李觉 教授
硕士招生类型：学术型
硕士招生专业：公共卫生与预防医学
博士招生类型：学术型
博士招生专业：临床医学（流行病与卫生统计学）
所在院系：医学院
联系方式：jueli@tongji.edu.cn
课题组链接：http://202.120.165.73/ktz/Group.aspx?id=43
研究方向
主要任职
科研业绩
（1）临床流行病学；
（2）营养与代谢流行病学；
（3）健康与疾病管理。
1982年12月毕业于南京中医药大学。1993年4月赴日本国留学，先后取得日本筑波大学健康教育学硕士学位和日本山梨医科大学预防医学博士学位。现为中国医师协会心血管分会委员，教育部高校教学指导委员会（预防医学）委员，上海市预防医学会理事，上海医学会临床流行病学专委会委员，上海市学位委员会学科评议组专家，中国医师协会代谢与血管生物学研究会秘书长，中国医师协会健康巡讲团专家，中国医师协会心血管专家共识委员会专家。同济大学教学名师。
在Euro Heart J、J Hypertens、JVS、Stroke、PLoS ONE、Nutrition、Metabolism、Circulation J、等SCI收录的国际刊物上发表了论文50余篇。并在中华心血管病杂志、中华医学杂志、中华内科杂志、中华流行病学杂志、中华预防医学杂志、中华老年医学杂志、中华内分泌代谢杂志等发表论文40余篇。
“天然谷物纤维的提取方法与用途”获国家发明专利（专利号：ZL32）。
共同编译《外周动脉疾病诊治指南》，副主编《冠心病现代治疗学》，参编国家级继续医学教育项目教材《心血管病学—第二辑》、《心血管疾病防治指南和共识2008》和参译《赫斯特心脏病学》。
主持和承担的研究项目主要有：1）日本厚生劳动省重点项目：（**）“过劳、应激与心血管疾病相关性研究”。（中方负责人，1400万日元，2010.06-2013.05）2）国家自然基金面上项目（**）：“中心动脉压与肱动脉压非一致性及无创检测的效度研究”（负责人，50万元，2012.01-2015.12）。3）国家科技部国际合作计划（2011DFB30010）：“干细胞治疗的基础与临床前研究及产品研发”（骨干，30/2040万2011.01-2013.12）。4) 国家科技部“973”项目：(2013CB531100)“心律失常与心力衰竭的基础与临床”，（骨干，60/3800万,2013.01-2015.12项目名称：The study of mechanisms of cardiac arrhythmia occurence and intervention the National Key Basic Research Program of China （toYi-Han Chen) 项目编号：2013CB531100）5）上海市卫生系统重要疾病联合攻关重大项目（2013ZYJB0902）：第二负责人，150万，2014.01-2016.12。
获奖：
1.“我国农村高血压流行趋势及低成本综合干预预防脑卒中研究” 获2010年获国家科技进步二等奖（5）。
2.“临床医学专业的社区预防医学基地建设探索。”获2009年上海市级教学成果奖三等奖（1）。
3.“辽宁省农村高血压流行趋势及低成本综合干预预防脑卒中研究”获2008年辽宁省一等奖（5）和中华医学二等奖（5）。
4.“踝臂指数诊断外周动脉疾病的敏感度及特异度研究” 获2008年中华医学老年医学分会一等奖（1）。
5. 第四届同济大学教学名师奖（2009）。
6. 结合预防医学教改探讨社区医学教学基地建设。同济大学2006年教学成果一等奖。
7. 指导本科生“食物频度问卷及国际体力活动问卷的信都效度研究”获同济大学第二期大学生创新实践计划(SITP-Ⅱ,2009年)一等奖。
8. 指导本科生论文“口罩小学问大”获上海慈善基金会2008年“唯爱天使杯”医学科普大赛入围奖。
主要发表论文
1. Lijuan Zhang, Yan Bao, Yimin Liu, Jue Li*. Downregulation of Nuclear Respiratory Factor-1
Contributes to Mitochondrial Events Induced byBenzo(a)pyrene. Environ Toxicol .29: 780–7, 2014
2. L Zhang, H Sang, Y Liu, Jue Li*. Manganese activates caspase-9-dependent apoptosis in human bronchial epithelial cells. Human and Experimental Toxicology. 32(11) 1155–1163, 2013
3. Jie Zhang*, Li Li, Luying Peng, Yingxian Sun, Jue Li*.An Efficient Weighted Graph Strategy to Identify Differentiation Associated Genes in Embryonic Stem Cells. PLoS ONE 8(4): e62716. 2013
4. Dachun Xu, Wei Chen, Xiankai Li, Yi Zhang, Xin Li, Hou Lei, Yidong Wei, Weiming Li,Dayi Hu, Nicole M. Wedick, Jinsong Wang, Yawei Xu, Jue Li*, Yunsheng Ma. Factors Associated with Blood Pressure Control in Hypertensive Patients with Coronary Heart Disease: Evidence from the Chinese Cholesterol Education Program. PLOS ONE. 8, e63135, 2013
5. Dachun Xu, Liling Zou, Yan Xing, Lei Hou, Yidong Wei, Ji Zhang, Yongxia Qiao, Dayi Hu, Yawei Xu, Jue Li*, Yunsheng Ma. Diagnostic Value of Ankle-Brachial Index in PeripheralArterial Disease: A Meta-Analysis. Canadian Journal of Cardiology. 29: 492-8, 2013
6. Guo Q, Zheng RJ, Zhu CT, Zou LL, Xiu JF, Jue Li*, Hu ZY. Pyrosequencing for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis: a meta-analysis. Int J Tuberc Lung Dis. 17(8):1008-13, 2013
7. Lezhou Wu, Lijuan Zhang, Zisheng Ai, Liling Zou, Yun Zhu, Yan Bao, Jun Li, Sheng Kang, Huimin Fan, Daifu Zhang, Lieying Fan, Zhongmin Liu, Jue Li*. Association between risk factors and left ventricularremodeling inmiddle-aged and aged population:a community-based study. J Hypertens 30:1862-73, 2012
8. Yan Cang , Jue Li*, Yuan-min Li , Yun Zhou, Yue-zhou Wu , Xian-kai Li , Chao-fan Wang , Hai-yan Yang, Ya-wei Xu. Relationship of a Low Ankle-brachial Index with All-causeMortality and Cardiovascular Mortality in Chinese Patients with Metabolic Syndrome after a 6-Year Follow-up: A Chinese Prospective Cohort Study. Internal medicine.51:452–7, 2012
9. Hao Sang , Lijuan Zhang , Jue Li*. Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrialpathway in human bronchiolar epithelium cells independent of the mitochondria permeability transition pore. Food and Chemical Toxicology. 50 : 2417–2423,2012
10. Lezhou Wu, Yong Wang, Liqiang Zheng, Jue Li* Dayi Hu, Yawei Xu, B Hasimu, Hong Yuan, Jingang Yang, Yinxian Sun, Yuansheng Ma. Distribution of brachial-ankle pulse wave velocity values and optimal cut-off in distinguishing subjects with clinical condition in Chinese Population. International Angiology. 31:252-259, 2012
11. Yongxia Qiao, Jing Wang , Jue Li, et al. Eff ects of depressive and anxiety symptoms during pregnancy on pregnant, obstetric and neonatal outcomes: A follow-up study. Journal of Obstetrics and Gynaecology. 32: 237–240, 2012
12. Lijuan Zhang, Yan Bao, Jue Li*. Nuclear Respiratory Factor-1 is Involved in Mitochondrial Dysfunction Induced by Benzo(a)pyrene in Human Bronchial Epithelial Cells. Basic & Clinical Pharmacology & Toxicology. 109:115-122, 2011
13. Yong Wang , Jue Li*, X Guo , Dongdong Zhao, Dayi Hu , Yidong Wei , L Hou , Y Xu , Y Ma . A U-shaped relationship between ankle-brachial index and carotid intima-media thickness in a Chinese population of inner Mongolia.Int Angiol. 30(5): 451-7 ,2011 (Co-first authors)
14. Zi-Sheng Ai, Jue Li, Zhong-Min Liu, Hui-Min Fan, Dai-Fu Zhang,Yun Zhu, Li-Juan Zhang, Wen-Qing Zhu1 and Yan Bao. Reference value of brachial-ankle pulse wave velocity for the eastern Chinese population and potential influencing factors. Brazilian Journal of Medical and Biological Research 44: 1000-1005, 2011.
15. Xiaofan Guo, Liling Zou, Xingang Zhang, Jue Li*, Liqiang Zheng, Zhaoqing Sun, Jian Hu,Nathan D Wong, Yingxian Sun. Prehypertension. A Meta-Analysis of the Epidemiology, Riek Factors, and Predictors of Progression.Texas Heart Institute Journal. 38:643-52, 2011
16. Y. Wang, Y. Xu, Jue Li*, Y. Wei, D. Zhao, L. Hou, B. Hasimu, J. Yang, H. Yuan and D. Hu.Characteristics of prevalence in peripheral arterial disease and correlative risk factors and comorbidities among female natural population in China. Int Angiol. 39: 305–311,2010
17. Dachun Xu, Jue Li*Liling Zou, Yawei Xu,Dayi Hu,Sherry L Pagoto and Yunsheng Ma.Sensitivity and specificity of the ankle–brachialindex to diagnose peripheral artery disease: a structured review. VMJ. 15:361-369, 2010
18. Yingyi Luo, Xiankai Li, Jue Li*, Xiaoming Wang, Yongxia Qiao, Dayi Hu, Philip A. Merriam, MSPH and Yunsheng Ma. Combined effects of smoking and peripheral arterial disease on all-cause and cardiovascular disease mortality in a Chinese male cohort.JVS. 51:673-678, 2010
19. Xiankai Li,Yingyi Luo,Yawei Xu, Jue Li* and Dayi Hu. Relationship of Ankle-brachial Index with All- cause Mortality and Cardiovascular Mortality after 3 years Follow up：The China Ankle-brachial Index Cohort Study.JHH.24:111-116, 2010
20. Yingyi Luo, Xiankai Li, Jue Li*, Xiaoming Wang, Yongxia Qiao, Dayi Hu, and Yunsheng Ma..Peripheral Arterial Disease, Chronic Kidney Disease, and Mortality:The Chinese ankle brachial index cohort study.VMJ. 15:107-112, 2010
21. Yong-quan Wu, Jue Li*, Yuan-xi Xu, et al. Predictive value of serum uric acid on cardiovascular disease and all-cause mortality in urban Chinese patients. Chinese Medical Journal 123:1387-1391,2010
22. Sheng Kang, Hui-Min Fan, Jue Li, Lie-Ying Fan, Ai-Yu Miao, Yan Bao, Le-Zhou Wu, Yun Zhu, Dai-Fu Zhang1, and Zhong-Min Liu. Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population. European Heart Journal 31, 2799–2807,2010
23. Jue Li, Yingyi Luo, Yawei Xu, Jingang Yang, Buaijiaer Hasimu, Liqiang Zheng, Jinming, Yu, Dayi Hu. Risk Factors of Peripheral Arterial Disease and Relationship between Low Ankle Brachial Index and Mortality from All-cause and Cardiovascular Disease in Chinese Patients with Type 2 Diabetes. Circulation J. 71:377-381, 2007
24. Jue Li, Buaijiaer Hasimu, Jingming Yu, Jing Wang, Dayi Hu. Prevalence of Peripheral Arterial Disease and Risk Factors for the Low and High Ankle-Brachial Index in Chinese Patients with Type 2 Diabetes. Journal of Health Science 52: 97-102, 2006
25. Jue Li, Jing Wang, Takashi Kaneko, Li-Qiang Qin, Akio Sato. Effects of fiber on th intake e blood pressure, lipids and heart rate in Goto Kakizaki rats. Nutrition 20:1003-1007, 2004
26. Jue Li, Takashi Kaneko, Li-Qiang Qin, Jing Wang, Yuan Wang, Akio Sato. Long-term effects of high dietary fiber intake on glucose tolerance and lipid metabolism in GK rats: Comparison among barley, rice, and corn-starch.Metabolism 52: 1206-1210, 2003
27. Jue Li, Takashi Kaneko, Li-Qiang Qin, Jing Wang, Yuan Wang. Effects of barley intake on the glucose tolerance, lipid metabolism and bowel function in women. Nutrition 19: 936-929, 2003
28. Jue Li, Takashi Kaneko, Yuan Wang, Jing Wang, Li-Qiang Qin, Akio Sato. Effect of aging on the development of glucose intolerance induced by a low-carbohydrate diet in rats. Journal of Health Science 49: 348-352, 2003
29. Jue Li, Takashi Kaneko, Yuan Wang, et al. Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats. Toxicology 176:91, 2002
30. Jue Li, Takashi Kaneko, Yuan Wang, et al. Effects of Dietary Fiber on the Glucose Tolerance in Spontaneously Diabetic Rats. Japanese Journal of Hygiene 58:281-286, 2003
31. Yingyi Luo, Jue Li, Yan Xin Liqiang Zheng, Jinming, Yu, Dayi Hu. Risk Factors of Peripheral Arterial Disease and Relationship between Low Ankle Brachial Index and Mortality from All-cause and Cardiovascular Disease in Chinese Patients with Hypertension. JHH. 21:461-466, 2007(Co-first authors)
32. 27. Yuanxi Xu, Jue Li, Yingyi Luo, Yongquan Wu, Liqiang Zheng, Jinming, Yu, Jun Ma, Jianyun Gu, Dayi Hu. The Association between Ankle-Brachial Index and Cardiovascular or All-cause Mortality in Metabolic Syndrome of Elderly Chinese. Hypertens Res. 30:613-619, 2007 (Co-first authors)
33. 28. Xiaoming Guo, Jue Li, Wenyue Pang, Mingzhong Zhao, Yingyi Luo, Yingxian Sun, Dayi Hu. Sensitivity and Specificity of Ankle-Brachial Index for Detecting Angiographic Stenosis of Peripheral Arteries. Circulation J. 72:605-610，2008 (Co-first authors)
34. 29. Dayi Hu, Jue Li, Xiankai. Investigation of Blood Lipid Levels and Statin Interventions in Outpatients With Coronary Heart Disease in
35. 30. Liqiang Zheng, Zhaoqing Sun, Jue Li, et al. Pulse Pressure and Mean Arterial Pressure in Relation to Ischemic Stroke Among Patients With Uncontrolled Hypertension in Rural Areas of
36. 31. Buaijiaer Hasimu, Jue Li, et al. Estimation of Medical Treatment for Peripheral Arterial Disease in Chinese High -Risk Patients。Circulation J. 71:95-99，2007
37. 32. Xiankai Li, Jue Li, Thach Nguyen, Mingzhong Zhao, Liqiang Zheng, Buaijiaer Hasimu, Jinming Yu, Yingyi Luo, Dayi Hu. Effect of Statins and Calcium Channel Blockers on All-cause Mortality and Cardiovascular and Cerebrovascular Disease Mortality in 958 Chinese Hospitalized Patients with Peripheral Arterial Disease after 13 Months of Follow-up. J.Health.Sic. 53:226-233, 2007
38. 33. Liqiang Zheng, Jue Li, et al. Differential Control of Systolic and Diastolic Blood Pressure: Factors Associated With Lack of Blood Pressure Control in Rural Community of
39. Buaijiaer Hasimu, Jue Li, et al. Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk. Hypertens Res. 29:23-28, 2006
40. LiQiang Qin, Jue Li, et al. The effects of nocturnal life on endocrine circadian patterns in healthy adults. Life Sciences 73:2467-2475, 2003
41. LiQiang Qin, Jue Li, et al. Effect of repeated intake of disaccharides and insulin secretion in healthy adults-comparison between sucrose and maltose. J.Health.Sic.49:226-228, 2003
42. Liqiang Zheng, Jue Li, Dayi Hu, , , et al. Association of low ankle-brachial index with mortality in patients with ischemic heart disease. Journal Atherosclerosis and Thrombosis. 17:759-67,2010
43. Jingang Yang , Jue Li , C Lu , B Hasimu , Y Yang , Dayi Hu .Chronic kidney disease, all-cause mortality and cardiovascular mortality among Chinese patients with established cardiovascular disease. Journal Atherosclerosis and Thrombosis. 17:395-401, 2010
44. Xiankai Li, Yawei Xu, Jue Li, Dayi Hu. The Gender Differences in Baseline Characters and Statins Intervention among Outpatients with Coronary Heart Disease in China: the China. Cholesterol Education Program (CCEP). Clin Cardiol. 2009;32(6):308-314.
45. LiQiang Qin, Takashi Kaneko, Jue Li, et al. The Effect of Nocturnal Life on the Circadian Patterns of Sex Hormones in Young Healthy Men. J.Health.Sic.51:33-40, 2005
46. C Xu, Z Sun, L Zheng, D Zhang, Jue Li, et al. Prevalence of and Risk Factors for Isolated Systolic Hypertension in the Rural Adult Population of
47. Zhaoqing Sun, Liqiang Zheng, Robert Detrano, Dayi Zhang, Xingang Zhang, Changlu Xu, Jue Li, et al. The Accelerating Epidemic of Hypertension Among Rural Chinese Women: Results From
48. Xingang Zhang, Zhaoqing Sun, Xinzhong Zhang, Liqiang Zheng, Shuangshuang Liu, Changlu Xu, Jiajin Li, Fenfen Zhao, Jue Li, et al. Prevalence and Associated Factors of Overweight and Obesity in Chinese Rural Population. Obesity.16:168-171, 2008
49. Xingang Zhang, Zhaoqing Sun, Xinzhong Zhang, Liqiang Zheng, Shuangshuang Liu, Changlu Xu, Jiajin Li, Fenfen Zhao, Jue Li, et al. Gender differences in blood lipids and the the risk of ischemic stroke among the hypertensive adults in rural
50. Wenyue Pang, Zhaoqing Sun, Liqiang Zheng, Jue Li, et al. Body Mass Index and the Prevalence of Prehypertension and Hypertension in a Chinese Rural Population. Inter Med. 47：893-897，2008
51. LiQiang Qin, PeiYu Wang, Jiaying Xu, Jue Li, et al. The effects of commercial whole milk on the prostate carcinogenesis in rets with or without induction by 2-amino-1-methyl-6 phenylimidazo[4,5-b]pyridine.J.Health.Sic.52:419-424, 2006
52. Yuan Wang, Yoshikazu Miura, Takashi Kaneko, Jue Li, et al. Glucose intolerance induced by a high-fat/low-carbohydrate diet in rats. Endocrine 17:185-191, 2002
53. LiQiang Qin, JiaYing Xu, PeiYu Wang, Dav Ganmaa, Jue Li, et al. Low-Fat Milk Promotes the Development of 7,12Dimethy(A) Anthracene(DMBA)-Induced Mammary tumors in Rats. Int J. Cancer. 110:491-496, 2004
54. Xingang Zhang, Zhaoqing Sun, Liqiang Zheng, Jue Li, et al. Prevalence of Dyslipidemia and Associated Among the Hypertensive Rural Chinese Population. Archives of medical Research 38;432-439, 2007
55. Zhaoqing Sun, Xingang Zhang, Yidong Wei, Jue Li, et al. Prevalence and Factors of the Rural Adult People Prehypertension Status in Liaoning Province of
56. Zhaoqing Sun, Xingang Zhang, Yidong Wei, Jue Li, et al. The Prevalence of Prehypertension and Hypertension Among Rural Adults in Liaoning Province of
57. .Hao Liu, Jinming Yu, Fang Chen, Jue Li, Dayi Hu. Inpatients with heart disease have a high prevalence of chronic kidney disease based on estimated glomerular filtration rate (eGFR) in
58. Zhang X, Sun Z, Zhang X, Zheng L, Jue Li, et al. Prevalence of Metabolic Syndrome in Han and Mongolian Rural Population with Hypertension. The Journal International Medical Research 35:597-599,2007
59. Liqiang Zheng, Zhaoqing Sun, Jue Li, et al. Mean Arterial Pressure: A Better Marker of Stroke in Patients with Uncontrolled Hypertension in Rural Areas of
