar;39(3):94544. doi: 10.1177/94544.
10.Jiujie Cui,Tian Xia, DachengXie, Yong Gao, ZhiliangJia, Daoyan Wei, Liang Wang, Suyun Huang, Ming Quan（Co-Corresponding author/共同通讯作者）, KepingXie. HGF/Met and FoxM1 form a positive feedback loop and render pancreatic cancer cells proliferation to Met inhibition and aggressive phenotypes. Oncogene. 2016 Sep 8;35(36):4708-18 (IF:7.971)
11.Quan M ,Jiujie Cui, Tian Xia, ZhiliangJia, DachengXie, Daoyan Wei, SuyunHuang, Qian Huang, Shaojiang Zheng, KepingXie. Merlin/NF2 Suppresses Pancreatic Cancer Growth and Metastasis by Attenuating FOXM1-mediated Wnt/β-Catenin Signaling Pathway.Cancer Res. 2015 Nov 15;75(22):4778-89.( IF: 9.727)
12.DachengXie, Jiujie Cui, Tian Xia, ZhiliangJia, Liang Wang, Wenfei Wei, Anna Zhu, Yong Gao, KepingXie, Ming Quan（Corresponding author/通讯作者）.Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression. Oncotarget, 2015 Nov 3;6(34):35949-63. (2015 IF: 6.359)
13.Jiujie Cui, Ming Quan(Co-First author/第一作者), Weihua Jiang, Hai Hu, Feng Jiao,Ning Li, ZiliangJin, Lei Wang, Yu Wang, Liwei Wang. Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype. Medical Oncology, 2015, 32:143 DOI: 10.1007/s12032-015-0589-8. （IF：2.834）
14.Quan M , Wang P, Cui J, Gao Y, Xie K. The roles of FOXM1 in pancreatic stem cells and carcinogenesis.Mol Cancer. 2013 Dec 10;12:159. doi: 10.1186/1476-4598-12-159 (IF: 15.302)