导师姓名范国平性别男
职称教授
硕士生导师科学学位专业名称人体解剖学与组织胚胎学
博士生导师科学学位专业名称生物医学工程
所在院系医学院
联系办法通讯地址:上海市四平路1239号同济大学医学院邮编:200092手机:15901901050Email:guopingfan@gmail.com
研究方向/主要特长
主要任职
学习经历:1994-2001美国麻省理工学院WhiteheadInstitute博士后1990-1995美国凯斯西储大学神经科学系，获博士学位1986-1990中科院上海细胞所研究生1982-1986南京大学生物化学系，获学士学位工作经历:2009-同济大学医学院干细胞中心讲座教授2001-美国加州大学洛杉矶分校医学院人类遗传学系终身教授
科研业绩
发表论文(2000-present的部分代表性文章):1.Feng,J.,Zhou,Y.,Campbell,SL.,Le,T.,Li,E.,Sweatt,JD.,Silva,AJ.,andFan,G.(2010).Dnmt1andDnmt3amaintainDNAmethylationandregulatesynapticfunctioninadultforebrainneurons.NatureNeuroscienceV13,423-430.PMID:20228804(highlightedintheNewsandViewsinthesameissueofNatureNeuroscience).2.LiuB,TahkS,YeeK.,FanG,ShuaiK.2010.TheLigasePIAS1RestrictsNaturalRegulatoryT-cellDifferentiationbyEpigeneticRepression.ScienceV.330:521-5.3.LiaoJL,YuJ,HuangK,HuJ,DiemerT,MaZ,DvashT,YangXJ,TravisGH,WilliamsDS,BokD,FanG.2010.MolecularSignatureofPrimaryRetinalPigmentEpitheliumandStem-CellderivedRPEcells.HumMolGenet.19(21):4229-38.4.Hutnick,LK.,Huang,X.,Loo,T-C.,Ma,Z.,andFanG.(2010)RepressionofretrotransposalelementsinmouseembryonicstemcellsisprimarilymediatedbyDNAmethylatoin-independentmechanism.JournalofBiologicalChemistry285(27):21082-91(OnlineversionpublishedonApril19,2010)PMID:204043205.Dvash,T.,Lavon,N.,andFan,G.(2010).VariationsofXchromosomeinactivationinearlypassagesofhumanembryonicstemcells.PLoSOne5(6):e11330.6.ZhipengFan,TakayoshiYamaza,JaniceSLee,JianhuaYu,SonglinWang,Fan,G.,SongtaoShi,Cun-YuWang.2009.BCORregulatesmesenchymalstemcellfunctionbyepigeneticmechanisms:acasestudyofararehumangeneticdisorderOFCD.NatureCellBiology2009Aug;11(8):1002-9.Epub2009Jul5.PMID:195783717.Hutnick,L.,Golshi,P.,Namihira,M.,Xue,Z.,Matynia,A.,Yang,W.,Silva,A.Schweizer,F.,Fan,G.(2009).DNAhypomethylationrestrictedtothemurineforebraininducescorticaldegenerationandimpairspostnatalneuronalmaturation.HumanMolecularGenetics18(15):2875-28885.8.Fouse,S.Shen,Y,Pellegrini,M.,Cole,S.,Meissner,A.,VanNeste,L.,andJaenisch,R.,Fan,G.(2008).PromoterCpGmethylationcontributestoEScell-specificgeneexpressioninparallelwiththeOct4/Nanog,PcGcomplex,andhistoneH3K4/K27trimethylation.CellStemCell2:160-169.PMID:183714379.Shen,Y.,Matsuno,Y.,Fouse,SD.,Rao,N.,Root,S.,Xu,R-H,Pellegrini,M.,Riggs,A.D.andFan,G.(2008)X-inactivationinfemalehumanembryonicstemcellsisinanon-randompatternandpronetoepigeneticalternations.PNAS105(12):4709-14.Epub2008Mar13.[PMCID:PMC2290804].10.WuH,KimKJ,MehtaK,PaxiaS,SundstromA,AnantharamanT,KuraishyAI,DoanT,GhoshJ,PyleAD,ClarkA,LowryW,FanG,BaxterT,MishraB,SunY,TeitellMA.(2008)CopyNumberVariantAnalysisofHumanEmbryonicStemCells.StemCells.26(6):1484-9.PMID:1836910011.FengJ.,Fouse,S.,andFan,G.(2007).Epigeneticregulationofneuralgeneexpressionandneuronalfunction.PediatricResearch.(Review).May;61(5Pt2):58R-63R200712.Golshani,P.,Hutnick,L.,Schweizer,F.,Fan,G.(2007).ConditionalDnmt1deletionindorsalforebraindisruptsdevelopmentofsomatosensorybarrelcortexandthalamocorticallong-termpotentiation.ThalamusandRelatedSystem3(3):227-233.29.13.Shen,Y.,Chow,J.,Wang,Z.,Fan,G.(2006).AbnormalCpGislandmethylationoccursduringinvitrodifferentiationofhumanembryonicstemcells.HumanMolecularGenetics.15:2623-2635.PMID:1687069114.Fan,G.,Martinowich,K.,Chin,M.,He,F.,Fouse,S.,Hutnick,D.,Hattori,D.,Ge,W.,Shen,Y.,Wu,H.,tenHoeve,T.,Shuai,K.,andSun,Y.(2005).DNAmethylationcontrolsthetimingofastrogliogenesisthroughregulationofJAK-STATsignaling.Development132:3345-3356.PMID:1601451315.Martinowich,K.,Hatorri,D.,Wu,H.,Fouse,S.,He,F.,Hu,Y.,Fan,G*.,Sun,Y*.(*Correspondingauthors)(2003).DNAmethylation-relatedchromatinremodelinginactivity-dependentBDNFgeneregulation.Science302,890-893.PMID:1459318416.Sun,Y.,Nadal-Vicens,M.,Misono,S.,Lin,M.Z.,Hua,X.,Fan,G.,GreenbergME.(2001)Neurogeninpromotesneurogenesisandinhibitsglialdifferentiationbyindependentmechanisms.Cell.104,365–376.PMID:1123939417.Rio,M.,Fan,G.,Fekete,C.,Kelly,J.,Bates,B.,Lechan,RM.,Jaenisch,J.(2001)Conditionaldeletionofbrain-drivedneurotrophicfactorinthepostnatalbraincauseshyperactivityandobesity.MolecularEndocrinology.15,1748-1757.18.Fan,G.,Beard,C.,Chen,R.,Csankovszki,G.,Sun,Y.,Siniaia,M.,Bates,B.,Lee,P.,Trumpp,A.,Poon,C.,Wilson,C.,andJaenisch,R.(2001)DNAhypomethylationperturbsthefunctionandsurvivalofCNSneuronsinpostnatalanimals.J.Neurosci.21,788-797.PMID:1115706519.Fan,G.,Copray,S.,Wong,E.,Yan,Q.,Jones,K.,Walro,J.,Jaenisch,R.,andKucera,J.(2000)Formationofthecranialproprioceptivesystemrequiresmultipleneurotrophins.DevelopmentalDynamics.218,359-370.20.Fan,G.,Egles,C.,Sun,Y.,Minichiello,L.,Renger,J.,Klein,R.,Liu,G.,andJaenisch,R.(2000)KnockingtheNT4geneintotheBDNFlocusrescuesBDNFdeficientmiceandrevealsdistinctNT4andBDNFactivities.NatureNeurosci.3,350-357.