导师姓名戈宝学性别男
职称教授
硕士生导师科学学位专业名称免疫学
博士生导师科学学位专业名称生物医学工程
所在院系病原微生物与免疫学系
联系办法baoxue_ge@tongji.edu.cn,021-65989011
研究方向/主要特长免疫系统中的信号转导
主要任职
同济大学特聘教授，医学院院长助理，Microbes&Infection编委
科研业绩主要研究免疫系统中的信号转导，相关研究成果相继发表在《Science》、《NatureImmunology》、《CellHost&Microbe》等国际杂志上。承担项目：（1）科技部973项目（2012CB518700）（2012,1-2016,12）重要病原菌与宿主相互作用分子机制的研究（戈宝学，首席科学家）（2）科技部973项目（2011CB505000）（2011,1-2015,12）动物流感病毒变异、跨种间传播及致病的分子机制研究（戈宝学，学术骨干）（3）国家基金委重点项目（31030028）（2011,1-2015,12）固有免疫中信号转导机制及应用研究（戈宝学，项目负责人）近五年作为通讯作者发表的文章：1.LiuHP，YuMC，GeB*2011SupervillinassociateswithKIR2DL1andregulatesthecytotoxicityofnaturalkillercells.CellSignal.23(2):487-962.ZhuQY,LiuQ,ChenJX,MiaoCandGeB^*2010MicroRNA-101targetsMKP-1toregulatetheactivationofMAPkinasesinmacrophages.JImmunol.185(12):7435-423.KongL,ZhangH,QinL,ZhuangZH,SunL,YuMC,ZhuJ,ChenZ.WangZGandGeB*2009AnessentialroleforRIG-IinToll-likereceptor-mediatedphagocytosis.CellHost&Microbe6(2):150-161.(Citedby“Facultyof1000Biology,HighlightedbyNatureChina)4.HuangZ,YanDP,GeB*2008JNKregulatescellmigrationthroughpromotionoftyrosinephosphorylationofpaxillin.CellSignal.20(11):2002-12.5.YuMC,SuLL,ZouL,LiuY,WuN,KongL,ZhuangZH,SunL,LiuHP,HuJH,LiD,StromingerJL,ZangJW,PeiG,GeB.*2008Anessentialfunctionforβ-arrestin2intheinhibitorysignalingofNaturalKillercells.NatureImmunology,9(8):898-907.(CommentedinNatureImmunology,HighlightedbyNatureChina)6.KongL,GeB*.2008MyD88-independentactivationofanovelactin-Cdc42/RacpathwayisrequiredforToll-likereceptor-stimulatedphagocytosis.CellRes.18(7):745-55(CoverStory)7.SunL,YuMC,KongL,ZhuangZH,HuJH,GeB*.2008MolecularidentificationandfunctionalcharacterizationofaDrosophiladual-specificityphosphataseDMKP-4whichisinvolvedinPGN-inducedactivationoftheJNKpathway.CellSignal.20(7):1329-1337.8.HuJH,ChenT,ZhuangZH,KongL.,YuMC,LiuY,ZangJWandGeBX*.2007FeedbackcontrolofMKP-1expressionbyp38.CellSignal.19(2):393-400.9.ZhuangZH,ZhouY,YuMC,SilvermanN,GeB*.2006RegulationofDrosophilap38activationbyspecificMAP2kinaseandMAP3kinaseinresponsetodifferentstimuli.CellSignal.18(4):441-8.10.ZhuangZH,SunL,KongL,HuJH,YuMC,ReinachP,ZangJW,GeB*2006DrosophilaTAB2isrequiredfortheimmuneactivationofJNKandNF-kappaB.CellSignal.18(7):964-70.11.QinLH,LongL,ShiGJ1,WangZT,GeB*2006AndrographolideInhibitstheProductionofTNF-αandInterleukin-12inLipopolysaccharide-stimulatedMacrophages:RoleofMitogen-ActivatedProteinKinases.BiolPharmBull.29:220-4.