姓名：高绍荣
学位：博士
导师情况：博士生导师
研究领域：干细胞与体细胞重编程
研究方向：1、体细胞重编程的分子机制
2、利用疾病特异iPS细胞研究疾病发生机制
3、哺乳动物早期胚胎发育的分子机制
E-mail：gaoshaorong@nibs.ac.cn
联系电话：010-80728967
通讯地址：北京昌平中关村生命科学园科学园路7号，北京生命科学研究所

个人简介：
主要从事体细胞重编程分子机制与干细胞研究。与中科院动物研究所周琪实验室在2009年分别独立报道了iPS小鼠的研究成果，从而在世界上首次证明了iPS细胞的真正多能性，被美国时代周刊评为2009年世界十大医学突破之一。已经在包括NatureGenetics,CellStemCell,PNAS,StemCells等国际知名学术期刊发表论文50余篇。

代表性文章：
1.WangY,ZhengC,JiangY,ZhangJ,ChenJ,YaoC,ZhaoQ,LiuS,ChenK,DuJ,YangZ,GaoS.(2012)Geneticcorrectionofβ-thalassemiapatient-specificiPScellsanditsuseinimprovinghemoglobinproductioninirradiatedSCIDmice.CellResearchFeb7.doi:10.1038/cr.2012.23.[Epubaheadofprint]
2.LiY,LiuY,HeJ,WangF,LiuS,ZhangY,KouZ,JuZ,ZhengG,XuJ,YuanW,GaoS,ChengT.(2011)Long-termsurvivalofexogenousembryonicstemcellsinadultbonemarrow.CellResearch21(7):1148-51.(Co-correspondence)
3.YangP.,WangY.,ChenJ.,LiH.,KangL.,ZhangY.,ChenS.,ZhuB.,GaoS.(2011)RCOR2isasubunitoftheLSD1complexthatregulatesEScellpropertyandsubstitutesforSOX2inreprogrammingsomaticcellsintopluripotency.StemCells29(5):791-801.
4.WuT.,WangH.,HeJ.,KangL.,JiangY.,LiuJ.,ZhangY.,KouZ.,LiuL.,ZhangX.,GaoS.(2011)ReprogrammingoftrophoblaststemcellsintopluripotentstemcellsbyOct4.StemCells29(5):755-63.
5.KangL.,WuT.,TaoY.,YuanY.,HeJ.,ZhangY.,LuoT.,KouZ.,GaoS.(2011)Viablemiceproducedfrom3-factorinducedpluripotentstem(iPS)cellsthroughtetraploidcomplementation.CellResearch21(3):546-9.
6.WangS.,KouZ.,JingZ.,ZhangY.,GuoX.,DongM.,WilmutI.,GaoS.(2010)Proteomeofmouseoocytesatdifferentdevelopmentalstages.Proc.Natl.Acad.Sci.USA107(41):17639-44.
7.HuJ,WangF,YuanY,ZhuX,WangY,ZhangY,KouZ,WangS,GaoS.(2010)Thenovelimportin-alphafamilymemberKpna7,isrequiredfornormalfertilityandfecundityinthemouse.J.Biol.Chem.285(43):33113-22.
8.KouZ.,KangL.,YuanY.,TaoY.,ZhangY.,WuT.,HeJ.,WangJ.,LiuZ.,GaoS..(2010)Miceclonedfrominducedpluripotentstemcells(iPSCs).Biol.Reprod.83:238-243.
9.ZhaoQ,WangJ,ZhangY,KouZ,LiuSandGaoS.(2010)Generationofhistocompatibleandrogeneticembryonicstemcellsusingspermatogeniccels.StemCells2010;28(2):229-239.
10.KangL,WangJ,ZhangY,KouZ,GaoS(2009)iPScellscansupportfulltermdevelopmentoftetraploidblastocyst-complementedembryos.CellStemCell5(2):135-138.
11.ZhangM,WangF,KouZ,ZhangY,GaoS(2009)Defectivechromatinstructureinsomaticcellclonedembryos.J.Biol.Chem.284(37):24981-7.
12.DingJ,GuoY,LiuS,YanY,ChangG,KouZ,ZhangY,JiangY,HeF,GaoS(2009)ESCellsderivedfromsomaticclonedandfertilizedblastocystsarepost-transcriptionallyindistinguishable:amicroRNAandproteinprofilecomparison.Proteomics9(10):2711-21.
13.GuoXandGaoS(2009)LGNregulatesmeioticspindleorganization,anchoringandinvolvesincorticalpolarizationduringmouseoocytesmaturation.CellResearch19(7):838-48.
14.WangY,JiangY,LiuS,SunX,GaoS(2009)Generationofinducedpluripotentstemcellsfromhumanbeta-thalassemiafibroblastcells.CellResearch19(9):1120-3.
15.HuangS,WangJ,LiuS,LiY,HuJ,KouZ,ZhangY,SunX,GaoS(2009)Differentiationofreprogrammedsomaticcellsintofunctionalhematopoieticcells.Differentiation.78(2-3):151-8.
16.WangJ,ZhangM,ZhangY,KouZ,HanZ,ChenDY,SunQY,GaoS.(2010)ThehistonedemethylaseJMJD2Cisstage-specificallyexpressedinpreimplantationmouseembryosandisrequiredforembryonicdevelopment.Biol.Reprod.82(1):105-11.
17.YaoH,LiB,WangS,KouZ,ZhangY,GaoS,GouK.(2009)Genome-wideandgenespecificpaternaldemethylationinandrogeneticembryos.FrontBiosci.14:3884-91.
18.WangS,HuJ,GuoX,LiuJX,GaoS(2009)ADP-ribosylationfactor1regulatesasymmetriccelldivisioninfemalemeiosisinMouse.Biol.Reprod.80:555-562.
19.ChangG,LiuS,WangF,KouZ,ZhangY,ChenDandGaoS(2009)DifferentialmethylationstatusofimprintedgenesinnucleartransferderivedES(NT-ES)cells.Genomics93(2):112-9.
20.LvS,LiuS,HeW,DuanC,LiY,LiuZ,HaoT,LiJ,WangCandGaoS(2008)BioreactorcultivationenhancesNTEBformationanddifferentiationofNTEScellsintocardiomyocytes.CloningStemCells10(3):363-370.
21.WangF,KouZ,ZhangYandGaoS(2007)Dynamicreprogrammingofhistoneacetylationandmethylationinthefirstcellcycleofclonedmouseembryos.Biol.Reprod.77:1007-1016.
22.VassenaR,HanZ,GaoS,BaldwinDA,SchultzRM,LathamKE(2007)Toughbeginning:Alternationsinthetranscriptomeofclonedembryosduringfirsttwocellcycles.Dev.Biol.304:75-89.
23.LathamKE,GaoS,HanZ(2007)Somaticcellnucleiincloning:strangerstravelinginaforeignland.Adv.Exp.Med.Biol.591:14-29.
24.SungLY*,GaoS*,ShenH,YuH,SongY,SmithSL,ChangCC,KuoL,LianJ,TianXC,TuckDP,WeissmanSM,YangXandChengT(2006)Differentiatedcellsaremoreefficientthanadultstemcellsforcloningbysomaticcellnucleartransfer.Nat.Genet.38(11):1323-1328.(*Co-firstauthor)
25.GaoS(2006)Protocolsfornucleartransferinthemice.MethodsinMolecularBiology,325:25-33.(Correspondingauthor)
26.ChungYG,GaoSandLathamKE(2006)Optimizationofproceduresforcloningbysomaticcellnucleartransferinmice.MethodsinMolecularBiology,348:111-124.
27.MiyaraF,HanZ,GaoS,VassenaRandLathamKE(2006)Non-equivalenceofembryonicandsomaticcellnucleiaffectingspindleformationinearlyclonedembryos.Dev.Biol.289(1):206-217.
28.GaoS,HanZ,KiharaM,AdashiE,andLathamKE(2005)ProteaseinhibitorMG132incloning:noendtothenightmare.TrendsBiotechnol.23:66-68.
29.GaoS,ChungYG,ParseghianMH,KingGJ,AdashiEY,LathamKE.(2004)RapidH1linkerhistonetransitionsfollowingfertilizationorsomaticcellnucleartransfer:Evidenceforauniformdevelopmentprograminmice.Dev.Biol.266(1):62-75.
30.WuG,HaoL,HanZ,GaoS,LathamKE,deVillenaFPM,SapienzaC.(2005)MaternaltransmissionratiodistortionatthemouseOmlocusresultsfrommeioticdriveatthesecondmeioticdivision.Genetics170(1):327-334.
31.GaoS,WuG,HanZ,delaCasa-EsperonE,SapienzaC,andLathamKE(2005)RecapitulationoftheOvummutant(Om)phenotypeandlossofOmlocuspolarityinclonedmouseembryos.Biol.Reprod.72:487-491.
32.NolenLD,GaoS,HanZ,MannMR,ChungYG,OtteAP,BartolomeiMSandLathamKE(2005)Xchromosomereactivationandregulationinclonedembryos.Dev.Biol.279:525-540.
33.HanZ,ChungYG,GaoS,LathamKE(2005)Thematernalgenomegovernstheearliesteffectsoftheembryonicgenomeonembryophenotype.Biol.Reprod.72:612-618.
34.GaoSandLathamKE(2004)Maternalandenvironmentalfactorsinearlyclonedembryodevelopment.CytogeneticandGenomeResearch105:279-284.
35.GaoS,CzirrE,ChungYG,HanZandLathamKE(2004)Geneticvariationinoocytephenotyperevealedthroughparthenogenesisandcloning:Correlationwithdifferencesinpronuclearepigeneticmodification.Biol.Reprod.70:1162-1170.
36.GaoS,McGarryM,LathamKEandWilmutI(2003)Cloningofmicebynucleartransfer.CloningandStemCells.5:287-294.(Correspondingauthor)
37.GaoS,ChungYG,WilliamsJW,RileyJ,MoleyK,LathamKE.(2003)Somaticcell-likefeaturesofclonedmouseembryospreparedwithculturedmyoblastnuclei.Biol.Reprod.69:48-56.
38.GaoS,McGarryM,FerrierT,FletcherJ,HarknessL,DeSousaPandWilmutI.(2003)Effectofdonoroocytesandcultureconditionsondevelopmentofclonedmiceembryos.Mol.Reprod.Dev.66:126-133.
39.GasparriniB,GaoS,AinslieA,FletcherJ,McGarryM,RitchieWA,SpringbettAJ,OverstromEW,WilmutIandDeSousaP.(2003)Clonedmiceproducedfromembryonicstemcellkaroplastsandactivatedcytoplastspreparedbyinducedenucleation.Biol.Reprod.68:1259-1266.
40.GaoS,McGarryM,FerrierT,PallanteB,PriddleH,GasparriniB,FletcherJ,HarknessL,DeSousaP,McWhirJandWilmutI(2003)Effectofcellconfluenceonproductionofclonemiceusinganinbredembryonicstemcellline.Biol.Reprod.68:595-603.
41.GaoS,GasparriniB,McGarryM,FerrierT,FletcherJ,HarknessL,DeSousaPandWilmutI.(2002)Germinalvesiclematerialisessentialfornuclearremodelingafternucleartransfer.Biol.Reprod.67:928-934.