石硕副教授硕士生导师
联系电话021-65982653-8546Emailshishuo@tongji.edu.cn
专业方向无机化学办公室化学馆546
研究方向：生物无机化学，化学生物学
个人介绍
石硕，男，博士，副教授，硕士生导师。2007年毕业于中山大学，获化学生物学专业理学博士学位（导师：中国科学院院士，计亮年教授），2012年美国加州理工学院（CaliforniaInstituteofTechnology,Caltech）VisitingAssociate（导师：美国国家科学院，美国艺术与科学院，美国哲学院三院院士：ProfessorJacquelineK.Barton）。2007年进入同济大学化学系工作至今，曾分别荣获同济大学青年岗位能手，同济大学优秀青年教师，同济大学骨干教师，同济大学青年教师讲课竞赛最佳教学内容、方法、手段奖，同济大学青年教师讲课竞赛最佳教学设计奖，同济大学本科生学科竞赛优秀指导老师，同济大学巴斯夫优秀科技论文奖指导老师等荣誉。研究兴趣集中于：（1）小分子化合物对生物大分子DNA,RNA,Protein的构象识别及功能调控；（2）金属抗癌药物的设计合成及抗肿瘤机制研究；（3）生物传感及检测。目前已发表SCI收录论文30余篇，IF>3.0（>20篇），H因子13，多篇研究论文被评为该领域的TOP10论文，并有多项已授权发明专利。受邀担任DaltonTrans,Biochimie,JournalofInorganicBiochemistry,DNAandCellBiology等10余种期刊审稿专家。
主持科研项目：
(1)靶向癌基因启动子区G-四链体的钌配合物的合成及抗肿瘤机制研究（国家自然科学基金）
(2)手性钌铱双核配合物对G-quadruplex和I-motif的选择性识别研究（国家自然科学基金）
(3)以DNAG-四链体为靶点的铂类药物的合成及对癌基因表达的调控研究（中央高校基本科研业务费）
(4)单双核钌配合物与DNA的键合性质研究（同济大学优秀青年人才）
教学：
主要承担“基础化学”、“生物无机化学”、“基础化学实验”的教学任务。
欢迎具有化学，生命科学，药学，医学，材料学等背景的同学报考本课题组的研究生，欢迎本科生到本实验室开展毕业论文及SITP项目工作。
发表论文:
n1.ShuoShi*,Hai-LiangHuang,XingGao,Jun-LiangYao,Chun-YanLv,JuanZhao,Wen-LiangSun,Tian-MingYao*,Liang-NianJi，AcomparativestudyoftheinteractionoftwostructurallyanalogousrutheniumcomplexeswithhumantelomericG-quadruplexDNA,JournalofInorganicBiochemistry,2013,121,19-27.
n2.WenliangSun,JunliangYao,TianmingYao*andShuoShi*,Label-freefluorescentDNAsensorforthedetectionofsilverionsbasedonmolecularlightswitchRucomplexandunmodifiedquantumdots,Analyst,2013,138,421-424.
n3.Jun-LiangYao,XingGao,WenliangSun,ShuoShi*andTian-MingYao*,[Ru(bpy)2dppz-idzo]2+:Acolorimetricmolecular“lightswitch”andpowerfulstabilizerforG-quadruplexDNA,DaltonTrans.,2013,inpress.
n4.ShuoShi,*JuanZhao,XingGao,ChunyanLv,LiYang,JianHao,HailiangHuang,JunliangYao,WenliangSun,TianmingYao,*andLiangnianJi,Molecular“lightswitch”forG-quadruplexesDNA:CyclingtheSwitchOnandOff,DaltonTrans,2012.,41,5789–5793.(Top20).
n5.ShuoShi,*ChunyanLv,XingGao,JuanZhao,JunliangYao,WenliangSun,HailingHuang,TianmingYao,*LiangnianJi,[Ru(bpy)2(bppp)]2+bindstwodifferentformsofthehumantelomericG-quadruplexstructure,InorganicChemistryCommunications,2012,24,212–215.
n6.YaoJunliang,GaoXing,SunWenliang,FanXuezhong,ShiShuo*,YaoTianming*,ANaked-EyeOn–Off–OnMolecular“LightSwitch”BasedonaReversible“ConformationalSwitch”ofG-QuadruplexDNA,Inorg.Chem.,2012,51,12591-12593.
n7.WenliangSun,TianmingYao*andShuoShi*,AmolecularlightswitchRucomplexandquantumdotsforthelabel-free,aptamer-baseddetectionofthrombin,Analyst,2012,137,1550–1552.
n8.Dan-JingYang,ShuoShi*,Tian-MingYao*,Liang-NianJi,CooperativefoldingoftaupeptidebycoordinationofgroupIIBmetalcationsduringheparin-inducedaggregation,Biometals,2012,25,361–372.
n9.ShuoShi,*JuanZhao,XiaotingGeng,TianmingYao,*HailiangHuang,TianlinLiu,LengfengZheng,ZonghuiLi,DanjingYang,andLiangnianJi,Molecular“lightswitch”forG-quadruplexesandi-motifofhumantelomericDNA:[Ru(phen)2(dppz)]2+,DaltonTrans,2010,39，2490-2493.(Top10)
n10.ShuoShi*,XiaotingGeng,Juan.Zhao,TianmingYao*,ChaoranWang,DanjingYang,LengfengZheng,LiangnianJi,Interactionof[Ru(bpy)2(dppz)]2+withhumantelomericDNA:preferentialbindingtoG-quadruplexesoveri-motif,Biochimie,2010,92,370-377.(Top10)
n11.ShuoShi*,Tian-mingYao,Xiao-tingGeng,Ling-fengJiang,JieLiu,Qing-yuanYang,andLiangnianJi,Synthesis,characterizationandDNA-bindingofchiralcomplexesD-andL-[Ru(bpy)2(pyip)]2+,Chirality,2009,21,276-283.(Top25)
n12.ShuoShi*,TianXie,Tian-MingYao,Chao-RanWang,Xiao-TingGeng,Dan-JingYang,Lin-JieHan,Liang-NianJi,Synthesis,characterization,DNA-bindingandDNA-photocleavagestudiesof[Ru(bpy)2(pmip)]2+and[Ru(phen)2(pmip)]2+(pmip=2-(2′-pyrimidyl)imidazo[4,5-f][1,10]phenanthroline,Polyhedron,2009,18,1355–1361.
n13.ShuoShi,JieLiu,TianmingYao,XiaotingGeng,LingfengJiang,QingyuanYang,LinCheng,andLiangnianJi,PromotingtheFormationandStabilizationofG-QuadruplexbyDinuclearRuIIComplexRu2(obip)L4,InorganicChemistry,2008,47(8),2910-2912.
n14.ShuoShi*,Tian-mingYao,Xiao-tingGeng,Liang-nianJi,1,2-Bis[amino(pyrimidin-2-yl)methylene]hydrazinedehydrate,ActaCrystallographicaSectionE,2008,o272.
n15.ShuoShi,Cai-PingTan,JieLiu,andLiang-NianJi,ConformationConversionandStabilizationofG-QuadruplexbyDinuclearRuIIComplex[(bpy)2Ru(obip)Ru(bpy)2]4+,Journalofbiomolecularstructuredynamics,2007,24,706.
n16.ShuoShi,JieLiu,JunLi,Kang-ChengZheng,Xiao-MeiHuang,Cai-PingTan,Lan-MeiChenandLiang-NianJi,Synthesis,characterizationandDNA-bindingofnovelchiralcomplexesD-andL-[Ru(bpy)2L]2+(L=o-mopipandp-mopip),JournalofInorganicBiochemistry,100(2006)385–395.
n17.ShuoShi,JieLiu,JunLi,KangC.Zheng,CaiP.Tan,LanM.ChenandLiangN.Ji,Electroniceffectofdifferentpositionsofthe–NO2groupontheDNA-intercalatorofchiralcomplexes[Ru(bpy)2L]2+(L=o-npip,m-npipandp-npip),J.Chem.Soc.,DaltonTrans.,2005,2038–2046.
n18.JuanZhao,ShuoShi,*TianmingYao*andZhongfeiTan,Aqua[4?-(4-chlorophenyl)-2,2?:6?,2??-terpyridine]nitratocopper(II)nitrate[4?-(4-chlorophenyl)-2,2?:6?,2??-terpyridine]dinitratocopper(II)monohydrate,ActaCryst.(2011).E67,m346.
n19.DuLiu,YananLiu,ChuanWang,ShuoShi,DongdongSun,FengGao,*QianlingZhang,*andJieLiu*,PolypyridylComplexesofRuthenium(II):StabilizationofG-quadruplexDNAandInhibitionofTelomeraseActivity,ChemPlusChem,2012,77,551-562.
n20.Dan-JingYang,ShuoShi,Tian-MingYao,*andLiang-NianJi,TheImpactsofHg(II)TightlyBindingontheAlzheimer’sTauConstructR3:MisfoldingandAggregation,Bull.Chem.Soc.Jpn.2011,84,1362-1367.
n21.WenliangSun,ShuoShiandTianmingYao*,Grapheneoxide–Rucomplexforlabel-freeassayofDNAsequenceandpotassiumionsviafluorescenceresonanceenergytransfer,Anal.Methods,2011,3,2472–2474.
n22.Dan-JingYang,ShuoShi,Leng-FengZheng,Tian-MingYao*,Liang-NianJi,Mercury(II)PromotestheInVitroAggregationofTauFragmentCorrespondingtotheSecondRepeatofMicrotubule-BindingDomain:CoordinationandConformationalTransition,Biopolymers,2010,93,1100-1107.
n23.Lin-JieHan,ShuoShi,Leng-FengZheng,Dan-JingYang,Tian-MingYao*andLiang-NianJi,FlavonoidsInhibitHeparin-InducedAggregationoftheThirdRepeat(R3)ofMicrotubule-BindingDomainofAlzheimer’sTauProtein,Bull.Chem.Soc.Jpn.2010,83,911–922.
n24.Lian-CaiXu,ShuoShi,JunLi,Si-YanLiao,Kang-ChengZhengandLiang-NianJi，AcombinedcomputationalandexperimentalstudyonDNA-photocleavageofRu(II)polypyridylcomplexes[Ru(bpy)2(L)]2+(L=pip,o-mopipandp-mopip),J.Chem.Soc.,DaltonTrans.,2008,291-301.
n25.Ya-NanLiu,ShuoShi,Wen-JieMei,Cai-PingTan,LanMeiChen,JieLiu,Wen-JieZhengandLiang-NianJi,Invitroandinvivoinvestigationsontheantiviralactivityofaseriesofmixed-valencerareearthborotungstateheteropolyblues,EuropeanJournalofMedicinalChemistry,2008,43,1963-1970.
n26.JieLiu,ShuoShi,Liang-NianJiandWen-JieMei,InvestigationonDNAbindingandphoto-cleavagepropertiesofwater-solubleporphyrinandmetalloporphyrins,TransitionMetalChemistry;2005,30,684-690.
n27.LiuJie,MeiWenjie,ShiShuo,TanCaiping,ChenJincan,ZhengKangcheng,JiLiangnian，Synthesis,AntitumorActivityandStructure-ActivityRelationshipsofaSeriesofRu(II)Complexes,JournalofInorganicBiochemistry,102(2008)193-202.
n28.Xu,Lian-Cai;Li,Jun;Shi,Shuo;Zheng,Kang-Cheng;Ji,Liang-Nian.DFT/TDDFTstudiesonelectronicabsorptionandemissionspectraof[Ru(bpy)2(L)]2+(L=pip,o-mopipandp-mopip)inaqueoussolution.THEOCHEM(2008),855(1-3),77-81.
n29.CaipingTan,JieLiu,LanmeiChen,ShuoShiandLiangnianJi,Synthesis,StructuralCharacteristics,DNABindingPropertiesandCytotoxicityStudiesofaSeriesofRu(III)Complexes.JournalofInorganicBiochemistry,102(2008)1644-1653.
n30.CaipingTan,JieLiu,HongLi,WenjieZheng,ShuoShi,LanmeiChenandLiangnianJi,DifferencesinStructure,PhysiologicalStability,Electrochemistry,Cytotoxicity,DNAandProteinBindingPropertiesbetweenTwoRu(III)Complexes,JournalofInorganicBiochemistry,102(2008)347-358.
n31.Lan-MeiChen,JieLiu,Jin-CanChen,Cai-PingTan,ShuoShi,Kang-ChengZhengandLiang-NianJi.Synthesis,characterization,DNA-bindingandspectralpropertiesofcomplexes[Ru(L)4(dppz)]2+(L=ImandMeIm),JournalofInorganicBiochemistry,102(2008)330-341.
n32.Lan-MeiChen,JieLiu,Jin-CanChen,ShuoShi,Cai-PingTan,Kang-ChengZhengandLiang-NianJi,ExperimentalandtheoreticalstudiesontheDNA-bindingandspectralpropertiesofwater-solublecomplex[Ru(MeIm)4(dpq)]2+,JournalofMolecularStructure,881,2008,156-166.
n33.JieLiu,Wen-JieMei,An-WuXu,Cai-PingTan,ShuoShi,Liang-NianJi,Synthesis,characterizationandantiviralactivityagainstinfluenzavirusofaseriesofnovelmanganese-substitutedrareearthborotungstatesheteropolyoxometalates,AntiviralResearch,2004,62,65-71.
