吕立夏 教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：基础医学
所在院系：医学院
联系方式：lulixia@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

视网膜变性的分子机制研究及相关的细胞干预和基因治疗。Mechanistic study on retinal degeneration and its relevant cell therapy and gene therapy
ARVO 会员，中国生物化学与分子生物学学会会员会员
ARVO member，Chinese society of Biochemistry and molecular biology （CSBMB）member
课题：
1.国家重点研发计划（开发人胚胎干细胞向视网膜细胞分化和辅基的关键技术、种子细胞优化及组织工程化视网膜片构建（2017YFA**）2017-2021 （骨干）
2.上海市自然科学基金（17ZR**）GMFB引起视网膜变性的机制研究及干预 2017-2019
3.863课题骨干（2011AA020109）临床级干细胞分离培养、扩增诱导和保存运输等产业化关键技术研发 20万（2013-2015）
4.973课题骨干（2011CB965102）ES和iPS细胞向RPE分化，治疗视网膜变性眼病有效性和临床安全性间的差异及预编程机制（2011-2015)
5.课题骨干（2011DFB30010） 科技部国际合作干细胞治疗的基础与临床前研究及产品研发（2011-2013)
Publications （selected of first author, co-corresponding and corresponding paper）
1. Li Z, Wang J, Gao F, Zhang J, Tian H, Shi X, Lian C, Sun Y, Li W, Xu JY, Li P, Zhang J, Gao Z, Xu J, Wang F, Lu L, Xu GT.Human Adipose-derived Stem Cells Delay Retinal Degeneration in Royal College of Surgeons Rats through Anti-apoptotic and VEGF-mediated Neuroprotective Effects. Curr Mol Med. 2016;16(6):553-66.2016 Jun 6. [Epub ahead of print] PMID: ** (co-corresponding author)
2. Li P, Tian H, Li Z, Wang L, Gao F, Ou Q, Lian C, Li W, Jin C, Zhang J, Xu JY, Wang J, Zhang J, Wang F, Lu L, Xu GT. Subpopulations of bone marrow mesenchymal stem cells exhibit differential effects in delaying retinal degeneration. Curr Mol Med. Curr Mol Med. 2016;16(6):567-81.2016 Jun 6. [Epub ahead of print] PMID: ** (co-corresponding author)
3. Zeng Y, Yang K, Wang F, Zhou L, Hu Y, Tang M, Zhang S, Jin S, Zhang J, Wang J, Li W, Lu L, Xu GT.The glucagon like peptide 1 analogue, Exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression. Exp Eye Res. 2016 May 19. pii: S0014-4835(16)30105-1. doi: 10.1016/j.exer.2016.05.002. [Epub ahead of print] PMID: ** (co-corresponding author)
4. Wang J, Chen X, Wang F, Zhang J, Li P, Li Z, Xu J, Gao F, Jin C, Tian H, Zhang J, Li W, Lu L, Xu GT.OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Models。PLoS One. 2016 May 19;11(5):e**. doi: 10.1371/journal.pone.**. eCollection 2016.PMID: ** (co-corresponding author)
5. Gu H, Huang Z, Yin X, Zhang J, Gong L, Chen J, Rong K, Xu J, Lu L, Cui L. Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells.Exp Cell Res. 2015 Aug 10. pii: S0014-4827(15)30067-7. doi: 10.1016/j.yexcr.2015.08.005. [Epub ahead of print] (co-corresponding author) PMID: **
6. Zhuge CC, Xu JY, Zhang J, Li W, Li P, Li Z, Chen L, Liu X, Shang P, Xu H, Lu Y, Wang F, Lu L, Xu GT.Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1.Invest Ophthalmol Vis Sci. 2014 May 20;55(7):4628-38. doi: 10.1167/iovs.13-13732 (co-corresponding author).
7. Erythropoietin exerts neuroprotective function against glutamate neurotoxicity in experimental diabetic retina.Gu L, Xu H, Wang F, Xu G, Sinha D, Wang J, Xu J, Tian H, Gao F, Li W, Lu L, Zhang J, Xu GT.Invest Ophthalmol Vis Sci. 2014 Oct 21. pii: IOVS-14-14435. doi: 10.1167/iovs.14-14435. [Epub ahead of print] （Co-corresponding author）
8.Lu L,Neff F, Fischer DA, Henze C, Hirsch EC, Oertel WH, Schlegel J, HartmannA.Regional vulnerability of mesencephalic dopaminergic neurons prone todegenerate in Parkinson's disease: a post-mortem study in human control subjects. Neurobiol Dis. 2006 Aug;23(2):409-21.
9.Lu L, Neff F, Alvarez-Fischer D, Henze C, Xie Y, Oertel WH, Schlegel J,Hartmann A.Gene expression profiling of Lewy body-bearing neurons in Parkinson's disease.Lu L, Neff F, Alvarez-Fischer D, Henze C, Xie Y,Oertel WH, Schlegel J, Hartmann A. Exp Neurol. 2005 Sep;195(1):27-39.
10.Lu L,Neff F, Dun Z, Hemmer B, Oertel WH, Schlegel J, Hartmann A. Gene expression profiles derived from single cells in human postmortem brain. Brain Res Brain Res Protoc. 2004 Apr;13(1):18-25.
11. Li J, Shi X, Wang J, Jia S, Xu L, Xu Gt, Lu L. Comprehensive Experiment- Clinical Biochemistry: Determination of Blood Glucose and Triglycerides in Normal and Diabetic Rats. Biochemistry and Molecular Biology Education. 2015, 43(1):47-51.
12. Wang J, Gao FR, Li J, Zhang JP,Li SG, Xu GT, Xu L, Chen JJ,Lu L.The Usability of WeChat as a Mobile and Interactive Medium in Student-Centered Medical Teaching. Biochemistry and molecular biology education, 2017 Jun 5. doi: 10.1002/bmb.21065