姚天明教授博士生导师
联系电话021-65983292Emailtmyao@tongji.edu.cn
专业方向无机化学办公室生物无机化学研究室
研究方向：生物无机化学，化学生物学
个人介绍
【简介】
教授，博士生导师。1994年毕业于南京大学化学系，获博士学位。1996年同济大学化学系副教授，无机化学教研室主任。1997年被评为上海市优秀高校青年教师，同济大学优秀青年教师。2002年被评为同济大学教授，2003年博士生导师。2006~2009年任同济大学化学系副主任，化学系本科教学指导委员会主任。1999年赴台湾中山大学访问研究，博士后研究员，从事有机合成无水无氧操作。2001~2003年获日本学术振兴会（JSPS）资助赴日本大阪药科大学从事关于tau蛋白结构及变化与AD之间关系的研究，外国人特别研究员。先后主持国家自然科学基金面上项目（3项）、上海市科委重点科技攻关项目（1项）。还获得：教育部留学回国人员基金、教育部高校骨干教师资助计划、教育部国家重点实验室高级访问学者专项、南京大学配位化学重点实验室开放基金、中科院上海有机化学所生命有机国家重点实验室开放基金、中山大学教育部生物无机开放实验室基金等多项基金资助。从事tau蛋白与核酸化学生物学方面的研究。期间曾获宝钢优秀教师奖、李国豪奖、同济大学教学名师奖、同济大学教学成果一等奖等。
【近年代表性论文】
●YaoJunliang,GaoXing,SunWenliang,FanXuezhong,ShiShuo*,YaoTianming*,ANaked-EyeOn–Off–OnMolecular“LightSwitch”BasedonaReversible“ConformationalSwitch”ofG-QuadruplexDNA,Inorg.Chem.,2012,51,12591.●WenliangSun,JunliangYao,TianmingYao*andShuoShi*,Label-freefluorescentDNAsensorforthedetection
ofsilverionsbasedonmolecularlightswitchRucomplexandunmodifiedquantumdots,Analyst,2013,138,421.
●ShuoShi*,Hai-LiangHuang,XingGao,Jun-LiangYao,Chun-YanLv,JuanZhao,Wen-LiangSun,Tian-MingYao*,Liang-NianJi，AcomparativestudyoftheinteractionoftwostructurallyanalogousrutheniumcomplexeswithhumantelomericG-quadruplexDNA,JournalofInorganicBiochemistry,2013,inpress.
●Dan-JingYang,ShuoShi*,Tian-MingYao*,Liang-NianJi,CooperativefoldingoftaupeptidebycoordinationofgroupIIBmetalcationsduringheparin-inducedaggregation,Biometals,2012,25,361-372
●WenliangSun,TianmingYao*andShuoShi*,AmolecularlightswitchRucomplexandquantumdotsforthelabel-free,aptamer-baseddetectionofthrombin,Analyst,2012,137,1550–1552.
●ShuoShi,*JuanZhao,XingGao,ChunyanLv,LiYang,JianHao,HailiangHuang,JunliangYao,WenliangSun,TianmingYao*andLiangnianJi,Molecular“lightswitch”forG-quadruplexDNA:cyclingtheswitchonandoff,DaltonTrans.,2012,41,5789-5793.
●Dan-JingYang,ShuoShi,Tian-MingYao*,andLiang-NianJi,TheImpactsofHg(II)TightlyBindingontheAlzheimer’sTauConstructR3:MisfoldingandAggregation,Bull.Chem.Soc.Jpn.,2011,84,1362-1367.
●WenliangSun,ShuoShiandTianmingYao*,Grapheneoxide–Rucomplexforlabel-freeassayofDNAsequenceandpotassiumionsviafluorescenceresonanceenergytransfer,Anal.Methods(RSC),2011,3,2472.
●Dan-JingYang,ShuoShi,Leng-FengZheng,Tian-MingYao*,andLiang-NianJi,Mercury(II)PromotestheinvitroAggregationofTauFragmentCorrespondingtotheSecondRepeatofMicrotubule-BindingDomain:CoordinationandConformationalTransition,Biopolymers,2010,931100.
●Lin-JieHan,ShuoShi,Leng-FengZheng,Dan-JingYang,Tian-MingYao*,Liang-NianJi,FlavonoidsInhibitHeparin-InducedAggregationoftheThirdRepeat(R3)ofMBDofAlzheimer'sTauProtein,Bull.Chem.Soc.Jpn.,2010,83,911.
●ShuoShi*,JuanZhao,XiaotingGeng,TianmingYao*,HailiangHuang,TianlinLiu,LengfengZheng,ZonghuiLi,DanjingYang,LiangnianJi,Molecular“lightswitch”forG-quadruplexesandi-motifofhumantelomericDNA:[Ru(phen)2(dppz)]2+,DaltonTrans.,2010,39,2490.
●ShuoShi*,XiaotingGeng,Juan.Zhao,TianmingYao*,ChaoranWang,DanjingYang,LengfengZheng,LiangnianJi,Interactionof[Ru(bpy)2(dppz)]2+withhumantelomericDNA:preferentialbindingtoG-quadruplexesoveri-motif,Biochimie,2010,92,370.
●ShiS,YaoTM,GengXT,JiangLF,LiuJ,YangQY,JiLN,Synthesis,characterization,andDNA-bindingofchiralcomplexesdelta-andlambda-[Ru(bpy)2(pyip)]2+,Chirality,2009,21,276
●ShuoShi*,TianXie,Tian-MingYao*,Chao-RanWang,Xiao-TingGeng,Dan-JingYang,Lin-JieHan,Liang-NianJi,Synthesis,characterization,DNA-bindingandDNA-photocleavagestudiesof[Ru(bpy)2(pmip)]2+and[Ru(phen)2(pmip)]2+(pmip=2-(2′-pyrimidyl)imidazo[4,5-f][1,10]phenanthroline,Polyhedron,2009,18,1355.
●ShuoShi,JieLiu,TianmingYao,XiaotingGeng,LingfengJiang,QingyuanYang,LinCheng,andLiangnianJi*,PromotingtheFormationandStabilizationofG-QuadruplexbyDinuclearRuIIComplexRu2(obip)L4,Inorg.Chem.,2008,47,2910
●Ling-FengJiang,Tian-MingYao*,Zhi-LiangZhu,Liang-NianJi,“ImpactsofCd(II)ontheconformationandself-aggregationofAlzheimer’staufragmentcorrespondingtothethirdrepeatofmicrotubule-bindingdomain”BiochimicaetBiophysicaActa-ProteinsandProteomics,2007，1774:1414-1421.
●KojiTomoo,Tian-MingYao*,ToshimasaIshida,etal."PossibleRoleofEachRepeatStructureoftheMicrotubule-BindingDomainoftheTauProteininInVitroAggregation",JournalofBiochemistry,2005,138:413-423.
●KatsuhikoMinoura,Tian-MingYao*,KojiTomoo,ToshimasaIshida,etal."Differentassociationalandconformationalbehaviorsbetweenthesecondandthirdrepeatfragmentsintaumicrotubule-bindingdomain",EuropeanJournalofBiochemistry,2004,271:545-552.
●ShukoHiraoka,Tian-MingYao,KojiTomoo,ToshimasaIshida,etal,"ConformationalTransitionStateIsResponsibleforAssemblyofMicrotuble-bindingDomainofTauProtein",BiochemBiophysResCommun.2004,315(3):659-663.
●Tian-MingYao*,KojiTomoo,ToshimasaIshida,etal."AggregationAnalysisoftheMicrotubuleBindingDomaininTauProteinbySpectroscopicMethods",JournalofBiochemistry,2003,134:91-99.
