韩华 副教授
硕士招生类型：学术型
硕士招生专业：药学
博士招生类型：无
博士招生专业：无
所在院系：医学院
联系方式：hanhua@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

从海洋及陆地生物中快速发现结构新颖的活性化合物、先导化合物的结构优化、药理活性及作用机制研究，获得具有药用价值的生物新资源及药物先导化合物；药品、功能性食品新资源的筛选和创新天然药物的研究开发。
Study on the rapid discovery of novel biological active compounds from natural products in orgnisms, and optimizing lead compounds structure, screening their pharmacological activities and mechanism of action.Thus we could obtain drug lead compounds and new biological resources with medicinal value; developing drugs, functional food resources and innovative natural medicine research.
上海药学会海洋药物专业委员会委员
中国生物化学与分子生物学学会海洋生物化学与分子生物学分会委员会委员
等审稿人

主持和参加项目（近几年）：
1.2017年7月-2021年12月，横向课题：天然多糖类等产品对抑制细胞迁移的影响研究。30万
2.2012年1月-2016年12月，公益性行业（农业）科研专项项目（03）：淡水池塘工程化改造与环境修复技术研究与示范-池塘养殖环境调控机制研究与污染评价。107万，课题骨干(2/2)。
3.2011年1月-2013年12月，浙江省淡水养殖科技创新团队项目：养殖三角帆蚌对淡水湖泊的生态学效应。14.6万，主持人。
4.2009年1月-2010年12月，博士后基金项目Y：乌皱辐肛参中抗肿瘤活性成分及其结构修饰。主持人。
5.2008年1月-2010年12月，浙江省教育厅科研项目Y：海参中生物活性成分的研究。主持人。
已在国内、外刊物发表论文30余篇。其中，十多篇论文发表在国际著名的专业核心SCI刊物（如“Planta medica”、“Chemistry & biodiversity”等）上，论文多次被引用；获国家发明专利3项
发表论文（SCI）：
1.Kang JX, Kang YF, Han H* Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster Hesperus[J]. Marine Drugs, 2016, 14: 189-210.
2.Wang JJ, Han H (co-author), Chen XF, Yi YH, Sun HX. Cytotoxic and Apoptosis-inducing Activity of Triterpene Glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells[J]. Marine Drugs, 2014, 12: 4274-4290.
3.Wang XH, Zou ZR, Yi YH, Han H(corresponding author), Li L, Pan MX. Variegatusides: New Non-Sulphated Triterpene Glycosides from the Sea Cucumber Stichopus variegates Semper[J]. Marine Drugs, 2014, 12: 2004-2018.
4.La MP, Li C , Li,L , Sun P , Tang H , Liu BS ,Gong W , Han H , et al. New Bioactive Sulfated Alkenes from the Sea Cucumber Apostichopus japonicus[J]. Chemistry & Biodiversity, 2012 , 9( 6): 1166-1171.
5.Han H, Yi Y, Wang X, et al. Cytotoxic Active Triterpene Glycosides from Sea Cucumber Holothuria scabra[J]. Chinese Herbal Medicines, 2012, 4(3):183-188.
6.Han H, Yi Y, Li L, et al. Cytotoxic Active Triterpene Glycosides from sea cucumber Holothuria leucospilota[J]. Chinese Pharmaceutical Journal, 2012, 47(15): 1194-1198
7.Han H, Xu Q, Tang H, et al. Cytotoxic Holostane-Type Triterpene Glycosides from the Sea Cucumber Pentacta quadrangularis[J]. Planta medica, 2010, 76: 1900-1904.
8.Han H, Zhang W, Yi Y, et al. A novel Sulfated Holostane Glycoside from Sea Cucumber Holothuria leucospilota[J]. Chemistry & biodiversity, 2010, 7(7): 1764-1768.
9.Han H, Xu Q, Yi Y, et al. Two New Cytotoxic Disulfated Holostane Glycosides from the Sea Cucumber Pentacta quadrangularis[J].Chemistry & biodiversity, 2010, 7(1): 158-167.
Manege and participate in the project (recent years):1.2017.7-2021.12, Horizontal project: Effects of natural polysaccharides products on cell migration inhibition.300 thousand
2.2012.1-2016.12, Public welfare industry (Agriculture) scientific research special project (03): Research and demonstration of freshwater pond engineering transformation and environmental remediation technology - research on pond aquaculture environment regulation and pollution assessment.1.07 million，Main participant (2/2)
3.2011.1-2013.12, Innovative team project of freshwater aquaculture science and technology from Zhejiang Province: Ecological effects of cultured Hyriopsis cumingii on freshwater lakes. 146 thousand, Principal of the project.
4.2009.1-2010.12, Postdoctoral foundation project Y: Study on antitumor constituents from Actinopyga miliaris and modification of their structure.50 thousand, Principal of the project.
5.2008.1-2010.12, Scientific research project of Zhejiang Provincial Education Department Y: Study on bioactive constituents from the sea cucumbers. 30 thousand, Principal of the project.
Nearly 40 papers published. Among papers, about 20 papers published in the international famous professional Journals (SCI) (“Planta medica”、“Chemistry & biodiversity”etc), the papers have been cited many times; two national invention patents have been obtained
Papers (recent years, SCI):
1.Kang JX, Kang YF, Han H* Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster Hesperus[J]. Marine Drugs, 2016, 14: 189-210.
2.Wang JJ, Han H (co-author), Chen XF, Yi YH, Sun HX. Cytotoxic and Apoptosis-inducing Activity of Triterpene Glycosides from Holothuria scabra and Cucumaria frondosa against HepG2 cells[J]. Marine Drugs, 2014, 12: 4274-4290.
3.Wang XH, Zou ZR, Yi YH, Han H(corresponding author), Li L, Pan MX. Variegatusides: New Non-Sulphated Triterpene Glycosides from the Sea Cucumber Stichopus variegates Semper[J]. Marine Drugs, 2014, 12: 2004-2018.
4.La MP, Li C , Li,L , Sun P , Tang H , Liu BS ,Gong W , Han H , et al. New Bioactive Sulfated Alkenes from the Sea Cucumber Apostichopus japonicus[J]. Chemistry & Biodiversity, 2012 , 9( 6): 1166-1171.
5.Han H, Yi Y, Wang X, et al. Cytotoxic Active Triterpene Glycosides from Sea Cucumber Holothuria scabra[J]. Chinese Herbal Medicines, 2012, 4(3):183-188.
6.Han H, Yi Y, Li L, et al. Cytotoxic Active Triterpene Glycosides from sea cucumber Holothuria leucospilota[J]. Chinese Pharmaceutical Journal, 2012, 47(15): 1194-1198
7.Han H, Xu Q, Tang H, et al. Cytotoxic Holostane-Type Triterpene Glycosides from the Sea Cucumber Pentacta quadrangularis[J]. Planta medica, 2010, 76: 1900-1904.
8.Han H, Zhang W, Yi Y, et al. A novel Sulfated Holostane Glycoside from Sea Cucumber Holothuria leucospilota[J]. Chemistry & biodiversity, 2010, 7(7): 1764-1768.
9.Han H, Xu Q, Yi Y, et al. Two New Cytotoxic Disulfated Holostane Glycosides from the Sea Cucumber Pentacta quadrangularis[J].Chemistry & biodiversity, 2010, 7(1): 158-167.