陈炳地 副研究员
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：学术型
博士招生专业：临床医学（生物医学方向）
所在院系：医学院（纳米院）
联系方式：Inanochen@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩


1.肿瘤液体活检：循环肿瘤细胞（CTC）、循环肿瘤DNA（ctDNA）、外泌体的检测纳米技术研发；
2. 癌症康复治疗：针对癌症常规治疗之后的营养、情绪、免疫系统等康复治疗研究；
3.肿瘤靶向影像： MRI、CT、超声、荧光成像等多模态医学影像造影剂的构建及靶向诊断研究。




上海市卫计委优秀青年医学人才；
同济大学青年岗位能手；
同济大学青年优秀人才培养对象；
全国卫生产业企业管理协会转化医学专家委员会委；
全国抗衰老协会肿瘤风险评估与系统康复专委会委员；
中国抗癌协会肿瘤标志物委员会CTC专家委员会委员；
中国微循环学会转化医学专业委员会青年委员；
白求恩精神研究会检验医学分会理事；
国家/上海市大学生创新计划指导教师；
福建省引才“****”专家



2005年于吉林大学获学士学位，2005-2010在浙江大学硕博连读，师从著名半导体专家阙端麟院士和杨德仁院士；2010年获博士学位，同年进入同济大学，2014年晋升为副教授，博士生导师。进入同济大学以来，与海外****、美籍华人科学家崔征教授合作，在全世界首创粒细胞抗癌疗法。通过医工交叉，结合纳米技术，开展癌症的诊断、治疗、康复研究。目前在癌症检测、粒细胞抗癌免疫治疗、营养抗癌等方向已取得突破性进展。部分科研项目已进入临床转化阶段，并获得福建省****、福建海峡人才计划等支持。
作为项目负责人承担十余项国家及省部级科研项目，包括国家自然科学基金面上项目、青年项目、教育部博士点基金、上海市科委生物医药科技支撑项目、上海市科委西医引导项目、上海市卫计委优青计划、中国博士后科学基金特别资助和面上资助项目、同济大学青年优秀人才培养行动计划项目等。同时作为主要研究人员参与国家973 项目、****项目、国家863 项目等多项国家级项目的研究。作为第一作者或通信作者在Advanced Materials(IF=25.809)、ACS Nano（IF=13.903）、Nano Research(IF=8.515)、Theranostics（IF=8.063）等国际知名学术期刊发表论文50 余篇，平均影响因子5.13，总引用次数超过1900次，H-index达到19。申请国家发明专利 8 项，已授权 5项。
主持项目：
1.国家自然科学基金面上项目：批准号：**；基于癌细胞表面电荷特性的循环肿瘤细胞高效捕获与无损释放纳米技术在临床诊断中的应用研究；起止时间：2018/01~2021/12
2.上海市科委生物医药科技支撑项目：批准号：**；基于新型纳米技术的循环肿瘤细胞检测试剂盒的研发；起止时间：2018/04~2021/06
3.上海市卫计委优秀青年医学人才计划：批准号：2017YQ051；新型循环肿瘤细胞检测纳米技术在临床诊断中的应用研究；起止时间：2017/07~2020/06
4.上海市科委西医引导项目：批准号：**；基于癌细胞表面电荷特性的新型循环肿瘤细胞检测技术在临床诊断中的应用研究；起止时间：2017/06~2020/06
5.国家自然科学基金青年项目：批准号：**；新型单壁碳纳米管集成系统在乳腺癌诊疗中的应用基础研究；起止时间：2013/01~2016/12
6.教育部博士点基金：批准号：20**9；新型单壁碳纳米管集成系统在乳腺癌诊疗中的应用基础研究；起止时间：2014/01~2016/12
7.上海市卫计委青年科研项目：批准号：20144Y0248；用于循环肿瘤细胞快速灵敏检测的多功能纳米试剂盒的研发；起止时间：2015/01~2017/12
8.硅材料国家重点实验室开放课题：批准号：SKL2014-11；基于微/纳复合结构的新型柔性纤维状光伏器件的构筑及应用研究；起止时间：2014/08~2016/07
9.同济大学青年优秀人才培养计划：批准号：2012KJ022；基于新型非对称纳米结构的痕量肿瘤细胞检测方法研究；起止时间：2012/12~2014/12
10.中国博士后基金特别资助：批准号：2012T50435；基于新型非对称纳米结构的痕量肿瘤细胞检测方法研究；起止时间：2012/06~2013/06
11：中国博士后基金面上项目：批准号：；基于单壁碳纳米管的纳米集成系统的构建及其在乳腺癌诊疗中的应用研究；起止时间：2010/12~2012/12
代表性论文：
1. M. L. Wu, W. J. Le, T. X.Mei, Y. C. Wang, B. D. Chen*, Z. M. Liu, C. Y. Xue*, Cellmembrane camouflaged nanoparticles: a new biomimetic platform for cancerphotothermal therapy. International Journal ofNanomedicine 2019, 14:4431-4448 (IF=4.471)
2. X. Huang, W. J. Le, Q. Chen,J. Y. Chen, Y. Q. Zhu, D. L. Shi, B. D. Chen* , Z. Cui*, Suppressionof the innate cancer-killing activity in human granulocytes by stress reactionas a possible mechanism for affecting cancer development. Stress2019, DOI: 10.1080/**. 2019.**. (IF=2.168)
3. W. J. Le, B. D. Chen, Z. Cui, Z.M. Liu*, D. L. Shi*, Detection of cancer cells based on glycolytic-regulatedsurface electrical charges. Biophysics Reports 2019,5, 1:10-18
4. 朱欢欢，李晓峰，朱晋峰，黄鑫，何奇，陈炳地，曹玮，基于氧化石墨烯/金纳米棒的表面增强拉曼散色技术检测循环肿瘤细胞。第二军医大学学报，2019，40（6）：643-650.
5. B. B. Zhang,W. Yan, Y. J. Zhu, W.T. Yang, W. J. Le, B.D. Chen*, R. R. Zhu*, L. M. Cheng*,Nanomaterials in Neural‐Stem‐Cell‐MediatedRegenerative Medicine: Imaging and Treatment of Neurological Diseases. AdvancedMaterials 2018, 30, ** (IF=25.809)
6. X. Huang, C. Q. Fan, H. H. Zhu, W. J. Le, S. B. Cui,X. Chen, W. Li, F. Zhang, Y. Huang, D. L. Shi, Z. Cui, C. W. Shao*, B. D. Chen*,Glypican-1-antibody-conjugated Gd–Au nanoclusters for FI/MRI dual-modaltargeted detection of pancreatic cancer. International Journal ofNanomedicine 2018, 13:2585-2599 (IF=4.471)
7. Y. L. Tang, L. F. Dong, S. Mao, H. B. Gu, T.Malkoske, B. D. Chen*, Enhanced Photocatalytic Removal of Tetrabromobisphenol A by MagneticCoO@graphene Nanocomposites under Visible-Light Irradiation. ACS AppliedEnergy Materials 2018, 1, 2698-2708
8. W. J. Le, B. D. Chen,, D. Maharaj, Z.Cui*, Natural cancer-killing activity of human granulocytes. IntegrativeCancer Science and Therapeutics 2018, 5, 1-7
9. B. M. Sun, J. Wu, S. B. Cui, H. H. Zhu, W. An, Q. Fu, C. W. Shao, A. H. Yao*, B. D. Chen*, D. L. Shi, In Situ Synthesis of GrapheneOxide/Gold Nanorods Theranostic Hybrids for Efficient Tumor CT Imaging andPhotothermal Therapy. Nano Research 2017, 10(1):37-48 (IF=8.515)
10. X. Chen, H. H. Zhu, X. Huang, P. S. Wang, F. L.Zhang, W. Li, G. Chen*, B.D. Chen*, Novel iodinated gold nanoclusters for precise diagnosis ofthyroid cancer. Nanoscale,2017, 9(6): 2219-2231(IF=6.97)
11. B. D. Chen, W.J. Le, Y. L. Wang, Z. Q. Li, D. Wang, L. Lin, S. B. Cui, J. J. Hu, Y. H. Hu, P. Y. Yang, R. C. Ewing, D. L. Shi*,Z. Cui* Targeting Negative Surface Charges of Cancer Cells by MultifunctionalNanoprobes. Theranostics 2016, 6, 11:1887-1898 (IF=8.063)
12. W. J. Le, S. B. Cui, B. M. Sun, Z. Cui, B.D. Chen*, Non-invasive in vivo targeting human pancreatic cancer bymagnetic resonance imaging. Nanomedicine: Nanotechnology, Biology,and Medicine, 2016, 12(2):529-530 (IF=5.57)
13. F. Liu^#, W. J. Le^#, T. X. Mei,T. G. Wang, L. G. Chen, Y. Lei, S. B. Cui, B. D. Chen*, Z.Cui, C. W. Shao*, In vitro and in vivo targeting imaging of pancreatic cancerusing a Fe₃O₄ @SiO₂ nanoprobemodified with anti-mesothelin antibody. International Journal ofNanomedicine, 2016, 11:2195-2207 (IF=4.471)
14. W. J. Le^#, S. B. Cui^#, X.Chen, H. H. Zhu, B. D. Chen*, Z. Cui*, Facile Synthesis ofGd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents. Nanomaterials,2016, 6(4):65 (IF=4.034)
15. Y. L. Tang, J. L. Tian, M. Tyler, W. J. Le, B.D. Chen*. Facile ultrasonic synthesis of novel zinc sulfide/carbonnanotubes coaxial nanocables for enhanced photodegradation of Methyl Orange. Journalof Materials Science,2017, 52(3):1581-1589 (IF=3.442)
16. C. X. Peng^#, B. D. Chen^#,Y. Qin, S. H. Yang, S. L. Liu and J. F. Yang, Facile ultrasonic synthesis ofCoO quantum dot/Graphene nanosheet composites with high lithium storagecapacity, ACS Nano, 2012, 6(2): 1074-1081 (Co-FirstAuthor). (IF=13.903) (ESI)
17. B. D. Chen, H. Zhang, C. X. Zhai,N. Du, C. Sun, J. X. Xue, D. R. Yang, H. Huang, B. Zhang, Q. P. Xie and Y. L.Wu, Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficientcontrast agents for multimodal cellular, J. Mater. Chem., 2010,20(44): 9895-9902 (IF=8.867)
18. B. D. Chen*, H.Zhang, N. Du, B. Zhang, Y. L. Wu, D. L. Shi and D. R. Yang,Magnetic-fluorescent nanohybrids of carbon nanotubes coated with Eu, Gdco-doped LaF₃ as a multimodal imaging probe, J.Colloid Interf. Sci., 2012, 367(1): 61-66. (IF=6.361)
19. B. D. Chen, H. Zhang, N. Du, D. S. Li,X. Y. Ma and D. R. Yang, Hybrid nanostructures of Au nanocrystals and ZnOnanorods: layer-by-layer assembly and tunable blue-shift band gapemission, Mater. Res. Bull. 2009, 44(4): 889-892. (IF=3.355)
20. B. D. Chen, C. X. Peng and Z.Cui, Facile ultrasonic synthesis of CoO/graphene nanohybrids as highperformance anode materials for lithium ion batteries, T. Nonferr.Metal. SOC. 2012, 22(10): 2517?2522 (IF=2.338)
21.B. D. Chen, Y. Y. Li, B. B. Zhang, B.Zhang, Y. L. Wu and D. L. Shi, Ultraconvenient synthesis of lanthanide basedmagnetic-fluorescent hydrogels for multimodal cellular imaging, Adv.Mater. Res. 2011, 266, 118-121 (EI)
22.B. D. Chen, T. Zhou, B. Zhang and A. H.Yao, Novel single walled carbon nanotube based magnetic-fluorescent nanohybridsas dual-modal MRI/optical imaging probes, Adv. Mater. Res. 2012,476-478, 1134-1137 (EI)
23. 陈炳地，单壁碳纳米管与稀土螯合物的磁性-荧光复合体系的制备及其多模成像应用研究，纳米科技，2012,9: 16-21.
24. 周雪，韩俊，吴一凡，陈炳地*，纳米技术在肿瘤靶向诊疗中的研究进展，转化医学电子杂志，2017，4（2）：10-16.
25. 韩俊，周雪，吴一凡，陈炳地*，崔征，时东陆，一种用于前列腺癌细胞体外检测生物导航纳米探针的制备，第二军医大学学报，2017，38（6）：715-719.
26. F. Zhang, D. Chen, Y. Wang, L. Zhang, W. Dong, J.Dai, C. Jin, X. Dong, Y. Sun, H. Zhao, K. Fan, H. Liu, B. Chen,H. Zou, W. Li. Lysosome-dependent necrosis specifically evoked in cancer cellsby gold nanorods. Nanomedicine, 2017, 12(13): 1575–1589 (IF=4.717)
27. X. Han, Z. Deng, Z. Yang, Y. Wang, H. Zhu, B.Chen, Z. Cui, RC. Ewing, D. Shi. Biomarkerless targeting andphotothermal cancer cell killing by surface-electrically-chargedsuperparamagnetic Fe3O4 composite nanoparticles. Nanoscale, 2017,9:1457-1465. (IF=6.97)
28. Z. H. Xue, T. Wang, B. D. Chen ,M. Tyler, S. Yu, Y. L. Tang*. Degradation of Tetracycline with BiFeO3Prepared by a Simple Hydrothermal Method. Materials, 2015,8: 6360-6378 (IF=3.872)
29. Y. L. Wang, S. Liang, B. D. Chen,F. Guo, S. Yu and Y. Tang, Synergistic removal of Pb(II), Cd(II) and humic acidby Fe3O4@mesoporous silica-graphene oxide composites, PLOS ONE 2013,8, e65634:1-8 (2013) (IF=2.776)
30. H. Lin*, K. Imakita, M. Fujii*, C. Sun*, B.D. Chen, T. Kanno, H. Sugimoto, New insights into the red luminescentbovine serum albumin conjugated gold nanospecies. Journal of Alloysand Compounds 2017, 691: 860-865 (2017) (IF=4.175)
31. 卢明智，乐文俊，崔少斌，孙兵妹，陈炳地，邵成伟. Mesothelin抗体修饰的纳米探针对人胰腺癌细胞BxPC3的体外靶向研究。 中华胰腺病杂志，2014，14（6）:389-391
32. N. Du, H. Zhang, B. D. Chen, X.Y. Ma, Z. H. Liu, J. B. Wu and D. R. Yang, Porous indium oxide nanotubes: layer-by-layerassembly on carbon-nanotube templates and application for room-temperature NH₃ gassensors, Adv. Mater. 2007, 19, 1641-1645 (IF=25.809)(ESI)
33. N. Du, H. Zhang, B. D. Chen, J.B. Wu, X. Y. Ma, Z. H. Liu Y. Q. Zhang, D. R. Yang, X. H. Huang and J. P. Tu,Porous Co₃O₄ nanotubes derived from Co₄(CO)₁₂ clusterson carbon nanotube templates: a highly efficient material for Li-batteryapplications, Adv. Mater. 2007, 19, 4505-4509 (IF=25.809)(ESI)
34. N. Du, H. Zhang, B. D. Chen, X.Y. Ma and D. R. Yang, One-pot, large-scale synthesis of SnO₂ nanotubesat room temperature, Chem. Commun. 2008, 3028-3030(IF=6.164)
35. B. B. Zhang, B. D. Chen, Y. L.Wang, F. F. Guo, Z. Q. Li and D. L. Shi, Preparation of highly fluorescentmagnetic nanoparticles for analytes-enrichment and subsequentbiodetection, J. Colloid Interf. Sci. 2011, 426-432(IF=6.361)
36. Y. L. Wang, F. Wang, B. D. Chen,H. Xu and D. L. Shi, Facile one-pot synthesis of yolk–shell superparamagneticnanocomposites via ternary phase separations, Chem. Commun. 2011,47, 10350-10352 (IF=6.164)
37. N. Du, H. Zhang, B. D. Chen, X.Ma and D. R. Yang, Ligand-free self-assembly of ceria nanocrystals intonanorods by oriented attachment at low temperature, J. Phys. Chem. C 2007,111, 12677-12680 (IF=4.309)
38. H. Zhang, N. Du, P. Wu, B. D. Chen andD. R. Yang, Functionalization of carbon nanotubes with magnetic nanoparticlesgeneral nonaqueous synthesis and magnetic properties, Nanotechnology 2008,19, 315604-315609 (IF=3.399)
39. N. Du, H. Zhang, B. D. Chen, J.Wu, D. Li and D. R. Yang, Low temperature chemical reaction synthesis ofsingle-crystalline Eu(OH)₃ nanorods and their thermalconversion to Eu₂O₃ nanorods, Nanotechnology 2007,18, 065605-065608 (IF=3.399)
40. C. X. Zhai, H. Zhang, N. Du, B. D. Chen,H. Huang, Y. Wu and D. R. Ynag, One-pot synthesis of biocompatible CdSe/CdSquantum dots and their applications as fluorescent biological labels, NanoscaleRes. Lett. 2010, 6, 31-35 (IF=3.159)
41. N. Du, H. Zhang, B. D. Chen, J.Wu and D. R. Yang, Low-temperature chenmical reaction route for ZnO basedsulfide coxial nanocables: general synthesis and gas sensor application, Nanotechnology 2007,18, 115619-115625 (IF=3.399)
42. T. F. Cui, H. Zhang, N. Du, B. D. Chen,D. Li and Deren Yang, Morphology and phase selective synthesis of EuF3nanostructures by polyelectrolyte assisted chemical reaction and their opticalproperties, Mater. Chem. Phys.2009, 115, 562-566 (IF=2.781)
43. H. Zhang, N. Du, B. D. Chen, T.F. Cui and D. R. Yang, Sub-2 nm SnO₂ nanocrystals: areduction/oxidation chemical reaction synthesis and optical properties, Mater.Res. Bull. 2008, 43, 3164-3170 (IF=3.355)
44. N. Du, H. Zhang, B. D. Chen, X.Ma, X. Huang, J. Tu And D. R. Yang, Synthesis of polycrystalline SnO2 nanotubeson carbon nanotube template for anode material of lithium-ion battery, Mater.Res. Bull. 2009, 44, 211-215 (IF=3.355)
45. N. Du, H. Zhang, J. Chen, J. Y. Sun, B.D. Chen and D. R. Yang, Metal oxide and sulfide hollow spheres:layer-by-layer synthesis and their application in lithium-ion battery, J.Phys. Chem. B 2008, 112, 14836-14842 (IF=2.923)
46. H. Zhang, N. Du, B. D. Chen, D.Li and D. R. Yang, Carbon Nanotube-ZnO Nanosphere Heterostructures:Low-Temperature Chemical Reaction Synthesis, Photoluminescence, and TheirApplication for Room Temperature NH₃ Gas Sensor, Sci.Adv. Mater. 2009, 1, 13-17 (IF=1.158)
47. B. B. Zhang, H. Jin, Y. Li, B. D. Chen,S. Liu and D. L. Shi, Bioinspired synthesis of gadolinium-based hybridnanoparticles as MRI blood pool contrast agents with high relaxivity, J.Mater. Chem. 2012, 22, 14494-14501 (IF=8.867)
48. F. Wang, Y. Tang, B. Zhang, B. D. Chen andY. L. Wang, Preparation of novel magnetic hollow mesoporous silica microspheresand their efficient adsorption, J. Colloid Interf. Sci. 2012,386, 129-134 (IF=6.361)